Refined structure (7W2Z) of Go - ghrelin receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 213 from structure (60.2%), 141 from model (39.8%)
Residue sidechains - 208 from structure (58.8%), 146 from model (41.2%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 E G.HN.33 Structure Structure
G.HN 10 R G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 L G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 A G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 E G.HN.44 Structure Structure
G.HN 21 K G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 K G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 I G.HN.52 Structure Structure
G.HN 29 S G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 K G.hns1.03 Structure Structure
G.S1 33 D G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure AF2
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 Structure Structure
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 D G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 F G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 G H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 D H.HA.03 AF2 AF2
H.HA 66 V H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 P H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 L H.HA.19 AF2 AF2
H.HA 82 A H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 V H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 D H.HA.27 AF2 AF2
H.HA 90 T H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 G H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 E H.hahb.05 AF2 AF2
H.hahb 95 Y H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 K H.hahb.09 AF2 AF2
H.HB 99 E H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 K H.HB.03 AF2 AF2
H.HB 102 A H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 K H.HB.07 AF2 AF2
H.HB 106 M H.HB.08 AF2 AF2
H.HB 107 V H.HB.09 AF2 AF2
H.HB 108 C H.HB.10 AF2 AF2
H.HB 109 D H.HB.11 AF2 AF2
H.HB 110 V H.HB.12 AF2 AF2
H.HB 111 V H.HB.13 AF2 AF2
H.HB 112 S H.HB.14 AF2 AF2
H.hbhc 113 R H.hbhc.01 AF2 AF2
H.hbhc 114 M H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 D H.hbhc.04 AF2 AF2
H.hbhc 117 T H.hbhc.05 AF2 AF2
H.hbhc 118 E H.hbhc.12 AF2 AF2
H.hbhc 119 P H.hbhc.13 AF2 AF2
H.hbhc 120 F H.hbhc.14 AF2 AF2
H.hbhc 121 S H.hbhc.15 AF2 AF2
H.HC 122 A H.HC.01 AF2 AF2
H.HC 123 E H.HC.02 AF2 AF2
H.HC 124 L H.HC.03 AF2 AF2
H.HC 125 L H.HC.04 AF2 AF2
H.HC 126 S H.HC.05 AF2 AF2
H.HC 127 A H.HC.06 AF2 AF2
H.HC 128 M H.HC.07 AF2 AF2
H.HC 129 M H.HC.08 AF2 AF2
H.HC 130 R H.HC.09 AF2 AF2
H.HC 131 L H.HC.10 AF2 AF2
H.HC 132 W H.HC.11 AF2 AF2
H.HC 133 G H.HC.12 AF2 AF2
H.hchd 134 D H.hchd.01 AF2 AF2
H.HD 135 S H.HD.01 AF2 AF2
H.HD 136 G H.HD.02 AF2 AF2
H.HD 137 I H.HD.03 AF2 AF2
H.HD 138 Q H.HD.04 AF2 AF2
H.HD 139 E H.HD.05 AF2 AF2
H.HD 140 C H.HD.06 AF2 AF2
H.HD 141 F H.HD.07 AF2 AF2
H.HD 142 N H.HD.08 AF2 AF2
H.HD 143 R H.HD.09 AF2 AF2
H.HD 144 S H.HD.10 AF2 AF2
H.HD 145 R H.HD.11 AF2 AF2
H.HD 146 E H.HD.12 AF2 AF2
H.hdhe 147 Y H.hdhe.01 AF2 AF2
H.hdhe 148 Q H.hdhe.02 AF2 AF2
H.hdhe 149 L H.hdhe.03 AF2 AF2
H.hdhe 150 N H.hdhe.04 AF2 AF2
H.hdhe 151 D H.hdhe.05 AF2 AF2
H.HE 152 S H.HE.01 AF2 AF2
H.HE 153 A H.HE.02 AF2 AF2
