Refined structure (8J24) of Gi1 - FFA2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 215 from structure (60.7%), 139 from model (39.3%)
Residue sidechains - 204 from structure (57.6%), 150 from model (42.4%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 AF2 AF2
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure AF2
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure AF2
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 AF2 AF2
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure AF2
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure AF2
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure AF2
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure AF2
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 258 from structure (85.7%), 43 from model (14.3%)
Residue sidechains - 250 from structure (83.1%), 51 from model (16.9%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 L - AF2 AF2
TM1 3 P 1.28x28 AF2 AF2
TM1 4 D 1.29x29 Structure Structure
TM1 5 W 1.30x30 Structure Structure
TM1 6 K 1.31x31 Structure Structure
TM1 7 S 1.32x32 Structure Structure
TM1 8 S 1.33x33 Structure Structure
TM1 9 L 1.34x34 Structure Structure
TM1 10 I 1.35x35 Structure Structure
TM1 11 L 1.36x36 Structure Structure
TM1 12 M 1.37x37 Structure Structure
TM1 13 A 1.38x38 Structure Structure
TM1 14 Y 1.39x39 Structure Structure
TM1 15 I 1.40x40 Structure Structure
TM1 16 I 1.41x41 Structure Structure
TM1 17 I 1.42x42 Structure Structure
TM1 18 F 1.43x43 Structure Structure
TM1 19 L 1.44x44 Structure Structure
TM1 20 T 1.45x45 Structure Structure
TM1 21 G 1.46x46 Structure Structure
TM1 22 L 1.47x47 Structure Structure
TM1 23 P 1.48x48 Structure Structure
TM1 24 A 1.49x49 Structure Structure
TM1 25 N 1.50x50 Structure Structure
TM1 26 L 1.51x51 Structure Structure
TM1 27 L 1.52x52 Structure Structure
TM1 28 A 1.53x53 Structure Structure
TM1 29 L 1.54x54 Structure Structure
TM1 30 R 1.55x55 Structure Structure
TM1 31 A 1.56x56 Structure Structure
TM1 32 F 1.57x57 Structure Structure
TM1 33 V 1.58x58 Structure Structure
TM1 34 G 1.59x59 Structure Structure
TM1 35 R 1.60x60 Structure Structure
TM1 36 I 1.61x61 Structure AF2
TM1 37 R 1.62x62 Structure Structure
TM1 38 Q 1.63x63 Structure Structure
ICL1 39 P - Structure Structure
ICL1 40 Q - Structure Structure
ICL1 41 P - Structure Structure
TM2 42 A 2.37x37 Structure Structure
TM2 43 P 2.38x38 Structure Structure
TM2 44 V 2.39x39 Structure Structure
TM2 45 H 2.40x40 Structure Structure
TM2 46 I 2.41x41 Structure Structure
TM2 47 L 2.42x42 Structure Structure
TM2 48 L 2.43x43 Structure Structure
TM2 49 L 2.44x44 Structure Structure
TM2 50 S 2.45x45 Structure Structure
TM2 51 L 2.46x46 Structure Structure
TM2 52 T 2.47x47 Structure Structure
TM2 53 L 2.48x48 Structure Structure
TM2 54 A 2.49x49 Structure Structure
TM2 55 D 2.50x50 Structure Structure
TM2 56 L 2.51x51 Structure Structure
TM2 57 L 2.52x52 Structure Structure
TM2 58 L 2.53x53 Structure Structure
TM2 59 L 2.54x54 Structure Structure
TM2 60 L 2.55x55 Structure Structure
TM2 61 L 2.56x56 Structure Structure
TM2 62 L 2.57x57 Structure Structure
TM2 63 P 2.58x58 Structure Structure
TM2 64 F 2.59x59 Structure Structure
TM2 65 K 2.60x60 Structure Structure
TM2 66 I 2.61x61 Structure Structure
TM2 67 I 2.62x62 Structure Structure
TM2 68 E 2.63x63 Structure Structure
TM2 69 A 2.64x64 Structure Structure
TM2 70 A 2.65x65 Structure Structure
TM2 71 S 2.66x66 Structure Structure
ECL1 72 N - Structure Structure
ECL1 73 F - Structure Structure
ECL1 74 R 23.49x49 Structure Structure
ECL1 75 W 23.50x50 Structure Structure
ECL1 76 Y 23.51x51 Structure Structure
ECL1 77 L 23.52x52 Structure Structure
TM3 78 P 3.21x21 Structure Structure
TM3 79 K 3.22x22 Structure Structure
TM3 80 V 3.23x23 Structure AF2
TM3 81 V 3.24x24 Structure Structure
TM3 82 C 3.25x25 Structure Structure
TM3 83 A 3.26x26 Structure Structure
TM3 84 L 3.27x27 Structure Structure
TM3 85 T 3.28x28 Structure Structure
