Refined structure (7X9C) of Gi1 - Y4 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 217 from structure (61.3%), 137 from model (38.7%)
Residue sidechains - 196 from structure (55.4%), 158 from model (44.6%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure AF2
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure AF2
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure AF2
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure AF2
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure AF2
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure AF2
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure AF2
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure AF2
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure AF2
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure AF2
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 298 from structure (85.9%), 49 from model (14.1%)
Residue sidechains - 285 from structure (82.1%), 62 from model (17.9%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 N - AF2 AF2
N-term 3 T - AF2 AF2
N-term 4 S - AF2 AF2
N-term 5 H - AF2 AF2
N-term 6 L - AF2 AF2
N-term 7 L - AF2 AF2
N-term 8 A - AF2 AF2
N-term 9 L - AF2 AF2
N-term 10 L - AF2 AF2
N-term 11 L - AF2 AF2
N-term 12 P - AF2 AF2
N-term 13 K - AF2 AF2
N-term 14 S - AF2 AF2
N-term 15 P - AF2 AF2
N-term 16 Q - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 E - AF2 AF2
N-term 19 N - AF2 AF2
N-term 20 R - AF2 AF2
N-term 21 S - AF2 AF2
N-term 22 K - AF2 AF2
N-term 23 P - AF2 AF2
N-term 24 L - AF2 AF2
N-term 25 G - AF2 AF2
N-term 26 T - AF2 AF2
N-term 27 P - AF2 AF2
N-term 28 Y - AF2 AF2
N-term 29 N - AF2 AF2
N-term 30 F - AF2 AF2
N-term 31 S - AF2 AF2
N-term 32 E - AF2 AF2
N-term 33 H - AF2 AF2
N-term 34 C - AF2 AF2
N-term 35 Q - AF2 AF2
N-term 36 D - AF2 AF2
TM1 37 S 1.28x28 AF2 AF2
TM1 38 V 1.29x29 AF2 AF2
TM1 39 D 1.30x30 Structure Structure
TM1 40 V 1.31x31 Structure Structure
TM1 41 M 1.32x32 Structure Structure
TM1 42 V 1.33x33 Structure Structure
TM1 43 F 1.34x34 Structure AF2
TM1 44 I 1.35x35 Structure Structure
TM1 45 V 1.36x36 Structure Structure
TM1 46 T 1.37x37 Structure Structure
TM1 47 S 1.38x38 Structure Structure
TM1 48 Y 1.39x39 Structure Structure
TM1 49 S 1.40x40 Structure Structure
TM1 50 I 1.41x41 Structure Structure
TM1 51 E 1.42x42 Structure Structure
TM1 52 T 1.43x43 Structure Structure
TM1 53 V 1.44x44 Structure Structure
TM1 54 V 1.45x45 Structure Structure
TM1 55 G 1.46x46 Structure Structure
TM1 56 V 1.47x47 Structure Structure
TM1 57 L 1.48x48 Structure AF2
TM1 58 G 1.49x49 Structure Structure
TM1 59 N 1.50x50 Structure Structure
TM1 60 L 1.51x51 Structure AF2
TM1 61 C 1.52x52 Structure Structure
TM1 62 L 1.53x53 Structure Structure
TM1 63 M 1.54x54 Structure Structure
TM1 64 C 1.55x55 Structure Structure
TM1 65 V 1.56x56 Structure Structure
TM1 66 T 1.57x57 Structure Structure
TM1 67 V 1.58x58 Structure Structure
TM1 68 R 1.59x59 Structure Structure
TM1 69 Q 1.60x60 Structure Structure
ICL1 70 K 12.48x48 Structure AF2
ICL1 71 E 12.49x49 Structure AF2
ICL1 72 K 12.50x50 Structure AF2
ICL1 73 A 12.51x51 Structure Structure
TM2 74 N 2.37x37 Structure Structure
TM2 75 V 2.38x38 Structure Structure
TM2 76 T 2.39x39 Structure Structure
TM2 77 N 2.40x40 Structure Structure
TM2 78 L 2.41x41 Structure Structure
TM2 79 L 2.42x42 Structure Structure
TM2 80 I 2.43x43 Structure Structure
TM2 81 A 2.44x44 Structure Structure
TM2 82 N 2.45x45 Structure Structure
TM2 83 L 2.46x46 Structure Structure
