Refined structure (8WZ2) of Gq - QRFP receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 207 from structure (57.7%), 152 from model (42.3%)
Residue sidechains - 110 from structure (30.6%), 249 from model (69.4%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 AF2 AF2
G.HN 10 C G.HN.10 AF2 AF2
G.HN 11 L G.HN.11 Structure Structure
G.HN 12 S G.HN.30 Structure Structure
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure Structure
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure AF2
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure Structure
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure Structure
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure AF2
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure Structure
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure AF2
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure Structure
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure AF2
G.H1 56 I G.H1.05 Structure AF2
G.H1 57 K G.H1.06 Structure Structure
G.H1 58 Q G.H1.07 Structure Structure
G.H1 59 M G.H1.08 Structure Structure
G.H1 60 R G.H1.09 Structure Structure
G.H1 61 I G.H1.10 Structure Structure
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 AF2 AF2
G.hfs2 183 R G.hfs2.02 AF2 AF2
G.hfs2 184 V G.hfs2.03 AF2 AF2
G.hfs2 185 P G.hfs2.04 AF2 AF2
G.hfs2 186 T G.hfs2.05 Structure Structure
G.hfs2 187 T G.hfs2.06 Structure Structure
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure Structure
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 Structure AF2
G.s3h2 209 Q G.s3h2.03 Structure Structure
G.H2 210 R G.H2.01 Structure Structure
G.H2 211 S G.H2.02 Structure AF2
G.H2 212 E G.H2.03 Structure Structure
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure Structure
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure AF2
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure AF2
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure AF2
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure AF2
G.s4h3 237 Q G.s4h3.06 AF2 AF2
G.s4h3 238 V G.s4h3.07 AF2 AF2
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 AF2 AF2
G.s4h3 241 E G.s4h3.10 AF2 AF2
G.s4h3 242 S G.s4h3.11 AF2 AF2
G.s4h3 243 D G.s4h3.12 AF2 AF2
G.s4h3 244 N G.s4h3.13 AF2 AF2
G.s4h3 245 E G.s4h3.14 AF2 AF2
G.s4h3 246 N G.s4h3.15 AF2 AF2
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure Structure
G.H3 251 S G.H3.05 Structure AF2
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure AF2
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure AF2
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure Structure
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure AF2
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 AF2 AF2
G.hgh4 292 F G.hgh4.02 AF2 AF2
G.hgh4 293 P G.hgh4.03 AF2 AF2
G.hgh4 294 E G.hgh4.04 AF2 AF2
G.hgh4 295 Y G.hgh4.05 AF2 AF2
G.hgh4 296 D G.hgh4.06 AF2 AF2
G.hgh4 297 G G.hgh4.07 AF2 AF2
G.hgh4 298 P G.hgh4.08 AF2 AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure AF2
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure AF2
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure AF2
G.H4 311 K G.H4.13 Structure Structure
