S1P1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7EW7

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41422-021-00566-X

PUBLICATION DATE

Sept. 29, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

37 interactions (Click to see)

LIGANDS

SEW2871 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

sphingosylphosphorylcholine, sphingosine 1-phosphate, dihydrosphingosine 1-phosphate



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 151 - G.S1 V 34 G.S1.02
Ionic ICL3 K 239 - G.H5 D 341 G.H5.13
Polar ICL3 K 239 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 K 239 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 M 149 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 M 149 - G.H5 I 343 G.H5.15
Hydrophobic TM3 M 146 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 M 146 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 M 149 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 K 239 - G.H5 F 334 G.H5.06
Hydrophobic TM3 M 146 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 M 146 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL3 R 238 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 R 238 - G.H5 F 334 G.H5.06
Ionic TM6 K 250 6x29 G.H5 D 341 G.H5.13
Polar TM6 K 250 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 K 250 6x29 G.H5 D 341 G.H5.13
Hydrophobic ICL2 M 149 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 M 149 - G.H5 N 347 G.H5.19
Hydrophobic TM5 I 224 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL3 T 236 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 238 - G.H5 K 330 G.H5.02
Hydrophobic TM5 R 231 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 231 5x68 G.H5 I 344 G.H5.16
Ionic TM2 R 78 2x37 G.H5 D 350 G.H5.22
Polar TM2 R 78 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 78 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 78 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM3 M 146 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL3 T 236 - G.H5 D 337 G.H5.09
Hydrophobic ICL2 M 149 - G.H5 T 340 G.H5.12
Hydrophobic ICL3 F 237 - G.H5 Q 333 G.H5.05
Hydrophobic ICL2 L 151 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 L 254 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 254 6x33 G.H5 L 353 G.H5.25
Polar TM3 R 142 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 142 3x50 G.H5 C 351 G.H5.23
Polar ICL2 N 153 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 N 153 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 N 153 - G.H5 D 350 G.H5.22
Hydrophobic TM6 K 250 6x29 G.H5 L 348 G.H5.20
Hydrophobic TM3 M 146 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 M 146 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 151 - G.H5 I 343 G.H5.15
Hydrophobic ICL3 L 235 - G.H5 T 340 G.H5.12
Hydrophobic TM5 S 232 5x69 G.H5 I 344 G.H5.16
Polar ICL3 R 238 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 R 238 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 R 238 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 L 235 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 L 235 - G.H5 D 337 G.H5.09
Hydrophobic TM2 M 80 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 M 80 2x39 G.H5 C 351 G.H5.23
Hydrophobic H8 N 315 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 142 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 K 239 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 K 239 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 V 228 5x65 G.H5 L 348 G.H5.20