CCK2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8IA7

RESOLUTION

3.1 Å

REFERENCE

10.1038/S41421-022-00420-3

PUBLICATION DATE

Dec. 6, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

67 interactions (Click to see)

LIGANDS

CHEMBL216166 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

desulfated cholecystokinin-8, CCK-39, desulfated gastrin-17, desulfated gastrin-14, CCK-4, gastrin-17, desulfated gastrin-71, gastrin-14, CCK-8, gastrin-71, CCK-33, gastrin-34, CCK-58, desulfated gastrin-34



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL4 H 394 - G.H5 N 351 G.H5.18
Hydrophobic TM3 R 152 3x50 G.H5 L 352 G.H5.19
Hydrophobic TM6 L 335 6x37 G.H5 L 352 G.H5.19
Hydrophobic ICL2 P 159 34x50 G.H5 L 343 G.H5.10
Hydrophobic TM3 I 156 3x54 G.H5 L 347 G.H5.14
Van-der-waals TM3 I 156 3x54 G.H5 L 347 G.H5.14
Polar H8 R 395 8x48 G.H5 V 353 G.H5.20
Van-der-waals H8 R 395 8x48 G.H5 V 353 G.H5.20
Hydrophobic ICL2 P 159 34x50 G.H5 K 339 G.H5.06
Hydrophobic TM3 I 156 3x54 G.H5 L 352 G.H5.19
Van-der-waals TM3 I 156 3x54 G.H5 L 352 G.H5.19
Polar ICL2 V 164 34x55 G.HN R 32 G.HN.50
Hydrophobic ICL2 V 164 34x55 G.HN R 32 G.HN.50
Van-der-waals ICL2 V 164 34x55 G.HN R 32 G.HN.50
Hydrophobic TM2 V 88 2x38 G.H5 Y 350 G.H5.17
Hydrophobic TM3 I 156 3x54 G.H5 L 343 G.H5.10
Van-der-waals TM3 I 156 3x54 G.H5 L 343 G.H5.10
Hydrophobic ICL2 P 159 34x50 G.H5 I 342 G.H5.09
Van-der-waals ICL2 P 159 34x50 G.H5 I 342 G.H5.09
Hydrophobic TM4 T 167 4x38 G.HN R 31 G.HN.49
Polar ICL2 R 163 34x54 G.HN R 31 G.HN.49
Polar ICL2 R 163 34x54 G.HN E 33 G.HN.51
Hydrophobic TM3 E 151 3x49 G.H5 Y 350 G.H5.17
Hydrophobic TM6 A 327 6x29 G.H5 V 353 G.H5.20
Polar ICL2 Q 166 34x57 G.H5 Y 350 G.H5.17
Hydrophobic ICL2 Q 166 34x57 G.H5 Y 350 G.H5.17
Van-der-waals ICL2 Q 166 34x57 G.H5 Y 350 G.H5.17
Hydrophobic TM6 V 331 6x33 G.H5 V 353 G.H5.20
Hydrophobic ICL2 L 160 34x51 G.S2 V 193 G.S2.05
Hydrophobic TM6 V 331 6x33 G.H5 L 352 G.H5.19
Van-der-waals TM6 V 331 6x33 G.H5 L 352 G.H5.19
Hydrophobic TM2 T 89 2x39 G.H5 Y 350 G.H5.17
Polar TM3 A 155 3x53 G.H5 N 346 G.H5.13
Hydrophobic TM3 A 155 3x53 G.H5 N 346 G.H5.13
Van-der-waals TM3 A 155 3x53 G.H5 N 346 G.H5.13
Hydrophobic TM5 I 241 5x61 G.H5 L 352 G.H5.19
Hydrophobic ICL2 L 160 34x51 G.H5 F 335 G.H5.02
Van-der-waals ICL2 L 160 34x51 G.H5 F 335 G.H5.02
Hydrophobic TM3 A 155 3x53 G.H5 Y 350 G.H5.17
Van-der-waals TM3 A 155 3x53 G.H5 Y 350 G.H5.17
Polar TM3 R 152 3x50 G.H5 Y 350 G.H5.17
Hydrophobic TM3 R 152 3x50 G.H5 Y 350 G.H5.17
Polar ICL2 V 164 34x55 G.HN R 31 G.HN.49
Van-der-waals ICL2 V 164 34x55 G.HN R 31 G.HN.49
Polar ICL2 R 163 34x54 G.HN R 32 G.HN.50
Hydrophobic TM3 I 156 3x54 G.H5 N 346 G.H5.13
Van-der-waals TM3 I 156 3x54 G.H5 N 346 G.H5.13
Hydrophobic ICL1 T 87 - G.H5 E 349 G.H5.16
Hydrophobic ICL2 L 160 34x51 G.H5 I 342 G.H5.09
Hydrophobic ICL2 R 163 34x54 G.HN L 34 G.HN.52
Van-der-waals ICL2 R 163 34x54 G.HN L 34 G.HN.52
Hydrophobic TM5 L 245 5x65 G.H5 L 347 G.H5.14