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure Structure
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 Structure AF2
G.s6h5 332 T G.s6h5.04 Structure AF2
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure Structure
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure AF2
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 322 from structure (89.0%), 40 from model (11.0%)
Residue sidechains - 301 from structure (83.1%), 61 from model (16.9%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 Q - AF2 AF2
N-term 3 A - AF2 AF2
N-term 4 L - AF2 AF2
N-term 5 N - AF2 AF2
N-term 6 I - AF2 AF2
N-term 7 T - AF2 AF2
N-term 8 P - AF2 AF2
N-term 9 E - Structure AF2
N-term 10 Q - Structure AF2
N-term 11 F - Structure AF2
N-term 12 S - Structure Structure
N-term 13 R - Structure AF2
N-term 14 L - Structure AF2
N-term 15 L - Structure AF2
N-term 16 R - Structure AF2
N-term 17 D - Structure AF2
N-term 18 H - Structure AF2
N-term 19 N - Structure AF2
N-term 20 L - Structure AF2
N-term 21 T - Structure AF2
N-term 22 R - Structure AF2
N-term 23 E - Structure AF2
N-term 24 Q - Structure AF2
N-term 25 F - Structure AF2
N-term 26 I - Structure AF2
N-term 27 A - Structure Structure
N-term 28 L - Structure AF2
N-term 29 Y - Structure AF2
N-term 30 R - Structure AF2
N-term 31 L - Structure AF2
N-term 32 R - Structure Structure
N-term 33 P - Structure Structure
N-term 34 L - Structure Structure
N-term 35 V - Structure Structure
N-term 36 Y - Structure Structure
N-term 37 T - Structure Structure
N-term 38 P - Structure Structure
N-term 39 E - Structure Structure
N-term 40 L - Structure Structure
TM1 41 P 1.28x28 Structure Structure
TM1 42 G 1.29x29 Structure Structure
TM1 43 R 1.30x30 Structure Structure
TM1 44 A 1.31x31 Structure Structure
TM1 45 K 1.32x32 Structure Structure
TM1 46 L 1.33x33 Structure Structure
TM1 47 A 1.34x34 Structure Structure
TM1 48 L 1.35x35 Structure Structure
TM1 49 V 1.36x36 Structure Structure
TM1 50 L 1.37x37 Structure Structure
TM1 51 T 1.38x38 Structure Structure
TM1 52 G 1.39x39 Structure Structure
TM1 53 V 1.40x40 Structure Structure
TM1 54 L 1.41x41 Structure Structure
TM1 55 I 1.42x42 Structure Structure
TM1 56 F 1.43x43 Structure Structure
TM1 57 A 1.44x44 Structure Structure
TM1 58 L 1.45x45 Structure Structure
TM1 59 A 1.46x46 Structure Structure
TM1 60 L 1.47x47 Structure Structure
TM1 61 F 1.48x48 Structure Structure
TM1 62 G 1.49x49 Structure Structure
TM1 63 N 1.50x50 Structure Structure
TM1 64 A 1.51x51 Structure Structure
TM1 65 L 1.52x52 Structure Structure
TM1 66 V 1.53x53 Structure Structure
TM1 67 F 1.54x54 Structure Structure
TM1 68 Y 1.55x55 Structure Structure
TM1 69 V 1.56x56 Structure Structure
TM1 70 V 1.57x57 Structure Structure
TM1 71 T 1.58x58 Structure Structure
TM1 72 R 1.59x59 Structure Structure
TM1 73 S 1.60x60 Structure Structure
ICL1 74 K 12.48x48 Structure Structure
ICL1 75 A 12.49x49 Structure Structure
ICL1 76 M 12.50x50 Structure Structure
ICL1 77 R 12.51x51 Structure Structure
TM2 78 T 2.37x37 Structure Structure
TM2 79 V 2.38x38 Structure Structure
TM2 80 T 2.39x39 Structure Structure
TM2 81 N 2.40x40 Structure Structure
TM2 82 I 2.41x41 Structure Structure
TM2 83 F 2.42x42 Structure Structure