TM2 84 A 2.47x47 Structure Structure
TM2 85 F 2.48x48 Structure Structure
TM2 86 S 2.49x49 Structure Structure
TM2 87 D 2.50x50 Structure Structure
TM2 88 F 2.51x51 Structure Structure
TM2 89 L 2.52x52 Structure Structure
TM2 90 M 2.53x53 Structure Structure
TM2 91 C 2.54x54 Structure Structure
TM2 92 L 2.55x55 Structure Structure
TM2 93 L 2.56x551 Structure Structure
TM2 94 C 2.57x56 Structure Structure
TM2 95 Q 2.58x57 Structure Structure
TM2 96 P 2.59x58 Structure Structure
TM2 97 L 2.60x59 Structure Structure
TM2 98 T 2.61x60 Structure Structure
TM2 99 A 2.62x61 Structure Structure
TM2 100 V 2.63x62 Structure Structure
TM2 101 Y 2.64x63 Structure Structure
TM2 102 T 2.65x64 Structure Structure
TM2 103 I 2.66x65 Structure Structure
TM2 104 M 2.67x66 Structure Structure
TM2 105 D 2.68x67 Structure Structure
ECL1 106 Y 23.49x49 Structure Structure
ECL1 107 W 23.50x50 Structure Structure
ECL1 108 I 23.51x51 Structure Structure
ECL1 109 F 23.52x52 Structure Structure
TM3 110 G 3.21x21 Structure Structure
TM3 111 E 3.22x22 Structure Structure
TM3 112 T 3.23x23 Structure Structure
TM3 113 L 3.24x24 Structure Structure
TM3 114 C 3.25x25 Structure Structure
TM3 115 K 3.26x26 Structure Structure
TM3 116 M 3.27x27 Structure Structure
TM3 117 S 3.28x28 Structure Structure
TM3 118 A 3.29x29 Structure Structure
TM3 119 F 3.30x30 Structure Structure
TM3 120 I 3.31x31 Structure Structure
TM3 121 Q 3.32x32 Structure Structure
TM3 122 C 3.33x33 Structure Structure
TM3 123 M 3.34x34 Structure Structure
TM3 124 S 3.35x35 Structure Structure
TM3 125 V 3.36x36 Structure Structure
TM3 126 T 3.37x37 Structure Structure
TM3 127 V 3.38x38 Structure Structure
TM3 128 S 3.39x39 Structure Structure
TM3 129 I 3.40x40 Structure Structure
TM3 130 L 3.41x41 Structure Structure
TM3 131 S 3.42x42 Structure Structure
TM3 132 L 3.43x43 Structure Structure
TM3 133 V 3.44x44 Structure Structure
TM3 134 L 3.45x45 Structure Structure
TM3 135 V 3.46x46 Structure Structure
TM3 136 A 3.47x47 Structure Structure
TM3 137 L 3.48x48 Structure Structure
TM3 138 E 3.49x49 Structure Structure
TM3 139 R 3.50x50 Structure Structure
TM3 140 H 3.51x51 Structure Structure
TM3 141 Q 3.52x52 Structure Structure
TM3 142 L 3.53x53 Structure Structure
TM3 143 I 3.54x54 Structure Structure
TM3 144 I 3.55x55 Structure Structure
TM3 145 N 3.56x56 Structure Structure
ICL2 146 P - Structure Structure
ICL2 147 T - Structure Structure
ICL2 148 G - Structure Structure
ICL2 149 W - Structure Structure
ICL2 150 K - Structure Structure
ICL2 151 P - Structure Structure
TM4 152 S 4.38x38 Structure Structure
TM4 153 I 4.39x39 Structure Structure
TM4 154 S 4.40x40 Structure Structure
TM4 155 Q 4.41x41 Structure Structure
TM4 156 A 4.42x42 Structure Structure
TM4 157 Y 4.43x43 Structure Structure
TM4 158 L 4.44x44 Structure Structure
TM4 159 G 4.45x45 Structure Structure
TM4 160 I 4.46x46 Structure Structure
TM4 161 V 4.47x47 Structure Structure
TM4 162 L 4.48x48 Structure Structure
TM4 163 I 4.49x49 Structure Structure
TM4 164 W 4.50x50 Structure Structure
TM4 165 V 4.51x51 Structure Structure
TM4 166 I 4.52x52 Structure Structure
TM4 167 A 4.53x53 Structure Structure
TM4 168 C 4.54x54 Structure Structure
TM4 169 V 4.55x55 Structure Structure
TM4 170 L 4.56x56 Structure Structure
TM4 171 S 4.57x57 Structure Structure
TM4 172 L 4.58x59 Structure Structure
TM4 173 P 4.59x60 Structure Structure
TM4 174 F 4.60x61 Structure Structure
TM4 175 L 4.61x62 Structure Structure
TM4 176 A 4.62x63 Structure Structure
TM4 177 N 4.63x64 Structure Structure
