ETB receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

C

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.5 Å

REFERENCE

PUBLICATION DATE

March 22, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

ENDOTHELIN - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

endothelin-3, endothelin-2, endothelin-1



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Van-der-waals TM2 N 137 2x40 G.H5 N 357 G.H5.24
Hydrophobic H8 F 393 8x50 G.H5 N 357 G.H5.24
Hydrophobic ICL2 R 208 - G.H5 M 351 G.H5.18
Hydrophobic TM5 M 300 5x65 G.H5 L 353 G.H5.20
Van-der-waals TM5 M 300 5x65 G.H5 L 353 G.H5.20
Hydrophobic H8 R 392 8x49 G.H5 N 357 G.H5.24
Van-der-waals H8 R 392 8x49 G.H5 N 357 G.H5.24
Hydrophobic TM2 P 136 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 P 136 2x39 G.H5 Y 356 G.H5.23
Polar TM3 D 198 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 198 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 198 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM5 M 296 5x61 G.H5 L 358 G.H5.25
Hydrophobic TM7 V 389 7x56 G.H5 L 358 G.H5.25
Van-der-waals TM7 V 389 7x56 G.H5 L 358 G.H5.25
Hydrophobic TM3 R 199 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 199 3x50 G.H5 L 358 G.H5.25
Hydrophobic ICL2 R 208 - G.H5 N 352 G.H5.19
Van-der-waals ICL2 R 208 - G.H5 N 352 G.H5.19
Hydrophobic TM6 V 321 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 V 321 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM3 R 199 3x50 G.H5 Y 356 G.H5.23
Polar TM3 A 202 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 A 202 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 202 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 S 207 - G.H5 I 348 G.H5.15
Polar H8 S 390 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 S 390 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 S 390 8x47 G.H5 N 357 G.H5.24
Polar ICL2 S 207 - G.HN R 31 G.HN.49
Hydrophobic TM6 V 321 6x33 G.H5 L 353 G.H5.20
Polar TM3 A 202 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 202 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 202 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM5 M 300 5x65 G.H5 L 349 G.H5.16
Hydrophobic TM7 L 386 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 L 386 7x53 G.H5 N 357 G.H5.24
Hydrophobic ICL2 W 206 - G.HN R 32 G.HN.50
Hydrophobic TM3 V 203 3x54 G.H5 L 353 G.H5.20
Van-der-waals ICL1 N 134 12x52 G.H5 E 355 G.H5.22
Polar ICL2 I 209 - G.H5 E 355 G.H5.22
Van-der-waals ICL2 I 209 - G.H5 E 355 G.H5.22
Ionic TM6 R 318 6x30 G.H5 D 346 G.H5.13
Polar TM6 R 318 6x30 G.H5 D 346 G.H5.13
Hydrophobic TM6 R 318 6x30 G.H5 L 349 G.H5.16
Van-der-waals TM6 R 318 6x30 G.H5 L 349 G.H5.16
Hydrophobic H8 R 392 8x49 G.h4s6 R 321 G.h4s6.12
Hydrophobic ICL2 W 206 - G.H5 I 348 G.H5.15