HCA2 receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

March 6, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

butyric acid, β-D-hydroxybutyric acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 H 133 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 H 133 - G.H5 T 340 G.H5.12
Polar TM2 S 62 2x39 G.H5 G 350 G.H5.22
Van-der-waals TM2 S 62 2x39 G.H5 G 350 G.H5.22
Hydrophobic TM5 L 215 5x65 G.H5 I 344 G.H5.16
Van-der-waals TM5 L 215 5x65 G.H5 I 344 G.H5.16
Polar TM6 A 229 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 229 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 229 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 R 218 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 218 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL4 S 297 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 S 297 - G.H5 G 352 G.H5.24
Hydrophobic TM6 A 229 6x33 G.H5 L 348 G.H5.20
Polar TM5 R 218 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM5 R 218 5x68 G.H5 T 340 G.H5.12
Van-der-waals TM5 R 218 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM6 I 233 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM2 S 62 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM6 R 228 6x32 G.H5 Y 354 G.H5.26
Polar TM3 D 124 3x49 G.H5 C 351 G.H5.23
Hydrophobic ICL3 M 220 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 M 220 - G.H5 I 344 G.H5.16
Ionic TM6 H 223 6x27 G.h4s6 E 318 G.h4s6.12
Polar TM6 H 223 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 H 223 6x27 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 H 223 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 H 133 - G.H5 I 343 G.H5.15
Polar ICL4 S 298 - G.H5 G 352 G.H5.24
Hydrophobic ICL4 S 298 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 S 298 - G.H5 G 352 G.H5.24
Hydrophobic TM3 R 125 3x50 G.H5 L 353 G.H5.25
Ionic TM5 R 218 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 218 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 218 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 218 5x68 G.H5 D 341 G.H5.13
Polar TM3 R 125 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 125 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 125 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 K 225 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 225 6x29 G.H5 Y 354 G.H5.26
Polar TM3 R 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 128 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 I 226 6x30 G.H5 Y 354 G.H5.26
Van-der-waals TM6 I 226 6x30 G.H5 Y 354 G.H5.26
Hydrophobic ICL3 M 220 - G.H5 D 341 G.H5.13
Hydrophobic TM3 R 128 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 129 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 129 3x54 G.H5 L 348 G.H5.20
Polar ICL2 P 132 - G.H5 N 347 G.H5.19
Hydrophobic TM6 I 226 6x30 G.H5 L 348 G.H5.20
Hydrophobic ICL4 S 297 - G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 132 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 H 133 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 H 133 - G.S3 L 195 G.S3.01
Hydrophobic TM6 F 232 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 132 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 132 - G.H5 I 344 G.H5.16