TM4 178 S 4.64x65 Structure Structure
ECL2 179 I - Structure AF2
ECL2 180 L - Structure Structure
ECL2 181 E - Structure Structure
ECL2 182 N - Structure Structure
ECL2 183 V - Structure Structure
ECL2 184 F - Structure Structure
ECL2 185 H - Structure Structure
ECL2 186 K - Structure AF2
ECL2 187 N - Structure Structure
ECL2 188 H - Structure Structure
ECL2 189 S - Structure Structure
ECL2 190 K - Structure Structure
ECL2 191 A - Structure Structure
ECL2 192 L - Structure Structure
ECL2 193 E - Structure Structure
ECL2 194 F - Structure Structure
ECL2 195 L - Structure Structure
ECL2 196 A - Structure Structure
ECL2 197 D - Structure AF2
ECL2 198 K - Structure Structure
ECL2 199 V - Structure Structure
ECL2 200 V - Structure Structure
ECL2 201 C 45.50x50 Structure Structure
ECL2 202 T 45.51x51 Structure Structure
ECL2 203 E 45.52x52 Structure Structure
ECL2 204 S - Structure Structure
ECL2 205 W - Structure Structure
ECL2 206 P - Structure Structure
TM5 207 L 5.31x32 Structure Structure
TM5 208 A 5.32x33 Structure Structure
TM5 209 H 5.33x34 Structure Structure
TM5 210 H 5.34x35 Structure Structure
TM5 211 R 5.35x36 Structure Structure
TM5 212 T 5.36x37 Structure Structure
TM5 213 I 5.37x38 Structure Structure
TM5 214 Y 5.38x39 Structure Structure
TM5 215 T 5.39x40 Structure Structure
TM5 216 T 5.40x41 Structure Structure
TM5 217 F 5.41x42 Structure Structure
TM5 218 L 5.42x43 Structure Structure
TM5 219 L 5.43x44 Structure Structure
TM5 220 L 5.44x45 Structure Structure
TM5 221 F 5.45x46 Structure Structure
TM5 222 Q 5.46x461 Structure Structure
TM5 223 Y 5.47x47 Structure Structure
TM5 224 C 5.48x48 Structure Structure
TM5 225 L 5.49x49 Structure Structure
TM5 226 P 5.50x50 Structure Structure
TM5 227 L 5.51x51 Structure Structure
TM5 228 G 5.52x52 Structure Structure
TM5 229 F 5.53x53 Structure Structure
TM5 230 I 5.54x54 Structure Structure
TM5 231 L 5.55x55 Structure Structure
TM5 232 V 5.56x56 Structure Structure
TM5 233 C 5.57x57 Structure Structure
TM5 234 Y 5.58x58 Structure Structure
TM5 235 A 5.59x59 Structure Structure
TM5 236 R 5.60x60 Structure Structure
TM5 237 I 5.61x61 Structure Structure
TM5 238 Y 5.62x62 Structure Structure
TM5 239 R 5.63x63 Structure Structure
TM5 240 R 5.64x64 Structure Structure
TM5 241 L 5.65x65 Structure Structure
TM5 242 Q 5.66x66 Structure Structure
TM5 243 R 5.67x67 Structure Structure
TM5 244 Q 5.68x68 Structure Structure
TM5 245 G 5.69x69 Structure Structure
TM5 246 R 5.70x70 Structure Structure
TM5 247 V 5.71x71 Structure Structure
TM5 248 F 5.72x72 Structure Structure
ICL3 249 H - Structure Structure
ICL3 250 K - Structure Structure
ICL3 251 G - AF2 AF2
ICL3 252 T - AF2 AF2
ICL3 253 Y - AF2 AF2
TM6 254 S 6.24x24 AF2 AF2
TM6 255 L 6.25x25 AF2 AF2
TM6 256 R 6.26x26 Structure Structure
TM6 257 A 6.27x27 Structure Structure
TM6 258 G 6.28x28 Structure Structure
TM6 259 H 6.29x29 Structure Structure
TM6 260 M 6.30x30 Structure Structure
TM6 261 K 6.31x31 Structure Structure
TM6 262 Q 6.32x32 Structure Structure
TM6 263 V 6.33x33 Structure Structure
TM6 264 N 6.34x34 Structure Structure
TM6 265 V 6.35x35 Structure Structure
TM6 266 V 6.36x36 Structure Structure
TM6 267 L 6.37x37 Structure Structure
TM6 268 V 6.38x38 Structure Structure
TM6 269 V 6.39x39 Structure Structure
TM6 270 M 6.40x40 Structure Structure
TM6 271 V 6.41x41 Structure Structure
TM6 272 V 6.42x42 Structure Structure
TM6 273 A 6.43x43 Structure Structure
TM6 274 F 6.44x44 Structure Structure
TM6 275 A 6.45x45 Structure Structure
