Refined structure (7XOW) of Gq - CCK2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 219 from structure (61.0%), 140 from model (39.0%)
Residue sidechains - 13 from structure (3.6%), 346 from model (96.4%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 Structure AF2
G.HN 6 I G.HN.06 Structure AF2
G.HN 7 M G.HN.07 Structure AF2
G.HN 8 A G.HN.08 Structure AF2
G.HN 9 C G.HN.09 Structure AF2
G.HN 10 C G.HN.10 Structure AF2
G.HN 11 L G.HN.11 Structure AF2
G.HN 12 S G.HN.30 Structure AF2
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure AF2
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure AF2
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure Structure
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure AF2
G.HN 26 E G.HN.44 Structure AF2
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure AF2
G.HN 29 L G.HN.47 Structure AF2
G.HN 30 R G.HN.48 Structure AF2
G.HN 31 R G.HN.49 Structure Structure
G.HN 32 D G.HN.50 Structure AF2
G.HN 33 K G.HN.51 Structure AF2
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure AF2
G.hns1 37 R G.hns1.02 Structure AF2
G.hns1 38 R G.hns1.03 Structure AF2
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure AF2
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure AF2
G.S1 43 L G.S1.05 Structure AF2
G.S1 44 L G.S1.06 Structure AF2
G.S1 45 L G.S1.07 Structure AF2
G.s1h1 46 G G.s1h1.01 Structure AF2
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure AF2
G.s1h1 51 G G.s1h1.06 Structure AF2
G.H1 52 K G.H1.01 Structure AF2
G.H1 53 S G.H1.02 Structure AF2
G.H1 54 T G.H1.03 Structure AF2
G.H1 55 F G.H1.04 Structure AF2
G.H1 56 I G.H1.05 Structure Structure
G.H1 57 K G.H1.06 Structure AF2
G.H1 58 Q G.H1.07 Structure AF2
G.H1 59 M G.H1.08 AF2 AF2
G.H1 60 R G.H1.09 AF2 AF2
G.H1 61 I G.H1.10 AF2 AF2
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 Structure AF2
G.hfs2 183 R G.hfs2.02 Structure AF2
G.hfs2 184 V G.hfs2.03 Structure AF2
G.hfs2 185 P G.hfs2.04 Structure AF2
G.hfs2 186 T G.hfs2.05 Structure AF2
G.hfs2 187 T G.hfs2.06 Structure AF2
G.hfs2 188 G G.hfs2.07 Structure AF2
G.S2 189 I G.S2.01 Structure AF2
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure AF2
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure AF2
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure AF2
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure AF2
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure AF2
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure AF2
G.S3 206 V G.S3.08 Structure AF2
G.s3h2 207 G G.s3h2.01 Structure AF2
G.s3h2 208 G G.s3h2.02 Structure AF2
G.s3h2 209 Q G.s3h2.03 Structure AF2
G.H2 210 R G.H2.01 Structure AF2
G.H2 211 S G.H2.02 Structure AF2
G.H2 212 E G.H2.03 Structure AF2
G.H2 213 R G.H2.04 Structure AF2
G.H2 214 R G.H2.05 Structure AF2
G.H2 215 K G.H2.06 Structure AF2
G.H2 216 W G.H2.07 Structure AF2
G.H2 217 I G.H2.08 Structure AF2
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure AF2