TM3 86 S 3.29x29 Structure AF2
TM3 87 F 3.30x30 Structure Structure
TM3 88 G 3.31x31 Structure Structure
TM3 89 F 3.32x32 Structure Structure
TM3 90 Y 3.33x33 Structure Structure
TM3 91 S 3.34x34 Structure Structure
TM3 92 S 3.35x35 Structure Structure
TM3 93 I 3.36x36 Structure Structure
TM3 94 Y 3.37x37 Structure Structure
TM3 95 C 3.38x38 Structure Structure
TM3 96 S 3.39x39 Structure Structure
TM3 97 T 3.40x40 Structure Structure
TM3 98 W 3.41x41 Structure Structure
TM3 99 L 3.42x42 Structure Structure
TM3 100 L 3.43x43 Structure Structure
TM3 101 A 3.44x44 Structure Structure
TM3 102 G 3.45x45 Structure Structure
TM3 103 I 3.46x46 Structure Structure
TM3 104 S 3.47x47 Structure Structure
TM3 105 I 3.48x48 Structure Structure
TM3 106 E 3.49x49 Structure Structure
TM3 107 R 3.50x50 Structure Structure
TM3 108 Y 3.51x51 Structure Structure
TM3 109 L 3.52x52 Structure Structure
TM3 110 G 3.53x53 Structure Structure
TM3 111 V 3.54x54 Structure Structure
TM3 112 A 3.55x55 Structure Structure
TM3 113 F 3.56x56 Structure Structure
ICL2 114 P 34.50x50 Structure Structure
ICL2 115 V 34.51x51 Structure Structure
ICL2 116 Q 34.52x52 Structure Structure
ICL2 117 Y 34.53x53 Structure Structure
ICL2 118 K 34.54x54 Structure Structure
ICL2 119 L 34.55x55 Structure Structure
ICL2 120 S 34.56x56 Structure Structure
ICL2 121 R 34.57x57 Structure Structure
TM4 122 R 4.38x38 Structure Structure
TM4 123 P 4.39x39 Structure Structure
TM4 124 L 4.40x40 Structure Structure
TM4 125 Y 4.41x41 Structure Structure
TM4 126 G 4.42x42 Structure Structure
TM4 127 V 4.43x43 Structure Structure
TM4 128 I 4.44x44 Structure Structure
TM4 129 A 4.45x45 Structure Structure
TM4 130 A 4.46x46 Structure Structure
TM4 131 L 4.47x47 Structure Structure
TM4 132 V 4.48x48 Structure Structure
TM4 133 A 4.49x49 Structure Structure
TM4 134 W 4.50x50 Structure Structure
TM4 135 V 4.51x51 Structure Structure
TM4 136 M 4.52x52 Structure Structure
TM4 137 S 4.53x53 Structure Structure
TM4 138 F 4.54x54 Structure Structure
TM4 139 G 4.55x55 Structure Structure
TM4 140 H 4.56x56 Structure Structure
TM4 141 C 4.57x57 Structure Structure
TM4 142 T 4.58x58 Structure Structure
TM4 143 I 4.59x59 Structure Structure
TM4 144 V 4.60x60 Structure Structure
TM4 145 I 4.61x61 Structure Structure
TM4 146 I 4.62x62 Structure Structure
TM4 147 V 4.63x63 Structure Structure
TM4 148 Q 4.64x64 Structure Structure
TM4 149 Y 4.65x65 AF2 AF2
TM4 150 L 4.66x66 AF2 AF2
TM4 151 N 4.67x67 AF2 AF2
TM4 152 T 4.68x68 AF2 AF2
ECL2 153 T - AF2 AF2
ECL2 154 E - AF2 AF2
ECL2 155 Q - AF2 AF2
ECL2 156 V - AF2 AF2
ECL2 157 R - AF2 AF2
ECL2 158 S - AF2 AF2
ECL2 159 G - AF2 AF2
ECL2 160 N - AF2 AF2
ECL2 161 E - AF2 AF2
ECL2 162 I - AF2 AF2
ECL2 163 T - Structure Structure
ECL2 164 C 45.50x50 Structure Structure
ECL2 165 Y 45.51x51 Structure Structure
ECL2 166 E 45.52x52 Structure Structure
ECL2 167 N - Structure Structure
ECL2 168 F - Structure Structure
ECL2 169 T - Structure Structure
ECL2 170 D - Structure Structure
ECL2 171 N - Structure AF2
TM5 172 Q 5.31x32 Structure Structure
TM5 173 L 5.32x33 Structure Structure
TM5 174 D 5.33x34 Structure Structure
TM5 175 V 5.34x35 Structure Structure
TM5 176 V 5.35x36 Structure Structure
TM5 177 L 5.36x37 Structure Structure
TM5 178 P 5.37x38 Structure Structure
TM5 179 V 5.38x39 Structure Structure
TM5 180 R 5.39x40 Structure Structure
TM5 181 L 5.40x41 Structure Structure
TM5 182 E 5.41x42 Structure Structure
TM5 183 L 5.42x43 Structure Structure
TM5 184 C 5.43x44 Structure Structure
TM5 185 L 5.44x45 Structure Structure
TM5 186 V 5.45x46 Structure Structure
TM5 187 L 5.46x461 Structure Structure
TM5 188 F 5.47x47 Structure Structure
TM5 189 F 5.48x48 Structure Structure
TM5 190 I 5.49x49 Structure Structure
TM5 191 P 5.50x50 Structure Structure
TM5 192 M 5.51x51 Structure Structure
TM5 193 A 5.52x52 Structure Structure
TM5 194 V 5.53x53 Structure Structure
TM5 195 T 5.54x54 Structure Structure
TM5 196 I 5.55x55 Structure Structure