H.HE 154 K H.HE.03 AF2 AF2
H.HE 155 Y H.HE.04 AF2 AF2
H.HE 156 Y H.HE.05 AF2 AF2
H.HE 157 L H.HE.06 AF2 AF2
H.HE 158 D H.HE.07 AF2 AF2
H.HE 159 S H.HE.08 AF2 AF2
H.HE 160 L H.HE.09 AF2 AF2
H.HE 161 D H.HE.10 AF2 AF2
H.HE 162 R H.HE.11 AF2 AF2
H.HE 163 I H.HE.12 AF2 AF2
H.HE 164 G H.HE.13 AF2 AF2
H.hehf 165 A H.hehf.01 AF2 AF2
H.hehf 166 A H.hehf.02 AF2 AF2
H.hehf 167 D H.hehf.03 AF2 AF2
H.hehf 168 Y H.hehf.04 AF2 AF2
H.hehf 169 Q H.hehf.05 AF2 AF2
H.hehf 170 P H.hehf.06 AF2 AF2
H.hehf 171 T H.hehf.07 AF2 AF2
H.HF 172 E H.HF.01 AF2 AF2
H.HF 173 Q H.HF.02 AF2 AF2
H.HF 174 D H.HF.03 AF2 AF2
H.HF 175 I H.HF.04 AF2 AF2
H.HF 176 L H.HF.05 AF2 AF2
H.HF 177 R H.HF.06 AF2 AF2
G.hfs2 178 T G.hfs2.01 AF2 AF2
G.hfs2 179 R G.hfs2.02 AF2 AF2
G.hfs2 180 V G.hfs2.03 AF2 AF2
G.hfs2 181 K G.hfs2.04 AF2 AF2
G.hfs2 182 T G.hfs2.05 AF2 AF2
G.hfs2 183 T G.hfs2.06 Structure Structure
G.hfs2 184 G G.hfs2.07 Structure Structure
G.S2 185 I G.S2.01 Structure Structure
G.S2 186 V G.S2.02 Structure Structure
G.S2 187 E G.S2.03 Structure Structure
G.S2 188 T G.S2.04 Structure Structure
G.S2 189 H G.S2.05 Structure Structure
G.S2 190 F G.S2.06 Structure Structure
G.S2 191 T G.S2.07 Structure Structure
G.S2 192 F G.S2.08 Structure Structure
G.s2s3 193 K G.s2s3.01 Structure Structure
G.s2s3 194 N G.s2s3.02 Structure Structure
G.S3 195 L G.S3.01 Structure Structure
G.S3 196 H G.S3.02 Structure Structure
G.S3 197 F G.S3.03 Structure Structure
G.S3 198 R G.S3.04 Structure Structure
G.S3 199 L G.S3.05 Structure Structure
G.S3 200 F G.S3.06 Structure Structure
G.S3 201 D G.S3.07 Structure Structure
G.S3 202 V G.S3.08 Structure Structure
G.s3h2 203 G G.s3h2.01 Structure Structure
G.s3h2 204 G G.s3h2.02 Structure Structure
G.s3h2 205 Q G.s3h2.03 Structure Structure
G.H2 206 R G.H2.01 Structure Structure
G.H2 207 S G.H2.02 Structure Structure
G.H2 208 E G.H2.03 Structure Structure
G.H2 209 R G.H2.04 Structure Structure
G.H2 210 K G.H2.05 Structure Structure
G.H2 211 K G.H2.06 Structure Structure
G.H2 212 W G.H2.07 Structure Structure
G.H2 213 I G.H2.08 Structure Structure
G.H2 214 H G.H2.09 Structure Structure
G.H2 215 C G.H2.10 Structure Structure
G.h2s4 216 F G.h2s4.01 Structure Structure
G.h2s4 217 E G.h2s4.02 Structure Structure
G.h2s4 218 D G.h2s4.03 Structure Structure
G.h2s4 219 V G.h2s4.04 Structure Structure
G.h2s4 220 T G.h2s4.05 Structure Structure
G.S4 221 A G.S4.01 Structure Structure
G.S4 222 I G.S4.02 Structure Structure
G.S4 223 I G.S4.03 Structure Structure
G.S4 224 F G.S4.04 Structure Structure
G.S4 225 C G.S4.05 Structure Structure
G.S4 226 V G.S4.06 Structure Structure
G.S4 227 A G.S4.07 Structure AF2
G.s4h3 228 L G.s4h3.01 Structure Structure
G.s4h3 229 S G.s4h3.02 Structure Structure
G.s4h3 230 G G.s4h3.03 AF2 AF2
G.s4h3 231 Y G.s4h3.04 AF2 AF2
G.s4h3 232 D G.s4h3.05 AF2 AF2
G.s4h3 233 Q G.s4h3.06 AF2 AF2
G.s4h3 234 V G.s4h3.07 AF2 AF2
G.s4h3 235 L G.s4h3.08 AF2 AF2
G.s4h3 236 H G.s4h3.09 AF2 AF2
G.s4h3 237 E G.s4h3.10 AF2 AF2
G.s4h3 238 D G.s4h3.11 AF2 AF2
G.s4h3 239 E G.s4h3.12 AF2 AF2
G.s4h3 240 T G.s4h3.13 AF2 AF2
G.s4h3 241 T G.s4h3.14 AF2 AF2
G.s4h3 242 N G.s4h3.15 Structure Structure
G.H3 243 R G.H3.01 Structure Structure