TM2 84 I 2.43x43 Structure Structure
TM2 85 C 2.44x44 Structure Structure
TM2 86 S 2.45x45 Structure Structure
TM2 87 L 2.46x46 Structure Structure
TM2 88 A 2.47x47 Structure Structure
TM2 89 L 2.48x48 Structure Structure
TM2 90 S 2.49x49 Structure Structure
TM2 91 D 2.50x50 Structure Structure
TM2 92 L 2.51x51 Structure Structure
TM2 93 L 2.52x52 Structure Structure
TM2 94 I 2.53x53 Structure Structure
TM2 95 T 2.54x54 Structure Structure
TM2 96 F 2.55x55 Structure Structure
TM2 97 F 2.56x551 Structure Structure
TM2 98 C 2.57x56 Structure Structure
TM2 99 I 2.58x57 Structure Structure
TM2 100 P 2.59x58 Structure Structure
TM2 101 V 2.60x59 Structure Structure
TM2 102 T 2.61x60 Structure Structure
TM2 103 M 2.62x61 Structure Structure
TM2 104 L 2.63x62 Structure Structure
TM2 105 Q 2.64x63 Structure Structure
TM2 106 N 2.65x64 Structure Structure
TM2 107 I 2.66x65 Structure Structure
TM2 108 S 2.67x66 Structure Structure
ECL1 109 D - Structure Structure
ECL1 110 N 23.49x49 Structure Structure
ECL1 111 W 23.50x50 Structure Structure
ECL1 112 L 23.51x51 Structure Structure
ECL1 113 G 23.52x52 Structure Structure
ECL1 114 G - Structure Structure
ECL1 115 A - Structure Structure
TM3 116 F 3.23x23 Structure Structure
TM3 117 I 3.24x24 Structure Structure
TM3 118 C 3.25x25 Structure Structure
TM3 119 K 3.26x26 Structure Structure
TM3 120 M 3.27x27 Structure Structure
TM3 121 V 3.28x28 Structure Structure
TM3 122 P 3.29x29 Structure Structure
TM3 123 F 3.30x30 Structure Structure
TM3 124 V 3.31x31 Structure Structure
TM3 125 Q 3.32x32 Structure Structure
TM3 126 S 3.33x33 Structure Structure
TM3 127 T 3.34x34 Structure Structure
TM3 128 A 3.35x35 Structure Structure
TM3 129 V 3.36x36 Structure Structure
TM3 130 V 3.37x37 Structure Structure
TM3 131 T 3.38x38 Structure Structure
TM3 132 E 3.39x39 Structure Structure
TM3 133 I 3.40x40 Structure Structure
TM3 134 L 3.41x41 Structure Structure
TM3 135 T 3.42x42 Structure Structure
TM3 136 M 3.43x43 Structure Structure
TM3 137 T 3.44x44 Structure Structure
TM3 138 C 3.45x45 Structure Structure
TM3 139 I 3.46x46 Structure Structure
TM3 140 A 3.47x47 Structure Structure
TM3 141 V 3.48x48 Structure Structure
TM3 142 E 3.49x49 Structure Structure
TM3 143 R 3.50x50 Structure Structure
TM3 144 H 3.51x51 Structure Structure
TM3 145 Q 3.52x52 Structure Structure
TM3 146 G 3.53x53 Structure Structure
TM3 147 L 3.54x54 Structure Structure
TM3 148 V 3.55x55 Structure Structure
TM3 149 H 3.56x56 Structure Structure
ICL2 150 P 34.50x50 Structure Structure
ICL2 151 F 34.51x51 Structure Structure
ICL2 152 K 34.52x52 Structure Structure
ICL2 153 M 34.53x53 Structure Structure
ICL2 154 K 34.54x54 Structure Structure
ICL2 155 W 34.55x55 Structure Structure
ICL2 156 Q 34.56x56 Structure Structure
ICL2 157 Y 34.57x57 Structure Structure
TM4 158 T 4.38x38 Structure Structure
TM4 159 N 4.39x39 Structure Structure
TM4 160 R 4.40x40 Structure Structure
TM4 161 R 4.41x41 Structure Structure
TM4 162 A 4.42x42 Structure Structure
TM4 163 F 4.43x43 Structure Structure
TM4 164 T 4.44x44 Structure Structure
TM4 165 M 4.45x45 Structure Structure
TM4 166 L 4.46x46 Structure Structure
TM4 167 G 4.47x47 Structure Structure