TM6 276 V 6.46x46 Structure Structure
TM6 277 L 6.47x47 Structure Structure
TM6 278 W 6.48x48 Structure Structure
TM6 279 L 6.49x49 Structure Structure
TM6 280 P 6.50x50 Structure Structure
TM6 281 L 6.51x51 Structure Structure
TM6 282 H 6.52x52 Structure Structure
TM6 283 V 6.53x53 Structure Structure
TM6 284 F 6.54x54 Structure Structure
TM6 285 N 6.55x55 Structure Structure
TM6 286 S 6.56x56 Structure Structure
TM6 287 L 6.57x57 Structure Structure
TM6 288 E 6.58x58 Structure Structure
TM6 289 D 6.59x59 Structure Structure
TM6 290 W 6.60x60 Structure Structure
TM6 291 H 6.61x61 Structure Structure
ECL3 292 H - Structure Structure
ECL3 293 E - Structure Structure
ECL3 294 A - Structure Structure
ECL3 295 I - Structure Structure
ECL3 296 P - Structure Structure
TM7 297 I 7.28x27 Structure Structure
TM7 298 C 7.29x28 Structure Structure
TM7 299 H 7.30x29 Structure Structure
TM7 300 G 7.31x30 Structure Structure
TM7 301 N 7.32x31 Structure Structure
TM7 302 L 7.33x32 Structure Structure
TM7 303 I 7.34x33 Structure Structure
TM7 304 F 7.35x34 Structure Structure
TM7 305 L 7.36x35 Structure Structure
TM7 306 V 7.37x36 Structure Structure
TM7 307 C 7.38x37 Structure Structure
TM7 308 H 7.39x38 Structure Structure
TM7 309 L 7.40x39 Structure Structure
TM7 310 L 7.41x40 Structure Structure
TM7 311 A 7.42x41 Structure Structure
TM7 312 M 7.43x42 Structure Structure
TM7 313 A 7.44x43 Structure Structure
TM7 314 S 7.45x45 Structure Structure
TM7 315 T 7.46x46 Structure Structure
TM7 316 C 7.47x47 Structure Structure
TM7 317 V 7.48x48 Structure Structure
TM7 318 N 7.49x49 Structure Structure
TM7 319 P 7.50x50 Structure Structure
TM7 320 F 7.51x51 Structure Structure
TM7 321 I 7.52x52 Structure Structure
TM7 322 Y 7.53x53 Structure Structure
TM7 323 G 7.54x54 Structure Structure
TM7 324 F 7.55x55 Structure Structure
TM7 325 L 7.56x56 Structure Structure
H8 326 N 8.47x47 Structure Structure
H8 327 T 8.48x48 Structure Structure
H8 328 N 8.49x49 Structure Structure
H8 329 F 8.50x50 Structure Structure
H8 330 K 8.51x51 Structure Structure
H8 331 K 8.52x52 Structure Structure
H8 332 E 8.53x53 Structure Structure
H8 333 I 8.54x54 Structure Structure
H8 334 K 8.55x55 Structure AF2
H8 335 A 8.56x56 Structure Structure
H8 336 L 8.57x57 Structure Structure
H8 337 V 8.58x58 Structure AF2
C-term 338 L - Structure Structure
C-term 339 T - Structure AF2
C-term 340 C - Structure Structure
C-term 341 Q - Structure AF2
C-term 342 Q - AF2 AF2
C-term 343 S - AF2 AF2
C-term 344 A - AF2 AF2
C-term 345 P - AF2 AF2
C-term 346 L - AF2 AF2
C-term 347 E - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 T 76 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 76 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 76 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 263 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 M 260 6x30 G.H5 K 345 G.H5.17
Polar H8 T 327 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 T 327 8x48 G.H5 G 352 G.H5.24
Hydrophobic ICL2 T 147 - G.S3 L 194 G.S3.01
Polar ICL2 G 148 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 G 148 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 G 148 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 146 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 146 - G.H5 I 344 G.H5.16
Hydrophobic TM6 V 266 6x36 G.H5 L 353 G.H5.25
Polar ICL3 T 252 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 T 252 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 L 255 6x25 G.h4s6 K 314 G.h4s6.08