G.H3 244 M G.H3.02 Structure Structure
G.H3 245 H G.H3.03 Structure Structure
G.H3 246 E G.H3.04 Structure Structure
G.H3 247 S G.H3.05 Structure Structure
G.H3 248 L G.H3.06 Structure Structure
G.H3 249 M G.H3.07 Structure Structure
G.H3 250 L G.H3.08 Structure Structure
G.H3 251 F G.H3.09 Structure Structure
G.H3 252 D G.H3.10 Structure Structure
G.H3 253 S G.H3.11 Structure Structure
G.H3 254 I G.H3.12 Structure Structure
G.H3 255 C G.H3.13 Structure Structure
G.H3 256 N G.H3.14 Structure Structure
G.H3 257 N G.H3.15 Structure Structure
G.H3 258 K G.H3.16 Structure Structure
G.H3 259 F G.H3.17 Structure Structure
G.H3 260 F G.H3.18 Structure Structure
G.h3s5 261 I G.h3s5.01 Structure Structure
G.h3s5 262 D G.h3s5.02 Structure Structure
G.h3s5 263 T G.h3s5.03 Structure Structure
G.S5 264 S G.S5.01 Structure Structure
G.S5 265 I G.S5.02 Structure Structure
G.S5 266 I G.S5.03 Structure Structure
G.S5 267 L G.S5.04 Structure Structure
G.S5 268 F G.S5.05 Structure Structure
G.S5 269 L G.S5.06 Structure Structure
G.S5 270 N G.S5.07 Structure Structure
G.s5hg 271 K G.s5hg.01 Structure Structure
G.HG 272 K G.HG.01 Structure Structure
G.HG 273 D G.HG.02 Structure Structure
G.HG 274 L G.HG.03 Structure Structure
G.HG 275 F G.HG.04 Structure Structure
G.HG 276 G G.HG.05 Structure Structure
G.HG 277 E G.HG.06 Structure Structure
G.HG 278 K G.HG.07 Structure Structure
G.HG 279 I G.HG.08 Structure Structure
G.HG 280 K G.HG.09 Structure Structure
G.HG 281 K G.HG.12 Structure Structure
G.HG 282 S G.HG.13 Structure Structure
G.HG 283 P G.HG.14 Structure Structure
G.HG 284 L G.HG.15 Structure Structure
G.HG 285 T G.HG.16 Structure Structure
G.HG 286 I G.HG.17 Structure Structure
G.hgh4 287 C G.hgh4.01 Structure Structure
G.hgh4 288 F G.hgh4.02 Structure Structure
G.hgh4 289 P G.hgh4.03 Structure Structure
G.hgh4 290 E G.hgh4.04 Structure Structure
G.hgh4 291 Y G.hgh4.05 Structure Structure
G.hgh4 292 T G.hgh4.06 Structure Structure
G.hgh4 293 G G.hgh4.07 Structure Structure
G.hgh4 294 P G.hgh4.08 Structure Structure
G.H4 295 N G.H4.01 Structure Structure
G.H4 296 T G.H4.02 Structure Structure
G.H4 297 Y G.H4.03 Structure Structure
G.H4 298 E G.H4.04 Structure Structure
G.H4 299 D G.H4.05 Structure Structure
G.H4 300 A G.H4.06 Structure Structure
G.H4 301 A G.H4.07 Structure Structure
G.H4 302 A G.H4.08 Structure Structure
G.H4 303 Y G.H4.10 Structure Structure
G.H4 304 I G.H4.11 Structure Structure
G.H4 305 Q G.H4.12 Structure Structure
G.H4 306 A G.H4.13 Structure Structure
G.H4 307 Q G.H4.14 Structure Structure
G.H4 308 F G.H4.15 Structure Structure
G.H4 309 E G.H4.16 Structure Structure
G.H4 310 S G.H4.17 Structure Structure
G.h4s6 311 K G.h4s6.01 Structure Structure
G.h4s6 312 N G.h4s6.02 Structure Structure
G.h4s6 313 R G.h4s6.03 Structure Structure
G.h4s6 314 S G.h4s6.08 Structure Structure
G.h4s6 315 P G.h4s6.09 Structure Structure
G.h4s6 316 N G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 C G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 M G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 N G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 I G.H5.04 Structure AF2
