NK1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7P02

RESOLUTION

2.9 Å

REFERENCE

10.1126/SCIADV.ABK2872

PUBLICATION DATE

Dec. 15, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

77 interactions (Click to see)

LIGANDS

substance P - Agonist pubchem gtoplig chembl_ligand gtoplig gtoplig

PHYSIOLOGICAL LIGANDS

neurokinin A, neuropeptide-γ, substance P, hemokinin 1, neuropeptide K, neurokinin B



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 242 6x29 G.H5 L 377 G.H5.26
Van-der-waals TM6 A 242 6x29 G.H5 L 377 G.H5.26
Hydrophobic H8 F 312 8x50 G.H5 E 375 G.H5.24
Van-der-waals H8 F 312 8x50 G.H5 E 375 G.H5.24
Hydrophobic ICL2 L 138 - G.H5 R 363 G.H5.12
Hydrophobic ICL2 L 138 - G.S3 V 210 G.S3.01
Hydrophobic ICL2 L 138 - G.H5 F 359 G.H5.08
Van-der-waals ICL2 L 138 - G.H5 F 359 G.H5.08
Hydrophobic ICL1 M 63 12x50 G.H5 E 375 G.H5.24
Van-der-waals ICL1 M 63 12x50 G.H5 E 375 G.H5.24
Polar TM6 Q 239 6x26 G.H5 R 372 G.H5.21
Hydrophobic TM7 L 308 7x56 G.H5 L 376 G.H5.25
Van-der-waals TM7 L 308 7x56 G.H5 L 376 G.H5.25
Hydrophobic TM6 M 250 6x37 G.H5 L 376 G.H5.25
Polar TM4 S 143 4x38 G.hns1 R 31 G.hns1.02
Hydrophobic TM4 S 143 4x38 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 S 143 4x38 G.hns1 R 31 G.hns1.02
Polar TM6 Q 239 6x26 G.h4s6 Y 341 G.h4s6.20
Hydrophobic TM6 Q 239 6x26 G.H5 R 368 G.H5.17
Van-der-waals TM6 Q 239 6x26 G.H5 R 368 G.H5.17
Polar H8 N 309 8x47 G.H5 E 375 G.H5.24
Hydrophobic H8 N 309 8x47 G.H5 E 375 G.H5.24
Van-der-waals H8 N 309 8x47 G.H5 E 375 G.H5.24
Hydrophobic TM6 K 243 6x30 G.H5 L 371 G.H5.20
Hydrophobic TM3 A 133 3x53 G.H5 Y 374 G.H5.23
Van-der-waals TM3 A 133 3x53 G.H5 Y 374 G.H5.23
Hydrophobic TM6 V 246 6x33 G.H5 L 376 G.H5.25
Van-der-waals TM6 V 246 6x33 G.H5 L 376 G.H5.25
Hydrophobic ICL2 P 137 - G.H5 R 363 G.H5.12
Hydrophobic TM3 A 133 3x53 G.H5 H 370 G.H5.19
Van-der-waals TM3 A 133 3x53 G.H5 H 370 G.H5.19
Hydrophobic TM6 V 246 6x33 G.H5 L 377 G.H5.26
Van-der-waals TM6 V 246 6x33 G.H5 L 377 G.H5.26
Polar TM2 T 67 2x39 G.H5 Q 373 G.H5.22
Hydrophobic TM2 T 67 2x39 G.H5 Q 373 G.H5.22
Van-der-waals TM2 T 67 2x39 G.H5 Q 373 G.H5.22
Hydrophobic TM2 T 67 2x39 G.H5 Y 374 G.H5.23
Van-der-waals TM2 T 67 2x39 G.H5 Y 374 G.H5.23
Hydrophobic ICL2 P 137 - G.H5 Q 367 G.H5.16
Polar ICL2 L 138 - G.S1 H 34 G.S1.02
Hydrophobic ICL2 L 138 - G.S1 H 34 G.S1.02
Van-der-waals ICL2 L 138 - G.S1 H 34 G.S1.02
Van-der-waals TM7 L 308 7x56 G.H5 L 377 G.H5.26
Hydrophobic H8 N 309 8x47 G.H5 L 377 G.H5.26
Van-der-waals H8 N 309 8x47 G.H5 L 377 G.H5.26
Polar TM2 N 68 2x40 G.H5 E 375 G.H5.24
Hydrophobic TM2 N 68 2x40 G.H5 E 375 G.H5.24
Van-der-waals TM2 N 68 2x40 G.H5 E 375 G.H5.24
Hydrophobic TM3 I 134 3x54 G.H5 L 371 G.H5.20
Polar ICL2 P 137 - G.H5 H 370 G.H5.19
Hydrophobic ICL2 P 137 - G.H5 H 370 G.H5.19
Polar ICL2 R 141 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 141 - G.hns1 R 31 G.hns1.02
Hydrophobic TM3 R 130 3x50 G.H5 L 376 G.H5.25
Van-der-waals TM3 R 130 3x50 G.H5 L 376 G.H5.25
Polar TM3 I 135 3x55 G.H5 R 363 G.H5.12
Van-der-waals TM3 I 135 3x55 G.H5 R 363 G.H5.12
Hydrophobic TM6 M 249 6x36 G.H5 L 376 G.H5.25
Van-der-waals TM6 M 249 6x36 G.H5 L 376 G.H5.25
Hydrophobic ICL2 L 138 - G.S3 F 212 G.S3.03
Hydrophobic ICL2 L 138 - G.H5 I 366 G.H5.15
Hydrophobic ICL2 P 137 - G.H5 I 366 G.H5.15
Van-der-waals ICL2 P 137 - G.H5 I 366 G.H5.15
Polar TM3 I 134 3x54 G.H5 Q 367 G.H5.16
Hydrophobic TM3 I 134 3x54 G.H5 Q 367 G.H5.16
Van-der-waals TM3 I 134 3x54 G.H5 Q 367 G.H5.16
Polar ICL2 R 141 - G.H5 Y 374 G.H5.23
Hydrophobic ICL2 R 141 - G.H5 Y 374 G.H5.23
Van-der-waals ICL2 R 141 - G.H5 Y 374 G.H5.23
Hydrophobic ICL2 L 138 - G.H5 C 362 G.H5.11
Polar TM3 R 130 3x50 G.H5 Y 374 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 Y 374 G.H5.23
Hydrophobic ICL2 P 140 - G.hns1 R 31 G.hns1.02
Hydrophobic TM3 D 129 3x49 G.H5 Y 374 G.H5.23
Van-der-waals TM3 D 129 3x49 G.H5 Y 374 G.H5.23
Hydrophobic TM5 L 223 5x65 G.H5 L 371 G.H5.20
Hydrophobic TM6 Q 239 6x26 G.H5 L 377 G.H5.26
Van-der-waals TM6 Q 239 6x26 G.H5 L 377 G.H5.26
Hydrophobic TM3 I 134 3x54 G.H5 L 376 G.H5.25