Refined structure (8I9S) of Go - C3a receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-07-12

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 210 from structure (59.3%), 144 from model (40.7%)
Residue sidechains - 178 from structure (50.3%), 176 from model (49.7%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 AF2 AF2
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 E G.HN.33 Structure AF2
G.HN 10 R G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 L G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 A G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 E G.HN.44 Structure AF2
G.HN 21 K G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 K G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure AF2
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 I G.HN.52 Structure Structure
G.HN 29 S G.HN.53 Structure AF2
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 K G.hns1.03 Structure Structure
G.S1 33 D G.S1.01 Structure AF2
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure AF2
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure AF2
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure AF2
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 D G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 F G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 G H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 D H.HA.03 AF2 AF2
H.HA 66 V H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 P H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 L H.HA.19 AF2 AF2
H.HA 82 A H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 V H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 D H.HA.27 AF2 AF2
H.HA 90 T H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 G H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 E H.hahb.05 AF2 AF2
H.hahb 95 Y H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 K H.hahb.09 AF2 AF2
H.HB 99 E H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 K H.HB.03 AF2 AF2
H.HB 102 A H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 K H.HB.07 AF2 AF2
H.HB 106 M H.HB.08 AF2 AF2
H.HB 107 V H.HB.09 AF2 AF2
H.HB 108 C H.HB.10 AF2 AF2
H.HB 109 D H.HB.11 AF2 AF2
H.HB 110 V H.HB.12 AF2 AF2
H.HB 111 V H.HB.13 AF2 AF2
H.HB 112 S H.HB.14 AF2 AF2
H.hbhc 113 R H.hbhc.01 AF2 AF2
H.hbhc 114 M H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 D H.hbhc.04 AF2 AF2
H.hbhc 117 T H.hbhc.05 AF2 AF2
H.hbhc 118 E H.hbhc.12 AF2 AF2
H.hbhc 119 P H.hbhc.13 AF2 AF2
H.hbhc 120 F H.hbhc.14 AF2 AF2
H.hbhc 121 S H.hbhc.15 AF2 AF2
H.HC 122 A H.HC.01 AF2 AF2
H.HC 123 E H.HC.02 AF2 AF2
H.HC 124 L H.HC.03 AF2 AF2
H.HC 125 L H.HC.04 AF2 AF2
H.HC 126 S H.HC.05 AF2 AF2
H.HC 127 A H.HC.06 AF2 AF2
H.HC 128 M H.HC.07 AF2 AF2
H.HC 129 M H.HC.08 AF2 AF2
H.HC 130 R H.HC.09 AF2 AF2
H.HC 131 L H.HC.10 AF2 AF2
H.HC 132 W H.HC.11 AF2 AF2
H.HC 133 G H.HC.12 AF2 AF2
H.hchd 134 D H.hchd.01 AF2 AF2
H.HD 135 S H.HD.01 AF2 AF2
H.HD 136 G H.HD.02 AF2 AF2
H.HD 137 I H.HD.03 AF2 AF2
H.HD 138 Q H.HD.04 AF2 AF2
H.HD 139 E H.HD.05 AF2 AF2
H.HD 140 C H.HD.06 AF2 AF2
H.HD 141 F H.HD.07 AF2 AF2
H.HD 142 N H.HD.08 AF2 AF2
H.HD 143 R H.HD.09 AF2 AF2
H.HD 144 S H.HD.10 AF2 AF2
H.HD 145 R H.HD.11 AF2 AF2
H.HD 146 E H.HD.12 AF2 AF2
H.hdhe 147 Y H.hdhe.01 AF2 AF2
H.hdhe 148 Q H.hdhe.02 AF2 AF2
H.hdhe 149 L H.hdhe.03 AF2 AF2
H.hdhe 150 N H.hdhe.04 AF2 AF2
H.hdhe 151 D H.hdhe.05 AF2 AF2
H.HE 152 S H.HE.01 AF2 AF2
H.HE 153 A H.HE.02 AF2 AF2
H.HE 154 K H.HE.03 AF2 AF2
H.HE 155 Y H.HE.04 AF2 AF2