G.h2s4 220 F G.h2s4.01 Structure AF2
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure AF2
G.h2s4 224 T G.h2s4.05 Structure AF2
G.S4 225 S G.S4.01 Structure AF2
G.S4 226 I G.S4.02 Structure AF2
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure AF2
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure AF2
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure Structure
G.s4h3 233 S G.s4h3.02 AF2 AF2
G.s4h3 234 E G.s4h3.03 AF2 AF2
G.s4h3 235 Y G.s4h3.04 AF2 AF2
G.s4h3 236 D G.s4h3.05 AF2 AF2
G.s4h3 237 Q G.s4h3.06 AF2 AF2
G.s4h3 238 V G.s4h3.07 AF2 AF2
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 Structure AF2
G.s4h3 241 E G.s4h3.10 Structure AF2
G.s4h3 242 S G.s4h3.11 Structure AF2
G.s4h3 243 D G.s4h3.12 Structure AF2
G.s4h3 244 N G.s4h3.13 Structure AF2
G.s4h3 245 E G.s4h3.14 Structure AF2
G.s4h3 246 N G.s4h3.15 Structure AF2
G.H3 247 R G.H3.01 Structure AF2
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure AF2
G.H3 251 S G.H3.05 Structure AF2
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure AF2
G.H3 255 F G.H3.09 Structure AF2
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure AF2
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure AF2
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure AF2
G.S5 269 V G.S5.02 Structure AF2
G.S5 270 I G.S5.03 Structure AF2
G.S5 271 L G.S5.04 Structure AF2
G.S5 272 F G.S5.05 Structure AF2
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure AF2
G.s5hg 275 K G.s5hg.01 Structure AF2
G.HG 276 K G.HG.01 Structure Structure
G.HG 277 D G.HG.02 Structure AF2
G.HG 278 L G.HG.03 Structure AF2
G.HG 279 L G.HG.04 Structure AF2
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure AF2
G.HG 282 K G.HG.07 Structure AF2
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure Structure
G.HG 286 S G.HG.13 Structure AF2
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 Structure AF2
G.hgh4 292 F G.hgh4.02 Structure AF2
G.hgh4 293 P G.hgh4.03 Structure AF2
G.hgh4 294 E G.hgh4.04 Structure AF2
G.hgh4 295 Y G.hgh4.05 Structure AF2
G.hgh4 296 D G.hgh4.06 Structure AF2
G.hgh4 297 G G.hgh4.07 Structure AF2
G.hgh4 298 P G.hgh4.08 Structure AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure Structure
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure AF2
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure AF2
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure AF2
G.H4 309 I G.H4.11 Structure AF2
G.H4 310 L G.H4.12 Structure Structure
G.H4 311 K G.H4.13 Structure AF2
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure AF2
G.H4 314 V G.H4.16 Structure AF2
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure AF2
G.h4s6 320 S G.h4s6.11 Structure Structure
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure AF2
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure AF2
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure AF2
G.S6 328 F G.S6.05 Structure AF2
