GPCRdb

Refined structure (6D9H) of G_i2 - A₁ receptor

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G_i/o

DATE

2024-02-01

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Structure

GPCR

Gα

Gβ

Gγ
Model

AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 209 from structure (58.9%), 146 from model (41.1%)
Residue sidechains - 205 from structure (57.7%), 150 from model (42.3%)

Showing 1 to 355 of 355 entries

Search:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from
	:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from

G.HN	1	M	G.HN.01	AF2	AF2
G.HN	2	G	G.HN.02	AF2	AF2
G.HN	3	C	G.HN.09	AF2	AF2
G.HN	4	T	G.HN.10	AF2	AF2
G.HN	5	V	G.HN.11	AF2	AF2
G.HN	6	S	G.HN.30	AF2	AF2
G.HN	7	A	G.HN.31	AF2	AF2
G.HN	8	E	G.HN.32	AF2	AF2
G.HN	9	D	G.HN.33	AF2	AF2
G.HN	10	K	G.HN.34	AF2	AF2
G.HN	11	A	G.HN.35	Structure	Structure
G.HN	12	A	G.HN.36	Structure	Structure
G.HN	13	A	G.HN.37	Structure	Structure
G.HN	14	E	G.HN.38	Structure	Structure
G.HN	15	R	G.HN.39	Structure	Structure
G.HN	16	S	G.HN.40	Structure	Structure
G.HN	17	K	G.HN.41	Structure	Structure
G.HN	18	M	G.HN.42	Structure	Structure
G.HN	19	I	G.HN.43	Structure	Structure
G.HN	20	D	G.HN.44	Structure	Structure
G.HN	21	K	G.HN.45	Structure	Structure
G.HN	22	N	G.HN.46	Structure	Structure
G.HN	23	L	G.HN.47	Structure	Structure
G.HN	24	R	G.HN.48	Structure	Structure
G.HN	25	E	G.HN.49	Structure	Structure
G.HN	26	D	G.HN.50	Structure	Structure
G.HN	27	G	G.HN.51	Structure	Structure
G.HN	28	E	G.HN.52	Structure	Structure
G.HN	29	K	G.HN.53	Structure	Structure
G.hns1	30	A	G.hns1.01	Structure	Structure
G.hns1	31	A	G.hns1.02	Structure	Structure
G.hns1	32	R	G.hns1.03	Structure	Structure
G.S1	33	E	G.S1.01	Structure	Structure
G.S1	34	V	G.S1.02	Structure	Structure
G.S1	35	K	G.S1.03	Structure	Structure
G.S1	36	L	G.S1.04	Structure	Structure
G.S1	37	L	G.S1.05	Structure	Structure
G.S1	38	L	G.S1.06	Structure	Structure
G.S1	39	L	G.S1.07	Structure	Structure
G.s1h1	40	G	G.s1h1.01	Structure	Structure
G.s1h1	41	A	G.s1h1.02	AF2	AF2
G.s1h1	42	G	G.s1h1.03	AF2	AF2
G.s1h1	43	E	G.s1h1.04	AF2	AF2
G.s1h1	44	S	G.s1h1.05	Structure	Structure
G.s1h1	45	G	G.s1h1.06	Structure	Structure
G.H1	46	K	G.H1.01	Structure	Structure
G.H1	47	S	G.H1.02	Structure	AF2
G.H1	48	T	G.H1.03	Structure	Structure
G.H1	49	I	G.H1.04	Structure	Structure
G.H1	50	V	G.H1.05	Structure	Structure
G.H1	51	K	G.H1.06	Structure	Structure
G.H1	52	Q	G.H1.07	Structure	Structure
G.H1	53	M	G.H1.08	Structure	Structure
G.H1	54	K	G.H1.09	Structure	Structure
G.H1	55	I	G.H1.10	Structure	Structure
G.H1	56	I	G.H1.11	Structure	Structure
G.H1	57	H	G.H1.12	AF2	AF2
G.h1ha	58	E	G.h1ha.01	AF2	AF2
G.h1ha	59	D	G.h1ha.02	AF2	AF2
G.h1ha	60	G	G.h1ha.03	AF2	AF2
G.h1ha	61	Y	G.h1ha.04	AF2	AF2
G.h1ha	62	S	G.h1ha.05	AF2	AF2
H.HA	63	E	H.HA.01	AF2	AF2
H.HA	64	E	H.HA.02	AF2	AF2
H.HA	65	E	H.HA.03	AF2	AF2
H.HA	66	C	H.HA.04	AF2	AF2
H.HA	67	R	H.HA.05	AF2	AF2
H.HA	68	Q	H.HA.06	AF2	AF2
H.HA	69	Y	H.HA.07	AF2	AF2
H.HA	70	R	H.HA.08	AF2	AF2
H.HA	71	A	H.HA.09	AF2	AF2
H.HA	72	V	H.HA.10	AF2	AF2
H.HA	73	V	H.HA.11	AF2	AF2
H.HA	74	Y	H.HA.12	AF2	AF2
H.HA	75	S	H.HA.13	AF2	AF2
H.HA	76	N	H.HA.14	AF2	AF2
H.HA	77	T	H.HA.15	AF2	AF2
H.HA	78	I	H.HA.16	AF2	AF2
H.HA	79	Q	H.HA.17	AF2	AF2
H.HA	80	S	H.HA.18	AF2	AF2
H.HA	81	I	H.HA.19	AF2	AF2
