Structure information

ETB receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8HCX

SPECIES

Homo sapiens

RESOLUTION

3.500

PREFERRED CHAIN

C

REFERENCE

PUBLICATION DATE

March 22, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ENDOTHELIN P93 N-term hydrophobic
ENDOTHELIN E165 ECL1 polar (hydrogen bond with backbone)
ENDOTHELIN E165 ECL1 Van der Waals
ENDOTHELIN W167 23.50x50 ECL1 Van der Waals
ENDOTHELIN W167 23.50x50 ECL1 hydrophobic
ENDOTHELIN Q181 3.32x32 TM3 Van der Waals
ENDOTHELIN Q181 3.32x32 TM3 polar (hydrogen bond)
ENDOTHELIN K182 3.33x33 TM3 Van der Waals
ENDOTHELIN E236 4.60x61 TM4 Van der Waals
ENDOTHELIN Y247 ECL2 aromatic (face-to-edge)
ENDOTHELIN Y247 ECL2 Van der Waals
ENDOTHELIN R253 ECL2 Van der Waals
ENDOTHELIN I254 ECL2 hydrophobic
ENDOTHELIN I254 ECL2 Van der Waals
ENDOTHELIN C255 45.50x50 ECL2 Van der Waals
ENDOTHELIN L256 45.51x51 ECL2 hydrophobic
ENDOTHELIN L256 45.51x51 ECL2 Van der Waals
ENDOTHELIN P259 ECL2 hydrophobic
ENDOTHELIN P259 ECL2 Van der Waals
ENDOTHELIN K270 5.35x36 TM5 Van der Waals
ENDOTHELIN L277 5.42x43 TM5 hydrophobic
ENDOTHELIN L277 5.42x43 TM5 Van der Waals
ENDOTHELIN W336 6.48x48 TM6 hydrophobic
ENDOTHELIN W336 6.48x48 TM6 Van der Waals
ENDOTHELIN L339 6.51x51 TM6 hydrophobic
ENDOTHELIN L339 6.51x51 TM6 Van der Waals
ENDOTHELIN H340 6.52x52 TM6 aromatic (face-to-edge)
ENDOTHELIN H340 6.52x52 TM6 Van der Waals
ENDOTHELIN R343 6.55x55 TM6 Van der Waals
ENDOTHELIN K346 6.58x58 TM6 Van der Waals
ENDOTHELIN Y350 ECL3 Van der Waals
ENDOTHELIN L361 7.28x27 TM7 Van der Waals
ENDOTHELIN L361 7.28x27 TM7 hydrophobic
ENDOTHELIN L365 7.32x31 TM7 hydrophobic
ENDOTHELIN L365 7.32x31 TM7 Van der Waals
ENDOTHELIN D368 7.35x34 TM7 polar (charge-assisted hydrogen bond)
ENDOTHELIN Y369 7.36x35 TM7 hydrophobic
ENDOTHELIN Y369 7.36x35 TM7 Van der Waals
ENDOTHELIN I372 7.39x38 TM7 hydrophobic
ENDOTHELIN I372 7.39x38 TM7 Van der Waals

Ligands

ENDOTHELIN

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Residue Diagrams

S N G I I G L V F V L C S V V T N I Y K 1 A S L A L G D L L H I I V D I P I N V Y K 2 A C L S L V T I G V S A K Q I F P V L K 3 T A V E I V L I W V V S V V L A V P E 4 Y F F A T I A L P L C F Y F S F L W W D K 5 F C L V L V F A L C W L P L H L S R I L 6 I P N I C S N L S A M N I G I Y D L V 7
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ICL1 K C M R N ICL1ECL1 E D W P F ECL1ICL2 W S R I K G I G ICL2ECL2 D I I T M D Y K G S Y L R I C L L H P V Q K ECL2ICL3 Q I A L ICL3ECL3 N Q N D P N ECL3N-term M Q P P P S L C G R A L V A L V L A C G L S R I W G E E R G F P P D R A T P L L Q T A E I M T P P T K T L W P K G S N A S L A R S L A P A E V P K G D R T A G S P P R T I S P P P C N-termC-term W C Q S F E E K Q S L E E K Q S C L K F K A N D H G Y D N F R S S N K Y S S S C-term Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L R I I Y K N G P N I L I A S L A L G D L L H I V I D I P I N V Y K L L A G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A S V P K W T A V E I V L I W V V S V V L A V P E A I G F T A F M Q F Y K T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R K K S G M N D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L S R I L K L T L Y R C E L L S F L L V L D Y I G I N M A S L N S C I N P I A L Y L V S K R F K S F K N C C L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
ETB receptor
ECL1
23x50 23.50x50 W167
TM3
3x32 3.32x32 Q181
3x33 3.33x33 K182
TM4
4x61 4.60x61 E236
ECL2
45x50 45.50x50 C255
45x51 45.51x51 L256
TM5
5x36 5.35x36 K270
5x43 5.42x43 L277
TM6
6x48 6.48x48 W336
6x51 6.51x51 L339
6x52 6.52x52 H340
6x55 6.55x55 R343
6x58 6.58x58 K346
TM7
7x27 7.28x27 L361
7x31 7.32x31 L365
7x34 7.35x34 D368
7x35 7.36x35 Y369
7x38 7.39x38 I372