Refined structure (8HCX) of Gq - ETB receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

3D VIEW

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Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 219 from structure (61.0%), 140 from model (39.0%)
Residue sidechains - 39 from structure (10.9%), 320 from model (89.1%)

REFINED GPCR RESIDUES

Residue backbones - 285 from structure (69.0%), 128 from model (31.0%)
Residue sidechains - 254 from structure (61.5%), 159 from model (38.5%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
E31G.HNM19M22I23D27T28L29H.HAK01Y06K07Y08E09H.hahbH01N02K03A04R10H.HBY04G.S2Y02G.S6F08K12D13Q17N19E22Y23N24V26G.H5GproteinR34x52R6x30G2x38R8x49Q6x29E5x64C12x49R12x51G34x55H6x26K12x48G34x57W34x50I34x56S34x51M12x50S8x47I34x53N12x52A3x53V7x56R-GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.HNH.HAH.hahbH.HBG.S2G.S6G.H5GPCR segments:N-termICL1TM2ICL2TM3TM5TM6TM7H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
Res. Pos.

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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