Refined structure (7CRH) of Gs - D1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 236 from structure (59.9%), 158 from model (40.1%)
Residue sidechains - 218 from structure (55.3%), 176 from model (44.7%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 Structure AF2
G.HN 12 Q G.HN.29 Structure AF2
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure AF2
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure AF2
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure AF2
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure Structure
G.s1h1 50 E G.s1h1.04 Structure Structure
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure Structure
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure AF2
G.H1 59 Q G.H1.07 Structure AF2
G.H1 60 M G.H1.08 Structure AF2
G.H1 61 R G.H1.09 Structure AF2
G.H1 62 I G.H1.10 Structure AF2
G.H1 63 L G.H1.11 Structure AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure AF2
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure AF2
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure Structure
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 Structure Structure
G.s4h3 255 M G.s4h3.06 Structure Structure
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 Structure Structure
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure Structure
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure AF2
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure Structure
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure AF2
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure AF2
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure AF2
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 272 from structure (77.3%), 80 from model (22.7%)
Residue sidechains - 264 from structure (75.0%), 88 from model (25.0%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 R - AF2 AF2
N-term 3 T - AF2 AF2
N-term 4 L - AF2 AF2
N-term 5 N - AF2 AF2
N-term 6 T - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 A - AF2 AF2
N-term 9 M - AF2 AF2
N-term 10 D - AF2 AF2
N-term 11 G - AF2 AF2
N-term 12 T - AF2 AF2
N-term 13 G - AF2 AF2
N-term 14 L - AF2 AF2
N-term 15 V - AF2 AF2
N-term 16 V - AF2 AF2
N-term 17 E - AF2 AF2
N-term 18 R - AF2 AF2
N-term 19 D - AF2 AF2
N-term 20 F - AF2 AF2
TM1 21 S 1.30x30 Structure Structure
TM1 22 V 1.31x31 Structure Structure
TM1 23 R 1.32x32 Structure Structure
TM1 24 I 1.33x33 Structure Structure
TM1 25 L 1.34x34 Structure Structure
TM1 26 T 1.35x35 Structure Structure
TM1 27 A 1.36x36 Structure Structure
TM1 28 C 1.37x37 Structure Structure
TM1 29 F 1.38x38 Structure Structure
TM1 30 L 1.39x39 Structure Structure
TM1 31 S 1.40x40 Structure Structure
TM1 32 L 1.41x41 Structure Structure
TM1 33 L 1.42x42 Structure Structure
TM1 34 I 1.43x43 Structure Structure
TM1 35 L 1.44x44 Structure Structure
TM1 36 S 1.45x45 Structure Structure
TM1 37 T 1.46x46 Structure Structure
TM1 38 L 1.47x47 Structure Structure
TM1 39 L 1.48x48 Structure Structure
