MCH1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8WSS

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41421-024-00679-8

PUBLICATION DATE

June 19, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

62 interactions (Click to see)

LIGANDS

pro-MCH - Agonist

PHYSIOLOGICAL LIGANDS

melanin-concentrating hormone



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals ICL2 P 217 - G.H5 T 340 G.H5.12
Hydrophobic TM6 L 318 6x28 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 323 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL3 P 310 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 P 310 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 P 217 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 217 - G.H5 I 344 G.H5.16
Polar TM3 R 210 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 210 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 210 3x50 G.H5 C 351 G.H5.23
Polar TM3 A 213 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 213 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 213 3x53 G.H5 N 347 G.H5.19
Ionic TM6 R 314 6x24 G.h4s6 D 315 G.h4s6.09
Polar TM6 R 314 6x24 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM2 P 147 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 R 322 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 322 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL3 P 310 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 I 218 - G.H5 F 336 G.H5.08
Ionic H8 E 385 8x48 G.H5 K 349 G.H5.21
Polar H8 E 385 8x48 G.H5 K 349 G.H5.21
Hydrophobic ICL2 I 218 - G.S3 L 194 G.S3.01
Hydrophobic TM4 K 225 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 K 225 4x38 G.HN E 28 G.HN.52
Hydrophobic TM5 I 300 5x61 G.H5 L 353 G.H5.25
Van-der-waals ICL3 T 305 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 M 304 - G.H5 L 348 G.H5.20
Hydrophobic TM3 R 210 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 210 3x50 G.H5 L 353 G.H5.25
Polar TM6 S 315 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 S 315 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM2 P 147 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 217 - G.H5 I 343 G.H5.15
Ionic TM6 R 319 6x29 G.H5 D 341 G.H5.13
Polar TM6 R 319 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 319 6x29 G.H5 D 341 G.H5.13
Hydrophobic TM6 S 315 6x25 G.h4s6 T 316 G.h4s6.10
Hydrophobic ICL2 I 218 - G.H5 I 343 G.H5.15
Hydrophobic ICL3 A 309 - G.S6 Y 320 G.S6.02
Polar H8 C 384 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 C 384 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 V 323 6x33 G.H5 L 353 G.H5.25
Polar TM6 Q 313 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 Q 313 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 T 214 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 T 214 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL3 S 306 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 S 306 - G.H5 D 341 G.H5.13
Polar TM6 S 315 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 V 323 6x33 G.H5 F 354 G.H5.26
Polar TM6 T 326 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 326 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 326 6x36 G.H5 L 353 G.H5.25
Hydrophobic H8 E 385 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 385 8x48 G.H5 F 354 G.H5.26
Polar TM6 S 315 6x25 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM6 S 315 6x25 G.h4s6 K 317 G.h4s6.11
Van-der-waals TM6 S 315 6x25 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM6 I 316 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 I 316 6x26 G.h4s6 E 318 G.h4s6.12
Polar ICL3 S 306 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 S 306 - G.H5 D 337 G.H5.09
Polar TM6 S 315 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 315 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 315 6x25 G.h4s6 E 318 G.h4s6.12
Aromatic TM6 R 319 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 319 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 319 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 319 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 319 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM3 T 214 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL3 S 306 - G.H5 T 340 G.H5.12
Polar ICL2 T 221 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 221 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 221 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 R 319 6x29 G.H5 L 348 G.H5.20