G.s6h5 329 T G.s6h5.01 Structure AF2
G.s6h5 330 C G.s6h5.02 Structure AF2
G.s6h5 331 A G.s6h5.03 Structure AF2
G.s6h5 332 T G.s6h5.04 Structure AF2
G.s6h5 333 D G.s6h5.05 Structure AF2
G.H5 334 T G.H5.01 Structure AF2
G.H5 335 E G.H5.02 Structure AF2
G.H5 336 N G.H5.03 Structure AF2
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure AF2
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure AF2
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure AF2
G.H5 346 D G.H5.13 Structure AF2
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure AF2
G.H5 349 L G.H5.16 Structure AF2
G.H5 350 Q G.H5.17 Structure AF2
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure AF2
G.H5 353 L G.H5.20 Structure AF2
G.H5 354 K G.H5.21 AF2 AF2
G.H5 355 E G.H5.22 AF2 AF2
G.H5 356 Y G.H5.23 AF2 AF2
G.H5 357 N G.H5.24 AF2 AF2
G.H5 358 L G.H5.25 AF2 AF2
G.H5 359 V G.H5.26 AF2 AF2

REFINED GPCR RESIDUES

Residue backbones - 275 from structure (75.5%), 89 from model (24.5%)
Residue sidechains - 274 from structure (75.3%), 90 from model (24.7%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 L - AF2 AF2
N-term 4 L - AF2 AF2
N-term 5 K - AF2 AF2
N-term 6 L - AF2 AF2
N-term 7 N - AF2 AF2
N-term 8 R - AF2 AF2
N-term 9 S - AF2 AF2
N-term 10 V - AF2 AF2
N-term 11 Q - AF2 AF2
N-term 12 G - AF2 AF2
N-term 13 T - AF2 AF2
N-term 14 G - AF2 AF2
N-term 15 P - AF2 AF2
N-term 16 G - AF2 AF2
N-term 17 P - AF2 AF2
N-term 18 G - AF2 AF2
N-term 19 A - AF2 AF2
N-term 20 S - AF2 AF2
N-term 21 L - AF2 AF2
N-term 22 C - AF2 AF2
N-term 23 R - AF2 AF2
N-term 24 P - AF2 AF2
N-term 25 G - AF2 AF2
N-term 26 A - AF2 AF2
N-term 27 P - AF2 AF2
N-term 28 L - AF2 AF2
N-term 29 L - AF2 AF2
N-term 30 N - AF2 AF2
N-term 31 S - AF2 AF2
N-term 32 S - AF2 AF2
N-term 33 S - AF2 AF2
N-term 34 V - AF2 AF2
N-term 35 G - AF2 AF2
N-term 36 N - AF2 AF2
N-term 37 L - AF2 AF2
N-term 38 S - AF2 AF2
N-term 39 C - AF2 AF2
N-term 40 E - AF2 AF2
N-term 41 P - AF2 AF2
N-term 42 P - AF2 AF2
N-term 43 R - AF2 AF2
N-term 44 I - AF2 AF2
N-term 45 R - AF2 AF2
N-term 46 G - AF2 AF2
N-term 47 A - AF2 AF2
N-term 48 G - AF2 AF2
N-term 49 T - AF2 AF2
N-term 50 R - AF2 AF2
N-term 51 E - AF2 AF2
TM1 52 L 1.30x30 AF2 AF2
TM1 53 E 1.31x31 AF2 AF2
TM1 54 L 1.32x32 Structure Structure
TM1 55 A 1.33x33 Structure Structure
TM1 56 I 1.34x34 Structure Structure
TM1 57 R 1.35x35 Structure Structure
TM1 58 I 1.36x36 Structure Structure
TM1 59 T 1.37x37 Structure Structure
TM1 60 L 1.38x38 Structure Structure
TM1 61 Y 1.39x39 Structure Structure
TM1 62 A 1.40x40 Structure Structure
TM1 63 V 1.41x41 Structure Structure
TM1 64 I 1.42x42 Structure Structure
TM1 65 F 1.43x43 Structure Structure
TM1 66 L 1.44x44 Structure Structure
TM1 67 M 1.45x45 Structure Structure
TM1 68 S 1.46x46 Structure Structure
TM1 69 V 1.47x47 Structure Structure
TM1 70 G 1.48x48 Structure Structure
TM1 71 G 1.49x49 Structure Structure
TM1 72 N 1.50x50 Structure Structure
TM1 73 M 1.51x51 Structure Structure