TM1 40 G 1.49x49 Structure Structure
TM1 41 N 1.50x50 Structure Structure
TM1 42 T 1.51x51 Structure Structure
TM1 43 L 1.52x52 Structure Structure
TM1 44 V 1.53x53 Structure Structure
TM1 45 C 1.54x54 Structure Structure
TM1 46 A 1.55x55 Structure Structure
TM1 47 A 1.56x56 Structure Structure
TM1 48 V 1.57x57 Structure Structure
TM1 49 I 1.58x58 Structure Structure
TM1 50 R 1.59x59 Structure Structure
TM1 51 F 1.60x60 Structure Structure
ICL1 52 R 12.48x48 Structure Structure
ICL1 53 H 12.49x49 Structure Structure
ICL1 54 L 12.50x50 Structure Structure
ICL1 55 R 12.51x51 Structure AF2
ICL1 56 S 12.52x52 Structure Structure
TM2 57 K 2.37x37 Structure Structure
TM2 58 V 2.38x38 Structure Structure
TM2 59 T 2.39x39 Structure Structure
TM2 60 N 2.40x40 Structure Structure
TM2 61 F 2.41x41 Structure Structure
TM2 62 F 2.42x42 Structure Structure
TM2 63 V 2.43x43 Structure Structure
TM2 64 I 2.44x44 Structure Structure
TM2 65 S 2.45x45 Structure Structure
TM2 66 L 2.46x46 Structure Structure
TM2 67 A 2.47x47 Structure Structure
TM2 68 V 2.48x48 Structure Structure
TM2 69 S 2.49x49 Structure Structure
TM2 70 D 2.50x50 Structure Structure
TM2 71 L 2.51x51 Structure Structure
TM2 72 L 2.52x52 Structure Structure
TM2 73 V 2.53x53 Structure Structure
TM2 74 A 2.54x54 Structure Structure
TM2 75 V 2.55x55 Structure Structure
TM2 76 L 2.56x551 Structure Structure
TM2 77 V 2.57x56 Structure Structure
TM2 78 M 2.58x57 Structure Structure
TM2 79 P 2.59x58 Structure Structure
TM2 80 W 2.60x59 Structure Structure
TM2 81 K 2.61x60 Structure Structure
TM2 82 A 2.62x61 Structure Structure
TM2 83 V 2.63x62 Structure Structure
TM2 84 A 2.64x63 Structure Structure
TM2 85 E 2.65x64 Structure Structure
TM2 86 I 2.66x65 Structure Structure
TM2 87 A 2.67x66 Structure Structure
TM2 88 G 2.68x67 Structure Structure
ECL1 89 F 23.49x49 Structure Structure
ECL1 90 W 23.50x50 Structure Structure
ECL1 91 P 23.51x51 Structure Structure
ECL1 92 F 23.52x52 Structure Structure
TM3 93 G 3.22x22 Structure Structure
TM3 94 S 3.23x23 Structure Structure
TM3 95 F 3.24x24 Structure Structure
TM3 96 C 3.25x25 Structure Structure
TM3 97 N 3.26x26 Structure Structure
TM3 98 I 3.27x27 Structure Structure
TM3 99 W 3.28x28 Structure Structure
TM3 100 V 3.29x29 Structure Structure
TM3 101 A 3.30x30 Structure Structure
TM3 102 F 3.31x31 Structure Structure
TM3 103 D 3.32x32 Structure Structure
TM3 104 I 3.33x33 Structure Structure
TM3 105 M 3.34x34 Structure Structure
TM3 106 C 3.35x35 Structure Structure
TM3 107 S 3.36x36 Structure Structure
TM3 108 T 3.37x37 Structure Structure
TM3 109 A 3.38x38 Structure Structure
TM3 110 S 3.39x39 Structure Structure
TM3 111 I 3.40x40 Structure Structure
TM3 112 L 3.41x41 Structure Structure
TM3 113 N 3.42x42 Structure Structure
TM3 114 L 3.43x43 Structure Structure
TM3 115 C 3.44x44 Structure Structure
TM3 116 V 3.45x45 Structure Structure
TM3 117 I 3.46x46 Structure Structure
TM3 118 S 3.47x47 Structure Structure
TM3 119 V 3.48x48 Structure Structure
TM3 120 D 3.49x49 Structure Structure
