β3-adrenoceptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Canis lupus familiaris

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7DH5

RESOLUTION

3.2 Å

REFERENCE

10.1016/J.MOLCEL.2021.06.024

PUBLICATION DATE

Aug. 4, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

47 interactions (Click to see)

LIGANDS

mirabegron - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 R 244 - G.H4 L 336 G.H4.16
Aromatic TM3 R 135 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 135 3x50 G.H5 Y 381 G.H5.23
Van-der-waals TM3 R 135 3x50 G.H5 Y 381 G.H5.23
Polar TM3 T 140 3x55 G.H5 R 370 G.H5.12
Hydrophobic TM3 A 138 3x53 G.H5 Y 381 G.H5.23
Van-der-waals TM3 A 138 3x53 G.H5 Y 381 G.H5.23
Polar TM3 V 139 3x54 G.H5 Q 374 G.H5.16
Van-der-waals TM3 V 139 3x54 G.H5 Q 374 G.H5.16
Hydrophobic ICL2 P 142 34x50 G.H5 I 373 G.H5.15
Van-der-waals ICL2 P 142 34x50 G.H5 I 373 G.H5.15
Polar TM3 A 138 3x53 G.H5 H 377 G.H5.19
Hydrophobic TM3 A 138 3x53 G.H5 H 377 G.H5.19
Van-der-waals TM3 A 138 3x53 G.H5 H 377 G.H5.19
Hydrophobic ICL2 L 143 34x51 G.H5 I 373 G.H5.15
Van-der-waals ICL2 L 143 34x51 G.H5 I 373 G.H5.15
Hydrophobic ICL2 A 147 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM5 L 238 5x72 G.H5 L 384 G.H5.26
Hydrophobic TM6 R 289 6x32 G.H5 E 382 G.H5.24
Hydrophobic TM5 L 238 5x72 G.h4s6 Y 348 G.h4s6.20
Van-der-waals TM5 L 238 5x72 G.h4s6 Y 348 G.h4s6.20
Hydrophobic ICL2 L 143 34x51 G.H5 C 369 G.H5.11
Hydrophobic TM3 V 139 3x54 G.H5 H 377 G.H5.19
Hydrophobic ICL3 F 245 - G.H4 R 337 G.H4.17
Van-der-waals ICL3 F 245 - G.H4 R 337 G.H4.17
Hydrophobic ICL2 P 142 34x50 G.H5 H 377 G.H5.19
Ionic TM5 E 241 5x75 G.H5 R 375 G.H5.17
Hydrophobic TM3 V 139 3x54 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 L 143 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL3 F 245 - G.H4 L 336 G.H4.16
Hydrophobic ICL2 P 142 34x50 G.H5 R 370 G.H5.12
Van-der-waals ICL2 P 142 34x50 G.H5 R 370 G.H5.12
Polar TM5 Q 234 5x68 G.H5 Q 374 G.H5.16
Hydrophobic TM5 Q 234 5x68 G.H5 Q 374 G.H5.16
Van-der-waals TM5 Q 234 5x68 G.H5 Q 374 G.H5.16
Hydrophobic TM6 T 293 6x36 G.H5 L 383 G.H5.25
Hydrophobic TM6 L 294 6x37 G.H5 L 383 G.H5.25
Van-der-waals TM6 L 294 6x37 G.H5 L 383 G.H5.25
Hydrophobic TM5 Q 234 5x68 G.H5 L 384 G.H5.26
Hydrophobic TM6 R 289 6x32 G.H5 L 384 G.H5.26
Hydrophobic ICL2 P 142 34x50 G.H5 Q 374 G.H5.16
Van-der-waals ICL2 P 142 34x50 G.H5 Q 374 G.H5.16
Hydrophobic ICL2 Y 145 34x53 G.H5 H 377 G.H5.19
Hydrophobic TM5 A 231 5x65 G.H5 L 383 G.H5.25
Van-der-waals TM5 A 231 5x65 G.H5 L 383 G.H5.25
Hydrophobic TM5 V 227 5x61 G.H5 L 383 G.H5.25
Van-der-waals TM5 V 227 5x61 G.H5 L 383 G.H5.25
Polar TM5 Q 234 5x68 G.H5 R 375 G.H5.17
Hydrophobic TM5 Q 234 5x68 G.H5 R 375 G.H5.17
Van-der-waals TM5 Q 234 5x68 G.H5 R 375 G.H5.17
Polar TM6 T 293 6x36 G.H5 E 382 G.H5.24
Van-der-waals TM6 T 293 6x36 G.H5 E 382 G.H5.24
Hydrophobic ICL2 L 143 34x51 G.S3 F 219 G.S3.03
Hydrophobic ICL2 L 143 34x51 G.H5 F 366 G.H5.08
Van-der-waals ICL2 L 143 34x51 G.H5 F 366 G.H5.08
Hydrophobic ICL3 F 245 - G.H4 D 333 G.H4.13
Hydrophobic ICL2 L 143 34x51 G.H5 R 370 G.H5.12
Van-der-waals ICL2 L 143 34x51 G.H5 R 370 G.H5.12
Polar ICL2 R 144 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 144 34x52 G.s2s3 D 215 G.s2s3.01
Polar TM3 N 141 3x56 G.H5 R 370 G.H5.12
Polar TM5 Q 234 5x68 G.H5 D 371 G.H5.13
Van-der-waals TM5 Q 234 5x68 G.H5 D 371 G.H5.13
Hydrophobic TM3 V 139 3x54 G.H5 L 378 G.H5.20
Van-der-waals TM3 V 139 3x54 G.H5 L 378 G.H5.20
Hydrophobic ICL2 L 143 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 143 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 R 144 34x52 G.S3 V 217 G.S3.01
Hydrophobic TM5 Q 234 5x68 G.H5 L 378 G.H5.20
Hydrophobic TM5 A 231 5x65 G.H5 L 378 G.H5.20
Hydrophobic TM6 A 290 6x33 G.H5 L 383 G.H5.25
Van-der-waals TM6 A 290 6x33 G.H5 L 383 G.H5.25