H.HA	82	M	H.HA.20	AF2	AF2
H.HA	83	A	H.HA.21	AF2	AF2
H.HA	84	I	H.HA.22	AF2	AF2
H.HA	85	V	H.HA.23	AF2	AF2
H.HA	86	K	H.HA.24	AF2	AF2
H.HA	87	A	H.HA.25	AF2	AF2
H.HA	88	M	H.HA.26	AF2	AF2
H.HA	89	G	H.HA.27	AF2	AF2
H.HA	90	N	H.HA.28	AF2	AF2
H.HA	91	L	H.HA.29	AF2	AF2
H.hahb	92	Q	H.hahb.01	AF2	AF2
H.hahb	93	I	H.hahb.04	AF2	AF2
H.hahb	94	D	H.hahb.05	AF2	AF2
H.hahb	95	F	H.hahb.06	AF2	AF2
H.hahb	96	A	H.hahb.07	AF2	AF2
H.hahb	97	D	H.hahb.08	AF2	AF2
H.hahb	98	P	H.hahb.09	AF2	AF2
H.HB	99	S	H.HB.01	AF2	AF2
H.HB	100	R	H.HB.02	AF2	AF2
H.HB	101	A	H.HB.03	AF2	AF2
H.HB	102	D	H.HB.04	AF2	AF2
H.HB	103	D	H.HB.05	AF2	AF2
H.HB	104	A	H.HB.06	AF2	AF2
H.HB	105	R	H.HB.07	AF2	AF2
H.HB	106	Q	H.HB.08	AF2	AF2
H.HB	107	L	H.HB.09	AF2	AF2
H.HB	108	F	H.HB.10	AF2	AF2
H.HB	109	A	H.HB.11	AF2	AF2
H.HB	110	L	H.HB.12	AF2	AF2
H.HB	111	S	H.HB.13	AF2	AF2
H.HB	112	C	H.HB.14	AF2	AF2
H.hbhc	113	T	H.hbhc.01	AF2	AF2
H.hbhc	114	A	H.hbhc.02	AF2	AF2
H.hbhc	115	E	H.hbhc.03	AF2	AF2
H.hbhc	116	E	H.hbhc.04	AF2	AF2
H.hbhc	117	Q	H.hbhc.11	AF2	AF2
H.hbhc	118	G	H.hbhc.12	AF2	AF2
H.hbhc	119	V	H.hbhc.13	AF2	AF2
H.hbhc	120	L	H.hbhc.14	AF2	AF2
H.hbhc	121	P	H.hbhc.15	AF2	AF2
H.HC	122	D	H.HC.01	AF2	AF2
H.HC	123	D	H.HC.02	AF2	AF2
H.HC	124	L	H.HC.03	AF2	AF2
H.HC	125	S	H.HC.04	AF2	AF2
H.HC	126	G	H.HC.05	AF2	AF2
H.HC	127	V	H.HC.06	AF2	AF2
H.HC	128	I	H.HC.07	AF2	AF2
H.HC	129	R	H.HC.08	AF2	AF2
H.HC	130	R	H.HC.09	AF2	AF2
H.HC	131	L	H.HC.10	AF2	AF2
H.HC	132	W	H.HC.11	AF2	AF2
H.HC	133	A	H.HC.12	AF2	AF2
H.hchd	134	D	H.hchd.01	AF2	AF2
H.HD	135	H	H.HD.01	AF2	AF2
H.HD	136	G	H.HD.02	AF2	AF2
H.HD	137	V	H.HD.03	AF2	AF2
H.HD	138	Q	H.HD.04	AF2	AF2
H.HD	139	A	H.HD.05	AF2	AF2
H.HD	140	C	H.HD.06	AF2	AF2
H.HD	141	F	H.HD.07	AF2	AF2
H.HD	142	G	H.HD.08	AF2	AF2
H.HD	143	R	H.HD.09	AF2	AF2
H.HD	144	S	H.HD.10	AF2	AF2
H.HD	145	R	H.HD.11	AF2	AF2
H.HD	146	E	H.HD.12	AF2	AF2
H.hdhe	147	Y	H.hdhe.01	AF2	AF2
H.hdhe	148	Q	H.hdhe.02	AF2	AF2
H.hdhe	149	L	H.hdhe.03	AF2	AF2
H.hdhe	150	N	H.hdhe.04	AF2	AF2
H.hdhe	151	D	H.hdhe.05	AF2	AF2
H.HE	152	S	H.HE.01	AF2	AF2
H.HE	153	A	H.HE.02	AF2	AF2
H.HE	154	A	H.HE.03	AF2	AF2
H.HE	155	Y	H.HE.04	AF2	AF2
H.HE	156	Y	H.HE.05	AF2	AF2
H.HE	157	L	H.HE.06	AF2	AF2
H.HE	158	N	H.HE.07	AF2	AF2
H.HE	159	D	H.HE.08	AF2	AF2
H.HE	160	L	H.HE.09	AF2	AF2
H.HE	161	E	H.HE.10	AF2	AF2
H.HE	162	R	H.HE.11	AF2	AF2
H.HE	163	I	H.HE.12	AF2	AF2
H.HE	164	A	H.HE.13	AF2	AF2
H.hehf	165	Q	H.hehf.01	AF2	AF2
H.hehf	166	S	H.hehf.02	AF2	AF2
H.hehf	167	D	H.hehf.03	AF2	AF2
H.hehf	168	Y	H.hehf.04	AF2	AF2
H.hehf	169	I	H.hehf.05	AF2	AF2
H.hehf	170	P	H.hehf.06	AF2	AF2
H.hehf	171	T	H.hehf.07	AF2	AF2
H.HF	172	Q	H.HF.01	AF2	AF2
H.HF	173	Q	H.HF.02	AF2	AF2
H.HF	174	D	H.HF.03	AF2	AF2
H.HF	175	V	H.HF.04	AF2	AF2
H.HF	176	L	H.HF.05	AF2	AF2
H.HF	177	R	H.HF.06	AF2	AF2
G.hfs2	178	T	G.hfs2.01	AF2	AF2
G.hfs2	179	R	G.hfs2.02	AF2	AF2
G.hfs2	180	V	G.hfs2.03	AF2	AF2
G.hfs2	181	K	G.hfs2.04	AF2	AF2
G.hfs2	182	T	G.hfs2.05	AF2	AF2
G.hfs2	183	T	G.hfs2.06	AF2	AF2
G.hfs2	184	G	G.hfs2.07	Structure	Structure
G.S2	185	I	G.S2.01	Structure	Structure
G.S2	186	V	G.S2.02	Structure	Structure
G.S2	187	E	G.S2.03	Structure	Structure
G.S2	188	T	G.S2.04	Structure	Structure
G.S2	189	H	G.S2.05	Structure	Structure
G.S2	190	F	G.S2.06	Structure	Structure
G.S2	191	T	G.S2.07	Structure	Structure
G.S2	192	F	G.S2.08	Structure	Structure