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 V G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure AF2
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 I G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 A G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 R G.H5.21 Structure Structure
G.H5 350 G G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 Y G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 301 from structure (85.5%), 51 from model (14.5%)
Residue sidechains - 301 from structure (85.5%), 51 from model (14.5%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 W - AF2 AF2
N-term 3 N - AF2 AF2
N-term 4 A - AF2 AF2
N-term 5 T - AF2 AF2
N-term 6 P - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 E - AF2 AF2
N-term 9 E - AF2 AF2
N-term 10 P - AF2 AF2
N-term 11 G - AF2 AF2
N-term 12 F - AF2 AF2
N-term 13 N - AF2 AF2
N-term 14 L - AF2 AF2
N-term 15 T - AF2 AF2
N-term 16 L - AF2 AF2
N-term 17 A - AF2 AF2
N-term 18 D - AF2 AF2
N-term 19 L - AF2 AF2
N-term 20 D - AF2 AF2
N-term 21 W - AF2 AF2
N-term 22 D - AF2 AF2
N-term 23 A - AF2 AF2
N-term 24 S - AF2 AF2
N-term 25 P - AF2 AF2
N-term 26 G - AF2 AF2
N-term 27 N - AF2 AF2
N-term 28 D - AF2 AF2
N-term 29 S - AF2 AF2
N-term 30 L - AF2 AF2
N-term 31 G - AF2 AF2
N-term 32 D - AF2 AF2
N-term 33 E - AF2 AF2
N-term 34 L - AF2 AF2
N-term 35 L - Structure Structure
N-term 36 Q - Structure Structure
N-term 37 L - Structure Structure
N-term 38 F - Structure Structure
TM1 39 P 1.28x28 Structure Structure
TM1 40 A 1.29x29 Structure Structure
TM1 41 P 1.30x30 Structure Structure
TM1 42 L 1.31x31 Structure Structure
TM1 43 L 1.32x32 Structure Structure
TM1 44 A 1.33x33 Structure Structure
TM1 45 G 1.34x34 Structure Structure
TM1 46 V 1.35x35 Structure Structure
TM1 47 T 1.36x36 Structure Structure
TM1 48 A 1.37x37 Structure Structure
TM1 49 T 1.38x38 Structure Structure
TM1 50 C 1.39x39 Structure Structure
TM1 51 V 1.40x40 Structure Structure
TM1 52 A 1.41x41 Structure Structure
TM1 53 L 1.42x42 Structure Structure
TM1 54 F 1.43x43 Structure Structure
TM1 55 V 1.44x44 Structure Structure
TM1 56 V 1.45x45 Structure Structure
TM1 57 G 1.46x46 Structure Structure
TM1 58 I 1.47x47 Structure Structure
TM1 59 A 1.48x48 Structure Structure
TM1 60 G 1.49x49 Structure Structure
TM1 61 N 1.50x50 Structure Structure
TM1 62 L 1.51x51 Structure Structure
TM1 63 L 1.52x52 Structure Structure
TM1 64 T 1.53x53 Structure Structure
TM1 65 M 1.54x54 Structure Structure
TM1 66 L 1.55x55 Structure Structure
TM1 67 V 1.56x56 Structure Structure
TM1 68 V 1.57x57 Structure Structure
TM1 69 S 1.58x58 Structure Structure
TM1 70 R 1.59x59 Structure Structure
TM1 71 F 1.60x60 Structure Structure
ICL1 72 R 12.48x48 Structure Structure
ICL1 73 E 12.49x49 Structure Structure
ICL1 74 L 12.50x50 Structure Structure
ICL1 75 R 12.51x51 Structure Structure
TM2 76 T 2.37x37 Structure Structure
TM2 77 T 2.38x38 Structure Structure
TM2 78 T 2.39x39 Structure Structure
TM2 79 N 2.40x40 Structure Structure
TM2 80 L 2.41x41 Structure Structure
TM2 81 Y 2.42x42 Structure Structure
TM2 82 L 2.43x43 Structure Structure
TM2 83 S 2.44x44 Structure Structure
TM2 84 S 2.45x45 Structure Structure
TM2 85 M 2.46x46 Structure Structure
