C5a1 receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

Oct. 18, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

C5a - Agonist

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Ionic ICL3 R 233 - G.H5 D 341 G.H5.13
Polar ICL3 R 233 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 233 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 233 - G.H5 D 341 G.H5.13
Hydrophobic TM6 V 245 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 141 - G.H5 I 343 G.H5.15
Polar TM2 N 71 2x39 G.H5 G 350 G.H5.22
Van-der-waals TM2 N 71 2x39 G.H5 G 350 G.H5.22
Polar TM6 K 240 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 240 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 240 6x32 G.H5 Y 354 G.H5.26
Hydrophobic ICL3 K 234 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 T 236 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 I 142 - G.H5 I 343 G.H5.15
Hydrophobic TM5 L 226 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 L 226 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL3 T 236 - G.H5 A 345 G.H5.17
Van-der-waals ICL3 T 236 - G.H5 A 345 G.H5.17
Hydrophobic ICL2 I 142 - G.H5 T 340 G.H5.12
Polar ICL3 A 235 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 A 235 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 A 235 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 V 244 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 244 6x36 G.H5 L 353 G.H5.25
Van-der-waals ICL3 A 235 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 I 142 - G.H5 F 336 G.H5.08
Hydrophobic ICL2 K 146 - G.hns1 K 32 G.hns1.03
Polar TM6 T 241 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 241 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 241 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL3 A 235 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 T 236 - G.H5 Y 354 G.H5.26
Hydrophobic ICL2 I 142 - G.S3 L 195 G.S3.01
Ionic ICL3 R 233 - G.H5 D 337 G.H5.09
Polar ICL3 R 233 - G.H5 D 337 G.H5.09
Hydrophobic ICL2 P 141 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 141 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 S 238 - G.H5 Y 354 G.H5.26
Van-der-waals ICL3 S 238 - G.H5 Y 354 G.H5.26
Polar TM3 R 134 3x50 G.H5 C 351 G.H5.23