TRH1 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.7 Å

REFERENCE

PUBLICATION DATE

Dec. 28, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

TRH - Agonist pubchem

PHYSIOLOGICAL LIGANDS

TRH



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar H8 Q 325 8x48 G.H5 R 404 G.H5.21
Hydrophobic TM2 T 60 2x39 G.H5 N 407 G.H5.24
Polar TM3 E 122 3x49 G.H5 Y 406 G.H5.23
Hydrophobic TM3 E 122 3x49 G.H5 Y 406 G.H5.23
Hydrophobic ICL2 P 130 34x50 G.H5 I 398 G.H5.15
Van-der-waals ICL2 P 130 34x50 G.H5 I 398 G.H5.15
Hydrophobic TM6 V 264 6x33 G.H5 L 408 G.H5.25
Van-der-waals TM6 V 264 6x33 G.H5 L 408 G.H5.25
Hydrophobic TM2 T 58 2x37 G.H5 E 405 G.H5.22
Hydrophobic TM3 F 119 3x46 G.H5 Y 406 G.H5.23
Hydrophobic TM5 L 218 5x65 G.H5 L 403 G.H5.20
Polar TM7 Y 320 7x53 G.H5 N 407 G.H5.24
Van-der-waals TM7 Y 320 7x53 G.H5 N 407 G.H5.24
Hydrophobic ICL2 I 131 34x51 G.H5 I 398 G.H5.15
Hydrophobic TM3 I 127 3x54 G.H5 L 408 G.H5.25
Van-der-waals TM3 I 127 3x54 G.H5 L 408 G.H5.25
Polar TM2 T 60 2x39 G.H5 E 405 G.H5.22
Hydrophobic ICL2 P 130 34x50 G.H5 L 399 G.H5.16
Hydrophobic TM3 I 127 3x54 G.H5 L 403 G.H5.20
Hydrophobic ICL2 F 135 34x55 G.S1 E 33 G.S1.01
Hydrophobic TM3 R 123 3x50 G.H5 L 408 G.H5.25
Van-der-waals TM3 R 123 3x50 G.H5 L 408 G.H5.25
Hydrophobic ICL2 F 135 34x55 G.S1 L 34 G.S1.02
Polar ICL2 F 135 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 135 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 F 135 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM4 T 138 4x38 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 T 138 4x38 G.hns1 R 31 G.hns1.02
Hydrophobic TM6 V 264 6x33 G.H5 V 409 G.H5.26
Van-der-waals TM6 V 264 6x33 G.H5 V 409 G.H5.26
Polar ICL2 F 135 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 F 135 34x55 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 F 135 34x55 G.hns1 R 31 G.hns1.02
Polar TM6 R 261 6x30 G.H5 Q 400 G.H5.17
Hydrophobic TM6 R 261 6x30 G.H5 Q 400 G.H5.17
Van-der-waals TM6 R 261 6x30 G.H5 Q 400 G.H5.17
Hydrophobic H8 K 326 8x49 G.H5 R 404 G.H5.21
Polar TM6 S 260 6x29 G.H5 Q 400 G.H5.17
Hydrophobic TM6 L 268 6x37 G.H5 L 408 G.H5.25
Van-der-waals TM6 L 268 6x37 G.H5 L 408 G.H5.25
Hydrophobic TM3 I 127 3x54 G.H5 N 402 G.H5.19
Hydrophobic ICL2 Q 134 34x54 G.S1 L 34 G.S1.02
Van-der-waals ICL2 Q 134 34x54 G.S1 L 34 G.S1.02
Hydrophobic ICL2 I 131 34x51 G.S1 L 34 G.S1.02
Hydrophobic ICL2 Q 134 34x54 G.H5 I 398 G.H5.15
Van-der-waals ICL2 Q 134 34x54 G.H5 I 398 G.H5.15
Hydrophobic ICL2 I 131 34x51 G.H5 K 395 G.H5.12
Polar TM3 R 123 3x50 G.H5 N 407 G.H5.24
Hydrophobic TM3 R 123 3x50 G.H5 N 407 G.H5.24
Van-der-waals TM3 R 123 3x50 G.H5 N 407 G.H5.24
Polar ICL4 S 324 - G.H5 N 407 G.H5.24
Hydrophobic ICL4 S 324 - G.H5 N 407 G.H5.24
Van-der-waals ICL4 S 324 - G.H5 N 407 G.H5.24
Hydrophobic ICL2 I 131 34x51 G.H5 F 391 G.H5.08
Van-der-waals ICL2 I 131 34x51 G.H5 F 391 G.H5.08
Hydrophobic ICL2 I 131 34x51 G.S3 V 242 G.S3.01
Hydrophobic TM2 T 60 2x39 G.H5 Y 406 G.H5.23
Van-der-waals TM2 T 60 2x39 G.H5 Y 406 G.H5.23
Hydrophobic TM3 A 126 3x53 G.H5 N 402 G.H5.19
Hydrophobic TM6 S 260 6x29 G.H5 V 409 G.H5.26
Polar H8 Q 325 8x48 G.H5 V 409 G.H5.26
Hydrophobic H8 Q 325 8x48 G.H5 V 409 G.H5.26
Hydrophobic TM3 I 127 3x54 G.H5 L 399 G.H5.16
Van-der-waals TM3 I 127 3x54 G.H5 L 399 G.H5.16
Hydrophobic TM2 L 64 2x43 G.H5 N 407 G.H5.24
Van-der-waals TM2 L 64 2x43 G.H5 N 407 G.H5.24
Hydrophobic TM3 A 126 3x53 G.H5 Y 406 G.H5.23
Van-der-waals TM3 A 126 3x53 G.H5 Y 406 G.H5.23