TM1 74 L 1.52x52 Structure Structure
TM1 75 I 1.53x53 Structure Structure
TM1 76 I 1.54x54 Structure Structure
TM1 77 V 1.55x55 Structure Structure
TM1 78 V 1.56x56 Structure Structure
TM1 79 L 1.57x57 Structure Structure
TM1 80 G 1.58x58 Structure Structure
TM1 81 L 1.59x59 Structure Structure
TM1 82 S 1.60x60 Structure Structure
ICL1 83 R 12.48x48 Structure Structure
ICL1 84 R 12.49x49 Structure Structure
ICL1 85 L 12.50x50 Structure Structure
ICL1 86 R 12.51x51 Structure Structure
TM2 87 T 2.37x37 Structure Structure
TM2 88 V 2.38x38 Structure Structure
TM2 89 T 2.39x39 Structure Structure
TM2 90 N 2.40x40 Structure Structure
TM2 91 A 2.41x41 Structure Structure
TM2 92 F 2.42x42 Structure Structure
TM2 93 L 2.43x43 Structure Structure
TM2 94 L 2.44x44 Structure Structure
TM2 95 S 2.45x45 Structure Structure
TM2 96 L 2.46x46 Structure Structure
TM2 97 A 2.47x47 Structure Structure
TM2 98 V 2.48x48 Structure Structure
TM2 99 S 2.49x49 Structure Structure
TM2 100 D 2.50x50 Structure Structure
TM2 101 L 2.51x51 Structure Structure
TM2 102 L 2.52x52 Structure Structure
TM2 103 L 2.53x53 Structure Structure
TM2 104 A 2.54x54 Structure Structure
TM2 105 V 2.55x55 Structure Structure
TM2 106 A 2.56x551 Structure Structure
TM2 107 C 2.57x56 Structure Structure
TM2 108 M 2.58x57 Structure Structure
TM2 109 P 2.59x58 Structure Structure
TM2 110 F 2.60x59 Structure Structure
TM2 111 T 2.61x60 Structure Structure
TM2 112 L 2.62x61 Structure Structure
TM2 113 L 2.63x62 Structure Structure
TM2 114 P 2.64x63 Structure Structure
TM2 115 N 2.65x64 Structure Structure
TM2 116 L 2.66x65 Structure Structure
TM2 117 M 2.67x66 Structure Structure
TM2 118 G 2.68x67 Structure Structure
ECL1 119 T 23.49x49 Structure Structure
ECL1 120 F 23.50x50 Structure Structure
ECL1 121 I 23.51x51 Structure Structure
ECL1 122 F 23.52x52 Structure Structure
TM3 123 G 3.21x21 Structure Structure
TM3 124 T 3.22x22 Structure Structure
TM3 125 V 3.23x23 Structure Structure
TM3 126 I 3.24x24 Structure Structure
TM3 127 C 3.25x25 Structure Structure
TM3 128 K 3.26x26 Structure Structure
TM3 129 A 3.27x27 Structure Structure
TM3 130 V 3.28x28 Structure Structure
TM3 131 S 3.29x29 Structure Structure
TM3 132 Y 3.30x30 Structure Structure
TM3 133 L 3.31x31 Structure Structure
TM3 134 M 3.32x32 Structure Structure
TM3 135 G 3.33x33 Structure Structure
TM3 136 V 3.34x34 Structure Structure
TM3 137 S 3.35x35 Structure Structure
TM3 138 V 3.36x36 Structure Structure
TM3 139 S 3.37x37 Structure Structure
TM3 140 V 3.38x38 Structure Structure
TM3 141 S 3.39x39 Structure Structure
TM3 142 T 3.40x40 Structure Structure
TM3 143 L 3.41x41 Structure Structure
TM3 144 S 3.42x42 Structure Structure
TM3 145 L 3.43x43 Structure Structure
TM3 146 V 3.44x44 Structure Structure
TM3 147 A 3.45x45 Structure Structure
TM3 148 I 3.46x46 Structure Structure
TM3 149 A 3.47x47 Structure Structure
TM3 150 L 3.48x48 Structure Structure
