chemerin receptor 2 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8JJP

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Aug. 21, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

56 interactions (Click to see)

LIGANDS

chemerin C-terminal peptide - Agonist pubchem gtoplig chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

chemerin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 R 243 6x32 G.H5 C 351 G.H5.23
Van-der-waals TM6 R 243 6x32 G.H5 C 351 G.H5.23
Hydrophobic TM3 L 139 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 L 139 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM2 T 73 2x40 G.H5 F 354 G.H5.26
Hydrophobic ICL3 I 238 - G.H5 K 345 G.H5.17
Hydrophobic ICL4 V 305 - G.H5 F 354 G.H5.26
Van-der-waals ICL4 V 305 - G.H5 F 354 G.H5.26
Hydrophobic TM3 I 140 3x55 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 142 - G.H5 T 340 G.H5.12
Hydrophobic TM5 Y 226 5x58 G.H5 L 353 G.H5.25
Van-der-waals TM5 Y 226 5x58 G.H5 L 353 G.H5.25
Polar TM6 H 244 6x33 G.H5 C 351 G.H5.23
Hydrophobic TM6 H 244 6x33 G.H5 C 351 G.H5.23
Van-der-waals TM6 H 244 6x33 G.H5 C 351 G.H5.23
Hydrophobic TM2 F 76 2x43 G.H5 L 353 G.H5.25
Van-der-waals TM2 F 76 2x43 G.H5 L 353 G.H5.25
Polar TM3 H 138 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 H 138 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 H 138 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 H 146 - G.H5 I 343 G.H5.15
Hydrophobic ICL3 I 238 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 142 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 142 - G.H5 I 344 G.H5.16
Polar TM3 H 135 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM3 H 135 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 H 135 3x50 G.H5 G 352 G.H5.24
Polar ICL2 H 146 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 146 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 146 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 140 3x55 G.H5 L 348 G.H5.20
Polar TM3 H 135 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 H 135 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 H 135 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL1 W 67 - G.H5 F 354 G.H5.26
Van-der-waals ICL1 W 67 - G.H5 F 354 G.H5.26
Aromatic TM2 F 76 2x43 G.H5 F 354 G.H5.26
Hydrophobic TM2 F 76 2x43 G.H5 F 354 G.H5.26
Van-der-waals TM2 F 76 2x43 G.H5 F 354 G.H5.26
Hydrophobic TM6 T 247 6x36 G.H5 L 353 G.H5.25
Ionic TM5 R 236 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 236 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 236 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 236 5x68 G.H5 D 341 G.H5.13
Polar H8 K 309 8x48 G.H5 C 351 G.H5.23
Hydrophobic H8 K 309 8x48 G.H5 C 351 G.H5.23
Van-der-waals H8 K 309 8x48 G.H5 C 351 G.H5.23
Hydrophobic TM5 V 233 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 131 3x46 G.H5 L 353 G.H5.25
Ionic H8 K 309 8x48 G.H5 D 350 G.H5.22
Polar H8 K 309 8x48 G.H5 D 350 G.H5.22
Van-der-waals H8 K 309 8x48 G.H5 D 350 G.H5.22
Hydrophobic TM7 Y 304 7x53 G.H5 L 353 G.H5.25
Van-der-waals TM7 Y 304 7x53 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 142 - G.H5 I 343 G.H5.15
Hydrophobic TM5 R 236 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 236 5x68 G.H5 I 344 G.H5.16
Polar TM6 S 241 6x30 G.H5 C 351 G.H5.23
Hydrophobic TM6 S 241 6x30 G.H5 C 351 G.H5.23
Van-der-waals TM6 S 241 6x30 G.H5 C 351 G.H5.23