H.HE 156 Y H.HE.05 AF2 AF2
H.HE 157 L H.HE.06 AF2 AF2
H.HE 158 D H.HE.07 AF2 AF2
H.HE 159 S H.HE.08 AF2 AF2
H.HE 160 L H.HE.09 AF2 AF2
H.HE 161 D H.HE.10 AF2 AF2
H.HE 162 R H.HE.11 AF2 AF2
H.HE 163 I H.HE.12 AF2 AF2
H.HE 164 G H.HE.13 AF2 AF2
H.hehf 165 A H.hehf.01 AF2 AF2
H.hehf 166 A H.hehf.02 AF2 AF2
H.hehf 167 D H.hehf.03 AF2 AF2
H.hehf 168 Y H.hehf.04 AF2 AF2
H.hehf 169 Q H.hehf.05 AF2 AF2
H.hehf 170 P H.hehf.06 AF2 AF2
H.hehf 171 T H.hehf.07 AF2 AF2
H.HF 172 E H.HF.01 AF2 AF2
H.HF 173 Q H.HF.02 AF2 AF2
H.HF 174 D H.HF.03 AF2 AF2
H.HF 175 I H.HF.04 AF2 AF2
H.HF 176 L H.HF.05 AF2 AF2
H.HF 177 R H.HF.06 AF2 AF2
G.hfs2 178 T G.hfs2.01 AF2 AF2
G.hfs2 179 R G.hfs2.02 AF2 AF2
G.hfs2 180 V G.hfs2.03 AF2 AF2
G.hfs2 181 K G.hfs2.04 AF2 AF2
G.hfs2 182 T G.hfs2.05 AF2 AF2
G.hfs2 183 T G.hfs2.06 Structure Structure
G.hfs2 184 G G.hfs2.07 Structure Structure
G.S2 185 I G.S2.01 Structure Structure
G.S2 186 V G.S2.02 Structure Structure
G.S2 187 E G.S2.03 Structure Structure
G.S2 188 T G.S2.04 Structure Structure
G.S2 189 H G.S2.05 Structure Structure
G.S2 190 F G.S2.06 Structure Structure
G.S2 191 T G.S2.07 Structure Structure
G.S2 192 F G.S2.08 Structure Structure
G.s2s3 193 K G.s2s3.01 Structure Structure
G.s2s3 194 N G.s2s3.02 Structure Structure
G.S3 195 L G.S3.01 Structure Structure
G.S3 196 H G.S3.02 Structure Structure
G.S3 197 F G.S3.03 Structure Structure
G.S3 198 R G.S3.04 Structure Structure
G.S3 199 L G.S3.05 Structure Structure
G.S3 200 F G.S3.06 Structure Structure
G.S3 201 D G.S3.07 Structure Structure
G.S3 202 V G.S3.08 Structure Structure
G.s3h2 203 G G.s3h2.01 Structure Structure
G.s3h2 204 G G.s3h2.02 Structure Structure
G.s3h2 205 Q G.s3h2.03 Structure Structure
G.H2 206 R G.H2.01 Structure AF2
G.H2 207 S G.H2.02 Structure Structure
G.H2 208 E G.H2.03 Structure Structure
G.H2 209 R G.H2.04 Structure Structure
G.H2 210 K G.H2.05 Structure Structure
G.H2 211 K G.H2.06 Structure Structure
G.H2 212 W G.H2.07 Structure Structure
G.H2 213 I G.H2.08 Structure Structure
G.H2 214 H G.H2.09 Structure Structure
G.H2 215 C G.H2.10 Structure Structure
G.h2s4 216 F G.h2s4.01 Structure Structure
G.h2s4 217 E G.h2s4.02 Structure Structure
G.h2s4 218 D G.h2s4.03 Structure Structure
G.h2s4 219 V G.h2s4.04 Structure Structure
G.h2s4 220 T G.h2s4.05 Structure Structure
G.S4 221 A G.S4.01 Structure Structure
G.S4 222 I G.S4.02 Structure Structure
G.S4 223 I G.S4.03 Structure Structure
G.S4 224 F G.S4.04 Structure Structure
G.S4 225 C G.S4.05 Structure Structure
G.S4 226 V G.S4.06 Structure Structure
G.S4 227 A G.S4.07 Structure AF2
G.s4h3 228 L G.s4h3.01 Structure Structure
G.s4h3 229 S G.s4h3.02 Structure Structure
G.s4h3 230 G G.s4h3.03 Structure Structure
G.s4h3 231 Y G.s4h3.04 AF2 AF2
G.s4h3 232 D G.s4h3.05 AF2 AF2
G.s4h3 233 Q G.s4h3.06 AF2 AF2
G.s4h3 234 V G.s4h3.07 AF2 AF2
G.s4h3 235 L G.s4h3.08 AF2 AF2
G.s4h3 236 H G.s4h3.09 AF2 AF2
G.s4h3 237 E G.s4h3.10 AF2 AF2
G.s4h3 238 D G.s4h3.11 AF2 AF2
G.s4h3 239 E G.s4h3.12 AF2 AF2
G.s4h3 240 T G.s4h3.13 AF2 AF2
G.s4h3 241 T G.s4h3.14 AF2 AF2
G.s4h3 242 N G.s4h3.15 AF2 AF2
G.H3 243 R G.H3.01 Structure Structure
G.H3 244 M G.H3.02 Structure Structure
G.H3 245 H G.H3.03 Structure AF2
G.H3 246 E G.H3.04 Structure Structure
G.H3 247 S G.H3.05 Structure Structure
G.H3 248 L G.H3.06 Structure Structure
G.H3 249 M G.H3.07 Structure AF2
G.H3 250 L G.H3.08 Structure Structure
G.H3 251 F G.H3.09 Structure Structure
G.H3 252 D G.H3.10 Structure Structure
G.H3 253 S G.H3.11 Structure Structure
