Y4 receptor (npy4r_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Neuropeptide Y receptors Y4 receptor
GENE
NPY4R (PPYR1)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Neuropeptide Y receptor type 4, NPY4-R, Pancreatic polypeptide receptor 1, PP1
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
T
|
S
|
H
|
L
|
L
|
A
|
L
|
L
|
10 |
L
|
P
|
K
|
S
|
P
|
Q
|
G
|
E
|
N
|
R
|
20 |
S
|
K
|
P
|
L
|
G
|
T
|
P
|
Y
|
N
|
F
|
30 |
TM1 | |||||||||
S
|
E
|
H
|
C
|
Q
|
D
|
S
|
V
|
D
|
V
|
40 |
M
|
V
|
F
|
I
|
V
|
T
|
S
|
Y
|
S
|
I
|
50 |
E
|
T
|
V
|
V
|
G
|
V
|
L
|
G
|
N
|
L
|
60 |
C
|
L
|
M
|
C
|
V
|
T
|
V
|
R
|
Q
|
K
|
70 |
ICL1 | TM2 | ||||||||
E
|
K
|
A
|
N
|
V
|
T
|
N
|
L
|
L
|
I
|
80 |
A
|
N
|
L
|
A
|
F
|
S
|
D
|
F
|
L
|
M
|
90 |
C
|
L
|
L
|
C
|
Q
|
P
|
L
|
T
|
A
|
V
|
100 |
ECL1 | |||||||||
Y
|
T
|
I
|
M
|
D
|
Y
|
W
|
I
|
F
|
G
|
110 |
TM3 | |||||||||
E
|
T
|
L
|
C
|
K
|
M
|
S
|
A
|
F
|
I
|
120 |
Q
|
C
|
M
|
S
|
V
|
T
|
V
|
S
|
I
|
L
|
130 |
S
|
L
|
V
|
L
|
V
|
A
|
L
|
E
|
R
|
H
|
140 |
ICL2 | |||||||||
Q
|
L
|
I
|
I
|
N
|
P
|
T
|
G
|
W
|
K
|
150 |
TM4 | |||||||||
P
|
S
|
I
|
S
|
Q
|
A
|
Y
|
L
|
G
|
I
|
160 |
V
|
L
|
I
|
W
|
V
|
I
|
A
|
C
|
V
|
L
|
170 |
S
|
L
|
P
|
F
|
L
|
A
|
N
|
S
|
I
|
L
|
180 |
ECL2 | |||||||||
E
|
N
|
V
|
F
|
H
|
K
|
N
|
H
|
S
|
K
|
190 |
A
|
L
|
E
|
F
|
L
|
A
|
D
|
K
|
V
|
V
|
200 |
TM5 | |||||||||
C
|
T
|
E
|
S
|
W
|
P
|
L
|
A
|
H
|
H
|
210 |
R
|
T
|
I
|
Y
|
T
|
T
|
F
|
L
|
L
|
L
|
220 |
F
|
Q
|
Y
|
C
|
L
|
P
|
L
|
G
|
F
|
I
|
230 |
L
|
V
|
C
|
Y
|
A
|
R
|
I
|
Y
|
R
|
R
|
240 |
L
|
Q
|
R
|
Q
|
G
|
R
|
V
|
F
|
H
|
K
|
250 |
ICL3 | TM6 | ||||||||
G
|
T
|
Y
|
S
|
L
|
R
|
A
|
G
|
H
|
M
|
260 |
K
|
Q
|
V
|
N
|
V
|
V
|
L
|
V
|
V
|
M
|
270 |
V
|
V
|
A
|
F
|
A
|
V
|
L
|
W
|
L
|
P
|
280 |
L
|
H
|
V
|
F
|
N
|
S
|
L
|
E
|
D
|
W
|
290 |
ECL3 | TM7 | ||||||||
H
|
H
|
E
|
A
|
I
|
P
|
I
|
C
|
H
|
G
|
300 |
N
|
L
|
I
|
F
|
L
|
V
|
C
|
H
|
L
|
L
|
310 |
A
|
M
|
A
|
S
|
T
|
C
|
V
|
N
|
P
|
F
|
320 |
H8 | |||||||||
I
|
Y
|
G
|
F
|
L
|
N
|
T
|
N
|
F
|
K
|
330 |
K
|
E
|
I
|
K
|
A
|
L
|
V
|
L
|
T
|
C
|
340 |
C-term | |||||||||
Q
|
Q
|
S
|
A
|
P
|
L
|
E
|
E
|
S
|
E
|
350 |
H
|
L
|
P
|
L
|
S
|
T
|
V
|
H
|
T
|
E
|
360 |
V
|
S
|
K
|
G
|
S
|
L
|
R
|
L
|
S
|
G
|
370 |
R
|
S
|
N
|
P
|
I
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PYY-(3-36), neuropeptide Y, peptide YY, pancreatic polypeptide
STRUCTURE MODELS
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 7X9C