TM3 121 R 3.50x50 Structure Structure
TM3 122 Y 3.51x51 Structure Structure
TM3 123 W 3.52x52 Structure Structure
TM3 124 A 3.53x53 Structure Structure
TM3 125 I 3.54x54 Structure Structure
TM3 126 S 3.55x55 Structure Structure
TM3 127 S 3.56x56 Structure Structure
ICL2 128 P 34.50x50 Structure Structure
ICL2 129 F 34.51x51 Structure Structure
ICL2 130 R 34.52x52 Structure Structure
ICL2 131 Y 34.53x53 Structure Structure
ICL2 132 E 34.54x54 Structure Structure
ICL2 133 R 34.55x55 Structure Structure
ICL2 134 K 34.56x56 Structure Structure
ICL2 135 M 34.57x57 Structure Structure
TM4 136 T 4.38x38 Structure Structure
TM4 137 P 4.39x39 Structure Structure
TM4 138 K 4.40x40 Structure Structure
TM4 139 A 4.41x41 Structure Structure
TM4 140 A 4.42x42 Structure Structure
TM4 141 F 4.43x43 Structure Structure
TM4 142 I 4.44x44 Structure Structure
TM4 143 L 4.45x45 Structure Structure
TM4 144 I 4.46x46 Structure Structure
TM4 145 S 4.47x47 Structure Structure
TM4 146 V 4.48x48 Structure Structure
TM4 147 A 4.49x49 Structure Structure
TM4 148 W 4.50x50 Structure Structure
TM4 149 T 4.51x51 Structure Structure
TM4 150 L 4.52x52 Structure Structure
TM4 151 S 4.53x53 Structure Structure
TM4 152 V 4.54x54 Structure Structure
TM4 153 L 4.55x55 Structure Structure
TM4 154 I 4.56x56 Structure Structure
TM4 155 S 4.57x57 Structure Structure
TM4 156 F 4.58x58 Structure Structure
TM4 157 I 4.59x59 Structure Structure
TM4 158 P 4.60x60 Structure Structure
TM4 159 V 4.61x61 Structure Structure
TM4 160 Q 4.62x62 Structure Structure
TM4 161 L 4.63x63 Structure Structure
TM4 162 S 4.64x64 Structure Structure
ECL2 163 W - Structure Structure
ECL2 164 H - Structure Structure
ECL2 165 K - Structure Structure
ECL2 166 A - AF2 AF2
ECL2 167 K - AF2 AF2
ECL2 168 P - AF2 AF2
ECL2 169 T - AF2 AF2
ECL2 170 S - AF2 AF2
ECL2 171 P - AF2 AF2
ECL2 172 S - AF2 AF2
ECL2 173 D - AF2 AF2
ECL2 174 G - AF2 AF2
ECL2 175 N - AF2 AF2
ECL2 176 A - AF2 AF2
ECL2 177 T - AF2 AF2
ECL2 178 S - AF2 AF2
ECL2 179 L - AF2 AF2
ECL2 180 A - AF2 AF2
ECL2 181 E - AF2 AF2
ECL2 182 T - AF2 AF2
ECL2 183 I - AF2 AF2
ECL2 184 D - AF2 AF2
ECL2 185 N - Structure Structure
ECL2 186 C 45.50x50 Structure Structure
ECL2 187 D 45.51x51 Structure Structure
ECL2 188 S 45.52x52 Structure Structure
ECL2 189 S - Structure Structure
ECL2 190 L - Structure Structure
TM5 191 S 5.35x36 Structure Structure
TM5 192 R 5.36x37 Structure Structure
TM5 193 T 5.37x38 Structure Structure
TM5 194 Y 5.38x39 Structure Structure
TM5 195 A 5.39x40 Structure Structure
TM5 196 I 5.40x41 Structure Structure
TM5 197 S 5.41x42 Structure Structure
TM5 198 S 5.42x43 Structure Structure
TM5 199 S 5.43x44 Structure Structure
TM5 200 V 5.44x45 Structure Structure
TM5 201 I 5.45x46 Structure Structure
TM5 202 S 5.46x461 Structure Structure
TM5 203 F 5.47x47 Structure Structure
TM5 204 Y 5.48x48 Structure Structure
TM5 205 I 5.49x49 Structure Structure
TM5 206 P 5.50x50 Structure Structure
TM5 207 V 5.51x51 Structure Structure