TM2 86 A 2.47x47 Structure Structure
TM2 87 F 2.48x48 Structure Structure
TM2 88 S 2.49x49 Structure Structure
TM2 89 D 2.50x50 Structure Structure
TM2 90 L 2.51x51 Structure Structure
TM2 91 L 2.52x52 Structure Structure
TM2 92 I 2.53x53 Structure Structure
TM2 93 F 2.54x54 Structure Structure
TM2 94 L 2.55x55 Structure Structure
TM2 95 C 2.56x56 Structure Structure
TM2 96 M 2.57x57 Structure Structure
TM2 97 P 2.58x58 Structure Structure
TM2 98 L 2.59x59 Structure Structure
TM2 99 D 2.60x60 Structure Structure
TM2 100 L 2.61x61 Structure Structure
TM2 101 V 2.62x62 Structure Structure
TM2 102 R 2.63x63 Structure Structure
TM2 103 L 2.64x64 Structure Structure
TM2 104 W 2.65x65 Structure Structure
TM2 105 Q 2.66x66 Structure Structure
TM2 106 Y 2.67x67 Structure Structure
ECL1 107 R - Structure Structure
ECL1 108 P 23.49x49 Structure Structure
ECL1 109 W 23.50x50 Structure Structure
ECL1 110 N 23.51x51 Structure Structure
ECL1 111 F 23.52x52 Structure Structure
TM3 112 G 3.21x21 Structure Structure
TM3 113 D 3.22x22 Structure Structure
TM3 114 L 3.23x23 Structure Structure
TM3 115 L 3.24x24 Structure Structure
TM3 116 C 3.25x25 Structure Structure
TM3 117 K 3.26x26 Structure Structure
TM3 118 L 3.27x27 Structure Structure
TM3 119 F 3.28x28 Structure Structure
TM3 120 Q 3.29x29 Structure Structure
TM3 121 F 3.30x30 Structure Structure
TM3 122 V 3.31x31 Structure Structure
TM3 123 S 3.32x32 Structure Structure
TM3 124 E 3.33x33 Structure Structure
TM3 125 S 3.34x34 Structure Structure
TM3 126 C 3.35x35 Structure Structure
TM3 127 T 3.36x36 Structure Structure
TM3 128 Y 3.37x37 Structure Structure
TM3 129 A 3.38x38 Structure Structure
TM3 130 T 3.39x39 Structure Structure
TM3 131 V 3.40x40 Structure Structure
TM3 132 L 3.41x41 Structure Structure
TM3 133 T 3.42x42 Structure Structure
TM3 134 I 3.43x43 Structure Structure
TM3 135 T 3.44x44 Structure Structure
TM3 136 A 3.45x45 Structure Structure
TM3 137 L 3.46x46 Structure Structure
TM3 138 S 3.47x47 Structure Structure
TM3 139 V 3.48x48 Structure Structure
TM3 140 E 3.49x49 Structure Structure
TM3 141 R 3.50x50 Structure Structure
TM3 142 Y 3.51x51 Structure Structure
TM3 143 F 3.52x52 Structure Structure
TM3 144 A 3.53x53 Structure Structure
TM3 145 I 3.54x54 Structure Structure
TM3 146 C 3.55x55 Structure Structure
TM3 147 F 3.56x56 Structure Structure
ICL2 148 P 34.50x50 Structure Structure
ICL2 149 L 34.51x51 Structure Structure
ICL2 150 R 34.52x52 Structure Structure
ICL2 151 A 34.53x53 Structure Structure
ICL2 152 K 34.54x54 Structure Structure
ICL2 153 V 34.55x55 Structure Structure
ICL2 154 V 34.56x56 Structure Structure
ICL2 155 V 34.57x57 Structure Structure
TM4 156 T 4.38x38 Structure Structure
TM4 157 K 4.39x39 Structure Structure
TM4 158 G 4.40x40 Structure Structure
TM4 159 R 4.41x41 Structure Structure
TM4 160 V 4.42x42 Structure Structure
TM4 161 K 4.43x43 Structure Structure
TM4 162 L 4.44x44 Structure Structure
TM4 163 V 4.45x45 Structure Structure
TM4 164 I 4.46x46 Structure Structure
TM4 165 F 4.47x47 Structure Structure
TM4 166 V 4.48x48 Structure Structure
TM4 167 I 4.49x49 Structure Structure
TM4 168 W 4.50x50 Structure Structure