G.s2s3	193	K	G.s2s3.01	Structure	Structure
G.s2s3	194	D	G.s2s3.02	Structure	Structure
G.S3	195	L	G.S3.01	Structure	Structure
G.S3	196	H	G.S3.02	Structure	Structure
G.S3	197	F	G.S3.03	Structure	Structure
G.S3	198	K	G.S3.04	Structure	Structure
G.S3	199	M	G.S3.05	Structure	Structure
G.S3	200	F	G.S3.06	Structure	Structure
G.S3	201	D	G.S3.07	Structure	Structure
G.S3	202	V	G.S3.08	Structure	Structure
G.s3h2	203	G	G.s3h2.01	Structure	Structure
G.s3h2	204	G	G.s3h2.02	Structure	AF2
G.s3h2	205	Q	G.s3h2.03	Structure	Structure
G.H2	206	R	G.H2.01	Structure	Structure
G.H2	207	S	G.H2.02	Structure	Structure
G.H2	208	E	G.H2.03	Structure	Structure
G.H2	209	R	G.H2.04	Structure	Structure
G.H2	210	K	G.H2.05	Structure	Structure
G.H2	211	K	G.H2.06	Structure	Structure
G.H2	212	W	G.H2.07	Structure	Structure
G.H2	213	I	G.H2.08	Structure	Structure
G.H2	214	H	G.H2.09	Structure	Structure
G.H2	215	C	G.H2.10	Structure	Structure
G.h2s4	216	F	G.h2s4.01	Structure	Structure
G.h2s4	217	E	G.h2s4.02	Structure	Structure
G.h2s4	218	G	G.h2s4.03	Structure	Structure
G.h2s4	219	V	G.h2s4.04	Structure	Structure
G.h2s4	220	T	G.h2s4.05	Structure	Structure
G.S4	221	A	G.S4.01	Structure	Structure
G.S4	222	I	G.S4.02	Structure	Structure
G.S4	223	I	G.S4.03	Structure	Structure
G.S4	224	F	G.S4.04	Structure	Structure
G.S4	225	C	G.S4.05	Structure	Structure
G.S4	226	V	G.S4.06	Structure	Structure
G.S4	227	A	G.S4.07	Structure	Structure
G.s4h3	228	L	G.s4h3.01	Structure	Structure
G.s4h3	229	S	G.s4h3.02	Structure	Structure
G.s4h3	230	A	G.s4h3.03	Structure	Structure
G.s4h3	231	Y	G.s4h3.04	Structure	Structure
G.s4h3	232	D	G.s4h3.05	Structure	Structure
G.s4h3	233	L	G.s4h3.06	Structure	Structure
G.s4h3	234	V	G.s4h3.07	Structure	Structure
G.s4h3	235	L	G.s4h3.08	AF2	AF2
G.s4h3	236	A	G.s4h3.09	AF2	AF2
G.s4h3	237	E	G.s4h3.10	AF2	AF2
G.s4h3	238	D	G.s4h3.11	AF2	AF2
G.s4h3	239	E	G.s4h3.12	AF2	AF2
G.s4h3	240	E	G.s4h3.13	AF2	AF2
G.s4h3	241	M	G.s4h3.14	Structure	Structure
G.s4h3	242	N	G.s4h3.15	Structure	Structure
G.H3	243	R	G.H3.01	Structure	Structure
G.H3	244	M	G.H3.02	Structure	Structure
G.H3	245	H	G.H3.03	Structure	Structure
G.H3	246	E	G.H3.04	Structure	AF2
G.H3	247	S	G.H3.05	Structure	Structure
G.H3	248	M	G.H3.06	Structure	Structure
G.H3	249	K	G.H3.07	Structure	Structure
G.H3	250	L	G.H3.08	Structure	Structure
G.H3	251	F	G.H3.09	Structure	Structure
G.H3	252	D	G.H3.10	Structure	Structure
G.H3	253	S	G.H3.11	Structure	Structure
G.H3	254	I	G.H3.12	Structure	Structure
G.H3	255	C	G.H3.13	Structure	Structure
G.H3	256	N	G.H3.14	Structure	Structure
G.H3	257	N	G.H3.15	Structure	Structure
G.H3	258	K	G.H3.16	Structure	Structure
G.H3	259	W	G.H3.17	Structure	Structure
G.H3	260	F	G.H3.18	Structure	Structure
G.h3s5	261	T	G.h3s5.01	Structure	Structure
G.h3s5	262	D	G.h3s5.02	Structure	Structure
G.h3s5	263	T	G.h3s5.03	Structure	Structure
G.S5	264	S	G.S5.01	Structure	Structure
G.S5	265	I	G.S5.02	Structure	Structure
G.S5	266	I	G.S5.03	Structure	Structure
G.S5	267	L	G.S5.04	Structure	Structure
G.S5	268	F	G.S5.05	Structure	Structure
G.S5	269	L	G.S5.06	Structure	Structure
G.S5	270	N	G.S5.07	Structure	Structure
G.s5hg	271	K	G.s5hg.01	Structure	Structure
G.HG	272	K	G.HG.01	Structure	Structure
G.HG	273	D	G.HG.02	Structure	Structure
G.HG	274	L	G.HG.03	Structure	Structure