TM4 168 V 4.48x48 Structure Structure
TM4 169 V 4.49x49 Structure Structure
TM4 170 W 4.50x50 Structure Structure
TM4 171 L 4.51x51 Structure Structure
TM4 172 V 4.52x52 Structure Structure
TM4 173 A 4.53x53 Structure Structure
TM4 174 V 4.54x54 Structure Structure
TM4 175 I 4.55x55 Structure Structure
TM4 176 V 4.56x56 Structure Structure
TM4 177 G 4.57x57 Structure Structure
TM4 178 S 4.58x58 Structure Structure
TM4 179 P 4.59x59 Structure Structure
TM4 180 M 4.60x60 Structure Structure
TM4 181 W 4.61x61 Structure Structure
TM4 182 H 4.62x62 Structure Structure
TM4 183 V 4.63x63 Structure Structure
TM4 184 Q 4.64x64 Structure Structure
ECL2 185 Q - Structure Structure
ECL2 186 L - Structure Structure
ECL2 187 E - Structure Structure
ECL2 188 I - Structure Structure
ECL2 189 K - Structure Structure
ECL2 190 Y - Structure Structure
ECL2 191 D - Structure Structure
ECL2 192 F - Structure Structure
ECL2 193 L - Structure Structure
ECL2 194 Y - Structure Structure
ECL2 195 E - Structure Structure
ECL2 196 K - Structure Structure
ECL2 197 E - Structure Structure
ECL2 198 H - Structure Structure
ECL2 199 I - Structure Structure
ECL2 200 C - Structure Structure
ECL2 201 C 45.50x50 Structure Structure
ECL2 202 L 45.51x51 Structure Structure
ECL2 203 E 45.52x52 Structure Structure
ECL2 204 E - Structure Structure
ECL2 205 W - Structure Structure
ECL2 206 T - Structure Structure
TM5 207 S 5.31x32 Structure Structure
TM5 208 P 5.32x33 Structure Structure
TM5 209 V 5.33x34 Structure Structure
TM5 210 H 5.34x35 Structure Structure
TM5 211 Q 5.35x36 Structure Structure
TM5 212 K 5.36x37 Structure Structure
TM5 213 I 5.37x38 Structure Structure
TM5 214 Y 5.38x39 Structure Structure
TM5 215 T 5.39x40 Structure Structure
TM5 216 T 5.40x41 Structure Structure
TM5 217 F 5.41x42 Structure Structure
TM5 218 I 5.42x43 Structure Structure
TM5 219 L 5.43x44 Structure Structure
TM5 220 V 5.44x45 Structure Structure
TM5 221 I 5.45x46 Structure Structure
TM5 222 L 5.46x461 Structure Structure
TM5 223 F 5.47x47 Structure Structure
TM5 224 L 5.48x48 Structure Structure
TM5 225 L 5.49x49 Structure Structure
TM5 226 P 5.50x50 Structure Structure
TM5 227 L 5.51x51 Structure Structure
TM5 228 M 5.52x52 Structure Structure
TM5 229 V 5.53x53 Structure Structure
TM5 230 M 5.54x54 Structure Structure
TM5 231 L 5.55x55 Structure Structure
TM5 232 I 5.56x56 Structure Structure
TM5 233 L 5.57x57 Structure Structure
TM5 234 Y 5.58x58 Structure Structure
TM5 235 S 5.59x59 Structure Structure
TM5 236 K 5.60x60 Structure Structure
TM5 237 I 5.61x61 Structure Structure
TM5 238 G 5.62x62 Structure Structure
TM5 239 Y 5.63x63 Structure Structure
TM5 240 E 5.64x64 Structure Structure
TM5 241 L 5.65x65 Structure Structure
TM5 242 W 5.66x66 Structure Structure
TM5 243 I 5.67x67 Structure Structure
TM5 244 K 5.68x68 Structure Structure
TM5 245 K 5.69x69 AF2 AF2
TM5 246 R 5.70x70 AF2 AF2
TM5 247 V 5.71x71 AF2 AF2
TM5 248 G 5.72x72 AF2 AF2
TM5 249 D 5.73x73 AF2 AF2
TM5 250 G 5.74x74 AF2 AF2
TM5 251 S 5.75x75 AF2 AF2
TM5 252 V 5.76x76 AF2 AF2
TM5 253 L 5.77x77 AF2 AF2
TM5 254 R 5.78x78 AF2 AF2
TM5 255 T 5.79x79 AF2 AF2
TM5 256 I 5.80x80 AF2 AF2
ICL3 257 H - AF2 AF2
ICL3 258 G - AF2 AF2