TM4 169 A 4.51x51 Structure Structure
TM4 170 V 4.52x52 Structure Structure
TM4 171 A 4.53x53 Structure Structure
TM4 172 F 4.54x54 Structure Structure
TM4 173 C 4.55x55 Structure Structure
TM4 174 S 4.56x56 Structure Structure
TM4 175 A 4.57x57 Structure Structure
TM4 176 G 4.58x59 Structure Structure
TM4 177 P 4.59x60 Structure Structure
TM4 178 I 4.60x61 Structure Structure
TM4 179 F 4.61x62 Structure Structure
TM4 180 V 4.62x63 Structure Structure
TM4 181 L 4.63x64 Structure Structure
TM4 182 V 4.64x65 Structure Structure
ECL2 183 G - Structure Structure
ECL2 184 V - Structure Structure
ECL2 185 E - Structure Structure
ECL2 186 H - Structure Structure
ECL2 187 E - Structure Structure
ECL2 188 N - Structure Structure
ECL2 189 G - Structure Structure
ECL2 190 T - Structure Structure
ECL2 191 D - Structure Structure
ECL2 192 P - Structure Structure
ECL2 193 W - Structure Structure
ECL2 194 D - Structure Structure
ECL2 195 T - Structure Structure
ECL2 196 N - Structure Structure
ECL2 197 E - Structure Structure
ECL2 198 C 45.50x50 Structure Structure
ECL2 199 R 45.51x51 Structure Structure
ECL2 200 P 45.52x52 Structure Structure
ECL2 201 T - Structure Structure
ECL2 202 E - Structure Structure
ECL2 203 F - Structure Structure
ECL2 204 A - Structure Structure
ECL2 205 V - Structure Structure
ECL2 206 R - Structure Structure
ECL2 207 S - Structure Structure
TM5 208 G 5.34x34 Structure Structure
TM5 209 L 5.35x35 Structure Structure
TM5 210 L 5.36x36 Structure Structure
TM5 211 T 5.37x37 Structure Structure
TM5 212 V 5.38x38 Structure Structure
TM5 213 M 5.39x39 Structure Structure
TM5 214 V 5.40x40 Structure Structure
TM5 215 W 5.41x41 Structure Structure
TM5 216 V 5.42x42 Structure Structure
TM5 217 S 5.43x43 Structure Structure
TM5 218 S 5.44x44 Structure Structure
TM5 219 I 5.45x45 Structure Structure
TM5 220 F 5.46x46 Structure Structure
TM5 221 F 5.47x47 Structure Structure
TM5 222 F 5.48x48 Structure Structure
TM5 223 L 5.49x49 Structure Structure
TM5 224 P 5.50x50 Structure Structure
TM5 225 V 5.51x51 Structure Structure
TM5 226 F 5.52x52 Structure Structure
TM5 227 C 5.53x53 Structure Structure
TM5 228 L 5.54x54 Structure Structure
TM5 229 T 5.55x55 Structure Structure
TM5 230 V 5.56x56 Structure Structure
TM5 231 L 5.57x57 Structure Structure
TM5 232 Y 5.58x58 Structure Structure
TM5 233 S 5.59x59 Structure Structure
TM5 234 L 5.60x60 Structure Structure
TM5 235 I 5.61x61 Structure Structure
TM5 236 G 5.62x62 Structure Structure
TM5 237 R 5.63x63 Structure Structure
TM5 238 K 5.64x64 Structure Structure
TM5 239 L 5.65x65 Structure Structure
TM5 240 W 5.66x66 Structure Structure
TM5 241 R 5.67x67 Structure Structure
TM5 242 R 5.68x68 Structure Structure
TM5 243 R 5.69x69 Structure Structure
TM5 244 R 5.70x70 Structure Structure
TM5 245 G 5.71x71 Structure Structure
TM5 246 D 5.72x72 AF2 AF2
ICL3 247 A - AF2 AF2
ICL3 248 V - AF2 AF2
ICL3 249 V - AF2 AF2
ICL3 250 G - AF2 AF2
ICL3 251 A - AF2 AF2
TM6 252 S 6.24x24 Structure Structure
TM6 253 L 6.25x25 Structure Structure
TM6 254 R 6.26x26 Structure Structure
TM6 255 D 6.27x27 Structure Structure
TM6 256 Q 6.28x28 Structure Structure
TM6 257 N 6.29x29 Structure Structure