TM5 208 A 5.52x52 Structure Structure
TM5 209 I 5.53x53 Structure Structure
TM5 210 M 5.54x54 Structure Structure
TM5 211 I 5.55x55 Structure Structure
TM5 212 V 5.56x56 Structure Structure
TM5 213 T 5.57x57 Structure Structure
TM5 214 Y 5.58x58 Structure Structure
TM5 215 T 5.59x59 Structure Structure
TM5 216 R 5.60x60 Structure Structure
TM5 217 I 5.61x61 Structure Structure
TM5 218 Y 5.62x62 Structure Structure
TM5 219 R 5.63x63 Structure Structure
TM5 220 I 5.64x64 Structure Structure
TM5 221 A 5.65x65 Structure Structure
TM5 222 Q 5.66x66 Structure Structure
TM5 223 K 5.67x67 Structure Structure
TM5 224 Q 5.68x68 Structure Structure
TM5 225 I 5.69x69 Structure Structure
TM5 226 R 5.70x70 Structure Structure
TM5 227 R 5.71x71 Structure Structure
TM5 228 I 5.72x72 Structure Structure
TM5 229 A 5.73x73 Structure Structure
TM5 230 A 5.74x74 Structure Structure
TM5 231 L 5.75x75 Structure Structure
TM5 232 E 5.76x76 Structure AF2
TM5 233 R 5.77x77 Structure AF2
TM5 234 A 5.78x78 Structure Structure
TM5 235 A 5.79x79 Structure Structure
TM5 236 V 5.80x80 Structure Structure
TM5 237 H 5.81x81 Structure Structure
TM5 238 A 5.82x82 AF2 AF2
TM5 239 K 5.83x83 AF2 AF2
TM5 240 N 5.84x84 AF2 AF2
TM5 241 C 5.85x85 AF2 AF2
TM5 242 Q 5.86x86 AF2 AF2
ICL3 243 T - AF2 AF2
ICL3 244 T - AF2 AF2
ICL3 245 T - AF2 AF2
ICL3 246 G - AF2 AF2
ICL3 247 N - AF2 AF2
ICL3 248 G - AF2 AF2
ICL3 249 K - AF2 AF2
ICL3 254 S - AF2 AF2
ICL3 255 Q - AF2 AF2
ICL3 256 P - AF2 AF2
ICL3 257 E - AF2 AF2
ICL3 258 S - AF2 AF2
ICL3 259 S - AF2 AF2
ICL3 260 F - AF2 AF2
TM6 261 K 6.24x24 AF2 AF2
TM6 262 M 6.25x25 AF2 AF2
TM6 263 S 6.26x26 Structure Structure
TM6 264 F 6.27x27 Structure Structure
TM6 265 K 6.28x28 Structure AF2
TM6 266 R 6.29x29 Structure Structure
TM6 267 E 6.30x30 Structure AF2
TM6 268 T 6.31x31 Structure Structure
TM6 269 K 6.32x32 Structure AF2
TM6 270 V 6.33x33 Structure Structure
TM6 271 L 6.34x34 Structure Structure
TM6 272 K 6.35x35 Structure Structure
TM6 273 T 6.36x36 Structure Structure
TM6 274 L 6.37x37 Structure Structure
TM6 275 S 6.38x38 Structure Structure
TM6 276 V 6.39x39 Structure Structure
TM6 277 I 6.40x40 Structure Structure
TM6 278 M 6.41x41 Structure Structure
TM6 279 G 6.42x42 Structure Structure
TM6 280 V 6.43x43 Structure Structure
TM6 281 F 6.44x44 Structure Structure
TM6 282 V 6.45x45 Structure Structure
TM6 283 C 6.46x46 Structure Structure
TM6 284 C 6.47x47 Structure Structure
TM6 285 W 6.48x48 Structure Structure
TM6 286 L 6.49x49 Structure Structure
TM6 287 P 6.50x50 Structure Structure
TM6 288 F 6.51x51 Structure Structure
TM6 289 F 6.52x52 Structure Structure
TM6 290 I 6.53x53 Structure Structure
TM6 291 L 6.54x54 Structure Structure
TM6 292 N 6.55x55 Structure Structure
TM6 293 C 6.56x56 Structure Structure
TM6 294 I 6.57x57 Structure Structure
TM6 295 L 6.58x58 Structure Structure
TM6 296 P 6.59x59 Structure Structure
TM6 297 F 6.60x60 Structure Structure
TM6 298 C 6.61x61 Structure Structure
ECL3 299 G - AF2 AF2
ECL3 300 S - AF2 AF2
ECL3 301 G - AF2 AF2