TM3 151 E 3.49x49 Structure Structure
TM3 152 R 3.50x50 Structure Structure
TM3 153 Y 3.51x51 Structure Structure
TM3 154 S 3.52x52 Structure Structure
TM3 155 A 3.53x53 Structure Structure
TM3 156 I 3.54x54 Structure Structure
TM3 157 C 3.55x55 Structure Structure
TM3 158 R 3.56x56 Structure Structure
ICL2 159 P 34.50x50 Structure Structure
ICL2 160 L 34.51x51 Structure Structure
ICL2 161 Q 34.52x52 Structure Structure
ICL2 162 A 34.53x53 Structure Structure
ICL2 163 R 34.54x54 Structure Structure
ICL2 164 V 34.55x55 Structure Structure
ICL2 165 W 34.56x56 Structure Structure
ICL2 166 Q 34.57x57 Structure Structure
TM4 167 T 4.38x38 Structure Structure
TM4 168 R 4.39x39 Structure Structure
TM4 169 S 4.40x40 Structure Structure
TM4 170 H 4.41x41 Structure Structure
TM4 171 A 4.42x42 Structure Structure
TM4 172 A 4.43x43 Structure Structure
TM4 173 R 4.44x44 Structure Structure
TM4 174 V 4.45x45 Structure Structure
TM4 175 I 4.46x46 Structure Structure
TM4 176 V 4.47x47 Structure Structure
TM4 177 A 4.48x48 Structure Structure
TM4 178 T 4.49x49 Structure Structure
TM4 179 W 4.50x50 Structure Structure
TM4 180 L 4.51x51 Structure Structure
TM4 181 L 4.52x52 Structure Structure
TM4 182 S 4.53x53 Structure Structure
TM4 183 G 4.54x54 Structure Structure
TM4 184 L 4.55x55 Structure Structure
TM4 185 L 4.56x56 Structure Structure
TM4 186 M 4.57x57 Structure Structure
TM4 187 V 4.58x59 Structure Structure
TM4 188 P 4.59x60 Structure Structure
TM4 189 Y 4.60x61 Structure Structure
TM4 190 P 4.61x62 Structure Structure
TM4 191 V 4.62x63 Structure Structure
TM4 192 Y 4.63x64 Structure Structure
TM4 193 T 4.64x65 Structure Structure
ECL2 194 V - Structure Structure
ECL2 195 V - Structure Structure
ECL2 196 Q - Structure Structure
ECL2 197 P - Structure Structure
ECL2 198 V - Structure Structure
ECL2 199 G - Structure Structure
ECL2 200 P - Structure Structure
ECL2 201 R - Structure Structure
ECL2 202 V - Structure Structure
ECL2 203 L - Structure Structure
ECL2 204 Q - Structure Structure
ECL2 205 C 45.50x50 Structure Structure
ECL2 206 V 45.51x51 Structure Structure
ECL2 207 H 45.52x52 Structure Structure
ECL2 208 R - Structure Structure
ECL2 209 W - Structure Structure
ECL2 210 P - Structure Structure
TM5 211 S 5.31x32 Structure Structure
TM5 212 A 5.32x33 Structure Structure
TM5 213 R 5.33x34 Structure Structure
TM5 214 V 5.34x35 Structure Structure
TM5 215 R 5.35x36 Structure Structure
TM5 216 Q 5.36x37 Structure Structure
TM5 217 T 5.37x38 Structure Structure
TM5 218 W 5.38x39 Structure Structure
TM5 219 S 5.39x40 Structure Structure
TM5 220 V 5.40x41 Structure Structure
TM5 221 L 5.41x42 Structure Structure
TM5 222 L 5.42x43 Structure Structure
TM5 223 L 5.43x44 Structure Structure
TM5 224 L 5.44x45 Structure Structure
TM5 225 L 5.45x46 Structure Structure
TM5 226 L 5.46x461 Structure Structure
TM5 227 F 5.47x47 Structure Structure
TM5 228 F 5.48x48 Structure Structure
TM5 229 I 5.49x49 Structure Structure
