ADGRE5 - Gq

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7YDM

RESOLUTION

2.9 Å

REFERENCE

10.1016/J.CHEMBIOL.2023.08.003

PUBLICATION DATE

July 12, 2023

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 V 644 - G.H5 N 387 G.H5.19
Polar ICL2 Q 648 - G.hns1 R 39 G.hns1.03
Hydrophobic ICL2 Q 646 - G.hns1 R 39 G.hns1.03
Hydrophobic TM5 E 724 5x67 G.h4s6 I 358 G.h4s6.20
Van-der-waals TM5 E 724 5x67 G.h4s6 I 358 G.h4s6.20
Aromatic ICL2 F 645 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 645 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 645 - G.H5 F 376 G.H5.08
Hydrophobic TM5 L 718 5x61 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 718 5x61 G.H5 L 388 G.H5.20
Ionic H8 K 792 8x49 G.H5 E 390 G.H5.22
Hydrophobic ICL2 G 647 - G.hns1 R 39 G.hns1.03
Hydrophobic TM6 Q 745 6x45 G.H5 L 393 G.H5.25
Van-der-waals TM6 Q 745 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 637 3x54 G.H5 L 393 G.H5.25
Polar TM3 L 640 3x57 G.H5 N 387 G.H5.19
Hydrophobic TM3 L 640 3x57 G.H5 N 387 G.H5.19
Van-der-waals TM5 L 718 5x61 G.H5 L 393 G.H5.25
Ionic TM5 K 721 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 721 5x64 G.H5 D 381 G.H5.13
Hydrophobic ICL2 F 645 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 645 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 V 644 - G.H5 L 384 G.H5.16
Van-der-waals ICL2 V 644 - G.H5 L 384 G.H5.16
Hydrophobic TM3 L 640 3x57 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 579 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM3 V 641 3x58 G.H5 L 384 G.H5.16
Hydrophobic ICL2 F 645 - G.H5 C 379 G.H5.11
Hydrophobic ICL2 V 644 - G.H5 K 380 G.H5.12
Hydrophobic TM3 V 641 3x58 G.H5 L 388 G.H5.20
Polar H8 N 790 8x47 G.H5 N 392 G.H5.24
Van-der-waals H8 N 790 8x47 G.H5 N 392 G.H5.24
Hydrophobic ICL2 F 645 - G.S1 L 41 G.S1.02
Hydrophobic TM6 T 741 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 741 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 725 5x68 G.H5 V 394 G.H5.26
Van-der-waals TM5 I 725 5x68 G.H5 V 394 G.H5.26
Hydrophobic TM5 I 725 5x68 G.H5 Q 385 G.H5.17
Van-der-waals TM5 I 725 5x68 G.H5 Q 385 G.H5.17
Hydrophobic ICL2 F 645 - G.H5 K 380 G.H5.12
Hydrophobic TM5 K 721 5x64 G.H5 L 384 G.H5.16
Polar ICL2 Q 646 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 Q 646 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Q 646 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 V 644 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 F 645 - G.S3 V 217 G.S3.01
Polar TM6 T 741 6x41 G.H5 V 394 G.H5.26