G.HG	275	F	G.HG.04	Structure	Structure
G.HG	276	E	G.HG.05	Structure	Structure
G.HG	277	E	G.HG.06	Structure	Structure
G.HG	278	K	G.HG.07	Structure	Structure
G.HG	279	I	G.HG.08	Structure	Structure
G.HG	280	T	G.HG.09	Structure	Structure
G.HG	281	H	G.HG.12	Structure	Structure
G.HG	282	S	G.HG.13	Structure	Structure
G.HG	283	P	G.HG.14	Structure	Structure
G.HG	284	L	G.HG.15	Structure	Structure
G.HG	285	T	G.HG.16	Structure	Structure
G.HG	286	I	G.HG.17	Structure	Structure
G.hgh4	287	C	G.hgh4.01	Structure	Structure
G.hgh4	288	F	G.hgh4.02	Structure	Structure
G.hgh4	289	P	G.hgh4.03	Structure	Structure
G.hgh4	290	E	G.hgh4.04	Structure	Structure
G.hgh4	291	Y	G.hgh4.05	Structure	Structure
G.hgh4	292	T	G.hgh4.06	Structure	Structure
G.hgh4	293	G	G.hgh4.07	Structure	Structure
G.hgh4	294	A	G.hgh4.08	Structure	Structure
G.H4	295	N	G.H4.01	Structure	Structure
G.H4	296	K	G.H4.02	Structure	Structure
G.H4	297	Y	G.H4.03	Structure	Structure
G.H4	298	D	G.H4.04	Structure	Structure
G.H4	299	E	G.H4.05	Structure	Structure
G.H4	300	A	G.H4.06	Structure	Structure
G.H4	301	A	G.H4.07	Structure	Structure
G.H4	302	S	G.H4.08	Structure	Structure
G.H4	303	Y	G.H4.10	Structure	Structure
G.H4	304	I	G.H4.11	Structure	Structure
G.H4	305	Q	G.H4.12	Structure	Structure
G.H4	306	S	G.H4.13	Structure	Structure
G.H4	307	K	G.H4.14	Structure	Structure
G.H4	308	F	G.H4.15	Structure	Structure
G.H4	309	E	G.H4.16	Structure	Structure
G.H4	310	D	G.H4.17	Structure	Structure
G.h4s6	311	L	G.h4s6.01	Structure	Structure
G.h4s6	312	N	G.h4s6.02	Structure	Structure
G.h4s6	313	K	G.h4s6.03	Structure	Structure
G.h4s6	314	R	G.h4s6.04	Structure	Structure
G.h4s6	315	K	G.h4s6.08	Structure	Structure
G.h4s6	316	D	G.h4s6.09	Structure	Structure
G.h4s6	317	T	G.h4s6.10	Structure	Structure
G.h4s6	318	K	G.h4s6.11	Structure	Structure
G.h4s6	319	E	G.h4s6.12	Structure	Structure
G.S6	320	I	G.S6.01	Structure	Structure
G.S6	321	Y	G.S6.02	Structure	Structure
G.S6	322	T	G.S6.03	Structure	Structure
G.S6	323	H	G.S6.04	Structure	Structure
G.S6	324	F	G.S6.05	Structure	Structure
G.s6h5	325	T	G.s6h5.01	Structure	Structure
G.s6h5	326	C	G.s6h5.02	Structure	Structure
G.s6h5	327	A	G.s6h5.03	Structure	AF2
G.s6h5	328	T	G.s6h5.04	Structure	Structure
G.s6h5	329	D	G.s6h5.05	Structure	Structure
G.H5	330	T	G.H5.01	Structure	Structure
G.H5	331	K	G.H5.02	Structure	Structure
G.H5	332	N	G.H5.03	Structure	Structure
G.H5	333	V	G.H5.04	Structure	Structure
G.H5	334	Q	G.H5.05	Structure	Structure
G.H5	335	F	G.H5.06	Structure	Structure
G.H5	336	V	G.H5.07	Structure	Structure
G.H5	337	F	G.H5.08	Structure	Structure
G.H5	338	D	G.H5.09	Structure	Structure
G.H5	339	A	G.H5.10	Structure	Structure
G.H5	340	V	G.H5.11	Structure	Structure
G.H5	341	T	G.H5.12	Structure	Structure
G.H5	342	D	G.H5.13	Structure	Structure
G.H5	343	V	G.H5.14	Structure	Structure
G.H5	344	I	G.H5.15	Structure	Structure
G.H5	345	I	G.H5.16	Structure	Structure
G.H5	346	K	G.H5.17	Structure	Structure
G.H5	347	N	G.H5.18	Structure	Structure
G.H5	348	N	G.H5.19	Structure	Structure
G.H5	349	L	G.H5.20	Structure	Structure
G.H5	350	K	G.H5.21	Structure	Structure
G.H5	351	D	G.H5.22	Structure	Structure
G.H5	352	C	G.H5.23	Structure	Structure
G.H5	353	G	G.H5.24	Structure	Structure
G.H5	354	L	G.H5.25	Structure	Structure
G.H5	355	F	G.H5.26	Structure	Structure

