A1 receptor - Gi2

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6D9H

RESOLUTION

3.6 Å

REFERENCE

10.1038/S41586-018-0236-6

PUBLICATION DATE

June 20, 2018

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

30 interactions (Click to see)

LIGANDS

adenosine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

ENDOGENOUS LIGANDS

adenosine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 108 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 108 3x53 G.H5 C 352 G.H5.23
Hydrophobic ICL2 L 113 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 L 113 34x51 G.H5 F 337 G.H5.08
Polar TM3 R 108 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 R 108 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM5 Q 210 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 Q 210 5x68 G.H5 I 345 G.H5.16
Hydrophobic ICL2 L 113 34x51 G.H5 T 341 G.H5.12
Ionic TM6 K 224 6x25 G.h4s6 D 316 G.h4s6.09
Polar TM6 K 224 6x25 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM6 K 224 6x25 G.h4s6 D 316 G.h4s6.09
Van-der-waals TM6 K 224 6x25 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM5 I 207 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM7 R 291 7x56 G.H5 G 353 G.H5.24
Polar TM3 R 105 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 105 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM6 K 228 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 228 6x29 G.H5 F 355 G.H5.26
Polar ICL2 P 112 34x50 G.H5 N 348 G.H5.19
Polar TM5 Q 210 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 Q 210 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 L 211 5x69 G.H5 K 346 G.H5.17
Hydrophobic ICL2 P 112 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 112 34x50 G.H5 I 345 G.H5.16
Van-der-waals TM2 F 45 2x40 G.H5 D 351 G.H5.22
Ionic TM3 R 108 3x53 G.H5 D 351 G.H5.22
Polar TM3 R 108 3x53 G.H5 D 351 G.H5.22
Hydrophobic TM3 R 108 3x53 G.H5 D 351 G.H5.22
Van-der-waals TM3 R 108 3x53 G.H5 D 351 G.H5.22
Ionic H8 K 294 8x49 G.H5 D 351 G.H5.22
Polar H8 K 294 8x49 G.H5 D 351 G.H5.22
Hydrophobic H8 K 294 8x49 G.H5 D 351 G.H5.22
Van-der-waals H8 K 294 8x49 G.H5 D 351 G.H5.22
Hydrophobic TM6 L 236 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 236 6x37 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 112 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 112 34x50 G.H5 I 344 G.H5.15
Ionic TM6 K 224 6x25 G.h4s6 E 319 G.h4s6.12
Polar TM6 K 224 6x25 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM5 I 207 5x65 G.H5 L 354 G.H5.25
Hydrophobic TM5 V 203 5x61 G.H5 L 354 G.H5.25
Hydrophobic H8 I 292 8x47 G.H5 G 353 G.H5.24
Hydrophobic ICL2 L 113 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM6 I 232 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 232 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM3 V 109 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 109 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM3 R 105 3x50 G.H5 L 354 G.H5.25
Ionic TM6 K 228 6x29 G.h4s6 D 316 G.h4s6.09
Polar TM6 K 228 6x29 G.h4s6 D 316 G.h4s6.09
Ionic TM5 K 213 5x71 G.H5 D 342 G.H5.13
Polar TM5 K 213 5x71 G.H5 D 342 G.H5.13
Hydrophobic H8 I 292 8x47 G.H5 C 352 G.H5.23
Van-der-waals H8 I 292 8x47 G.H5 C 352 G.H5.23
Hydrophobic TM6 I 232 6x33 G.H5 F 355 G.H5.26