GPR55 (gpr55_human)
FAMILY
Class A (Rhodopsin) Lipid receptors GPR18, GPR55 and GPR119 GPR55
GENE
GPR55
ORGANISM
Human (Homo sapiens)
ALT. NAMES
G-protein coupled receptor 55
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
S
|
Q
|
Q
|
N
|
T
|
S
|
G
|
D
|
C
|
10 |
TM1 | |||||||||
L
|
F
|
D
|
G
|
V
|
N
|
E
|
L
|
M
|
K
|
20 |
T
|
L
|
Q
|
F
|
A
|
V
|
H
|
I
|
P
|
T
|
30 |
F
|
V
|
L
|
G
|
L
|
L
|
L
|
N
|
L
|
L
|
40 |
A
|
I
|
H
|
G
|
F
|
S
|
T
|
F
|
L
|
K
|
50 |
ICL1 | TM2 | ||||||||
N
|
R
|
W
|
P
|
D
|
Y
|
A
|
A
|
T
|
S
|
60 |
I
|
Y
|
M
|
I
|
N
|
L
|
A
|
V
|
F
|
D
|
70 |
L
|
L
|
L
|
V
|
L
|
S
|
L
|
P
|
F
|
K
|
80 |
ECL1 | |||||||||
M
|
V
|
L
|
S
|
Q
|
V
|
Q
|
S
|
P
|
F
|
90 |
TM3 | |||||||||
P
|
S
|
L
|
C
|
T
|
L
|
V
|
E
|
C
|
L
|
100 |
Y
|
F
|
V
|
S
|
M
|
Y
|
G
|
S
|
V
|
F
|
110 |
T
|
I
|
C
|
F
|
I
|
S
|
M
|
D
|
R
|
F
|
120 |
ICL2 | |||||||||
L
|
A
|
I
|
R
|
Y
|
P
|
L
|
L
|
V
|
S
|
130 |
TM4 | |||||||||
H
|
L
|
R
|
S
|
P
|
R
|
K
|
I
|
F
|
G
|
140 |
I
|
C
|
C
|
T
|
I
|
W
|
V
|
L
|
V
|
W
|
150 |
T
|
G
|
S
|
I
|
P
|
I
|
Y
|
S
|
F
|
H
|
160 |
ECL2 | |||||||||
G
|
K
|
V
|
E
|
K
|
Y
|
M
|
C
|
F
|
H
|
170 |
TM5 | |||||||||
N
|
M
|
S
|
D
|
D
|
T
|
W
|
S
|
A
|
K
|
180 |
V
|
F
|
F
|
P
|
L
|
E
|
V
|
F
|
G
|
F
|
190 |
L
|
L
|
P
|
M
|
G
|
I
|
M
|
G
|
F
|
C
|
200 |
C
|
S
|
R
|
S
|
I
|
H
|
I
|
L
|
L
|
G
|
210 |
ICL3 | TM6 | ||||||||
R
|
R
|
D
|
H
|
T
|
Q
|
D
|
W
|
V
|
Q
|
220 |
Q
|
K
|
A
|
C
|
I
|
Y
|
S
|
I
|
A
|
A
|
230 |
S
|
L
|
A
|
V
|
F
|
V
|
V
|
S
|
F
|
L
|
240 |
P
|
V
|
H
|
L
|
G
|
F
|
F
|
L
|
Q
|
F
|
250 |
ECL3 | |||||||||
L
|
V
|
R
|
N
|
S
|
F
|
I
|
V
|
E
|
C
|
260 |
TM7 | |||||||||
R
|
A
|
K
|
Q
|
S
|
I
|
S
|
F
|
F
|
L
|
270 |
Q
|
L
|
S
|
M
|
C
|
F
|
S
|
N
|
V
|
N
|
280 |
C
|
C
|
L
|
D
|
V
|
F
|
C
|
Y
|
Y
|
F
|
290 |
H8 | |||||||||
V
|
I
|
K
|
E
|
F
|
R
|
M
|
N
|
I
|
R
|
300 |
A
|
H
|
R
|
P
|
S
|
R
|
V
|
Q
|
L
|
V
|
310 |
C-term | ||||||||
L
|
Q
|
D
|
T
|
T
|
I
|
S
|
R
|
G
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
anandamide, 2-arachidonoylglycerol, 2-arachidonoylglycerolphosphoinositol, N-palmitoylethanolamine, lysophosphatidylinositol
STRUCTURE MODELS
STRUCTURES
No structures available