ICL3 259 K - AF2 AF2
ICL3 260 E - AF2 AF2
TM6 261 M 6.23x23 Structure Structure
TM6 262 S 6.24x24 Structure Structure
TM6 263 K 6.25x25 Structure Structure
TM6 264 I 6.26x26 Structure Structure
TM6 265 A 6.27x27 Structure Structure
TM6 266 R 6.28x28 Structure Structure
TM6 267 K 6.29x29 Structure Structure
TM6 268 K 6.30x30 Structure Structure
TM6 269 K 6.31x31 Structure Structure
TM6 270 R 6.32x32 Structure Structure
TM6 271 A 6.33x33 Structure Structure
TM6 272 V 6.34x34 Structure Structure
TM6 273 I 6.35x35 Structure Structure
TM6 274 M 6.36x36 Structure Structure
TM6 275 M 6.37x37 Structure Structure
TM6 276 V 6.38x38 Structure Structure
TM6 277 T 6.39x39 Structure Structure
TM6 278 V 6.40x40 Structure Structure
TM6 279 V 6.41x41 Structure Structure
TM6 280 A 6.42x42 Structure Structure
TM6 281 L 6.43x43 Structure Structure
TM6 282 F 6.44x44 Structure Structure
TM6 283 A 6.45x45 Structure Structure
TM6 284 V 6.46x46 Structure Structure
TM6 285 C 6.47x47 Structure Structure
TM6 286 W 6.48x48 Structure Structure
TM6 287 A 6.49x49 Structure Structure
TM6 288 P 6.50x50 Structure Structure
TM6 289 F 6.51x51 Structure Structure
TM6 290 H 6.52x52 Structure Structure
TM6 291 V 6.53x53 Structure Structure
TM6 292 V 6.54x54 Structure Structure
TM6 293 H 6.55x55 Structure Structure
TM6 294 M 6.56x56 Structure Structure
TM6 295 M 6.57x57 Structure Structure
TM6 296 I 6.58x58 Structure Structure
TM6 297 E 6.59x59 Structure Structure
TM6 298 Y 6.60x60 Structure Structure
TM6 299 S 6.61x61 Structure Structure
ECL3 300 N - Structure Structure
ECL3 301 F - Structure Structure
ECL3 302 E - Structure Structure
ECL3 303 K - Structure Structure
ECL3 304 E - Structure Structure
ECL3 305 Y - Structure Structure
ECL3 306 D - Structure Structure
TM7 307 D 7.28x27 Structure Structure
TM7 308 V 7.29x28 Structure Structure
TM7 309 T 7.30x29 Structure Structure
TM7 310 I 7.31x30 Structure Structure
TM7 311 K 7.32x31 Structure Structure
TM7 312 M 7.33x32 Structure Structure
TM7 313 I 7.34x33 Structure Structure
TM7 314 F 7.35x34 Structure Structure
TM7 315 A 7.36x35 Structure Structure
TM7 316 I 7.37x36 Structure Structure
TM7 317 V 7.38x37 Structure Structure
TM7 318 Q 7.39x38 Structure Structure
TM7 319 I 7.40x39 Structure Structure
TM7 320 I 7.41x40 Structure Structure
TM7 321 G 7.42x41 Structure Structure
TM7 322 F 7.43x42 Structure Structure
TM7 323 S 7.44x43 Structure Structure
TM7 324 N 7.45x45 Structure Structure
TM7 325 S 7.46x46 Structure Structure
TM7 326 I 7.47x47 Structure Structure
TM7 327 C 7.48x48 Structure Structure
TM7 328 N 7.49x49 Structure Structure
TM7 329 P 7.50x50 Structure Structure
TM7 330 I 7.51x51 Structure Structure
TM7 331 V 7.52x52 Structure Structure
TM7 332 Y 7.53x53 Structure Structure
TM7 333 A 7.54x54 Structure Structure
TM7 334 F 7.55x55 Structure Structure
TM7 335 M 7.56x56 Structure Structure
H8 336 N 8.47x47 Structure Structure
H8 337 E 8.48x48 Structure Structure
H8 338 N 8.49x49 Structure Structure
H8 339 F 8.50x50 Structure Structure
H8 340 K 8.51x51 Structure Structure
H8 341 K 8.52x52 Structure Structure
H8 342 N 8.53x53 Structure Structure
H8 343 V 8.54x54 Structure Structure
H8 344 L 8.55x55 Structure Structure
