FZD6 - Gs

GPCR CLASS (FAMILY)

Class F (Frizzled)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

Jan. 17, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

Wnt-5a, Wnt-4, Wnt-3a



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM6 L 410 6x26 G.H5 L 393 G.H5.25
Polar ICL2 C 317 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 C 317 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 C 317 - G.H5 Y 391 G.H5.23
Hydrophobic TM5 V 396 5x72 G.H5 L 388 G.H5.20
Hydrophobic TM6 K 409 6x25 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 409 6x25 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 409 6x25 G.H5 L 394 G.H5.26
Polar ICL3 Q 407 - G.H5 L 394 G.H5.26
Van-der-waals ICL3 Q 407 - G.H5 L 394 G.H5.26
Ionic ICL1 R 226 - G.H5 E 392 G.H5.24
Polar ICL1 R 226 - G.H5 E 392 G.H5.24
Polar TM6 K 409 6x25 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 409 6x25 G.H5 E 392 G.H5.24
Hydrophobic TM6 F 413 6x29 G.H5 L 393 G.H5.25
Hydrophobic ICL2 K 314 - G.H5 Y 391 G.H5.23