FFA4 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8ID4

RESOLUTION

3.1 Å

REFERENCE

10.1126/SCIENCE.ADD6220

PUBLICATION DATE

March 15, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

39 interactions (Click to see)

LIGANDS

linoleic acid - Agonist pubchem gtoplig chembl_ligand drug_central drugbank

PHYSIOLOGICAL LIGANDS

myristic acid, α-linolenic acid, linoleic acid, oleic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 266 6x38 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 266 6x38 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 262 6x34 G.H5 L 348 G.H5.20
Hydrophobic TM3 E 135 3x49 G.H5 C 351 G.H5.23
Polar ICL3 Y 247 - G.H5 D 341 G.H5.13
Ionic TM5 R 240 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM3 R 136 3x50 G.H5 G 352 G.H5.24
Polar TM5 S 237 5x68 G.H5 K 345 G.H5.17
Polar TM6 R 254 6x26 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 R 254 6x26 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 L 262 6x34 G.H5 F 354 G.H5.26
Hydrophobic TM5 L 241 5x72 G.H5 A 338 G.H5.10
Hydrophobic ICL2 L 143 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 143 - G.H5 I 343 G.H5.15
Hydrophobic TM5 S 237 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 262 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 140 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 140 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 I 230 5x61 G.H5 L 348 G.H5.20
Polar TM3 C 139 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 139 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 S 248 6x20 G.H4 Q 304 G.H4.12
Van-der-waals TM6 S 248 6x20 G.H4 Q 304 G.H4.12
Polar TM3 C 139 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 C 139 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 C 139 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 230 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 241 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 L 241 5x72 G.S6 Y 320 G.S6.02
Van-der-waals ICL3 L 245 - G.S6 T 321 G.S6.03
Hydrophobic TM3 I 140 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 140 3x54 G.H5 N 347 G.H5.19
Ionic TM6 H 251 6x23 G.H4 E 308 G.H4.16
Polar TM6 S 248 6x20 G.H4 E 308 G.H4.16
Hydrophobic TM6 S 248 6x20 G.H4 E 308 G.H4.16
Van-der-waals TM6 S 248 6x20 G.H4 E 308 G.H4.16
Hydrophobic ICL3 A 246 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 L 143 - G.H5 T 340 G.H5.12
Hydrophobic TM5 I 233 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 I 233 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 241 5x72 G.H5 F 334 G.H5.06
Polar ICL2 L 143 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 L 143 - G.H5 N 347 G.H5.19
Hydrophobic TM5 L 241 5x72 G.H5 D 337 G.H5.09
Hydrophobic ICL3 A 246 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 A 246 - G.H5 F 334 G.H5.06
Hydrophobic ICL2 L 143 - G.H5 I 344 G.H5.16
Hydrophobic TM5 L 241 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 L 241 5x72 G.H5 D 341 G.H5.13
Polar TM3 R 136 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 136 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 T 265 6x37 G.H5 L 353 G.H5.25