PrRP receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Sept. 25, 2024

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Prolactin-releasing peptide PrRP20 - Agonist

PHYSIOLOGICAL LIGANDS

PrRP-20, neuropeptide Y, PrRP-31, PTHrP



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 L 167 - G.S3 V 194 G.S3.01
Polar TM3 V 162 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 V 162 3x53 G.H5 N 354 G.H5.19
Hydrophobic ICL2 L 167 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 L 167 - G.H5 I 350 G.H5.15
Polar ICL2 R 170 - G.H5 Y 358 G.H5.23
Van-der-waals ICL2 R 170 - G.H5 Y 358 G.H5.23
Van-der-waals TM6 T 276 6x33 G.H5 V 361 G.H5.26
Polar H8 H 339 8x47 G.H5 N 359 G.H5.24
Hydrophobic H8 H 339 8x47 G.H5 N 359 G.H5.24
Van-der-waals H8 H 339 8x47 G.H5 N 359 G.H5.24
Hydrophobic TM3 L 163 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 L 163 3x54 G.H5 L 355 G.H5.20
Hydrophobic TM5 L 252 5x65 G.H5 L 355 G.H5.20
Polar ICL2 P 166 - G.H5 N 354 G.H5.19
Hydrophobic TM3 L 163 3x54 G.H5 N 354 G.H5.19
Hydrophobic TM3 R 159 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 L 163 3x54 G.H5 L 360 G.H5.25
Van-der-waals TM3 L 163 3x54 G.H5 L 360 G.H5.25
Polar TM2 N 93 2x37 G.H5 E 357 G.H5.22
Hydrophobic TM2 N 93 2x37 G.H5 E 357 G.H5.22
Van-der-waals TM2 N 93 2x37 G.H5 E 357 G.H5.22
Polar ICL2 R 169 - G.HN Q 28 G.HN.52
Polar H8 S 341 8x49 G.H5 N 359 G.H5.24
Hydrophobic H8 S 341 8x49 G.H5 N 359 G.H5.24
Van-der-waals H8 S 341 8x49 G.H5 N 359 G.H5.24
Hydrophobic ICL2 P 166 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 166 - G.H5 I 350 G.H5.15
Hydrophobic TM3 R 159 3x50 G.H5 L 360 G.H5.25
Hydrophobic H8 F 342 8x50 G.H5 N 359 G.H5.24
Polar TM6 T 276 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM6 T 276 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 T 276 6x33 G.H5 L 360 G.H5.25
Hydrophobic ICL2 P 166 - G.H5 K 347 G.H5.12
Van-der-waals ICL2 P 166 - G.H5 K 347 G.H5.12
Hydrophobic ICL2 L 167 - G.S1 L 34 G.S1.02
Hydrophobic ICL2 P 166 - G.H5 L 351 G.H5.16
Polar TM3 D 158 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM6 L 280 6x37 G.H5 L 360 G.H5.25
Van-der-waals TM3 L 163 3x54 G.H5 L 351 G.H5.16
Hydrophobic TM3 V 162 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 V 162 3x53 G.H5 Y 358 G.H5.23
Polar TM2 T 95 2x39 G.H5 Y 358 G.H5.23
Hydrophobic TM2 T 95 2x39 G.H5 Y 358 G.H5.23
Van-der-waals TM2 T 95 2x39 G.H5 Y 358 G.H5.23