Structure information

CCK2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8IA7

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1038/S41421-022-00420-3

PUBLICATION DATE

Dec. 6, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL216166 P114 2.64x63 TM2 polar (hydrogen bond with backbone)
CHEMBL216166 P114 2.64x63 TM2 Van der Waals
CHEMBL216166 G118 ECL1 Van der Waals
CHEMBL216166 C127 3.25x25 TM3 Van der Waals
CHEMBL216166 S131 3.29x29 TM3 Van der Waals
CHEMBL216166 M134 3.32x32 TM3 polar (hydrogen bond)
CHEMBL216166 V138 3.36x36 TM3 Van der Waals
CHEMBL216166 V138 3.36x36 TM3 hydrophobic
CHEMBL216166 Y189 4.60x61 TM4 polar (hydrogen bond)
CHEMBL216166 Q204 ECL2 polar (hydrogen bond)
CHEMBL216166 C205 45.50x50 ECL2 Van der Waals
CHEMBL216166 C205 45.50x50 ECL2 polar (hydrogen bond with backbone)
CHEMBL216166 H207 45.52x52 ECL2 polar (hydrogen bond)
CHEMBL216166 H207 45.52x52 ECL2 Van der Waals
CHEMBL216166 V349 6.51x51 TM6 Van der Waals
CHEMBL216166 V349 6.51x51 TM6 hydrophobic
CHEMBL216166 A352 6.54x54 TM6 hydrophobic
CHEMBL216166 A352 6.54x54 TM6 Van der Waals
CHEMBL216166 N353 6.55x55 TM6 polar (hydrogen bond)
CHEMBL216166 N353 6.55x55 TM6 Van der Waals
CHEMBL216166 R356 6.58x58 TM6 Van der Waals
CHEMBL216166 A363 ECL3 hydrophobic
CHEMBL216166 A363 ECL3 Van der Waals
CHEMBL216166 H364 ECL3 Van der Waals
CHEMBL216166 S368 ECL3 polar (hydrogen bond)
CHEMBL216166 S368 ECL3 Van der Waals
CHEMBL216166 I372 7.35x34 TM7 hydrophobic
CHEMBL216166 I372 7.35x34 TM7 Van der Waals
CHEMBL216166 H376 7.39x38 TM7 polar (hydrogen bond)
CHEMBL216166 Y380 7.43x42 TM7 Van der Waals

Ligands

CHEMBL216166

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Residue Diagrams

M N G G V S M L F I V A Y L T I R I A L 1 L S L A V S D L L L A A V C M P F T L L P 2 A V L S L T S V S V S V G M L Y S V A K 3 A A R V I V A T W L L S G L L M V P Y 4 Y A V A M V V G P I F F L L L L L L V S W 5 L V I V V L F F L C W L P V Y S A N T W 6 L P N V C A S A Y S L L H I F S I P A 7
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ICL1 R R L R ICL1ECL1 T F I F ECL1ICL2 P L Q A R V W Q ICL2ECL2 V V Q P V G P R V L Q C V H R W P ECL2ICL3 S D S Q S R V R N Q G G L P G A V H Q N G R C R P E T G A V G E D S D G C Y V Q L P R S R P A L E L T A L T A P G P G S G S R P T ICL3ECL3 P G A H R A L S ECL3N-term M E L L K L N R S V Q G T G P G P G A S L C R P G A P L L N S S S V G N L S C E P P R I R G A G T R E N-termC-term A R C C P R P P R A R P R A L P D E D P P T P S I A S L S R L S Y T T I S T L G P G C-term L E L A I R I T L Y A V I F L M S V G G N M L I I V V L G L S T V T N A F L L S L A V S D L L L A V A C M P F T L L P N L M G G T V I C K A V S Y L M G V S V S V S T L S L V A I A L E R Y S A I C R T R S H A A R V I V A T W L L S G L L M V P Y P V Y T S A R V R Q T W S V L L L L L L F F I P G V V M A V A Y G L I S R E L Y L G L R F D G D S D Q A K L L A K K R V V R M L L V I V V L F F L C W L P V Y S A N T W R A F D G G A P I S F I H L L S Y A S A C V N P L V Y C F M H R R C L E F R Q A T C
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCK2 receptor
TM2
2x63 2.64x63 P114
TM3
3x25 3.25x25 C127
3x29 3.29x29 S131
3x32 3.32x32 M134
3x36 3.36x36 V138
TM4
4x61 4.60x61 Y189
ECL2
45x50 45.50x50 C205
45x52 45.52x52 H207
TM6
6x51 6.51x51 V349
6x54 6.54x54 A352
6x55 6.55x55 N353
6x58 6.58x58 R356
TM7
7x34 7.35x34 I372
7x38 7.39x38 H376
7x42 7.43x42 Y380