PTH2 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

Aug. 18, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

TIP39 - Agonist gtoplig

PHYSIOLOGICAL LIGANDS

PTHrP-(1-36), PTH, PTHrP, PTHrP-(1-34) (human), TIP39



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 T 347 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 343 5x64 G.H5 L 388 G.H5.20
Polar TM6 S 364 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 364 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 364 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 344 5x65 G.H5 L 394 G.H5.26
Polar TM5 K 343 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 343 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 343 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 264 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 264 3x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 269 - G.S3 F 219 G.S3.03
Van-der-waals ICL2 F 269 - G.S3 F 219 G.S3.03
Aromatic TM2 R 176 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 176 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 176 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 261 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 261 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 264 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 264 3x57 G.H5 Y 391 G.H5.23
Aromatic ICL2 F 269 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 269 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 269 - G.H5 F 376 G.H5.08
Hydrophobic TM5 L 340 5x61 G.H5 L 394 G.H5.26
Van-der-waals TM7 C 416 7x60 G.H5 E 392 G.H5.24
Aromatic ICL2 F 269 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 269 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 269 - G.S1 H 41 G.S1.02
Polar TM5 K 343 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 343 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 343 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 T 347 5x68 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 T 347 5x68 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 A 268 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 269 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 269 - G.S3 V 217 G.S3.01
Polar H8 G 418 8x48 G.H5 E 392 G.H5.24
Polar TM6 K 360 6x37 G.H5 E 392 G.H5.24
Hydrophobic TM7 Y 413 7x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 A 268 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 A 268 - G.H5 R 380 G.H5.12
Hydrophobic TM5 L 340 5x61 G.H5 L 388 G.H5.20
Polar TM3 I 265 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 265 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 265 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 343 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 343 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM6 L 368 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 265 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM3 L 261 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM2 H 180 2x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 269 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 269 - G.H5 I 383 G.H5.15
Ionic TM5 E 346 5x67 G.H5 R 385 G.H5.17
Polar TM5 E 346 5x67 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 340 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM3 Y 260 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 269 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 269 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 269 - G.H5 C 379 G.H5.11
Van-der-waals ICL2 F 269 - G.H5 C 379 G.H5.11
Hydrophobic TM6 K 360 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 K 360 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM5 K 343 5x64 G.H5 L 394 G.H5.26
Polar TM3 L 264 3x57 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 264 3x57 G.H5 Q 384 G.H5.16
Polar TM2 R 176 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 176 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM6 K 360 6x37 G.H5 L 394 G.H5.26