H8 345 S 8.56x56 Structure Structure
H8 346 A 8.57x57 Structure Structure
H8 347 V 8.58x58 AF2 AF2
H8 348 C 8.59x59 AF2 AF2
H8 349 Y 8.60x60 AF2 AF2
H8 350 C 8.61x61 AF2 AF2
H8 351 I 8.62x62 AF2 AF2
H8 352 V 8.63x63 AF2 AF2
C-term 353 N - AF2 AF2
C-term 354 K - AF2 AF2
C-term 355 T - AF2 AF2
C-term 356 F - AF2 AF2
C-term 357 S - AF2 AF2
C-term 358 P - AF2 AF2
C-term 359 A - AF2 AF2
C-term 360 Q - AF2 AF2
C-term 361 R - AF2 AF2
C-term 362 H - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 143 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 143 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM3 L 147 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 L 147 3x54 G.H5 L 349 G.H5.16
Hydrophobic H8 E 337 8x48 G.H5 K 354 G.H5.21
Hydrophobic ICL2 F 151 34x51 G.H5 V 344 G.H5.11
Van-der-waals ICL2 F 151 34x51 G.H5 V 344 G.H5.11
Hydrophobic TM5 L 253 5x77 G.S6 H 327 G.S6.04
Hydrophobic ICL2 F 151 34x51 G.S1 L 40 G.S1.02
Van-der-waals ICL2 F 151 34x51 G.S1 L 40 G.S1.02
Hydrophobic TM3 R 143 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 143 3x50 G.H5 Y 356 G.H5.23
Hydrophobic H8 N 336 8x47 G.H5 V 359 G.H5.26
Hydrophobic TM5 L 253 5x77 G.H5 D 346 G.H5.13
Van-der-waals TM5 L 253 5x77 G.H5 D 346 G.H5.13
Polar H8 N 336 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 N 336 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 N 336 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM4 T 158 4x38 G.hns1 R 37 G.hns1.02
Van-der-waals TM4 T 158 4x38 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 K 268 6x30 G.H5 L 353 G.H5.20
Hydrophobic TM5 T 255 5x79 G.H4 L 310 G.H4.12
Van-der-waals TM5 T 255 5x79 G.H4 L 310 G.H4.12
Hydrophobic TM6 A 271 6x33 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 150 34x50 G.H5 K 345 G.H5.12
Hydrophobic TM2 T 80 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM5 T 255 5x79 G.S6 F 328 G.S6.05
Hydrophobic TM3 L 147 3x54 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 F 151 34x51 G.S3 V 199 G.S3.01
Van-der-waals ICL2 F 151 34x51 G.S3 V 199 G.S3.01
Hydrophobic TM3 L 147 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 L 147 3x54 G.H5 L 358 G.H5.25
Hydrophobic TM5 D 249 5x73 G.H5 A 342 G.H5.09
Van-der-waals TM5 D 249 5x73 G.H5 A 342 G.H5.09
Polar TM3 E 142 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 E 142 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM5 V 252 5x76 G.H5 F 339 G.H5.06
Van-der-waals TM5 V 252 5x76 G.H5 F 339 G.H5.06
Hydrophobic TM6 A 271 6x33 G.H5 V 359 G.H5.26
Hydrophobic ICL2 P 150 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 150 34x50 G.H5 I 348 G.H5.15
Hydrophobic TM3 L 147 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM3 L 147 3x54 G.H5 N 352 G.H5.19
Hydrophobic ICL2 K 154 34x54 G.S1 L 40 G.S1.02
Van-der-waals ICL2 K 154 34x54 G.S1 L 40 G.S1.02
Hydrophobic H8 E 337 8x48 G.H5 V 359 G.H5.26
Van-der-waals H8 E 337 8x48 G.H5 V 359 G.H5.26
Hydrophobic TM5 L 253 5x77 G.S6 Y 325 G.S6.02
Van-der-waals TM5 L 253 5x77 G.S6 Y 325 G.S6.02
Hydrophobic ICL2 Y 157 34x57 G.H5 E 355 G.H5.22
Van-der-waals ICL2 Y 157 34x57 G.H5 E 355 G.H5.22
Hydrophobic ICL2 P 150 34x50 G.H5 L 349 G.H5.16
Van-der-waals ICL2 P 150 34x50 G.H5 L 349 G.H5.16
