ADGRL3 - Gi1

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Oct. 26, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM2 R 977 2x46 G.H5 C 351 G.H5.23
Van-der-waals TM2 R 977 2x46 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 1040 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 V 1040 - G.H5 I 344 G.H5.16
Hydrophobic TM3 L 1037 3x58 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 1037 3x58 G.H5 L 348 G.H5.20
Hydrophobic TM5 M 1114 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 M 1114 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 1037 3x58 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 1037 3x58 G.H5 N 347 G.H5.19
Hydrophobic TM5 K 1113 5x60 G.H5 L 348 G.H5.20
Van-der-waals TM5 K 1113 5x60 G.H5 L 348 G.H5.20
Polar ICL2 E 1044 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 1041 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 1041 - G.S3 L 194 G.S3.01
Hydrophobic TM3 L 1033 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 1111 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 1150 6x45 G.H5 L 353 G.H5.25
Hydrophobic TM5 H 1117 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 1117 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 1040 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 V 1040 - G.H5 I 343 G.H5.15
Polar TM3 M 1036 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 M 1036 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 M 1036 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 1037 3x58 G.H5 L 353 G.H5.25
Van-der-waals TM3 L 1037 3x58 G.H5 L 353 G.H5.25
Hydrophobic TM5 M 1114 5x61 G.H5 L 348 G.H5.20
Van-der-waals TM5 M 1114 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM3 L 1037 3x58 G.H5 C 351 G.H5.23
Hydrophobic ICL3 T 1118 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 F 1041 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 1041 - G.H5 I 343 G.H5.15
Polar TM2 R 977 2x46 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 977 2x46 G.H5 D 350 G.H5.22
Hydrophobic TM3 M 1036 3x57 G.H5 D 350 G.H5.22
Van-der-waals TM3 M 1036 3x57 G.H5 D 350 G.H5.22
Polar ICL2 S 1046 - G.HN E 28 G.HN.52
Hydrophobic TM5 A 1110 5x57 G.H5 L 353 G.H5.25
Hydrophobic TM3 M 1036 3x57 G.H5 C 351 G.H5.23
Polar ICL2 V 1040 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 V 1040 - G.H5 N 347 G.H5.19