PTH2 receptor (pth2r_human)
FAMILY
Class B1 (Secretin) Peptide receptors Parathyroid hormone receptors PTH2 receptor
GENE
PTH2R (PTHR2)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Parathyroid hormone 2 receptor, PTH2 receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
G
|
L
|
G
|
A
|
S
|
L
|
H
|
V
|
10 |
W
|
G
|
W
|
L
|
M
|
L
|
G
|
S
|
C
|
L
|
20 |
L
|
A
|
R
|
A
|
Q
|
L
|
D
|
S
|
D
|
G
|
30 |
T
|
I
|
T
|
I
|
E
|
E
|
Q
|
I
|
V
|
L
|
40 |
V
|
L
|
K
|
A
|
K
|
V
|
Q
|
C
|
E
|
L
|
50 |
N
|
I
|
T
|
A
|
Q
|
L
|
Q
|
E
|
G
|
E
|
60 |
G
|
N
|
C
|
F
|
P
|
E
|
W
|
D
|
G
|
L
|
70 |
I
|
C
|
W
|
P
|
R
|
G
|
T
|
V
|
G
|
K
|
80 |
I
|
S
|
A
|
V
|
P
|
C
|
P
|
P
|
Y
|
I
|
90 |
Y
|
D
|
F
|
N
|
H
|
K
|
G
|
V
|
A
|
F
|
100 |
R
|
H
|
C
|
N
|
P
|
N
|
G
|
T
|
W
|
D
|
110 |
F
|
M
|
H
|
S
|
L
|
N
|
K
|
T
|
W
|
A
|
120 |
N
|
Y
|
S
|
D
|
C
|
L
|
R
|
F
|
L
|
Q
|
130 |
TM1 | |||||||||
P
|
D
|
I
|
S
|
I
|
G
|
K
|
Q
|
E
|
F
|
140 |
F
|
E
|
R
|
L
|
Y
|
V
|
M
|
Y
|
T
|
V
|
150 |
G
|
Y
|
S
|
I
|
S
|
F
|
G
|
S
|
L
|
A
|
160 |
V
|
A
|
I
|
L
|
I
|
I
|
G
|
Y
|
F
|
R
|
170 |
ICL1 | TM2 | ||||||||
R
|
L
|
H
|
C
|
T
|
R
|
N
|
Y
|
I
|
H
|
180 |
M
|
H
|
L
|
F
|
V
|
S
|
F
|
M
|
L
|
R
|
190 |
A
|
T
|
S
|
I
|
F
|
V
|
K
|
D
|
R
|
V
|
200 |
ECL1 | |||||||||
V
|
H
|
A
|
H
|
I
|
G
|
V
|
K
|
E
|
L
|
210 |
E
|
S
|
L
|
I
|
M
|
Q
|
D
|
D
|
P
|
Q
|
220 |
N
|
S
|
I
|
E
|
A
|
T
|
S
|
V
|
D
|
K
|
230 |
TM3 | |||||||||
S
|
Q
|
Y
|
I
|
G
|
C
|
K
|
I
|
A
|
V
|
240 |
V
|
M
|
F
|
I
|
Y
|
F
|
L
|
A
|
T
|
N
|
250 |
Y
|
Y
|
W
|
I
|
L
|
V
|
E
|
G
|
L
|
Y
|
260 |
L
|
H
|
N
|
L
|
I
|
F
|
V
|
A
|
F
|
F
|
270 |
ICL2 | TM4 | ||||||||
S
|
D
|
T
|
K
|
Y
|
L
|
W
|
G
|
F
|
I
|
280 |
L
|
I
|
G
|
W
|
G
|
F
|
P
|
A
|
A
|
F
|
290 |
V
|
A
|
A
|
W
|
A
|
V
|
A
|
R
|
A
|
T
|
300 |
ECL2 | |||||||||
L
|
A
|
D
|
A
|
R
|
C
|
W
|
E
|
L
|
S
|
310 |
TM5 | |||||||||
A
|
G
|
D
|
I
|
K
|
W
|
I
|
Y
|
Q
|
A
|
320 |
P
|
I
|
L
|
A
|
A
|
I
|
G
|
L
|
N
|
F
|
330 |
I
|
L
|
F
|
L
|
N
|
T
|
V
|
R
|
V
|
L
|
340 |
A
|
T
|
K
|
I
|
W
|
E
|
T
|
N
|
A
|
V
|
350 |
ICL3 | TM6 | ||||||||
G
|
H
|
D
|
T
|
R
|
K
|
Q
|
Y
|
R
|
K
|
360 |
L
|
A
|
K
|
S
|
T
|
L
|
V
|
L
|
V
|
L
|
370 |
V
|
F
|
G
|
V
|
H
|
Y
|
I
|
V
|
F
|
V
|
380 |
ECL3 | TM7 | ||||||||
C
|
L
|
P
|
H
|
S
|
F
|
T
|
G
|
L
|
G
|
390 |
W
|
E
|
I
|
R
|
M
|
H
|
C
|
E
|
L
|
F
|
400 |
F
|
N
|
S
|
F
|
Q
|
G
|
F
|
F
|
V
|
S
|
410 |
H8 | |||||||||
I
|
I
|
Y
|
C
|
Y
|
C
|
N
|
G
|
E
|
V
|
420 |
Q
|
A
|
E
|
V
|
K
|
K
|
M
|
W
|
S
|
R
|
430 |
C-term | |||||||||
W
|
N
|
L
|
S
|
V
|
D
|
W
|
K
|
R
|
T
|
440 |
P
|
P
|
C
|
G
|
S
|
R
|
R
|
C
|
G
|
S
|
450 |
V
|
L
|
T
|
T
|
V
|
T
|
H
|
S
|
T
|
S
|
460 |
S
|
Q
|
S
|
Q
|
V
|
A
|
A
|
S
|
T
|
R
|
470 |
M
|
V
|
L
|
I
|
S
|
G
|
K
|
A
|
A
|
K
|
480 |
I
|
A
|
S
|
R
|
Q
|
P
|
D
|
S
|
H
|
I
|
490 |
T
|
L
|
P
|
G
|
Y
|
V
|
W
|
S
|
N
|
S
|
500 |
E
|
Q
|
D
|
C
|
L
|
P
|
H
|
S
|
F
|
H
|
510 |
E
|
E
|
T
|
K
|
E
|
D
|
S
|
G
|
R
|
Q
|
520 |
G
|
D
|
D
|
I
|
L
|
M
|
E
|
K
|
P
|
S
|
530 |
R
|
P
|
M
|
E
|
S
|
N
|
P
|
D
|
T
|
E
|
540 |
G
|
C
|
Q
|
G
|
E
|
T
|
E
|
D
|
V
|
L
|
550 |
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PTHrP-(1-36), PTH, PTHrP, PTHrP-(1-34) (human), TIP39
STRUCTURE MODELS
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 7F16