ECL3 302 E - AF2 AF2
ECL3 303 T - AF2 AF2
ECL3 304 Q - AF2 AF2
ECL3 305 P - AF2 AF2
ECL3 306 F - AF2 AF2
ECL3 307 C - Structure Structure
ECL3 308 I - Structure Structure
TM7 309 D 7.31x30 Structure Structure
TM7 310 S 7.32x31 Structure Structure
TM7 311 N 7.33x32 Structure AF2
TM7 312 T 7.34x33 Structure AF2
TM7 313 F 7.35x34 Structure Structure
TM7 314 D 7.36x35 Structure Structure
TM7 315 V 7.37x36 Structure Structure
TM7 316 F 7.38x37 Structure Structure
TM7 317 V 7.39x38 Structure Structure
TM7 318 W 7.40x39 Structure Structure
TM7 319 F 7.41x40 Structure Structure
TM7 320 G 7.42x41 Structure Structure
TM7 321 W 7.43x42 Structure Structure
TM7 322 A 7.44x43 Structure Structure
TM7 323 N 7.45x45 Structure Structure
TM7 324 S 7.46x46 Structure Structure
TM7 325 S 7.47x47 Structure Structure
TM7 326 L 7.48x48 Structure Structure
TM7 327 N 7.49x49 Structure Structure
TM7 328 P 7.50x50 Structure Structure
TM7 329 I 7.51x51 Structure Structure
TM7 330 I 7.52x52 Structure Structure
TM7 331 Y 7.53x53 Structure Structure
TM7 332 A 7.54x54 Structure Structure
TM7 333 F 7.55x55 Structure Structure
H8 334 N 8.47x47 Structure Structure
H8 335 A 8.48x48 Structure Structure
H8 336 D 8.49x49 Structure Structure
H8 337 F 8.50x50 Structure Structure
H8 338 R 8.51x51 Structure Structure
H8 339 K 8.52x52 Structure Structure
H8 340 A 8.53x53 Structure Structure
H8 341 F 8.54x54 Structure Structure
H8 342 S 8.55x55 Structure Structure
H8 343 T 8.56x56 Structure Structure
H8 344 L 8.57x57 Structure Structure
H8 345 L 8.58x58 AF2 AF2
H8 346 G 8.59x59 AF2 AF2
C-term 347 C - AF2 AF2
C-term 348 Y - AF2 AF2
C-term 349 R - AF2 AF2
C-term 350 L - AF2 AF2
C-term 351 C - AF2 AF2
C-term 352 P - AF2 AF2
C-term 353 A - AF2 AF2
C-term 354 T - AF2 AF2
C-term 355 N - AF2 AF2
C-term 356 N - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 T 244 - G.hgh4 E 314 G.hgh4.04
Hydrophobic ICL3 T 244 - G.hgh4 E 314 G.hgh4.04
Van-der-waals ICL3 T 244 - G.hgh4 E 314 G.hgh4.04
Hydrophobic ICL2 F 129 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 129 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM5 I 228 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 228 5x72 G.H5 R 385 G.H5.17
Polar TM5 Q 224 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 224 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 224 5x68 G.H5 R 385 G.H5.17
Hydrophobic ICL2 F 129 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 129 34x51 G.H5 R 380 G.H5.12
Ionic ICL2 E 132 34x54 G.hns1 R 38 G.hns1.02
Polar ICL2 E 132 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 E 132 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 132 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 F 129 34x51 G.S3 F 219 G.S3.03
Polar TM5 Q 242 5x86 G.H4 E 344 G.H4.14
Hydrophobic TM5 Q 242 5x86 G.H4 E 344 G.H4.14
Van-der-waals TM5 Q 242 5x86 G.H4 E 344 G.H4.14
Hydrophobic ICL2 P 128 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 128 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM3 I 125 3x54 G.H5 H 387 G.H5.19