TM6 258 H 6.30x30 Structure Structure
TM6 259 K 6.31x31 Structure Structure
TM6 260 Q 6.32x32 Structure Structure
TM6 261 T 6.33x33 Structure Structure
TM6 262 V 6.34x34 Structure Structure
TM6 263 K 6.35x35 Structure Structure
TM6 264 M 6.36x36 Structure Structure
TM6 265 L 6.37x37 Structure Structure
TM6 266 A 6.38x38 Structure Structure
TM6 267 V 6.39x39 Structure Structure
TM6 268 V 6.40x40 Structure Structure
TM6 269 V 6.41x41 Structure Structure
TM6 270 F 6.42x42 Structure Structure
TM6 271 A 6.43x43 Structure Structure
TM6 272 F 6.44x44 Structure Structure
TM6 273 I 6.45x45 Structure Structure
TM6 274 L 6.46x46 Structure Structure
TM6 275 C 6.47x47 Structure Structure
TM6 276 W 6.48x48 Structure Structure
TM6 277 L 6.49x49 Structure Structure
TM6 278 P 6.50x50 Structure Structure
TM6 279 F 6.51x51 Structure Structure
TM6 280 H 6.52x52 Structure Structure
TM6 281 V 6.53x53 Structure Structure
TM6 282 G 6.54x54 Structure Structure
TM6 283 R 6.55x55 Structure Structure
TM6 284 Y 6.56x56 Structure Structure
TM6 285 L 6.57x57 Structure Structure
TM6 286 F 6.58x58 Structure Structure
TM6 287 S 6.59x59 Structure Structure
TM6 288 K 6.60x60 Structure Structure
TM6 289 S 6.61x61 Structure Structure
TM6 290 F 6.62x62 Structure Structure
TM6 291 E 6.63x63 Structure Structure
ECL3 292 P - Structure Structure
ECL3 293 G - Structure Structure
ECL3 294 S - Structure Structure
TM7 295 L 7.25x24 Structure Structure
TM7 296 E 7.26x25 Structure Structure
TM7 297 I 7.27x26 Structure Structure
TM7 298 A 7.28x27 Structure Structure
TM7 299 Q 7.29x28 Structure Structure
TM7 300 I 7.30x29 Structure Structure
TM7 301 S 7.31x30 Structure Structure
TM7 302 Q 7.32x31 Structure Structure
TM7 303 Y 7.33x32 Structure Structure
TM7 304 C 7.34x33 Structure Structure
TM7 305 N 7.35x34 Structure Structure
TM7 306 L 7.36x35 Structure Structure
TM7 307 V 7.37x36 Structure Structure
TM7 308 S 7.38x37 Structure Structure
TM7 309 F 7.39x38 Structure Structure
TM7 310 V 7.40x39 Structure Structure
TM7 311 L 7.41x40 Structure Structure
TM7 312 F 7.42x41 Structure Structure
TM7 313 Y 7.43x42 Structure Structure
TM7 314 L 7.44x43 Structure Structure
TM7 315 S 7.45x45 Structure Structure
TM7 316 A 7.46x46 Structure Structure
TM7 317 A 7.47x47 Structure Structure
TM7 318 I 7.48x48 Structure Structure
TM7 319 N 7.49x49 Structure Structure
TM7 320 P 7.50x50 Structure Structure
TM7 321 I 7.51x51 Structure Structure
TM7 322 L 7.52x52 Structure Structure
TM7 323 Y 7.53x53 Structure Structure
TM7 324 N 7.54x54 Structure Structure
TM7 325 I 7.55x55 Structure Structure
TM7 326 M 7.56x56 Structure Structure
H8 327 S 8.47x47 Structure Structure
H8 328 K 8.48x48 Structure Structure
H8 329 K 8.49x49 Structure Structure
H8 330 Y 8.50x50 Structure Structure
H8 331 R 8.51x51 Structure Structure
H8 332 V 8.52x52 Structure Structure
H8 333 A 8.53x53 Structure Structure
H8 334 V 8.54x54 Structure Structure
H8 335 F 8.55x55 Structure Structure
H8 336 R 8.56x56 Structure Structure
H8 337 L 8.57x57 Structure Structure
H8 338 L 8.58x58 Structure Structure
H8 339 G 8.59x59 Structure Structure
H8 340 F 8.60x60 Structure Structure
H8 341 E 8.61x61 Structure Structure
H8 342 P 8.62x62 AF2 AF2