Polar H8 N 328 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 N 328 8x49 G.H5 K 349 G.H5.21
Polar TM2 N 74 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 76 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 76 2x39 G.H5 D 350 G.H5.22
Polar ICL2 P 146 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 146 - G.hns1 R 32 G.hns1.03
Van-der-waals TM6 Q 262 6x32 G.H5 L 353 G.H5.25
Polar H8 T 327 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 T 327 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 T 327 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 139 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 139 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 267 6x37 G.H5 L 353 G.H5.25
Hydrophobic H8 N 326 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 326 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 I 143 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 348 G.H5.20
Hydrophobic H8 N 328 8x49 G.H5 G 352 G.H5.24
Polar TM3 E 138 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 E 138 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 255 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 L 255 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 M 260 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 M 260 6x30 G.H5 F 354 G.H5.26
Polar TM3 L 142 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 142 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 142 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 V 263 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 263 6x33 G.H5 L 353 G.H5.25
Aromatic TM5 F 248 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM5 F 248 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 F 248 5x72 G.S6 Y 320 G.S6.02
Hydrophobic ICL2 P 146 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 146 - G.H5 I 343 G.H5.15
Hydrophobic TM3 L 142 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 142 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 T 147 - G.H5 I 343 G.H5.15
Hydrophobic TM5 F 248 5x72 G.H5 A 338 G.H5.10
Polar H8 N 328 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 N 328 8x49 G.H5 D 350 G.H5.22
Ionic TM6 R 256 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 256 6x26 G.h4s6 E 318 G.h4s6.12
Polar ICL2 T 147 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 147 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 T 252 - G.H4 E 308 G.H4.16
Hydrophobic TM5 F 248 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 F 248 5x72 G.H5 D 341 G.H5.13
Polar TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 241 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 Q 244 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 Q 244 5x68 G.H5 I 344 G.H5.16
Polar H8 N 326 8x47 G.H5 C 351 G.H5.23
Van-der-waals H8 N 326 8x47 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 263 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM5 F 248 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM6 M 260 6x30 G.H5 L 348 G.H5.20
Hydrophobic ICL2 T 147 - G.H5 T 340 G.H5.12
Aromatic TM6 H 259 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 H 259 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 H 259 6x29 G.H5 F 354 G.H5.26
Aromatic TM5 F 248 5x72 G.H5 F 334 G.H5.06
Hydrophobic TM5 F 248 5x72 G.H5 F 334 G.H5.06
Van-der-waals TM5 F 248 5x72 G.H5 F 334 G.H5.06
Hydrophobic TM6 M 270 6x40 G.H5 L 353 G.H5.25
Hydrophobic ICL2 K 150 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 150 - G.hns1 R 32 G.hns1.03