G.H3 254 I G.H3.12 Structure Structure
G.H3 255 C G.H3.13 Structure Structure
G.H3 256 N G.H3.14 Structure Structure
G.H3 257 N G.H3.15 Structure Structure
G.H3 258 K G.H3.16 Structure Structure
G.H3 259 F G.H3.17 Structure Structure
G.H3 260 F G.H3.18 Structure Structure
G.h3s5 261 I G.h3s5.01 Structure Structure
G.h3s5 262 D G.h3s5.02 Structure AF2
G.h3s5 263 T G.h3s5.03 Structure Structure
G.S5 264 S G.S5.01 Structure Structure
G.S5 265 I G.S5.02 Structure AF2
G.S5 266 I G.S5.03 Structure Structure
G.S5 267 L G.S5.04 Structure Structure
G.S5 268 F G.S5.05 Structure Structure
G.S5 269 L G.S5.06 Structure Structure
G.S5 270 N G.S5.07 Structure Structure
G.s5hg 271 K G.s5hg.01 Structure Structure
G.HG 272 K G.HG.01 Structure AF2
G.HG 273 D G.HG.02 Structure Structure
G.HG 274 L G.HG.03 Structure Structure
G.HG 275 F G.HG.04 Structure Structure
G.HG 276 G G.HG.05 Structure Structure
G.HG 277 E G.HG.06 Structure Structure
G.HG 278 K G.HG.07 Structure Structure
G.HG 279 I G.HG.08 Structure Structure
G.HG 280 K G.HG.09 Structure AF2
G.HG 281 K G.HG.12 Structure AF2
G.HG 282 S G.HG.13 Structure Structure
G.HG 283 P G.HG.14 Structure Structure
G.HG 284 L G.HG.15 Structure AF2
G.HG 285 T G.HG.16 Structure Structure
G.HG 286 I G.HG.17 Structure Structure
G.hgh4 287 C G.hgh4.01 Structure Structure
G.hgh4 288 F G.hgh4.02 Structure Structure
G.hgh4 289 P G.hgh4.03 Structure Structure
G.hgh4 290 E G.hgh4.04 Structure Structure
G.hgh4 291 Y G.hgh4.05 Structure AF2
G.hgh4 292 T G.hgh4.06 Structure Structure
G.hgh4 293 G G.hgh4.07 Structure Structure
G.hgh4 294 P G.hgh4.08 Structure Structure
G.H4 295 N G.H4.01 Structure Structure
G.H4 296 T G.H4.02 Structure Structure
G.H4 297 Y G.H4.03 Structure Structure
G.H4 298 E G.H4.04 Structure AF2
G.H4 299 D G.H4.05 Structure Structure
G.H4 300 A G.H4.06 Structure Structure
G.H4 301 A G.H4.07 Structure Structure
G.H4 302 A G.H4.08 Structure Structure
G.H4 303 Y G.H4.10 Structure Structure
G.H4 304 I G.H4.11 Structure Structure
G.H4 305 Q G.H4.12 Structure Structure
G.H4 306 A G.H4.13 Structure Structure
G.H4 307 Q G.H4.14 Structure Structure
G.H4 308 F G.H4.15 Structure Structure
G.H4 309 E G.H4.16 Structure Structure
G.H4 310 S G.H4.17 Structure Structure
G.h4s6 311 K G.h4s6.01 Structure Structure
G.h4s6 312 N G.h4s6.02 Structure Structure
G.h4s6 313 R G.h4s6.03 Structure Structure
G.h4s6 314 S G.h4s6.08 Structure AF2
G.h4s6 315 P G.h4s6.09 Structure Structure
G.h4s6 316 N G.h4s6.10 Structure AF2
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 C G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 M G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure AF2
G.s6h5 325 C G.s6h5.02 Structure AF2
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure AF2
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure AF2
G.H5 330 N G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 I G.H5.04 Structure AF2
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 V G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure AF2
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 I G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 A G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure AF2
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 R G.H5.21 Structure Structure
G.H5 350 G G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 Y G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 275 from structure (60.0%), 183 from model (40.0%)
