GPCR CLASS (FAMILY)
GPCR SPECIES
GPCR PREFERRED CHAIN
G PROTEIN (FAMILY)
G PROTEIN SPECIES
PDB CODE
RESOLUTION
REFERENCE
PUBLICATION DATE
LIGAND INTERACTIONS
LIGANDS
MRE-269 - Agonist pubchem gtoplig chembl_ligand
PHYSIOLOGICAL LIGANDS
PGE1, PGI2, thromboxane A2, PGF2α, PGD2, PGE2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | H8 | A | 298 | 8x49 | G.H5 | L | 384 | G.H5.26 |
Van-der-waals | H8 | A | 298 | 8x49 | G.H5 | L | 384 | G.H5.26 |
Aromatic | TM3 | H | 123 | 3x56 | G.H5 | R | 370 | G.H5.12 |
Hydrophobic | ICL3 | G | 222 | - | G.H4 | R | 332 | G.H4.12 |
Van-der-waals | ICL3 | G | 222 | - | G.H4 | R | 332 | G.H4.12 |
Hydrophobic | TM2 | A | 50 | 2x40 | G.H5 | L | 383 | G.H5.25 |
Hydrophobic | TM5 | H | 220 | 5x73 | G.S6 | H | 352 | G.S6.04 |
Ionic | TM6 | E | 234 | 6x30 | G.H5 | R | 375 | G.H5.17 |
Polar | TM6 | E | 234 | 6x30 | G.H5 | R | 375 | G.H5.17 |
Van-der-waals | TM6 | E | 234 | 6x30 | G.H5 | R | 375 | G.H5.17 |
Hydrophobic | TM3 | R | 117 | 3x50 | G.H5 | Y | 381 | G.H5.23 |
Van-der-waals | TM3 | R | 117 | 3x50 | G.H5 | Y | 381 | G.H5.23 |
Polar | ICL2 | Y | 125 | 34x51 | G.H5 | R | 370 | G.H5.12 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | R | 370 | G.H5.12 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.H5 | R | 370 | G.H5.12 |
Hydrophobic | TM5 | M | 213 | 5x66 | G.H5 | Q | 374 | G.H5.16 |
Van-der-waals | TM5 | M | 213 | 5x66 | G.H5 | Q | 374 | G.H5.16 |
Hydrophobic | TM3 | A | 120 | 3x53 | G.H5 | Y | 381 | G.H5.23 |
Van-der-waals | TM3 | A | 120 | 3x53 | G.H5 | Y | 381 | G.H5.23 |
Polar | TM3 | L | 121 | 3x54 | G.H5 | Q | 374 | G.H5.16 |
Hydrophobic | TM3 | L | 121 | 3x54 | G.H5 | Q | 374 | G.H5.16 |
Van-der-waals | TM3 | L | 121 | 3x54 | G.H5 | Q | 374 | G.H5.16 |
Hydrophobic | TM3 | L | 121 | 3x54 | G.H5 | Y | 381 | G.H5.23 |
Hydrophobic | TM5 | Q | 217 | 5x70 | G.H5 | R | 375 | G.H5.17 |
Van-der-waals | TM5 | Q | 217 | 5x70 | G.H5 | R | 375 | G.H5.17 |
Aromatic | TM5 | H | 220 | 5x73 | G.S6 | Y | 350 | G.S6.02 |
Hydrophobic | TM5 | H | 220 | 5x73 | G.S6 | Y | 350 | G.S6.02 |
Van-der-waals | TM5 | H | 220 | 5x73 | G.S6 | Y | 350 | G.S6.02 |
Hydrophobic | TM5 | Q | 221 | 5x74 | G.H4 | L | 336 | G.H4.16 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Polar | TM3 | S | 122 | 3x55 | G.H5 | R | 370 | G.H5.12 |
Van-der-waals | TM3 | S | 122 | 3x55 | G.H5 | R | 370 | G.H5.12 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.S3 | F | 219 | G.S3.03 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.S3 | F | 219 | G.S3.03 |
Ionic | ICL2 | D | 131 | 34x57 | G.hns1 | R | 38 | G.hns1.02 |
Polar | ICL2 | D | 131 | 34x57 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | D | 131 | 34x57 | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM6 | H | 237 | 6x33 | G.H5 | L | 378 | G.H5.20 |
Hydrophobic | TM6 | H | 237 | 6x33 | G.H5 | L | 378 | G.H5.20 |
Van-der-waals | TM6 | H | 237 | 6x33 | G.H5 | L | 378 | G.H5.20 |
Hydrophobic | ICL1 | A | 44 | - | G.H5 | L | 383 | G.H5.25 |
Hydrophobic | TM6 | E | 234 | 6x30 | G.H5 | L | 378 | G.H5.20 |
Polar | TM3 | E | 116 | 3x49 | G.H5 | Y | 381 | G.H5.23 |
Hydrophobic | TM3 | E | 116 | 3x49 | G.H5 | Y | 381 | G.H5.23 |
Van-der-waals | TM3 | E | 116 | 3x49 | G.H5 | Y | 381 | G.H5.23 |
Polar | TM5 | Q | 217 | 5x70 | G.h4s6 | Y | 348 | G.h4s6.20 |
Hydrophobic | TM5 | Q | 217 | 5x70 | G.h4s6 | Y | 348 | G.h4s6.20 |
Hydrophobic | TM6 | D | 233 | 6x29 | G.H5 | E | 382 | G.H5.24 |
Van-der-waals | TM6 | D | 233 | 6x29 | G.H5 | E | 382 | G.H5.24 |
Aromatic | ICL2 | Y | 127 | 34x53 | G.H5 | H | 377 | G.H5.19 |
