OR51E2 - Gs

GPCR CLASS (FAMILY)

Class O1 (fish-like odorant)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8F76

RESOLUTION

3.1 Å

REFERENCE

10.1038/S41586-023-05798-Y

PUBLICATION DATE

March 22, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

6 interactions (Click to see)

LIGANDS

propanoic acid - Agonist pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 H 131 - G.H5 H 387 G.H5.19
Aromatic ICL2 H 131 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 H 131 - G.H5 H 387 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 124 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 130 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 R 130 - G.S3 V 217 G.S3.01
Polar TM4 N 136 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM4 N 136 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 N 136 4x38 G.HN Q 35 G.HN.52
Hydrophobic ICL2 L 129 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 129 - G.H5 I 383 G.H5.15
Hydrophobic ICL4 K 294 - G.H5 E 392 G.H5.24
Van-der-waals ICL4 K 294 - G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 129 - G.H5 C 379 G.H5.11
Hydrophobic ICL2 P 128 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 128 - G.H5 H 387 G.H5.19
Hydrophobic TM3 R 121 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM2 M 58 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 M 58 2x39 G.H5 Y 391 G.H5.23
Polar H8 K 296 8x48 G.H5 R 389 G.H5.21
Van-der-waals H8 K 296 8x48 G.H5 R 389 G.H5.21
Polar TM6 T 239 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 239 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 239 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM5 I 220 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 220 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM6 K 235 6x32 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 235 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 235 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 A 236 6x33 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 128 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 128 - G.H5 Q 384 G.H5.16
Polar ICL2 H 131 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 H 131 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 A 132 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 A 132 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Polar TM3 A 124 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 H 387 G.H5.19
Ionic TM6 E 232 6x29 G.H5 R 385 G.H5.17
Polar TM6 E 232 6x29 G.H5 R 385 G.H5.17
Van-der-waals TM6 E 232 6x29 G.H5 R 385 G.H5.17
Ionic H8 K 296 8x48 G.H5 E 392 G.H5.24
Polar H8 K 296 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 296 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 296 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 129 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 129 - G.H5 F 376 G.H5.08
Polar H8 K 296 8x48 G.H5 L 394 G.H5.26
Hydrophobic TM5 V 224 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 224 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 125 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 129 - G.S3 V 217 G.S3.01
Hydrophobic ICL3 L 227 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 129 - G.H5 R 380 G.H5.12
Hydrophobic TM5 T 223 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 T 223 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 125 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL3 L 227 - G.H5 L 394 G.H5.26
Ionic ICL2 R 130 - G.s2s3 D 215 G.s2s3.01
Polar ICL2 R 130 - G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 R 130 - G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 130 - G.s2s3 D 215 G.s2s3.01
Polar TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 128 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 128 - G.H5 I 383 G.H5.15
Polar TM3 D 120 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 120 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 120 3x49 G.H5 Y 391 G.H5.23
Polar TM6 E 232 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic H8 T 295 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 T 295 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM2 M 58 2x39 G.H5 Q 390 G.H5.22
Van-der-waals TM2 M 58 2x39 G.H5 Q 390 G.H5.22
Polar TM6 A 236 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 236 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 236 6x33 G.H5 L 393 G.H5.25
Ionic H8 R 299 8x51 G.H5 E 392 G.H5.24
Hydrophobic TM5 V 224 5x65 G.H5 L 393 G.H5.25
Van-der-waals TM5 V 224 5x65 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 129 - G.S3 F 219 G.S3.03
Van-der-waals ICL2 L 129 - G.S3 F 219 G.S3.03
Hydrophobic ICL3 L 227 - G.H5 L 388 G.H5.20
Hydrophobic TM6 E 232 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 E 232 6x29 G.H5 L 394 G.H5.26
Polar TM6 T 239 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 239 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 129 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 129 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 P 128 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 128 - G.H5 R 380 G.H5.12
Hydrophobic TM4 N 136 4x38 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 N 136 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic TM6 C 240 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 C 240 6x37 G.H5 L 393 G.H5.25
Polar TM3 C 126 3x55 G.H5 R 380 G.H5.12
Hydrophobic TM3 C 126 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 C 126 3x55 G.H5 R 380 G.H5.12