Residue sidechains - 240 from structure (52.4%), 218 from model (47.6%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 A - AF2 AF2
N-term 3 S - AF2 AF2
N-term 4 F - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 A - AF2 AF2
N-term 7 E - AF2 AF2
N-term 8 T - AF2 AF2
N-term 9 N - AF2 AF2
N-term 10 S - AF2 AF2
N-term 11 T - AF2 AF2
N-term 12 D - AF2 AF2
N-term 13 L - AF2 AF2
N-term 14 L - AF2 AF2
N-term 15 S - AF2 AF2
N-term 16 Q - AF2 AF2
N-term 17 P - AF2 AF2
N-term 18 W - AF2 AF2
N-term 19 N - AF2 AF2
TM1 20 E 1.29x29 Structure AF2
TM1 21 P 1.30x30 Structure Structure
TM1 22 P 1.31x31 Structure Structure
TM1 23 V 1.32x32 Structure Structure
TM1 24 I 1.33x33 Structure Structure
TM1 25 L 1.34x34 Structure Structure
TM1 26 S 1.35x35 Structure Structure
TM1 27 M 1.36x36 Structure Structure
TM1 28 V 1.37x37 Structure Structure
TM1 29 I 1.38x38 Structure Structure
TM1 30 L 1.39x39 Structure Structure
TM1 31 S 1.40x40 Structure Structure
TM1 32 L 1.41x41 Structure Structure
TM1 33 T 1.42x42 Structure Structure
TM1 34 F 1.43x43 Structure Structure
TM1 35 L 1.44x44 Structure Structure
TM1 36 L 1.45x45 Structure Structure
TM1 37 G 1.46x46 Structure Structure
TM1 38 L 1.47x47 Structure Structure
TM1 39 P 1.48x48 Structure Structure
TM1 40 G 1.49x49 Structure Structure
TM1 41 N 1.50x50 Structure Structure
TM1 42 G 1.51x51 Structure Structure
TM1 43 L 1.52x52 Structure Structure
TM1 44 V 1.53x53 Structure Structure
TM1 45 L 1.54x54 Structure Structure
TM1 46 W 1.55x55 Structure Structure
TM1 47 V 1.56x56 Structure Structure
TM1 48 A 1.57x57 Structure Structure
TM1 49 G 1.58x58 Structure Structure
TM1 50 L 1.59x59 Structure Structure
TM1 51 K 1.60x60 Structure AF2
ICL1 52 M - Structure AF2
ICL1 53 Q - Structure Structure
ICL1 54 R - Structure Structure
TM2 55 T 2.37x37 Structure Structure
TM2 56 V 2.38x38 Structure Structure
TM2 57 N 2.39x39 Structure Structure
TM2 58 T 2.40x40 Structure AF2
TM2 59 I 2.41x41 Structure Structure
TM2 60 W 2.42x42 Structure Structure
TM2 61 F 2.43x43 Structure Structure
TM2 62 L 2.44x44 Structure Structure
TM2 63 H 2.45x45 Structure Structure
TM2 64 L 2.46x46 Structure Structure
TM2 65 T 2.47x47 Structure Structure
TM2 66 L 2.48x48 Structure Structure
TM2 67 A 2.49x49 Structure Structure
TM2 68 D 2.50x50 Structure Structure
TM2 69 L 2.51x51 Structure Structure
TM2 70 L 2.52x52 Structure Structure
TM2 71 C 2.53x53 Structure Structure
TM2 72 C 2.54x54 Structure Structure
TM2 73 L 2.55x55 Structure Structure
TM2 74 S 2.56x56 Structure Structure
TM2 75 L 2.57x57 Structure Structure
TM2 76 P 2.58x58 Structure Structure
TM2 77 F 2.59x59 Structure Structure
TM2 78 S 2.60x60 Structure Structure
TM2 79 L 2.61x61 Structure Structure
TM2 80 A 2.62x62 Structure Structure
TM2 81 H 2.63x63 Structure Structure
TM2 82 L 2.64x64 Structure AF2
TM2 83 A 2.65x65 Structure Structure
TM2 84 L 2.66x66 Structure Structure
TM2 85 Q 2.67x67 Structure AF2
ECL1 86 G - Structure Structure
ECL1 87 Q 23.49x49 Structure AF2
ECL1 88 W 23.50x50 Structure AF2
ECL1 89 P 23.51x51 Structure Structure
ECL1 90 Y 23.52x52 Structure Structure
TM3 91 G 3.21x21 Structure Structure
TM3 92 R 3.22x22 Structure Structure
TM3 93 F 3.23x23 Structure Structure
TM3 94 L 3.24x24 Structure AF2
TM3 95 C 3.25x25 Structure Structure
TM3 96 K 3.26x26 Structure AF2
TM3 97 L 3.27x27 Structure Structure
TM3 98 I 3.28x28 Structure AF2
TM3 99 P 3.29x29 Structure Structure
TM3 100 S 3.30x30 Structure Structure
TM3 101 I 3.31x31 Structure AF2
TM3 102 I 3.32x32 Structure Structure
TM3 103 V 3.33x33 Structure Structure