REFINED GPCR RESIDUES

Residue backbones - 287 from structure (88.6%), 37 from model (11.4%)
Residue sidechains - 287 from structure (88.6%), 37 from model (11.4%)

Showing 1 to 324 of 324 entries

Search:

Segment	Seq.num.	AA	GPCRdb#	Backbone from	Sidechain from

N-term	1	M	-	AF2	AF2
N-term	2	P	-	AF2	AF2
N-term	3	P	-	AF2	AF2
N-term	4	S	-	AF2	AF2
N-term	5	I	-	AF2	AF2
TM1	6	S	1.29x29	Structure	Structure
TM1	7	A	1.30x30	Structure	Structure
TM1	8	F	1.31x31	Structure	Structure
TM1	9	Q	1.32x32	Structure	Structure
TM1	10	A	1.33x33	Structure	Structure
TM1	11	A	1.34x34	Structure	Structure
TM1	12	Y	1.35x35	Structure	Structure
TM1	13	I	1.36x36	Structure	Structure
TM1	14	G	1.37x37	Structure	Structure
TM1	15	I	1.38x38	Structure	Structure
TM1	16	E	1.39x39	Structure	Structure
TM1	17	V	1.40x40	Structure	Structure
TM1	18	L	1.41x41	Structure	Structure
TM1	19	I	1.42x42	Structure	Structure
TM1	20	A	1.43x43	Structure	Structure
TM1	21	L	1.44x44	Structure	Structure
TM1	22	V	1.45x45	Structure	Structure
TM1	23	S	1.46x46	Structure	Structure
TM1	24	V	1.47x47	Structure	Structure
TM1	25	P	1.48x48	Structure	Structure
TM1	26	G	1.49x49	Structure	Structure
TM1	27	N	1.50x50	Structure	Structure
TM1	28	V	1.51x51	Structure	Structure
TM1	29	L	1.52x52	Structure	Structure
TM1	30	V	1.53x53	Structure	Structure
TM1	31	I	1.54x54	Structure	Structure
TM1	32	W	1.55x55	Structure	Structure
TM1	33	A	1.56x56	Structure	Structure
TM1	34	V	1.57x57	Structure	Structure
TM1	35	K	1.58x58	Structure	Structure
TM1	36	V	1.59x59	Structure	Structure
TM1	37	N	1.60x60	Structure	Structure
ICL1	38	Q	12.48x48	Structure	Structure
ICL1	39	A	12.49x49	Structure	Structure
ICL1	40	L	12.50x50	Structure	Structure
ICL1	41	R	12.51x51	Structure	Structure
TM2	42	D	2.37x37	Structure	Structure
TM2	43	A	2.38x38	Structure	Structure
TM2	44	T	2.39x39	Structure	Structure
TM2	45	F	2.40x40	Structure	Structure
TM2	46	C	2.41x41	Structure	Structure
TM2	47	F	2.42x42	Structure	Structure
TM2	48	I	2.43x43	Structure	Structure
TM2	49	V	2.44x44	Structure	Structure
TM2	50	S	2.45x45	Structure	Structure
TM2	51	L	2.46x46	Structure	Structure
TM2	52	A	2.47x47	Structure	Structure
TM2	53	V	2.48x48	Structure	Structure
TM2	54	A	2.49x49	Structure	Structure
TM2	55	D	2.50x50	Structure	Structure
TM2	56	V	2.51x51	Structure	Structure
TM2	57	A	2.52x52	Structure	Structure
TM2	58	V	2.53x53	Structure	Structure
TM2	59	G	2.54x54	Structure	Structure
TM2	60	A	2.55x55	Structure	Structure
TM2	61	L	2.56x551	Structure	Structure
TM2	62	V	2.57x56	Structure	Structure
TM2	63	I	2.58x57	Structure	Structure
TM2	64	P	2.59x58	Structure	Structure
TM2	65	L	2.60x59	Structure	Structure
TM2	66	A	2.61x60	Structure	Structure
TM2	67	I	2.62x61	Structure	Structure
TM2	68	L	2.63x62	Structure	Structure
TM2	69	I	2.64x63	Structure	Structure
TM2	70	N	2.65x64	Structure	Structure
TM2	71	I	2.66x65	Structure	Structure
TM2	72	G	2.67x66	Structure	Structure
ECL1	73	P	23.50x50	Structure	Structure
ECL1	74	Q	23.51x51	Structure	Structure
ECL1	75	T	23.52x52	Structure	Structure
TM3	76	Y	3.21x21	Structure	Structure
TM3	77	F	3.22x22	Structure	Structure
TM3	78	H	3.23x23	Structure	Structure
TM3	79	T	3.24x24	Structure	Structure
TM3	80	C	3.25x25	Structure	Structure
TM3	81	L	3.26x26	Structure	Structure
TM3	82	M	3.27x27	Structure	Structure
TM3	83	V	3.28x28	Structure	Structure
TM3	84	A	3.29x29	Structure	Structure
TM3	85	C	3.30x30	Structure	Structure
TM3	86	P	3.31x31	Structure	Structure
TM3	87	V	3.32x32	Structure	Structure
TM3	88	L	3.33x33	Structure	Structure
TM3	89	I	3.34x34	Structure	Structure
TM3	90	L	3.35x35	Structure	Structure
TM3	91	T	3.36x36	Structure	Structure
TM3	92	Q	3.37x37	Structure	Structure
TM3	93	S	3.38x38	Structure	Structure
TM3	94	S	3.39x39	Structure	Structure
TM3	95	I	3.40x40	Structure	Structure
TM3	96	L	3.41x41	Structure	Structure
TM3	97	A	3.42x42	Structure	Structure
TM3	98	L	3.43x43	Structure	Structure
TM3	99	L	3.44x44	Structure	Structure
TM3	100	A	3.45x45	Structure	Structure
TM3	101	I	3.46x46	Structure	Structure