TM5 230 P 5.50x50 Structure Structure
TM5 231 G 5.51x51 Structure Structure
TM5 232 V 5.52x52 Structure Structure
TM5 233 V 5.53x53 Structure Structure
TM5 234 M 5.54x54 Structure Structure
TM5 235 A 5.55x55 Structure Structure
TM5 236 V 5.56x56 Structure Structure
TM5 237 A 5.57x57 Structure Structure
TM5 238 Y 5.58x58 Structure Structure
TM5 239 G 5.59x59 Structure Structure
TM5 240 L 5.60x60 Structure Structure
TM5 241 I 5.61x61 Structure Structure
TM5 242 S 5.62x62 Structure Structure
TM5 243 R 5.63x63 Structure Structure
TM5 244 E 5.64x64 Structure Structure
TM5 245 L 5.65x65 Structure Structure
TM5 246 Y 5.66x66 Structure Structure
TM5 247 L 5.67x67 Structure Structure
TM5 248 G 5.68x68 Structure Structure
TM5 249 L 5.69x69 AF2 AF2
TM5 250 R 5.70x70 AF2 AF2
TM5 251 F 5.71x71 AF2 AF2
TM5 252 D 5.72x72 AF2 AF2
TM5 253 G 5.73x73 AF2 AF2
TM5 254 D 5.74x74 AF2 AF2
TM5 255 S 5.75x75 AF2 AF2
TM5 256 D 5.76x76 AF2 AF2
ICL3 257 S - AF2 AF2
ICL3 258 D - AF2 AF2
ICL3 259 S - AF2 AF2
ICL3 260 Q - AF2 AF2
ICL3 261 S - AF2 AF2
ICL3 262 R - AF2 AF2
ICL3 263 V - AF2 AF2
ICL3 315 G - AF2 AF2
ICL3 316 S - AF2 AF2
ICL3 317 G - AF2 AF2
ICL3 318 S - AF2 AF2
ICL3 319 R - AF2 AF2
ICL3 320 P - AF2 AF2
ICL3 321 T - AF2 AF2
TM6 322 Q 6.24x24 AF2 AF2
TM6 323 A 6.25x25 AF2 AF2
TM6 324 K 6.26x26 Structure Structure
TM6 325 L 6.27x27 Structure Structure
TM6 326 L 6.28x28 Structure Structure
TM6 327 A 6.29x29 Structure Structure
TM6 328 K 6.30x30 Structure Structure
TM6 329 K 6.31x31 Structure Structure
TM6 330 R 6.32x32 Structure Structure
TM6 331 V 6.33x33 Structure Structure
TM6 332 V 6.34x34 Structure Structure
TM6 333 R 6.35x35 Structure Structure
TM6 334 M 6.36x36 Structure Structure
TM6 335 L 6.37x37 Structure Structure
TM6 336 L 6.38x38 Structure Structure
TM6 337 V 6.39x39 Structure Structure
TM6 338 I 6.40x40 Structure Structure
TM6 339 V 6.41x41 Structure Structure
TM6 340 V 6.42x42 Structure Structure
TM6 341 L 6.43x43 Structure Structure
TM6 342 F 6.44x44 Structure Structure
TM6 343 F 6.45x45 Structure Structure
TM6 344 L 6.46x46 Structure Structure
TM6 345 C 6.47x47 Structure Structure
TM6 346 W 6.48x48 Structure Structure
TM6 347 L 6.49x49 Structure Structure
TM6 348 P 6.50x50 Structure Structure
TM6 349 V 6.51x51 Structure Structure
TM6 350 Y 6.52x52 Structure Structure
TM6 351 S 6.53x53 Structure Structure
TM6 352 A 6.54x54 Structure Structure
TM6 353 N 6.55x55 Structure Structure
TM6 354 T 6.56x56 Structure Structure
TM6 355 W 6.57x57 Structure Structure
TM6 356 R 6.58x58 Structure Structure
TM6 357 A 6.59x59 Structure Structure
TM6 358 F 6.60x60 Structure Structure
TM6 359 D 6.61x61 Structure Structure
TM6 360 G 6.62x62 Structure Structure
ECL3 361 P - Structure Structure
ECL3 362 G - Structure Structure
ECL3 363 A - Structure Structure
ECL3 364 H - Structure Structure
ECL3 365 R - Structure AF2
ECL3 366 A - Structure Structure
ECL3 367 L - Structure Structure
ECL3 368 S - Structure Structure