TM5 197 F 5.56x56 Structure Structure
TM5 198 C 5.57x57 Structure Structure
TM5 199 Y 5.58x58 Structure Structure
TM5 200 W 5.59x59 Structure Structure
TM5 201 R 5.60x60 Structure Structure
TM5 202 F 5.61x61 Structure Structure
TM5 203 V 5.62x62 Structure Structure
TM5 204 W 5.63x63 Structure Structure
TM5 205 I 5.64x64 Structure Structure
TM5 206 M 5.65x65 Structure Structure
TM5 207 L 5.66x66 Structure Structure
TM5 208 S 5.67x67 Structure AF2
TM5 209 Q 5.68x68 Structure Structure
ICL3 210 P - Structure Structure
ICL3 211 L - Structure AF2
ICL3 212 V - Structure Structure
TM6 213 G 6.26x27 Structure Structure
TM6 214 A 6.27x28 Structure Structure
TM6 215 Q 6.28x29 Structure Structure
TM6 216 R 6.29x30 Structure Structure
TM6 217 R 6.30x31 Structure Structure
TM6 218 R 6.31x32 Structure Structure
TM6 219 R 6.32x33 Structure Structure
TM6 220 A 6.33x34 Structure Structure
TM6 221 V 6.34x35 Structure Structure
TM6 222 G 6.35x36 Structure Structure
TM6 223 L 6.36x37 Structure Structure
TM6 224 A 6.37x38 Structure Structure
TM6 225 V 6.38x39 Structure Structure
TM6 226 V 6.39x40 Structure Structure
TM6 227 T 6.40x41 Structure Structure
TM6 228 L 6.41x42 Structure Structure
TM6 229 L 6.42x43 Structure Structure
TM6 230 N 6.43x44 Structure Structure
TM6 231 F 6.44x45 Structure Structure
TM6 232 L 6.45x46 Structure Structure
TM6 233 V 6.46x461 Structure Structure
TM6 234 C 6.47x47 Structure Structure
TM6 235 F 6.48x48 Structure Structure
TM6 236 G 6.49x49 Structure Structure
TM6 237 P 6.50x50 Structure Structure
TM6 238 Y 6.51x51 Structure Structure
TM6 239 N 6.52x52 Structure Structure
TM6 240 V 6.53x53 Structure Structure
TM6 241 S 6.54x54 Structure Structure
TM6 242 H 6.55x55 Structure Structure
TM6 243 L 6.56x56 Structure Structure
TM6 244 V 6.57x57 Structure Structure
TM6 245 G 6.58x58 Structure Structure
TM6 246 Y 6.59x59 Structure AF2
TM6 247 H 6.60x60 Structure AF2
TM6 248 Q 6.61x61 Structure Structure
TM6 249 R 6.62x62 Structure Structure
ECL3 250 K - Structure Structure
ECL3 251 S - Structure Structure
ECL3 252 P - Structure Structure
ECL3 253 W - Structure Structure
TM7 254 W 7.34x33 Structure Structure
TM7 255 R 7.35x34 Structure Structure
TM7 256 S 7.36x35 Structure Structure
TM7 257 I 7.37x36 Structure Structure
TM7 258 A 7.38x37 Structure Structure
TM7 259 V 7.39x38 Structure Structure
TM7 260 V 7.40x39 Structure Structure
TM7 261 F 7.41x40 Structure Structure
TM7 262 S 7.42x41 Structure Structure
TM7 263 S 7.43x42 Structure Structure
TM7 264 L 7.44x43 Structure Structure
TM7 265 N 7.45x45 Structure Structure
TM7 266 A 7.46x46 Structure Structure
TM7 267 S 7.47x47 Structure Structure
TM7 268 L 7.48x48 Structure Structure
TM7 269 D 7.49x49 Structure Structure
TM7 270 P 7.50x50 Structure Structure
TM7 271 L 7.51x51 Structure Structure
TM7 272 L 7.52x52 Structure Structure
TM7 273 F 7.53x53 Structure Structure
TM7 274 Y 7.54x54 Structure Structure
TM7 275 F 7.55x55 Structure Structure
TM7 276 S 7.56x56 AF2 AF2
H8 277 S 8.47x47 AF2 AF2
H8 278 S 8.48x48 AF2 AF2
H8 279 V 8.49x49 AF2 AF2
H8 280 V 8.50x50 AF2 AF2
H8 281 R 8.51x51 AF2 AF2
H8 282 R 8.52x52 AF2 AF2
H8 283 A 8.53x53 AF2 AF2
H8 284 F 8.54x54 AF2 AF2
H8 285 G 8.55x55 AF2 AF2
H8 286 R 8.56x56 AF2 AF2
H8 287 G 8.57x57 AF2 AF2
H8 288 L 8.58x58 AF2 AF2
H8 289 Q 8.59x59 AF2 AF2
H8 290 V 8.60x60 AF2 AF2
H8 291 L 8.61x61 AF2 AF2
C-term 292 R - AF2 AF2
C-term 293 N - AF2 AF2
C-term 294 Q - AF2 AF2
C-term 295 G - AF2 AF2
C-term 296 S - AF2 AF2
C-term 297 S - AF2 AF2
C-term 298 L - AF2 AF2
C-term 299 L - AF2 AF2
C-term 300 G - AF2 AF2
C-term 301 R - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 F 202 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 F 202 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Y 117 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 117 34x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 A 220 6x34 G.H5 L 348 G.H5.20
Van-der-waals ICL2 K 118 34x54 G.S1 V 34 G.S1.02