TM3	102	A	3.47x47	Structure	Structure
TM3	103	V	3.48x48	Structure	Structure
TM3	104	D	3.49x49	Structure	Structure
TM3	105	R	3.50x50	Structure	Structure
TM3	106	Y	3.51x51	Structure	Structure
TM3	107	L	3.52x52	Structure	Structure
TM3	108	R	3.53x53	Structure	Structure
TM3	109	V	3.54x54	Structure	Structure
TM3	110	K	3.55x55	Structure	Structure
TM3	111	I	3.56x56	Structure	Structure
ICL2	112	P	34.50x50	Structure	Structure
ICL2	113	L	34.51x51	Structure	Structure
ICL2	114	R	34.52x52	Structure	Structure
ICL2	115	Y	34.53x53	Structure	Structure
ICL2	116	K	34.54x54	Structure	Structure
ICL2	117	M	34.55x55	Structure	Structure
ICL2	118	V	34.56x56	Structure	Structure
ICL2	119	V	34.57x57	Structure	Structure
TM4	120	T	4.38x38	Structure	Structure
TM4	121	P	4.39x39	Structure	Structure
TM4	122	R	4.40x40	Structure	Structure
TM4	123	R	4.41x41	Structure	Structure
TM4	124	A	4.42x42	Structure	Structure
TM4	125	A	4.43x43	Structure	Structure
TM4	126	V	4.44x44	Structure	Structure
TM4	127	A	4.45x45	Structure	Structure
TM4	128	I	4.46x46	Structure	Structure
TM4	129	A	4.47x47	Structure	Structure
TM4	130	G	4.48x48	Structure	Structure
TM4	131	C	4.49x49	Structure	Structure
TM4	132	W	4.50x50	Structure	Structure
TM4	133	I	4.51x51	Structure	Structure
TM4	134	L	4.52x52	Structure	Structure
TM4	135	S	4.53x53	Structure	Structure
TM4	136	F	4.54x54	Structure	Structure
TM4	137	V	4.55x55	Structure	Structure
TM4	138	V	4.56x56	Structure	Structure
TM4	139	G	4.57x57	Structure	Structure
TM4	140	L	4.58x58	Structure	Structure
TM4	141	T	4.59x59	Structure	Structure
TM4	142	P	4.60x60	Structure	Structure
TM4	143	M	4.61x61	Structure	Structure
TM4	144	F	4.62x62	Structure	Structure
TM4	145	G	4.63x63	Structure	Structure
ECL2	146	W	-	Structure	Structure
ECL2	147	N	-	Structure	Structure
ECL2	148	N	-	Structure	Structure
ECL2	149	L	-	Structure	Structure
ECL2	150	S	-	Structure	Structure
ECL2	151	A	-	Structure	Structure
ECL2	152	V	-	Structure	Structure
ECL2	153	E	-	Structure	Structure
ECL2	154	R	-	Structure	Structure
ECL2	155	A	-	Structure	Structure
ECL2	156	W	-	Structure	Structure
ECL2	157	A	-	Structure	Structure
ECL2	158	A	-	Structure	Structure
ECL2	159	N	-	Structure	Structure
ECL2	160	G	-	Structure	Structure
ECL2	161	S	-	Structure	Structure
ECL2	162	M	-	Structure	Structure
ECL2	163	G	-	Structure	Structure
ECL2	164	E	-	Structure	Structure
ECL2	165	P	-	Structure	Structure
ECL2	166	V	-	Structure	Structure
ECL2	167	I	-	Structure	Structure
ECL2	168	K	-	Structure	Structure
ECL2	169	C	45.50x50	Structure	Structure
ECL2	170	E	45.51x51	Structure	Structure
ECL2	171	F	45.52x52	Structure	Structure
ECL2	172	E	-	Structure	Structure
ECL2	173	K	-	Structure	Structure
ECL2	174	V	-	Structure	Structure
ECL2	175	I	-	Structure	Structure
TM5	176	S	5.34x36	Structure	Structure
TM5	177	M	5.35x37	Structure	Structure
TM5	178	E	5.36x38	Structure	Structure
TM5	179	Y	5.37x39	Structure	Structure
TM5	180	M	5.38x40	Structure	Structure
TM5	181	V	5.39x41	Structure	Structure
TM5	182	Y	5.40x411	Structure	Structure
TM5	183	F	5.41x42	Structure	Structure
TM5	184	N	5.42x43	Structure	Structure
TM5	185	F	5.43x44	Structure	Structure
TM5	186	F	5.44x45	Structure	Structure
TM5	187	V	5.45x46	Structure	Structure
TM5	188	W	5.46x461	Structure	Structure
TM5	189	V	5.47x47	Structure	Structure
TM5	190	L	5.48x48	Structure	Structure
TM5	191	P	5.49x49	Structure	Structure
TM5	192	P	5.50x50	Structure	Structure
TM5	193	L	5.51x51	Structure	Structure
TM5	194	L	5.52x52	Structure	Structure
TM5	195	L	5.53x53	Structure	Structure
TM5	196	M	5.54x54	Structure	Structure
TM5	197	V	5.55x55	Structure	Structure
TM5	198	L	5.56x56	Structure	Structure
TM5	199	I	5.57x57	Structure	Structure
TM5	200	Y	5.58x58	Structure	Structure
TM5	201	L	5.59x59	Structure	Structure
TM5	202	E	5.60x60	Structure	Structure
TM5	203	V	5.61x61	Structure	Structure
TM5	204	F	5.62x62	Structure	Structure
TM5	205	Y	5.63x63	Structure	Structure
TM5	206	L	5.64x64	Structure	Structure
TM5	207	I	5.65x65	Structure	Structure
TM5	208	R	5.66x66	Structure	Structure
