mGlu2 receptor - Gi1

GPCR CLASS (FAMILY)

Class C (Glutamate)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

2

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

June 21, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

L-glutamic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 I 657 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Q 669 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 669 - G.hns1 A 31 G.hns1.02
Polar TM3 R 656 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 656 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL3 F 756 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 F 756 - G.H5 L 348 G.H5.20
Van-der-waals ICL2 A 668 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 I 660 3x57 G.H5 L 353 G.H5.25
Hydrophobic ICL1 K 599 - G.H5 L 353 G.H5.25
Van-der-waals ICL1 K 599 - G.H5 L 353 G.H5.25
Hydrophobic ICL1 G 602 - G.H5 L 353 G.H5.25
Hydrophobic ICL1 K 599 - G.H5 G 352 G.H5.24
Van-der-waals ICL1 K 599 - G.H5 G 352 G.H5.24
Hydrophobic TM3 I 660 3x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 G 667 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 G 667 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 660 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 F 661 3x58 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 671 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 671 - G.H5 N 347 G.H5.19
Hydrophobic ICL3 F 756 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 F 756 - G.H5 F 354 G.H5.26
Polar ICL2 A 668 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 668 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 A 668 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 I 674 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 I 674 - G.H5 C 351 G.H5.23
Ionic ICL2 R 670 - G.H5 D 350 G.H5.22
Polar ICL2 R 670 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 670 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 670 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 A 668 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 A 668 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 668 - G.H5 I 343 G.H5.15
Hydrophobic TM4 P 676 4x29 G.H5 C 351 G.H5.23
Hydrophobic ICL1 K 599 - G.H5 F 354 G.H5.26
Van-der-waals ICL1 K 599 - G.H5 F 354 G.H5.26
Polar ICL1 A 600 - G.H5 L 353 G.H5.25
Hydrophobic ICL1 A 600 - G.H5 L 353 G.H5.25
Van-der-waals ICL1 A 600 - G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 664 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 664 - G.H5 I 343 G.H5.15
Hydrophobic TM3 I 660 3x57 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 660 3x57 G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 664 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 664 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 A 668 - G.S1 V 34 G.S1.02
Hydrophobic ICL1 S 601 - G.H5 L 353 G.H5.25