C5a1 receptor (c5ar1_mouse)

FAMILY

Class A (Rhodopsin) Peptide receptors Complement peptide receptors C5a1 receptor

GENE

C5ar1 (C5ar, C5r1)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor, C5a-R, C5aR, CD88

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
D
P
I
D
N
S
S
F
E
10
                   
I
N
Y
D
H
Y
G
T
M
D
20
                   
P
N
I
P
A
D
G
I
H
L
30
      TM1        
P
K
R
Q
P
G
D
V
A
A
40
                   
L
I
I
Y
S
V
V
F
L
V
50
                   
G
V
P
G
N
A
L
V
V
W
60
          ICL1  
V
T
A
F
E
A
R
R
A
V
70
TM2              
N
A
I
W
F
L
N
L
A
V
80
                   
A
D
L
L
S
C
L
A
L
P
90
                   
V
L
F
T
T
V
L
N
H
N
100
ECL1 TM3      
Y
W
Y
F
D
A
T
A
C
I
110
                   
V
L
P
S
L
I
L
L
N
M
120
                   
Y
A
S
I
L
L
L
A
T
I
130
                   
S
A
D
R
F
L
L
V
F
K
140
ICL2            
P
I
W
C
Q
K
V
R
G
T
150
TM4              
G
L
A
W
M
A
C
G
V
A
160
                   
W
V
L
A
L
L
L
T
I
P
170
          ECL2  
S
F
V
Y
R
E
A
Y
K
D
180
                   
F
Y
S
E
H
T
V
C
G
I
190
          TM5    
N
Y
G
G
G
S
F
P
K
E
200
                   
K
A
V
A
I
L
R
L
M
V
210
                   
G
F
V
L
P
L
L
T
L
N
220
                   
I
C
Y
T
F
L
L
L
R
T
230
      ICL3      
W
S
R
K
A
T
R
S
T
K
240
TM6              
T
L
K
V
V
M
A
V
V
I
250
                   
C
F
F
I
F
W
L
P
Y
Q
260
                   
V
T
G
V
M
I
A
W
L
P
270
ECL3 TM7      
P
S
S
P
T
L
K
R
V
E
280
                   
K
L
N
S
L
C
V
S
L
A
290
                   
Y
I
N
C
C
V
N
P
I
I
300
          H8      
Y
V
M
A
G
Q
G
F
H
G
310
                   
R
L
L
R
S
L
P
S
I
I
320
C-term        
R
N
A
L
S
E
D
S
V
G
330
                   
R
D
S
K
T
F
T
P
S
T
340
                   
T
D
T
S
T
R
K
S
Q
A
350
 
V

LINKS

DIAGRAMS

ICL1 A R R ICL1ECL1 N Y W Y F ECL1ICL2 P I W C Q K V R ICL2ECL2 E A Y K D F Y S E H T V C G I N Y G G G ECL2ICL3 K A T R S ICL3ECL3 P P S ECL3N-term M D P I D N S S F E I N Y D H Y G T M D P N I P A D G I H L P K R N-termC-term L P S I I R N A L S E D S V G R D S K T F T P S T T D T S T R K S Q A V C-term Q P G D V A A L I I Y S V V F L V G V P G N A L V V W V T A F E A V N A I W F L N L A V A D L L S C L A L P V L F T T V L N H D A T A C I V L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K G T G L A W M A C G V A W V L A L L L T I P S F V Y R S F P K E K A V A I L R L M V G F V L P L L T L N I C Y T F L L L R T W S R T K T L K V V M A V V I C F F I F W L P Y Q V T G V M I A W L S P T L K R V E K L N S L C V S L A Y I N C C V N P I I Y V M A G Q G F L R S H G R L
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

A N G P V G V L F V V S Y I I L A A V D 1 L N L A V A D L L S C L A L P V L F T T 2 T A L L L I S A Y M N L L I L S P L V I 3 A W M A C G V A W V L A L L L T I P S 4 Y C I N L T L L P L V F G V M L R L I A V 5 M A V V I C F F I F W L P Y Q V T G V M 6 I P N V C C N I Y A L S V C L S N L K 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

No structure models have been generated as experimental structures are available (see below).

STRUCTURES

Found 2 structure(s) - view all details on the Structures page

PDBs: 8HPT, 8HQC