TM5	209	K	5.67x67	Structure	Structure
TM5	210	Q	5.68x68	Structure	Structure
TM5	211	L	5.69x69	Structure	Structure
TM5	212	N	5.70x70	Structure	Structure
TM5	213	K	5.71x71	Structure	Structure
TM5	214	K	5.72x72	AF2	AF2
TM5	215	V	5.73x73	AF2	AF2
ICL3	216	S	-	AF2	AF2
ICL3	217	A	-	AF2	AF2
ICL3	218	S	-	AF2	AF2
ICL3	219	S	-	AF2	AF2
ICL3	220	G	-	AF2	AF2
TM6	221	D	6.22x22	AF2	AF2
TM6	222	P	6.23x23	AF2	AF2
TM6	223	Q	6.24x24	Structure	Structure
TM6	224	K	6.25x25	Structure	Structure
TM6	225	Y	6.26x26	Structure	Structure
TM6	226	Y	6.27x27	Structure	Structure
TM6	227	G	6.28x28	Structure	Structure
TM6	228	K	6.29x29	Structure	Structure
TM6	229	E	6.30x30	Structure	Structure
TM6	230	L	6.31x31	Structure	Structure
TM6	231	K	6.32x32	Structure	Structure
TM6	232	I	6.33x33	Structure	Structure
TM6	233	A	6.34x34	Structure	Structure
TM6	234	K	6.35x35	Structure	Structure
TM6	235	S	6.36x36	Structure	Structure
TM6	236	L	6.37x37	Structure	Structure
TM6	237	A	6.38x38	Structure	Structure
TM6	238	L	6.39x39	Structure	Structure
TM6	239	I	6.40x40	Structure	Structure
TM6	240	L	6.41x41	Structure	Structure
TM6	241	F	6.42x42	Structure	Structure
TM6	242	L	6.43x43	Structure	Structure
TM6	243	F	6.44x44	Structure	Structure
TM6	244	A	6.45x45	Structure	Structure
TM6	245	L	6.46x46	Structure	Structure
TM6	246	S	6.47x47	Structure	Structure
TM6	247	W	6.48x48	Structure	Structure
TM6	248	L	6.49x49	Structure	Structure
TM6	249	P	6.50x50	Structure	Structure
TM6	250	L	6.51x51	Structure	Structure
TM6	251	H	6.52x52	Structure	Structure
TM6	252	I	6.53x53	Structure	Structure
TM6	253	L	6.54x54	Structure	Structure
TM6	254	N	6.55x55	Structure	Structure
TM6	255	C	6.56x56	Structure	Structure
TM6	256	I	6.57x57	Structure	Structure
TM6	257	T	6.58x58	Structure	Structure
TM6	258	L	6.59x59	Structure	Structure
TM6	259	F	6.60x60	Structure	Structure
TM6	260	C	6.61x61	Structure	Structure
ECL3	261	P	-	Structure	Structure
ECL3	262	S	-	Structure	Structure
ECL3	263	C	-	Structure	Structure
ECL3	264	H	-	Structure	Structure
ECL3	265	K	-	Structure	Structure
TM7	266	P	7.31x30	Structure	Structure
TM7	267	S	7.32x31	Structure	Structure
TM7	268	I	7.33x32	Structure	Structure
TM7	269	L	7.34x33	Structure	Structure
TM7	270	T	7.35x34	Structure	Structure
TM7	271	Y	7.36x35	Structure	Structure
TM7	272	I	7.37x36	Structure	Structure
TM7	273	A	7.38x37	Structure	Structure
TM7	274	I	7.39x38	Structure	Structure
TM7	275	F	7.40x39	Structure	Structure
TM7	276	L	7.41x40	Structure	Structure
TM7	277	T	7.42x41	Structure	Structure
TM7	278	H	7.43x42	Structure	Structure
TM7	279	G	7.44x43	Structure	Structure
TM7	280	N	7.45x45	Structure	Structure
TM7	281	S	7.46x46	Structure	Structure
TM7	282	A	7.47x47	Structure	Structure
TM7	283	M	7.48x48	Structure	Structure
TM7	284	N	7.49x49	Structure	Structure
TM7	285	P	7.50x50	Structure	Structure
TM7	286	I	7.51x51	Structure	Structure
TM7	287	V	7.52x52	Structure	Structure
TM7	288	Y	7.53x53	Structure	Structure
TM7	289	A	7.54x54	Structure	Structure
TM7	290	F	7.55x55	Structure	Structure
TM7	291	R	7.56x56	Structure	Structure
H8	292	I	8.47x47	Structure	Structure
H8	293	Q	8.48x48	Structure	Structure
H8	294	K	8.49x49	Structure	Structure
H8	295	F	8.50x50	Structure	Structure
H8	296	R	8.51x51	Structure	Structure
H8	297	V	8.52x52	Structure	Structure
H8	298	T	8.53x53	Structure	Structure
H8	299	F	8.54x54	Structure	Structure
H8	300	L	8.55x55	Structure	Structure
H8	301	K	8.56x56	Structure	Structure
H8	302	I	8.57x57	AF2	AF2
H8	303	W	8.58x58	AF2	AF2
H8	304	N	8.59x59	AF2	AF2
H8	305	D	8.60x60	AF2	AF2
H8	306	H	8.61x61	AF2	AF2
H8	307	F	8.62x62	AF2	AF2
H8	308	R	8.63x63	AF2	AF2
H8	309	C	8.64x64	AF2	AF2
H8	310	Q	8.65x65	AF2	AF2
H8	311	P	8.66x66	AF2	AF2
H8	312	A	8.67x67	AF2	AF2
H8	313	P	8.68x68	AF2	AF2
H8	314	P	8.69x69	AF2	AF2
C-term	315	I	-	AF2	AF2
C-term	316	D	-	AF2	AF2
C-term	317	E	-	AF2	AF2
C-term	318	D	-	AF2	AF2
C-term	319	L	-	AF2	AF2
C-term	320	P	-	AF2	AF2
C-term	321	E	-	AF2	AF2
C-term	322	E	-	AF2	AF2
C-term	323	R	-	AF2	AF2
C-term	324	P	-	AF2	AF2