TM3 104 L 3.34x34 Structure Structure
TM3 105 N 3.35x35 Structure AF2
TM3 106 M 3.36x36 Structure Structure
TM3 107 F 3.37x37 Structure Structure
TM3 108 A 3.38x38 Structure Structure
TM3 109 S 3.39x39 Structure Structure
TM3 110 V 3.40x40 Structure Structure
TM3 111 F 3.41x41 Structure Structure
TM3 112 L 3.42x42 Structure Structure
TM3 113 L 3.43x43 Structure Structure
TM3 114 T 3.44x44 Structure Structure
TM3 115 A 3.45x45 Structure Structure
TM3 116 I 3.46x46 Structure Structure
TM3 117 S 3.47x47 Structure Structure
TM3 118 L 3.48x48 Structure Structure
TM3 119 D 3.49x49 Structure Structure
TM3 120 R 3.50x50 Structure Structure
TM3 121 C 3.51x51 Structure Structure
TM3 122 L 3.52x52 Structure Structure
TM3 123 V 3.53x53 Structure Structure
TM3 124 V 3.54x54 Structure Structure
TM3 125 F 3.55x55 Structure Structure
TM3 126 K 3.56x56 Structure Structure
ICL2 127 P 34.50x50 Structure Structure
ICL2 128 I 34.51x51 Structure Structure
ICL2 129 W 34.52x52 Structure Structure
ICL2 130 C 34.53x53 Structure Structure
ICL2 131 Q 34.54x54 Structure Structure
ICL2 132 N 34.55x55 Structure Structure
ICL2 133 H 34.56x56 Structure Structure
ICL2 134 R 34.57x57 Structure Structure
TM4 135 N 4.38x38 Structure Structure
TM4 136 V 4.39x39 Structure Structure
TM4 137 G 4.40x40 Structure Structure
TM4 138 M 4.41x41 Structure Structure
TM4 139 A 4.42x42 Structure Structure
TM4 140 C 4.43x43 Structure Structure
TM4 141 S 4.44x44 Structure Structure
TM4 142 I 4.45x45 Structure Structure
TM4 143 C 4.46x46 Structure Structure
TM4 144 G 4.47x47 Structure Structure
TM4 145 C 4.48x48 Structure Structure
TM4 146 I 4.49x49 Structure Structure
TM4 147 W 4.50x50 Structure Structure
TM4 148 V 4.51x51 Structure Structure
TM4 149 V 4.52x52 Structure Structure
TM4 150 A 4.53x53 Structure Structure
TM4 151 F 4.54x54 Structure Structure
TM4 152 V 4.55x55 Structure Structure
TM4 153 M 4.56x56 Structure AF2
TM4 154 C 4.57x57 Structure Structure
TM4 155 I 4.58x59 Structure Structure
TM4 156 P 4.59x60 Structure Structure
TM4 157 V 4.60x61 Structure Structure
TM4 158 F 4.61x62 Structure Structure
TM4 159 V 4.62x63 Structure Structure
TM4 160 Y 4.63x64 Structure Structure
TM4 161 R 4.64x65 Structure Structure
ECL2 162 E - Structure Structure
ECL2 163 I - Structure Structure
ECL2 164 F - Structure AF2
ECL2 165 T - Structure Structure
ECL2 166 T - Structure AF2
ECL2 167 D - Structure AF2
ECL2 168 N - Structure AF2
ECL2 169 H - Structure AF2
ECL2 170 N - Structure AF2
ECL2 171 R - Structure AF2
ECL2 172 C 45.50x50 Structure Structure
ECL2 173 G 45.51x51 Structure Structure
ECL2 174 Y 45.52x52 Structure Structure
ECL2 175 K - AF2 AF2
ECL2 176 F - AF2 AF2
ECL2 177 G - AF2 AF2
ECL2 178 L - AF2 AF2
ECL2 179 S - AF2 AF2
ECL2 180 S - AF2 AF2
ECL2 181 S - AF2 AF2
ECL2 182 L - AF2 AF2
ECL2 183 D - AF2 AF2
ECL2 184 Y - AF2 AF2
ECL2 185 P - AF2 AF2
ECL2 186 D - AF2 AF2
ECL2 187 F - AF2 AF2
ECL2 188 Y - AF2 AF2
ECL2 189 G - AF2 AF2
ECL2 190 D - AF2 AF2
ECL2 191 P - AF2 AF2
ECL2 192 L - AF2 AF2
ECL2 193 E - AF2 AF2
ECL2 194 N - AF2 AF2
ECL2 195 R - AF2 AF2
ECL2 196 S - AF2 AF2
ECL2 197 L - AF2 AF2
ECL2 198 E - AF2 AF2
ECL2 199 N - AF2 AF2
ECL2 200 I - AF2 AF2
ECL2 201 V - AF2 AF2
ECL2 202 Q - AF2 AF2
ECL2 203 P - AF2 AF2
ECL2 204 P - AF2 AF2
ECL2 205 G - AF2 AF2
ECL2 206 E - AF2 AF2
ECL2 207 M - AF2 AF2
ECL2 208 N - AF2 AF2
ECL2 209 D - AF2 AF2
ECL2 210 R - AF2 AF2
ECL2 211 L - AF2 AF2
ECL2 212 D - AF2 AF2
ECL2 213 P - AF2 AF2
ECL2 214 S - AF2 AF2
ECL2 215 S - AF2 AF2
ECL2 216 F - AF2 AF2
ECL2 217 Q - AF2 AF2