TM7 369 G 7.32x31 Structure Structure
TM7 370 A 7.33x32 Structure Structure
TM7 371 P 7.34x33 Structure Structure
TM7 372 I 7.35x34 Structure Structure
TM7 373 S 7.36x35 Structure Structure
TM7 374 F 7.37x36 Structure Structure
TM7 375 I 7.38x37 Structure Structure
TM7 376 H 7.39x38 Structure Structure
TM7 377 L 7.40x39 Structure Structure
TM7 378 L 7.41x40 Structure Structure
TM7 379 S 7.42x41 Structure Structure
TM7 380 Y 7.43x42 Structure Structure
TM7 381 A 7.44x43 Structure Structure
TM7 382 S 7.45x45 Structure Structure
TM7 383 A 7.46x46 Structure Structure
TM7 384 C 7.47x47 Structure Structure
TM7 385 V 7.48x48 Structure Structure
TM7 386 N 7.49x49 Structure Structure
TM7 387 P 7.50x50 Structure Structure
TM7 388 L 7.51x51 Structure Structure
TM7 389 V 7.52x52 Structure Structure
TM7 390 Y 7.53x53 Structure Structure
TM7 391 C 7.54x54 Structure Structure
TM7 392 F 7.55x55 Structure Structure
TM7 393 M 7.56x56 Structure Structure
H8 394 H 8.47x47 Structure Structure
H8 395 R 8.48x48 Structure Structure
H8 396 R 8.49x49 Structure Structure
H8 397 F 8.50x50 Structure Structure
H8 398 R 8.51x51 Structure Structure
H8 399 Q 8.52x52 Structure Structure
H8 400 A 8.53x53 Structure Structure
H8 401 C 8.54x54 Structure Structure
H8 402 L 8.55x55 Structure Structure
H8 403 E 8.56x56 Structure Structure
H8 404 T 8.57x57 AF2 AF2
H8 405 C 8.58x58 AF2 AF2
C-term 406 A - AF2 AF2
C-term 407 R - AF2 AF2
C-term 408 C - AF2 AF2
C-term 409 C - AF2 AF2
C-term 410 P - AF2 AF2
C-term 411 R - AF2 AF2
C-term 412 P - AF2 AF2
C-term 413 P - AF2 AF2
C-term 414 R - AF2 AF2
C-term 415 A - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic H8 R 396 8x49 G.H5 K 354 G.H5.21
Hydrophobic TM3 A 155 3x53 G.H5 D 346 G.H5.13
Van-der-waals TM3 A 155 3x53 G.H5 D 346 G.H5.13
Hydrophobic ICL2 R 163 34x54 G.HN R 34 G.HN.52
Polar H8 H 394 8x47 G.H5 L 351 G.H5.18
Hydrophobic H8 H 394 8x47 G.H5 L 351 G.H5.18
Van-der-waals H8 H 394 8x47 G.H5 L 351 G.H5.18
Hydrophobic TM2 T 89 2x39 G.H5 Q 350 G.H5.17
Ionic ICL3 R 262 - G.hgh4 D 296 G.hgh4.06
Polar ICL3 R 262 - G.hgh4 D 296 G.hgh4.06
Hydrophobic ICL3 R 262 - G.hgh4 D 296 G.hgh4.06
Van-der-waals ICL3 R 262 - G.hgh4 D 296 G.hgh4.06
Polar TM3 R 152 3x50 G.H5 Q 350 G.H5.17
Hydrophobic ICL2 L 160 34x51 G.H5 A 342 G.H5.09
Hydrophobic TM6 A 327 6x29 G.H5 L 358 G.H5.25
Van-der-waals TM6 A 327 6x29 G.H5 L 358 G.H5.25
Polar ICL2 R 163 34x54 G.HN R 31 G.HN.49
Van-der-waals ICL2 R 163 34x54 G.HN R 31 G.HN.49
Hydrophobic ICL3 V 263 - G.H4 A 305 G.H4.07
Ionic TM3 R 152 3x50 G.H5 E 355 G.H5.22
Polar TM3 R 152 3x50 G.H5 E 355 G.H5.22
Van-der-waals TM3 R 152 3x50 G.H5 E 355 G.H5.22
Hydrophobic ICL3 R 262 - G.hgh4 P 298 G.hgh4.08
Van-der-waals ICL3 R 262 - G.hgh4 P 298 G.hgh4.08
Hydrophobic TM6 L 335 6x37 G.H5 Y 356 G.H5.23
Van-der-waals TM6 L 335 6x37 G.H5 Y 356 G.H5.23
Polar TM3 I 156 3x54 G.H5 D 346 G.H5.13
Hydrophobic TM3 I 156 3x54 G.H5 D 346 G.H5.13
Van-der-waals TM3 I 156 3x54 G.H5 D 346 G.H5.13
