HCA2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

April 3, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

butyric acid, β-D-hydroxybutyric acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 H 133 - G.S3 L 194 G.S3.01
Polar ICL2 H 133 - G.H5 T 340 G.H5.12
Polar TM2 S 62 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 132 - G.H5 T 340 G.H5.12
Hydrophobic TM5 L 215 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL3 D 221 - G.H5 K 345 G.H5.17
Hydrophobic TM6 A 229 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 229 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 226 6x30 G.H5 K 345 G.H5.17
Hydrophobic ICL3 H 223 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 D 221 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 D 221 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 I 233 6x37 G.H5 L 353 G.H5.25
Ionic ICL3 H 223 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 H 223 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 H 223 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 H 223 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 H 133 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 H 133 - G.H5 I 343 G.H5.15
Polar H8 S 298 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 298 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 298 8x47 G.H5 G 352 G.H5.24
Polar ICL3 H 223 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL3 H 223 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 H 223 - G.h4s6 K 314 G.h4s6.08
Hydrophobic TM3 R 125 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 128 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 125 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 K 225 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 225 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 A 229 6x33 G.H5 F 354 G.H5.26
Polar TM3 R 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 128 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 I 226 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 I 226 6x30 G.H5 F 354 G.H5.26
Ionic TM2 K 60 2x37 G.H5 D 350 G.H5.22
Polar TM2 K 60 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 K 60 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 K 60 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 128 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 128 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 129 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 129 3x54 G.H5 L 348 G.H5.20
Polar ICL2 P 132 - G.H5 N 347 G.H5.19
Polar TM6 R 228 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 228 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM5 Q 219 5x69 G.H5 I 344 G.H5.16
Hydrophobic TM6 I 226 6x30 G.H5 L 348 G.H5.20
Polar TM2 R 63 2x40 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 63 2x40 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 132 - G.H5 I 343 G.H5.15
Polar TM4 S 140 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 S 140 4x38 G.HN E 28 G.HN.52
Hydrophobic ICL2 L 136 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 N 137 - G.hns1 R 32 G.hns1.03
Hydrophobic H8 P 299 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 P 299 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 132 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 132 - G.H5 I 344 G.H5.16