ECL2 218 T - AF2 AF2
ECL2 219 N - AF2 AF2
ECL2 220 D - AF2 AF2
ECL2 221 H - AF2 AF2
ECL2 222 P - AF2 AF2
ECL2 223 W - AF2 AF2
ECL2 224 T - AF2 AF2
ECL2 225 V - AF2 AF2
ECL2 226 P - AF2 AF2
ECL2 227 T - AF2 AF2
ECL2 228 V - AF2 AF2
ECL2 229 F - AF2 AF2
ECL2 230 Q - AF2 AF2
ECL2 231 P - AF2 AF2
ECL2 232 Q - AF2 AF2
ECL2 233 T - AF2 AF2
ECL2 234 F - AF2 AF2
ECL2 235 Q - AF2 AF2
ECL2 236 R - AF2 AF2
ECL2 237 P - AF2 AF2
ECL2 238 S - AF2 AF2
ECL2 239 A - AF2 AF2
ECL2 240 D - AF2 AF2
ECL2 241 S - AF2 AF2
ECL2 242 L - AF2 AF2
ECL2 243 P - AF2 AF2
ECL2 244 R - AF2 AF2
ECL2 245 G - AF2 AF2
ECL2 246 S - AF2 AF2
ECL2 247 A - AF2 AF2
ECL2 248 R - AF2 AF2
ECL2 249 L - AF2 AF2
ECL2 250 T - AF2 AF2
ECL2 251 S - AF2 AF2
ECL2 252 Q - AF2 AF2
ECL2 253 N - AF2 AF2
ECL2 254 L - AF2 AF2
ECL2 255 Y - AF2 AF2
ECL2 256 S - AF2 AF2
ECL2 257 N - AF2 AF2
ECL2 258 V - AF2 AF2
ECL2 259 F - AF2 AF2
ECL2 260 K - AF2 AF2
ECL2 261 P - AF2 AF2
ECL2 262 A - AF2 AF2
ECL2 263 D - AF2 AF2
ECL2 264 V - AF2 AF2
ECL2 265 V - AF2 AF2
ECL2 266 S - AF2 AF2
ECL2 267 P - AF2 AF2
ECL2 268 K - AF2 AF2
ECL2 269 I - AF2 AF2
ECL2 270 P - AF2 AF2
ECL2 271 S - AF2 AF2
ECL2 272 G - AF2 AF2
ECL2 273 F - AF2 AF2
ECL2 274 P - AF2 AF2
ECL2 275 I - AF2 AF2
ECL2 276 E - AF2 AF2
ECL2 277 D - AF2 AF2
ECL2 278 H - AF2 AF2
ECL2 279 E - AF2 AF2
ECL2 280 T - AF2 AF2
ECL2 281 S - AF2 AF2
ECL2 282 P - AF2 AF2
ECL2 283 L - AF2 AF2
ECL2 284 D - AF2 AF2
ECL2 285 N - AF2 AF2
ECL2 286 S - AF2 AF2
ECL2 287 D - AF2 AF2
ECL2 288 A - AF2 AF2
ECL2 289 F - AF2 AF2
ECL2 290 L - AF2 AF2
ECL2 291 S - AF2 AF2
ECL2 292 T - AF2 AF2
ECL2 293 H - AF2 AF2
ECL2 294 L - AF2 AF2
ECL2 295 K - AF2 AF2
ECL2 296 L - AF2 AF2
ECL2 297 F - AF2 AF2
ECL2 298 P - AF2 AF2
ECL2 299 S - AF2 AF2
ECL2 300 A - AF2 AF2
ECL2 301 S - AF2 AF2
ECL2 302 S - AF2 AF2
ECL2 303 N - AF2 AF2
ECL2 304 S - AF2 AF2
ECL2 305 F - AF2 AF2
ECL2 306 Y - AF2 AF2
ECL2 307 E - AF2 AF2
ECL2 308 S - AF2 AF2
ECL2 309 E - AF2 AF2
ECL2 310 L - AF2 AF2
ECL2 311 P - AF2 AF2
ECL2 312 Q - AF2 AF2
ECL2 313 G - AF2 AF2
ECL2 314 F - AF2 AF2
ECL2 315 Q - AF2 AF2
ECL2 316 D - AF2 AF2
ECL2 317 Y - AF2 AF2
ECL2 318 Y - AF2 AF2
ECL2 319 N - AF2 AF2
ECL2 320 L - AF2 AF2
ECL2 321 G - AF2 AF2
ECL2 322 Q - AF2 AF2
ECL2 323 F - AF2 AF2
ECL2 324 T - AF2 AF2
ECL2 325 D - AF2 AF2
ECL2 326 D - AF2 AF2
ECL2 327 D - AF2 AF2
ECL2 328 Q - AF2 AF2
TM5 329 V 5.31x32 AF2 AF2
TM5 330 P 5.32x33 AF2 AF2
TM5 331 T 5.33x34 Structure Structure
TM5 332 P 5.34x35 Structure Structure
TM5 333 L 5.35x36 Structure Structure
TM5 334 V 5.36x37 Structure Structure
TM5 335 A 5.37x38 Structure Structure
TM5 336 I 5.38x39 Structure Structure
TM5 337 T 5.39x40 Structure Structure
TM5 338 I 5.40x41 Structure Structure
TM5 339 T 5.41x42 Structure AF2
TM5 340 R 5.42x43 Structure Structure
TM5 341 L 5.43x44 Structure Structure
TM5 342 V 5.44x45 Structure Structure
TM5 343 V 5.45x46 Structure Structure
TM5 344 G 5.46x461 Structure Structure
TM5 345 F 5.47x47 Structure Structure
TM5 346 L 5.48x48 Structure Structure
TM5 347 L 5.49x49 Structure Structure
TM5 348 P 5.50x50 Structure Structure
TM5 349 S 5.51x51 Structure Structure
TM5 350 V 5.52x52 Structure Structure
TM5 351 I 5.53x53 Structure Structure
TM5 352 M 5.54x54 Structure Structure
TM5 353 I 5.55x55 Structure Structure
TM5 354 A 5.56x56 Structure Structure
TM5 355 C 5.57x57 Structure Structure
TM5 356 Y 5.58x58 Structure Structure
TM5 357 S 5.59x59 Structure Structure
TM5 358 F 5.60x60 Structure Structure
TM5 359 I 5.61x61 Structure Structure