Hydrophobic | ICL2 | Y | 127 | 34x53 | G.H5 | H | 377 | G.H5.19 |
Van-der-waals | ICL2 | Y | 127 | 34x53 | G.H5 | H | 377 | G.H5.19 |
Hydrophobic | ICL2 | Q | 129 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Polar | ICL2 | L | 130 | 34x56 | G.hns1 | R | 38 | G.hns1.02 |
Polar | ICL2 | Y | 125 | 34x51 | G.H5 | F | 366 | G.H5.08 |
Aromatic | ICL2 | Y | 125 | 34x51 | G.H5 | F | 366 | G.H5.08 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | F | 366 | G.H5.08 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.H5 | F | 366 | G.H5.08 |
Polar | ICL2 | Q | 129 | 34x55 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 129 | 34x55 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL1 | R | 41 | - | G.H5 | L | 383 | G.H5.25 |
Aromatic | TM2 | F | 49 | 2x39 | G.H5 | Y | 381 | G.H5.23 |
Hydrophobic | TM2 | F | 49 | 2x39 | G.H5 | Y | 381 | G.H5.23 |
Van-der-waals | TM2 | F | 49 | 2x39 | G.H5 | Y | 381 | G.H5.23 |
Hydrophobic | ICL3 | G | 222 | - | G.hgh4 | D | 313 | G.hgh4.13 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | C | 369 | G.H5.11 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.H5 | C | 369 | G.H5.11 |
Polar | TM2 | S | 47 | 2x37 | G.H5 | Q | 380 | G.H5.22 |
Hydrophobic | TM2 | S | 47 | 2x37 | G.H5 | Q | 380 | G.H5.22 |
Van-der-waals | TM2 | S | 47 | 2x37 | G.H5 | Q | 380 | G.H5.22 |
Ionic | ICL2 | D | 131 | 34x57 | G.HN | K | 34 | G.HN.51 |
Polar | ICL2 | D | 131 | 34x57 | G.HN | K | 34 | G.HN.51 |
Hydrophobic | TM6 | H | 237 | 6x33 | G.H5 | E | 382 | G.H5.24 |
Polar | TM5 | R | 219 | 5x72 | G.H4 | R | 332 | G.H4.12 |
Van-der-waals | TM5 | M | 213 | 5x66 | G.H5 | D | 371 | G.H5.13 |
Hydrophobic | ICL2 | P | 124 | 34x50 | G.H5 | I | 373 | G.H5.15 |
Van-der-waals | ICL2 | P | 124 | 34x50 | G.H5 | I | 373 | G.H5.15 |
Hydrophobic | TM3 | A | 120 | 3x53 | G.H5 | H | 377 | G.H5.19 |
Van-der-waals | TM3 | A | 120 | 3x53 | G.H5 | H | 377 | G.H5.19 |
Polar | ICL2 | P | 124 | 34x50 | G.H5 | H | 377 | G.H5.19 |
Hydrophobic | ICL2 | P | 124 | 34x50 | G.H5 | H | 377 | G.H5.19 |
Polar | ICL2 | A | 128 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | A | 128 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM6 | H | 237 | 6x33 | G.H5 | Y | 381 | G.H5.23 |
Van-der-waals | TM6 | H | 237 | 6x33 | G.H5 | Y | 381 | G.H5.23 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | I | 373 | G.H5.15 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.H5 | I | 373 | G.H5.15 |
Aromatic | ICL2 | Y | 125 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | TM1 | L | 38 | 1x57 | G.H5 | L | 383 | G.H5.25 |
Van-der-waals | TM1 | L | 38 | 1x57 | G.H5 | L | 383 | G.H5.25 |
Hydrophobic | TM3 | L | 121 | 3x54 | G.H5 | L | 378 | G.H5.20 |
Van-der-waals | TM3 | L | 121 | 3x54 | G.H5 | L | 378 | G.H5.20 |
Hydrophobic | ICL2 | P | 124 | 34x50 | G.H5 | Q | 374 | G.H5.16 |
Van-der-waals | ICL2 | P | 124 | 34x50 | G.H5 | Q | 374 | G.H5.16 |
Polar | H8 | R | 296 | 8x47 | G.H5 | Y | 381 | G.H5.23 |
Hydrophobic | H8 | R | 296 | 8x47 | G.H5 | Y | 381 | G.H5.23 |
Van-der-waals | H8 | R | 296 | 8x47 | G.H5 | Y | 381 | G.H5.23 |
Polar | TM5 | Q | 221 | 5x74 | G.H4 | R | 332 | G.H4.12 |
Hydrophobic | TM2 | F | 49 | 2x39 | G.H5 | L | 383 | G.H5.25 |
Hydrophobic | ICL2 | P | 124 | 34x50 | G.H5 | R | 370 | G.H5.12 |
Van-der-waals | ICL2 | P | 124 | 34x50 | G.H5 | R | 370 | G.H5.12 |
Hydrophobic | TM5 | L | 210 | 5x63 | G.H5 | L | 378 | G.H5.20 |
Van-der-waals | TM5 | L | 210 | 5x63 | G.H5 | L | 378 | G.H5.20 |
Hydrophobic | ICL3 | G | 222 | - | G.H4 | L | 336 | G.H4.16 |
Van-der-waals | ICL3 | G | 222 | - | G.H4 | L | 336 | G.H4.16 |