Structure information

C5a1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8HPT

SPECIES

Mus musculus

RESOLUTION

3.390

PREFERRED CHAIN

A

REFERENCE

HTTPS://DOI.ORG/10.1016/J.CELL.2023.09.020

PUBLICATION DATE

Oct. 18, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
C5a L92 2.60x60 TM2 hydrophobic
C5a I116 3.32x32 TM3 hydrophobic
C5a L117 3.33x33 TM3 hydrophobic
C5a R175 ECL2 polar (charge-assisted hydrogen bond)
C5a Y178 ECL2 Van der Waals
C5a R207 5.42x43 TM5 Van der Waals
C5a Y259 6.51x51 TM6 polar (hydrogen bond with backbone)
C5a Y259 6.51x51 TM6 Van der Waals
C5a T262 6.54x54 TM6 polar (hydrogen bond)
C5a T262 6.54x54 TM6 Van der Waals
C5a G263 6.55x55 TM6 polar (hydrogen bond with backbone)
C5a G263 6.55x55 TM6 Van der Waals
C5a I266 6.58x58 TM6 Van der Waals
C5a E280 7.32x31 TM7 Van der Waals
C5a N283 7.35x34 TM7 polar (hydrogen bond)
C5a N283 7.35x34 TM7 polar (hydrogen bond)
C5a V287 7.39x38 TM7 hydrophobic
C5a V287 7.39x38 TM7 Van der Waals

Ligands

C5a

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Residue Diagrams

A N G P V G V L F V V S Y I I L A A V D 1 L N L A V A D L L S C L A L P V L F T T 2 T A L L L I S A Y M N L L I L S P L V I 3 A W M A C G V A W V L A L L L T I P S 4 Y C I N L T L L P L V F G V M L R L I A V 5 M A V V I C F F I F W L P Y Q V T G V M 6 I P N V C C N I Y A L S V C L S N L K 7
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ICL1 A R R ICL1ECL1 N Y W Y F ECL1ICL2 P I W C Q K V R ICL2ECL2 E A Y K D F Y S E H T V C G I N Y G G G ECL2ICL3 K A T R S ICL3ECL3 P P S ECL3N-term M D P I D N S S F E I N Y D H Y G T M D P N I P A D G I H L P K R N-termC-term L P S I I R N A L S E D S V G R D S K T F T P S T T D T S T R K S Q A V C-term Q P G D V A A L I I Y S V V F L V G V P G N A L V V W V T A F E A V N A I W F L N L A V A D L L S C L A L P V L F T T V L N H D A T A C I V L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K G T G L A W M A C G V A W V L A L L L T I P S F V Y R S F P K E K A V A I L R L M V G F V L P L L T L N I C Y T F L L L R T W S R T K T L K V V M A V V I C F F I F W L P Y Q V T G V M I A W L S P T L K R V E K L N S L C V S L A Y I N C C V N P I I Y V M A G Q G F L R S H G R L
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Residue Table


GPCRdb(A)
GPCRdb(A)
C5a1 receptor
TM2
2x60 2.60x60 L92
TM3
3x32 3.32x32 I116
3x33 3.33x33 L117
TM5
5x43 5.42x43 R207
TM6
6x51 6.51x51 Y259
6x54 6.54x54 T262
6x55 6.55x55 G263
6x58 6.58x58 I266
TM7
7x31 7.32x31 E280
7x34 7.35x34 N283
7x38 7.39x38 V287