C-term 343 F - AF2 AF2
C-term 344 S - AF2 AF2
C-term 345 Q - AF2 AF2
C-term 346 R - AF2 AF2
C-term 347 K - AF2 AF2
C-term 348 L - AF2 AF2
C-term 349 S - AF2 AF2
C-term 350 T - AF2 AF2
C-term 351 L - AF2 AF2
C-term 352 K - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 145 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 145 3x54 G.H5 L 348 G.H5.20
Polar TM3 A 144 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 144 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 144 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 L 265 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 265 6x37 G.H5 L 353 G.H5.25
Polar TM3 R 141 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 141 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 R 242 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 242 5x68 G.H5 I 344 G.H5.16
Ionic TM6 R 254 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term L 348 - G.H3 F 259 G.H3.17
Polar TM6 R 254 6x26 G.S6 Y 320 G.S6.02
Hydrophobic ICL2 L 149 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 149 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM5 L 239 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 T 261 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 144 3x53 G.H5 C 351 G.H5.23
Ionic TM6 R 254 6x26 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 148 34x50 G.H5 I 343 G.H5.15
Ionic TM5 R 242 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 148 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 148 34x50 G.H5 I 344 G.H5.16
Hydrophobic C-term S 349 - G.H3 F 259 G.H3.17
Hydrophobic TM6 T 261 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 149 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM6 L 253 6x25 G.h4s6 P 315 G.h4s6.09
Hydrophobic H8 K 328 8x48 G.H5 R 349 G.H5.21
Polar H8 K 328 8x48 G.H5 Y 354 G.H5.26
Hydrophobic H8 K 328 8x48 G.H5 Y 354 G.H5.26
Van-der-waals H8 K 328 8x48 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 P 148 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM6 M 264 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 149 34x51 G.H5 F 336 G.H5.08
Polar C-term S 349 - G.H3 K 258 G.H3.16
Polar C-term L 351 - G.H3 K 258 G.H3.16
Hydrophobic C-term L 351 - G.H3 K 258 G.H3.16
Van-der-waals C-term L 351 - G.H3 K 258 G.H3.16
Hydrophobic TM7 M 326 7x56 G.H5 Y 354 G.H5.26
Van-der-waals TM7 M 326 7x56 G.H5 Y 354 G.H5.26
Polar TM6 N 257 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 N 257 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 N 257 6x29 G.H5 Y 354 G.H5.26
Hydrophobic H8 S 327 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 H 258 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 145 3x54 G.H5 I 344 G.H5.16
Polar C-term K 352 - G.H2 K 210 G.H2.05
Hydrophobic C-term K 352 - G.H2 K 210 G.H2.05
Van-der-waals C-term K 352 - G.H2 K 210 G.H2.05
Hydrophobic C-term L 348 - G.h3s5 I 261 G.h3s5.01
Hydrophobic TM3 I 145 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM5 K 238 5x64 G.H5 I 344 G.H5.16
Polar C-term L 348 - G.H3 K 258 G.H3.16
Hydrophobic C-term L 348 - G.H3 K 258 G.H3.16
Van-der-waals C-term L 348 - G.H3 K 258 G.H3.16
Hydrophobic TM2 T 78 2x39 G.H5 C 351 G.H5.23