Y4 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7X9C

RESOLUTION

3.0 Å

REFERENCE

10.1126/SCIADV.ABM1232

PUBLICATION DATE

May 18, 2022

3D VIEW

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LIGAND INTERACTIONS

87 interactions (Click to see)

LIGANDS

Pancreatic polypeptide - Agonist pubchem

PHYSIOLOGICAL LIGANDS

PYY-(3-36), neuropeptide Y, peptide YY, pancreatic polypeptide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 241 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 263 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 266 6x36 G.H5 L 353 G.H5.25
Polar TM3 E 138 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 E 138 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 143 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 K 150 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 150 - G.hns1 R 32 G.hns1.03
Aromatic TM5 F 248 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM5 F 248 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 F 248 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM6 V 263 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 139 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 139 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 260 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 267 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 270 6x40 G.H5 L 353 G.H5.25
Hydrophobic ICL2 T 147 - G.H5 T 340 G.H5.12
Polar H8 N 328 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 N 328 8x49 G.H5 D 350 G.H5.22
Aromatic TM6 H 259 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 H 259 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 H 259 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 Q 262 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 256 6x26 G.H5 K 345 G.H5.17
Polar TM3 L 142 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 142 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 142 3x53 G.H5 N 347 G.H5.19
Polar ICL1 N 74 - G.H5 D 350 G.H5.22
Hydrophobic TM3 L 142 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 142 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 M 260 6x30 G.H5 K 345 G.H5.17
Polar ICL2 G 148 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 G 148 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 G 148 - G.hns1 R 32 G.hns1.03
Polar TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 F 248 5x72 G.H5 F 334 G.H5.06
Van-der-waals TM5 F 248 5x72 G.H5 F 334 G.H5.06
Polar ICL2 T 147 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 147 - G.hns1 R 32 G.hns1.03
Polar H8 T 327 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 T 327 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 T 327 8x48 G.H5 F 354 G.H5.26
Polar H8 T 327 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 T 327 8x48 G.H5 G 352 G.H5.24
Hydrophobic TM6 M 260 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 M 260 6x30 G.H5 F 354 G.H5.26
Polar H8 N 326 8x47 G.H5 C 351 G.H5.23
Van-der-waals H8 N 326 8x47 G.H5 C 351 G.H5.23
Hydrophobic ICL2 T 147 - G.S3 L 194 G.S3.01
Polar H8 N 328 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 N 328 8x49 G.H5 K 349 G.H5.21
Polar ICL2 P 146 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 146 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 146 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 146 - G.H5 I 343 G.H5.15
Hydrophobic TM2 T 76 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 76 2x39 G.H5 D 350 G.H5.22
Hydrophobic H8 N 326 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 326 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 N 328 8x49 G.H5 G 352 G.H5.24
Hydrophobic ICL2 T 147 - G.H5 I 343 G.H5.15
Hydrophobic TM5 Q 244 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 Q 244 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 F 248 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 F 248 5x72 G.H5 D 337 G.H5.09
Polar TM2 T 76 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 76 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 76 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 F 248 5x72 G.H5 A 338 G.H5.10
Hydrophobic TM5 F 248 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 F 248 5x72 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 146 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 146 - G.H5 I 344 G.H5.16
Hydrophobic TM6 V 263 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 263 6x33 G.H5 L 353 G.H5.25