CB2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

May 10, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

CHEMBL2179724 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

anandamide, 2-arachidonoylglycerol



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 Q 227 5x76 G.H5 F 334 G.H5.06
Van-der-waals TM5 Q 227 5x76 G.H5 F 334 G.H5.06
Polar TM2 S 69 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 69 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 69 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 H 219 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM3 C 134 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 C 134 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 C 134 3x53 G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 143 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 L 135 3x54 G.H5 L 348 G.H5.20
Polar ICL2 P 138 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 138 - G.H5 N 347 G.H5.19
Hydrophobic TM3 R 131 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 141 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 141 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 K 142 - G.H5 D 350 G.H5.22
Aromatic TM6 R 242 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 242 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 239 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 239 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 131 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 131 3x50 G.H5 L 353 G.H5.25
Hydrophobic H8 E 305 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 E 305 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM6 L 239 6x29 G.H5 K 345 G.H5.17
Hydrophobic ICL2 P 138 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 138 - G.H5 I 343 G.H5.15
Polar ICL2 K 142 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 K 142 - G.H5 N 347 G.H5.19
Hydrophobic TM6 L 239 6x29 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 223 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 L 223 5x72 G.H5 D 341 G.H5.13
Polar ICL4 S 303 - G.H5 G 352 G.H5.24
Hydrophobic ICL4 S 303 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 S 303 - G.H5 G 352 G.H5.24
Polar TM2 Y 70 2x40 G.H5 D 350 G.H5.22
Hydrophobic TM2 Y 70 2x40 G.H5 D 350 G.H5.22
Van-der-waals TM2 Y 70 2x40 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 247 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 139 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 P 139 - G.S3 L 194 G.S3.01
Hydrophobic TM5 L 223 5x72 G.H5 D 337 G.H5.09
Polar TM5 H 226 5x75 G.H5 Q 333 G.H5.05
Hydrophobic TM5 H 226 5x75 G.H5 Q 333 G.H5.05
Van-der-waals TM5 H 226 5x75 G.H5 Q 333 G.H5.05
Hydrophobic TM3 L 135 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 138 - G.H5 I 344 G.H5.16
Hydrophobic TM6 L 243 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 243 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 243 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 T 246 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 246 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 Q 227 5x76 G.S6 Y 320 G.S6.02
Van-der-waals TM5 Q 227 5x76 G.S6 Y 320 G.S6.02
Polar H8 G 304 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 239 6x29 G.H5 I 344 G.H5.16
Van-der-waals TM6 L 239 6x29 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 139 - G.H5 I 343 G.H5.15
Polar TM5 S 222 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 S 222 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 S 222 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM2 Y 70 2x40 G.H5 G 352 G.H5.24
Hydrophobic ICL4 S 303 - G.H5 F 354 G.H5.26
Van-der-waals ICL4 S 303 - G.H5 F 354 G.H5.26
Ionic TM5 H 219 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 219 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 219 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 219 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 219 5x68 G.H5 I 344 G.H5.16
Ionic TM5 H 226 5x75 G.H5 D 337 G.H5.09
Hydrophobic ICL1 K 67 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 K 67 - G.H5 D 350 G.H5.22
Polar TM5 H 226 5x75 G.H5 F 334 G.H5.06
Hydrophobic TM5 H 226 5x75 G.H5 F 334 G.H5.06
Van-der-waals TM5 H 226 5x75 G.H5 F 334 G.H5.06
Hydrophobic TM6 L 243 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL4 R 302 - G.H5 L 353 G.H5.25
Van-der-waals ICL4 R 302 - G.H5 L 353 G.H5.25
Polar TM5 H 226 5x75 G.H5 K 330 G.H5.02
Aromatic TM5 H 226 5x75 G.H5 K 330 G.H5.02
Hydrophobic TM5 H 226 5x75 G.H5 K 330 G.H5.02
Van-der-waals TM5 H 226 5x75 G.H5 K 330 G.H5.02
Polar TM3 C 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 134 3x53 G.H5 N 347 G.H5.19