GIP receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Bos taurus

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Oct. 18, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

gastric inhibitory polypeptide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 V 212 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 V 212 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 G 213 - G.S3 V 217 G.S3.01
Polar ICL2 S 215 - G.hns1 R 38 G.hns1.02
Polar TM3 E 201 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 201 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 201 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 205 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 L 205 3x54 G.H5 L 393 G.H5.25
Polar TM5 K 288 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 288 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 288 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 G 214 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 G 214 - G.hns1 A 39 G.hns1.03
Polar TM5 K 288 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 288 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 288 5x64 G.H5 R 385 G.H5.17
Polar TM2 R 133 2x46 G.H5 Y 391 G.H5.23
Aromatic TM2 R 133 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 133 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 133 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM5 T 291 5x67 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 288 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM6 R 305 6x40 G.H5 L 393 G.H5.25
Van-der-waals TM6 R 305 6x40 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 301 6x36 G.H5 L 394 G.H5.26
Van-der-waals TM6 L 301 6x36 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 289 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 281 5x57 G.H5 L 393 G.H5.25
Ionic TM5 K 288 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 288 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 288 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 288 5x64 G.H5 D 381 G.H5.13
Hydrophobic ICL4 I 359 - G.H5 E 392 G.H5.24
Hydrophobic TM3 L 209 3x58 G.H5 H 387 G.H5.19
Polar TM3 L 211 3x60 G.H5 R 380 G.H5.12
Hydrophobic TM3 L 211 3x60 G.H5 R 380 G.H5.12
Van-der-waals TM3 L 211 3x60 G.H5 R 380 G.H5.12
Hydrophobic TM5 I 284 5x60 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 285 5x61 G.H5 L 394 G.H5.26
Polar H8 E 362 8x49 G.H5 Q 390 G.H5.22
Polar TM2 R 133 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 133 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 133 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM5 L 285 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM3 Y 204 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 204 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 285 5x61 G.H5 L 388 G.H5.20
Ionic H8 K 361 8x48 G.H5 E 392 G.H5.24
Polar H8 K 361 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 361 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 361 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM5 R 292 5x68 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 R 292 5x68 G.h4s6 Y 358 G.h4s6.20
Polar TM3 L 209 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 209 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 209 3x58 G.H5 Q 384 G.H5.16
Polar ICL2 S 215 - G.hns1 A 39 G.hns1.03
Hydrophobic TM3 L 209 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 209 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM6 L 301 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 301 6x36 G.H5 L 393 G.H5.25
Polar TM3 L 208 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 208 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 208 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 205 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 205 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM6 F 309 6x44 G.H5 L 393 G.H5.25
Van-der-waals TM6 F 309 6x44 G.H5 L 393 G.H5.25
Hydrophobic TM5 K 288 5x64 G.H5 L 394 G.H5.26
Hydrophobic TM5 R 292 5x68 G.H5 R 385 G.H5.17