Polar TM2 T 80 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM2 T 80 2x39 G.H5 E 355 G.H5.22
Polar ICL2 K 154 34x54 G.S1 E 39 G.S1.01
Polar TM3 G 146 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 G 146 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 G 146 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM6 M 275 6x37 G.H5 L 358 G.H5.25
Van-der-waals TM6 M 275 6x37 G.H5 L 358 G.H5.25
Hydrophobic ICL2 F 151 34x51 G.H5 K 345 G.H5.12
Van-der-waals ICL2 F 151 34x51 G.H5 K 345 G.H5.12
Hydrophobic TM5 I 256 5x80 G.S6 Y 325 G.S6.02
Polar H8 N 338 8x49 G.H5 K 354 G.H5.21
Hydrophobic TM6 R 270 6x32 G.H5 V 359 G.H5.26
Polar TM5 T 255 5x79 G.S6 S 326 G.S6.03
Van-der-waals TM5 T 255 5x79 G.S6 S 326 G.S6.03
Polar ICL2 W 155 34x55 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 W 155 34x55 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 W 155 34x55 G.hns1 R 37 G.hns1.02
Ionic TM5 K 245 5x69 G.H5 D 346 G.H5.13
Polar TM5 K 245 5x69 G.H5 D 346 G.H5.13
Hydrophobic TM5 K 245 5x69 G.H5 D 346 G.H5.13
Van-der-waals TM5 K 245 5x69 G.H5 D 346 G.H5.13
Hydrophobic TM2 T 80 2x39 G.H5 N 357 G.H5.24
Van-der-waals TM2 T 80 2x39 G.H5 N 357 G.H5.24
Hydrophobic TM2 I 84 2x43 G.H5 N 357 G.H5.24
Van-der-waals TM2 I 84 2x43 G.H5 N 357 G.H5.24
Hydrophobic ICL2 F 151 34x51 G.S3 F 201 G.S3.03
Aromatic ICL2 F 151 34x51 G.H5 F 341 G.H5.08
Hydrophobic ICL2 F 151 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 F 151 34x51 G.H5 F 341 G.H5.08
Hydrophobic ICL3 H 257 - G.H4 V 314 G.H4.16
Van-der-waals ICL3 H 257 - G.H4 V 314 G.H4.16
Polar TM5 V 252 5x76 G.S6 H 327 G.S6.04
Hydrophobic TM5 V 252 5x76 G.S6 H 327 G.S6.04
Van-der-waals TM5 V 252 5x76 G.S6 H 327 G.S6.04
Polar ICL3 H 257 - G.H4 K 311 G.H4.13
Hydrophobic ICL3 H 257 - G.H4 K 311 G.H4.13
Van-der-waals ICL3 H 257 - G.H4 K 311 G.H4.13
Hydrophobic TM6 K 267 6x29 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 267 6x29 G.H5 V 359 G.H5.26
Aromatic ICL2 W 155 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 W 155 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 W 155 34x55 G.hns1 R 38 G.hns1.03
Aromatic ICL2 Y 157 34x57 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 Y 157 34x57 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 Y 157 34x57 G.H5 Y 356 G.H5.23
Polar TM3 G 146 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 G 146 3x53 G.H5 N 352 G.H5.19
Polar TM6 K 268 6x30 G.H5 Q 350 G.H5.17
Hydrophobic TM6 K 268 6x30 G.H5 Q 350 G.H5.17
Van-der-waals TM6 K 268 6x30 G.H5 Q 350 G.H5.17
Hydrophobic TM5 L 253 5x77 G.H5 F 339 G.H5.06
Hydrophobic TM5 K 245 5x69 G.H5 L 349 G.H5.16
Van-der-waals TM5 K 245 5x69 G.H5 L 349 G.H5.16
Polar ICL2 K 154 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 K 154 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 K 154 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 F 151 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 F 151 34x51 G.H5 I 348 G.H5.15
Ionic TM5 D 249 5x73 G.H5 K 345 G.H5.12
Ionic TM5 E 240 5x64 G.H5 K 345 G.H5.12
Polar TM5 E 240 5x64 G.H5 K 345 G.H5.12
Van-der-waals TM5 E 240 5x64 G.H5 K 345 G.H5.12
Hydrophobic TM6 K 263 6x25 G.h4s6 S 320 G.h4s6.11
Van-der-waals TM6 K 263 6x25 G.h4s6 S 320 G.h4s6.11