Polar TM5 Q 242 5x86 G.H4 R 347 G.H4.17
Hydrophobic TM5 Q 242 5x86 G.H4 R 347 G.H4.17
Van-der-waals TM5 Q 242 5x86 G.H4 R 347 G.H4.17
Hydrophobic ICL2 F 129 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 129 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM6 T 273 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 273 6x36 G.H5 L 393 G.H5.25
Polar TM5 C 241 5x85 G.hgh4 R 317 G.hgh4.07
Hydrophobic TM5 C 241 5x85 G.hgh4 R 317 G.hgh4.07
Van-der-waals TM5 C 241 5x85 G.hgh4 R 317 G.hgh4.07
Hydrophobic TM5 L 231 5x75 G.S6 P 361 G.S6.03
Hydrophobic TM6 L 274 6x37 G.H5 L 393 G.H5.25
Polar TM6 K 269 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 228 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 228 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 F 129 34x51 G.H5 C 379 G.H5.11
Aromatic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 Q 224 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 128 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM5 I 220 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 I 220 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM6 V 270 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 270 6x33 G.H5 L 393 G.H5.25
Polar TM2 T 59 2x39 G.H5 Y 391 G.H5.23
Aromatic ICL2 F 129 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 129 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 C 241 5x85 G.hgh4 E 314 G.hgh4.04
Van-der-waals TM5 C 241 5x85 G.hgh4 E 314 G.hgh4.04
Hydrophobic TM5 A 235 5x79 G.H4 L 346 G.H4.16
Van-der-waals TM5 A 235 5x79 G.H4 L 346 G.H4.16
Ionic TM6 K 269 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 269 6x32 G.H5 E 392 G.H5.24
Hydrophobic ICL2 R 133 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM5 C 241 5x85 G.hgh4 Y 318 G.hgh4.08
Van-der-waals TM5 C 241 5x85 G.hgh4 Y 318 G.hgh4.08
Hydrophobic TM5 I 217 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 217 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM3 A 124 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 128 34x50 G.H5 Q 384 G.H5.16
Polar TM5 A 238 5x82 G.H4 R 347 G.H4.17
Hydrophobic TM5 A 238 5x82 G.H4 R 347 G.H4.17
Van-der-waals TM5 A 238 5x82 G.H4 R 347 G.H4.17
Hydrophobic TM5 K 239 5x83 G.H4 R 347 G.H4.17
Van-der-waals TM5 K 239 5x83 G.H4 R 347 G.H4.17
Hydrophobic TM5 Q 242 5x86 G.hgh4 E 314 G.hgh4.04
Van-der-waals TM5 Q 242 5x86 G.hgh4 E 314 G.hgh4.04
Hydrophobic TM5 A 238 5x82 G.H4 D 343 G.H4.13
Van-der-waals TM5 A 238 5x82 G.H4 D 343 G.H4.13
Aromatic ICL2 F 129 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 129 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 129 34x51 G.H5 F 376 G.H5.08
Van-der-waals TM5 I 225 5x69 G.H5 L 394 G.H5.26
Polar TM3 S 126 3x55 G.H5 R 380 G.H5.12
Hydrophobic TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM6 I 277 6x40 G.H5 L 393 G.H5.25
Polar TM3 A 124 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 125 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 125 3x54 G.H5 L 388 G.H5.20