SMO - Gi1

GPCR CLASS (FAMILY)

Class F (Frizzled)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Sept. 30, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Cholesterol - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 G 347 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 G 347 - G.H5 I 343 G.H5.15
Hydrophobic ICL3 P 434 - G.H5 F 336 G.H5.08
Hydrophobic TM6 I 445 6x26 G.H5 L 348 G.H5.20
Hydrophobic ICL2 T 349 - G.S1 V 34 G.S1.02
Hydrophobic TM6 A 441 6x22 G.H5 D 341 G.H5.13
Van-der-waals TM6 A 441 6x22 G.H5 D 341 G.H5.13
Hydrophobic C-term W 535 - G.H5 L 353 G.H5.25
Van-der-waals C-term W 535 - G.H5 L 353 G.H5.25
Hydrophobic TM2 P 263 2x40 G.H5 C 351 G.H5.23
Hydrophobic ICL2 T 349 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 346 - G.H5 I 344 G.H5.16
Van-der-waals TM6 T 448 6x29 G.H5 L 353 G.H5.25
Hydrophobic ICL3 L 437 - G.H5 I 344 G.H5.16
Hydrophobic TM2 A 264 2x41 G.H5 G 352 G.H5.24
Polar ICL2 T 349 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL3 G 435 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 G 435 - G.H5 D 337 G.H5.09
Polar ICL3 L 436 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 L 436 - G.H5 D 337 G.H5.09
Polar ICL2 T 348 - G.hns1 R 32 G.hns1.03
Polar ICL2 S 354 - G.HN E 28 G.HN.52
Van-der-waals ICL2 S 354 - G.HN E 28 G.HN.52
Hydrophobic TM2 R 261 2x38 G.H5 G 352 G.H5.24
Hydrophobic ICL2 L 346 - G.H5 L 348 G.H5.20
Polar TM6 S 438 6x19 G.H5 D 341 G.H5.13
Hydrophobic TM6 S 438 6x19 G.H5 D 341 G.H5.13
Van-der-waals TM6 S 438 6x19 G.H5 D 341 G.H5.13
Ionic TM6 K 440 6x21 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 440 6x21 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 440 6x21 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 H 433 - G.H5 F 336 G.H5.08
Hydrophobic ICL3 G 435 - G.H5 F 336 G.H5.08
Hydrophobic ICL3 H 433 - G.H5 T 340 G.H5.12
Van-der-waals ICL3 H 433 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 T 348 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 T 348 - G.S3 L 194 G.S3.01
Hydrophobic TM6 K 444 6x25 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 444 6x25 G.H5 F 354 G.H5.26
Hydrophobic TM3 F 343 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 F 343 3x54 G.H5 L 353 G.H5.25
Polar TM3 S 342 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Y 350 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Y 350 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 P 434 - G.s2s3 K 192 G.s2s3.01
Polar TM6 R 451 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 451 6x32 G.H5 L 353 G.H5.25
Polar TM3 S 342 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 S 342 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 F 343 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM2 R 261 2x38 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 261 2x38 G.H5 D 350 G.H5.22
Hydrophobic TM3 F 343 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 F 343 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 346 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 L 346 - G.H5 N 347 G.H5.19
Polar TM3 W 339 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 W 339 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 W 339 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 429 5x72 G.H5 I 344 G.H5.16
Polar TM2 R 261 2x38 G.H5 K 349 G.H5.21
Hydrophobic TM2 R 261 2x38 G.H5 K 349 G.H5.21
Van-der-waals TM2 R 261 2x38 G.H5 K 349 G.H5.21
Hydrophobic TM3 W 339 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 W 339 3x50 G.H5 L 353 G.H5.25
Van-der-waals ICL3 G 435 - G.H5 Q 333 G.H5.05
Hydrophobic TM6 I 445 6x26 G.H5 I 344 G.H5.16
Hydrophobic ICL2 T 349 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 349 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 L 452 6x33 G.H5 L 353 G.H5.25