TM5 360 V 5.62x62 Structure Structure
TM5 361 F 5.63x63 Structure Structure
TM5 362 R 5.64x64 Structure Structure
TM5 363 M 5.65x65 Structure AF2
TM5 364 Q 5.66x66 Structure AF2
TM5 365 R 5.67x67 Structure Structure
ICL3 366 G - Structure Structure
ICL3 367 R - Structure Structure
ICL3 368 F - Structure Structure
ICL3 369 A - Structure Structure
ICL3 370 K - Structure AF2
ICL3 371 S - Structure Structure
ICL3 372 Q - Structure Structure
TM6 373 S 6.31x31 Structure Structure
TM6 374 K 6.32x32 Structure Structure
TM6 375 T 6.33x33 Structure Structure
TM6 376 F 6.34x34 Structure Structure
TM6 377 R 6.35x35 Structure Structure
TM6 378 V 6.36x36 Structure Structure
TM6 379 A 6.37x37 Structure Structure
TM6 380 V 6.38x38 Structure Structure
TM6 381 V 6.39x39 Structure Structure
TM6 382 V 6.40x40 Structure Structure
TM6 383 V 6.41x41 Structure Structure
TM6 384 A 6.42x42 Structure Structure
TM6 385 V 6.43x43 Structure Structure
TM6 386 F 6.44x44 Structure Structure
TM6 387 L 6.45x45 Structure Structure
TM6 388 V 6.46x46 Structure Structure
TM6 389 C 6.47x47 Structure Structure
TM6 390 W 6.48x48 Structure Structure
TM6 391 T 6.49x49 Structure Structure
TM6 392 P 6.50x50 Structure Structure
TM6 393 Y 6.51x51 Structure Structure
TM6 394 H 6.52x52 Structure Structure
TM6 395 I 6.53x53 Structure Structure
TM6 396 F 6.54x54 Structure Structure
TM6 397 G 6.55x55 Structure Structure
TM6 398 V 6.56x56 Structure Structure
TM6 399 L 6.57x57 Structure Structure
TM6 400 S 6.58x58 Structure Structure
TM6 401 L 6.59x59 Structure Structure
TM6 402 L 6.60x60 Structure AF2
TM6 403 T 6.61x61 Structure AF2
ECL3 404 D - Structure AF2
ECL3 405 P - Structure AF2
ECL3 406 E - Structure AF2
TM7 407 T 7.25x24 Structure Structure
TM7 408 P 7.26x25 Structure Structure
TM7 409 L 7.27x26 Structure AF2
TM7 410 G 7.28x27 Structure Structure
TM7 411 K 7.29x28 Structure AF2
TM7 412 T 7.30x29 Structure Structure
TM7 413 L 7.31x30 Structure Structure
TM7 414 M 7.32x31 Structure Structure
TM7 415 S 7.33x32 Structure Structure
TM7 416 W 7.34x33 Structure Structure
TM7 417 D 7.35x34 Structure Structure
TM7 418 H 7.36x35 Structure Structure
TM7 419 V 7.37x36 Structure Structure
TM7 420 C 7.38x37 Structure Structure
TM7 421 I 7.39x38 Structure Structure
TM7 422 A 7.40x39 Structure Structure
TM7 423 L 7.41x40 Structure Structure
TM7 424 A 7.42x41 Structure Structure
TM7 425 S 7.43x42 Structure Structure
TM7 426 A 7.44x43 Structure Structure
TM7 427 N 7.45x45 Structure Structure
TM7 428 S 7.46x46 Structure Structure
TM7 429 C 7.47x47 Structure Structure
TM7 430 F 7.48x48 Structure Structure
TM7 431 N 7.49x49 Structure Structure
TM7 432 P 7.50x50 Structure Structure
TM7 433 F 7.51x51 Structure Structure
TM7 434 L 7.52x52 Structure Structure
TM7 435 Y 7.53x53 Structure Structure
TM7 436 A 7.54x54 Structure Structure
TM7 437 L 7.55x55 Structure Structure
TM7 438 L 7.56x56 Structure Structure
H8 439 G 8.47x47 Structure Structure
H8 440 K 8.48x48 Structure AF2
H8 441 D 8.49x49 Structure AF2
H8 442 F 8.50x50 Structure Structure
H8 443 R 8.51x51 Structure Structure
H8 444 K 8.52x52 Structure AF2
H8 445 K 8.53x53 Structure Structure
H8 446 A 8.54x54 Structure Structure
H8 447 R 8.55x55 Structure Structure
H8 448 Q 8.56x56 Structure Structure
C-term 449 S - Structure Structure
C-term 450 I - Structure Structure
C-term 451 Q - AF2 AF2
C-term 452 G - AF2 AF2
C-term 453 I - AF2 AF2
C-term 454 L - AF2 AF2
C-term 455 E - AF2 AF2
C-term 456 A - AF2 AF2
C-term 457 A - AF2 AF2