Polar TM7 S 276 7x56 G.H5 C 351 G.H5.23
Hydrophobic ICL2 K 118 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM5 F 202 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM2 V 44 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 44 2x39 G.H5 C 351 G.H5.23
Polar ICL3 L 211 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 L 211 - G.H5 K 345 G.H5.17
Hydrophobic TM3 V 111 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 111 3x54 G.H5 L 348 G.H5.20
Aromatic TM6 R 216 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 216 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 216 6x30 G.H5 F 354 G.H5.26
Polar ICL2 R 121 34x57 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 121 34x57 G.hns1 R 32 G.hns1.03
Polar TM7 S 276 7x56 G.H5 L 353 G.H5.25
Polar TM7 S 276 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 S 276 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 S 276 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM6 A 220 6x34 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 114 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 114 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM2 V 44 2x39 G.H5 D 350 G.H5.22
Polar ICL1 Q 40 - G.HN G 27 G.HN.51
Hydrophobic ICL1 Q 40 - G.HN G 27 G.HN.51
Van-der-waals ICL1 Q 40 - G.HN G 27 G.HN.51
Hydrophobic ICL2 V 115 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL3 L 211 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 L 211 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 L 211 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 L 211 - G.S6 Y 320 G.S6.02
Polar TM7 S 276 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 S 276 7x56 G.H5 F 354 G.H5.26
Hydrophobic ICL3 L 211 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 L 211 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 119 34x55 G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 114 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 114 34x50 G.H5 I 344 G.H5.16
Polar TM3 R 107 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 107 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 107 3x50 G.H5 C 351 G.H5.23
Polar ICL2 P 114 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 114 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 V 115 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL1 Q 40 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 R 107 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 107 3x50 G.H5 L 353 G.H5.25
Polar TM2 H 45 2x40 G.H5 D 350 G.H5.22
Hydrophobic TM2 H 45 2x40 G.H5 D 350 G.H5.22
Van-der-waals TM2 H 45 2x40 G.H5 D 350 G.H5.22
Polar ICL2 L 119 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 119 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 119 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 118 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 M 206 5x65 G.H5 I 344 G.H5.16
Polar H8 S 277 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 277 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 277 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 V 115 34x51 G.S3 L 194 G.S3.01
Polar TM3 G 110 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 G 110 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 G 110 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 R 216 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 216 6x30 G.H5 K 345 G.H5.17
Hydrophobic TM6 L 223 6x37 G.H5 L 353 G.H5.25
Ionic ICL2 R 121 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 121 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL2 L 119 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 L 119 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 A 220 6x34 G.H5 L 353 G.H5.25
Hydrophobic ICL3 V 212 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 114 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM5 M 206 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 M 206 5x65 G.H5 L 348 G.H5.20
Polar ICL2 K 118 34x54 G.S1 E 33 G.S1.01