Hydrophobic TM6 M 334 6x36 G.H5 Y 356 G.H5.23
Van-der-waals TM6 M 334 6x36 G.H5 Y 356 G.H5.23
Hydrophobic TM6 A 327 6x29 G.H5 L 353 G.H5.20
Van-der-waals TM6 A 327 6x29 G.H5 L 353 G.H5.20
Hydrophobic ICL2 L 160 34x51 G.H5 F 339 G.H5.06
Van-der-waals ICL2 L 160 34x51 G.H5 F 339 G.H5.06
Polar ICL2 R 163 34x54 G.H2 H 218 G.H2.09
Hydrophobic ICL2 R 163 34x54 G.H2 H 218 G.H2.09
Van-der-waals ICL2 R 163 34x54 G.H2 H 218 G.H2.09
Hydrophobic TM6 M 334 6x36 G.H5 E 355 G.H5.22
Van-der-waals TM6 M 334 6x36 G.H5 E 355 G.H5.22
Hydrophobic ICL2 P 159 34x50 G.H5 F 339 G.H5.06
Van-der-waals ICL2 P 159 34x50 G.H5 F 339 G.H5.06
Hydrophobic TM2 T 89 2x39 G.H5 L 351 G.H5.18
Van-der-waals TM2 T 89 2x39 G.H5 L 351 G.H5.18
Polar TM3 R 152 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 152 3x50 G.H5 Y 356 G.H5.23
Polar H8 R 395 8x48 G.H5 V 359 G.H5.26
Hydrophobic H8 R 395 8x48 G.H5 V 359 G.H5.26
Van-der-waals H8 R 395 8x48 G.H5 V 359 G.H5.26
Polar H8 H 394 8x47 G.H5 K 354 G.H5.21
Hydrophobic H8 H 394 8x47 G.H5 K 354 G.H5.21
Van-der-waals H8 H 394 8x47 G.H5 K 354 G.H5.21
Hydrophobic TM2 L 93 2x43 G.H5 L 351 G.H5.18
Hydrophobic TM6 R 330 6x32 G.H5 N 357 G.H5.24
Hydrophobic TM6 V 331 6x33 G.H5 Y 356 G.H5.23
Van-der-waals TM6 V 331 6x33 G.H5 Y 356 G.H5.23
Hydrophobic TM6 R 330 6x32 G.H5 Y 356 G.H5.23
Van-der-waals TM6 R 330 6x32 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 P 159 34x50 G.H5 A 342 G.H5.09
Polar TM3 R 152 3x50 G.H5 N 352 G.H5.19
Hydrophobic TM3 R 152 3x50 G.H5 N 352 G.H5.19
Van-der-waals TM3 R 152 3x50 G.H5 N 352 G.H5.19
Hydrophobic TM3 R 158 3x56 G.H5 F 339 G.H5.06
Hydrophobic TM3 I 156 3x54 G.H5 T 347 G.H5.14
Polar ICL2 V 164 34x55 G.HN Q 28 G.HN.46
Hydrophobic TM7 V 389 7x52 G.H5 E 355 G.H5.22
Van-der-waals TM7 V 389 7x52 G.H5 E 355 G.H5.22
Ionic H8 H 394 8x47 G.H5 E 355 G.H5.22
Polar H8 H 394 8x47 G.H5 E 355 G.H5.22
Hydrophobic H8 H 394 8x47 G.H5 E 355 G.H5.22
Van-der-waals H8 H 394 8x47 G.H5 E 355 G.H5.22
Polar ICL2 R 163 34x54 G.HN D 32 G.HN.50
Hydrophobic H8 H 394 8x47 G.H5 V 359 G.H5.26
Hydrophobic TM6 I 338 6x40 G.H5 E 355 G.H5.22
Van-der-waals TM6 I 338 6x40 G.H5 E 355 G.H5.22
Hydrophobic TM6 V 331 6x33 G.H5 L 353 G.H5.20
Van-der-waals TM6 V 331 6x33 G.H5 L 353 G.H5.20
Hydrophobic TM7 M 393 7x56 G.H5 E 355 G.H5.22
Van-der-waals TM7 M 393 7x56 G.H5 E 355 G.H5.22
Aromatic ICL3 R 262 - G.hgh4 Y 291 G.hgh4.01
Hydrophobic ICL3 R 262 - G.hgh4 Y 291 G.hgh4.01
Van-der-waals ICL3 R 262 - G.hgh4 Y 291 G.hgh4.01
Hydrophobic TM6 V 331 6x33 G.H5 N 352 G.H5.19
Van-der-waals TM6 V 331 6x33 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 155 3x53 G.H5 Q 350 G.H5.17
Hydrophobic ICL2 P 159 34x50 G.H5 A 343 G.H5.10
Hydrophobic TM2 T 87 2x37 G.H5 L 349 G.H5.16
Van-der-waals TM2 T 87 2x37 G.H5 L 349 G.H5.16
Polar ICL2 V 164 34x55 G.HN R 31 G.HN.49
Van-der-waals ICL2 V 164 34x55 G.HN R 31 G.HN.49
Hydrophobic TM4 T 167 4x38 G.HN R 31 G.HN.49
Hydrophobic ICL2 V 164 34x55 G.HN D 32 G.HN.50