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Hydrophobic	TM3	R	105	3x50	G.H5	C	352	G.H5.23
Hydrophobic	TM3	R	108	3x53	G.H5	D	351	G.H5.22
Hydrophobic	TM5	L	211	5x69	G.H5	K	346	G.H5.17
Hydrophobic	TM7	R	291	7x56	G.H5	G	353	G.H5.24
Hydrophobic	TM5	I	207	5x65	G.H5	L	349	G.H5.20
Hydrophobic	TM3	R	105	3x50	G.H5	L	354	G.H5.25
Hydrophobic	TM3	V	109	3x54	G.H5	L	349	G.H5.20
Hydrophobic	TM6	I	232	6x33	G.H5	L	354	G.H5.25
Hydrophobic	H8	I	292	8x47	G.H5	C	352	G.H5.23
Hydrophobic	ICL2	L	113	34x51	G.H5	T	341	G.H5.12
Hydrophobic	TM5	I	207	5x65	G.H5	L	354	G.H5.25
Hydrophobic	ICL2	P	112	34x50	G.H5	I	344	G.H5.15
Hydrophobic	ICL3	S	219	-	G.H4	E	309	G.H4.16
Hydrophobic	TM5	K	214	5x72	G.H5	K	346	G.H5.17
Hydrophobic	TM6	L	236	6x37	G.H5	L	354	G.H5.25
Hydrophobic	TM6	I	232	6x33	G.H5	F	355	G.H5.26
Hydrophobic	H8	K	294	8x49	G.H5	D	351	G.H5.22
Hydrophobic	ICL2	L	113	34x51	G.H5	F	337	G.H5.08
Hydrophobic	TM3	R	108	3x53	G.H5	C	352	G.H5.23
Hydrophobic	ICL2	L	113	34x51	G.H5	I	344	G.H5.15
Hydrophobic	ICL2	P	112	34x50	G.H5	I	345	G.H5.16
Hydrophobic	ICL2	L	113	34x51	G.S3	L	195	G.S3.01
Hydrophobic	TM5	V	203	5x61	G.H5	L	354	G.H5.25
Hydrophobic	TM6	K	224	6x25	G.h4s6	D	316	G.h4s6.09
Hydrophobic	TM3	R	108	3x53	G.H5	N	348	G.H5.19
Hydrophobic	TM6	K	228	6x29	G.H5	F	355	G.H5.26
Hydrophobic	H8	I	292	8x47	G.H5	G	353	G.H5.24
Hydrophobic	TM5	Q	210	5x68	G.H5	I	345	G.H5.16
Ionic	TM6	K	224	6x25	G.h4s6	E	319	G.h4s6.12
Ionic	TM3	R	108	3x53	G.H5	D	351	G.H5.22
Ionic	TM6	K	228	6x29	G.h4s6	D	316	G.h4s6.09
Ionic	H8	K	294	8x49	G.H5	D	351	G.H5.22
Ionic	TM6	K	224	6x25	G.h4s6	D	316	G.h4s6.09
Polar	TM6	K	224	6x25	G.h4s6	E	319	G.h4s6.12
Polar	TM3	R	105	3x50	G.H5	C	352	G.H5.23
Polar	TM3	R	108	3x53	G.H5	D	351	G.H5.22
Polar	ICL3	S	219	-	G.H4	E	309	G.H4.16
Polar	TM6	K	228	6x29	G.h4s6	D	316	G.h4s6.09
Polar	ICL2	P	112	34x50	G.H5	N	348	G.H5.19
Polar	TM5	Q	210	5x68	G.H5	D	342	G.H5.13
Polar	H8	K	294	8x49	G.H5	D	351	G.H5.22
Polar	TM6	K	224	6x25	G.h4s6	D	316	G.h4s6.09
Polar	TM3	R	108	3x53	G.H5	N	348	G.H5.19
Van-der-waals	TM3	R	108	3x53	G.H5	D	351	G.H5.22
Van-der-waals	TM3	V	109	3x54	G.H5	L	349	G.H5.20
Van-der-waals	TM6	I	232	6x33	G.H5	L	354	G.H5.25
Van-der-waals	H8	I	292	8x47	G.H5	C	352	G.H5.23
Van-der-waals	ICL2	P	112	34x50	G.H5	I	344	G.H5.15
Van-der-waals	TM5	Q	210	5x68	G.H5	D	342	G.H5.13
Van-der-waals	TM5	K	214	5x72	G.H5	K	346	G.H5.17
Van-der-waals	TM6	L	236	6x37	G.H5	L	354	G.H5.25
Van-der-waals	H8	K	294	8x49	G.H5	D	351	G.H5.22
Van-der-waals	TM3	R	108	3x53	G.H5	C	352	G.H5.23
Van-der-waals	ICL2	P	112	34x50	G.H5	I	345	G.H5.16
Van-der-waals	TM6	K	224	6x25	G.h4s6	D	316	G.h4s6.09
Van-der-waals	TM2	F	45	2x40	G.H5	D	351	G.H5.22
Van-der-waals	TM6	K	228	6x29	G.H5	F	355	G.H5.26
Van-der-waals	TM5	Q	210	5x68	G.H5	I	345	G.H5.16

Showing 1 to 58 of 58 entries

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Main reference

Refined structure (6D9H) of Gi2 - A1 receptor Download Full

GPCR CLASS (FAMILY)

SPECIES

G PROTEIN FAMILY

DATE

3D VIEW

REFINED G PROTEIN RESIDUES

REFINED GPCR RESIDUES

GPCR - G protein interface interactions

Structures

Refined structure (6D9H) of G_i2 - A₁ receptor

Full