C-term 458 F - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 Q 131 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 Q 131 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 Q 131 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic TM2 N 57 2x39 G.H5 G 350 G.H5.22
Polar ICL3 R 367 - G.S6 Y 320 G.S6.02
Aromatic ICL3 R 367 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 367 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 367 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 P 127 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL3 F 368 - G.H5 Y 354 G.H5.26
Polar ICL3 R 367 - G.h4s6 K 317 G.h4s6.11
Hydrophobic ICL3 R 367 - G.h4s6 K 317 G.h4s6.11
Van-der-waals ICL3 R 367 - G.h4s6 K 317 G.h4s6.11
Hydrophobic ICL2 Q 131 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM3 V 123 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 120 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 F 368 - G.H5 A 345 G.H5.17
Polar TM6 T 375 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 375 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 Y 356 5x58 G.H5 L 353 G.H5.25
Polar ICL3 R 367 - G.S6 I 319 G.S6.01
Hydrophobic ICL3 R 367 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 R 367 - G.S6 I 319 G.S6.01
Polar TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Q 131 34x54 G.S1 V 34 G.S1.02
Van-der-waals ICL2 Q 131 34x54 G.S1 V 34 G.S1.02
Hydrophobic ICL2 I 128 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 I 128 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM5 I 359 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 359 5x61 G.H5 L 353 G.H5.25
Aromatic TM6 K 374 6x32 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 Q 131 34x54 G.S3 L 195 G.S3.01
Hydrophobic ICL3 F 368 - G.H5 D 341 G.H5.13
Polar ICL2 Q 131 34x54 G.hns1 A 31 G.hns1.02
Ionic ICL3 R 367 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 367 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 367 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 367 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 I 359 5x61 G.H5 L 348 G.H5.20
Hydrophobic ICL2 N 132 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 N 132 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic H8 G 439 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL3 F 368 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 F 368 - G.H5 I 344 G.H5.16
Hydrophobic TM5 R 362 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 378 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 378 6x36 G.H5 L 353 G.H5.25
Polar ICL3 K 370 - G.H5 Y 354 G.H5.26
Polar ICL2 N 132 34x55 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 N 132 34x55 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 I 128 34x51 G.s2s3 N 194 G.s2s3.02
Hydrophobic TM3 V 124 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 124 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 I 128 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 I 128 34x51 G.H5 T 340 G.H5.12
Polar ICL3 K 370 - G.h4s6 P 315 G.h4s6.09
Van-der-waals ICL3 K 370 - G.h4s6 P 315 G.h4s6.09
Hydrophobic ICL2 I 128 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL3 F 368 - G.H5 L 348 G.H5.20
Hydrophobic TM5 M 363 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 M 363 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 127 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL3 S 371 - G.H5 Y 354 G.H5.26
Hydrophobic TM3 V 124 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 124 3x54 G.H5 L 348 G.H5.20