GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

Aug. 21, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Retinoic acid receptor responder protein 2 - Agonist

PHYSIOLOGICAL LIGANDS

chemerin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic H8 K 310 8x49 G.H5 F 354 G.H5.26
Hydrophobic TM2 T 73 2x40 G.H5 F 354 G.H5.26
Hydrophobic ICL3 I 238 - G.H5 K 345 G.H5.17
Polar TM6 H 244 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM7 V 305 7x54 G.H5 F 354 G.H5.26
Van-der-waals TM7 V 305 7x54 G.H5 F 354 G.H5.26
Van-der-waals TM3 I 140 3x55 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 142 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 142 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL3 I 240 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 V 143 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 V 143 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM2 F 76 2x43 G.H5 L 353 G.H5.25
Van-der-waals TM2 F 76 2x43 G.H5 L 353 G.H5.25
Polar TM3 H 138 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 H 146 34x54 G.S3 L 194 G.S3.01
Hydrophobic ICL2 H 146 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL3 I 238 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 I 238 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 142 34x50 G.H5 I 344 G.H5.16
Polar TM3 H 135 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 H 135 3x50 G.H5 G 352 G.H5.24
Polar ICL2 H 146 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 146 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 H 135 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 H 146 34x54 G.S1 V 34 G.S1.02
Polar TM6 H 244 6x33 G.H5 G 352 G.H5.24
Hydrophobic TM6 H 244 6x33 G.H5 G 352 G.H5.24
Van-der-waals TM6 H 244 6x33 G.H5 G 352 G.H5.24
Hydrophobic TM2 F 76 2x43 G.H5 F 354 G.H5.26
Van-der-waals TM2 F 76 2x43 G.H5 F 354 G.H5.26
Hydrophobic TM6 T 247 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 247 6x36 G.H5 L 353 G.H5.25
Ionic TM5 R 236 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 236 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 236 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 V 233 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 233 5x65 G.H5 L 348 G.H5.20
Van-der-waals H8 K 310 8x49 G.H5 G 352 G.H5.24
Hydrophobic ICL2 V 143 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 142 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 142 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 R 236 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 236 5x68 G.H5 I 344 G.H5.16
Hydrophobic H8 S 308 8x47 G.H5 F 354 G.H5.26