GPCRdb

Refined structure (6WWZ) of G_o - CCR6

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G_i/o

DATE

2024-02-01

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Structure

GPCR

Gα

Gβ

Gγ
Model

AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 210 from structure (59.3%), 144 from model (40.7%)
Residue sidechains - 200 from structure (56.5%), 154 from model (43.5%)

Showing 1 to 354 of 354 entries

Search:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from
	:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from

G.HN	1	M	G.HN.01	AF2	AF2
G.HN	2	G	G.HN.02	AF2	AF2
G.HN	3	C	G.HN.09	AF2	AF2
G.HN	4	T	G.HN.10	AF2	AF2
G.HN	5	L	G.HN.11	Structure	Structure
G.HN	6	S	G.HN.30	Structure	Structure
G.HN	7	A	G.HN.31	Structure	Structure
G.HN	8	E	G.HN.32	Structure	Structure
G.HN	9	E	G.HN.33	Structure	Structure
G.HN	10	R	G.HN.34	Structure	Structure
G.HN	11	A	G.HN.35	Structure	Structure
G.HN	12	A	G.HN.36	Structure	Structure
G.HN	13	L	G.HN.37	Structure	Structure
G.HN	14	E	G.HN.38	Structure	Structure
G.HN	15	R	G.HN.39	Structure	Structure
G.HN	16	S	G.HN.40	Structure	Structure
G.HN	17	K	G.HN.41	Structure	Structure
G.HN	18	A	G.HN.42	Structure	Structure
G.HN	19	I	G.HN.43	Structure	Structure
G.HN	20	E	G.HN.44	Structure	Structure
G.HN	21	K	G.HN.45	Structure	Structure
G.HN	22	N	G.HN.46	Structure	Structure
G.HN	23	L	G.HN.47	Structure	Structure
G.HN	24	K	G.HN.48	Structure	Structure
G.HN	25	E	G.HN.49	Structure	Structure
G.HN	26	D	G.HN.50	Structure	Structure
G.HN	27	G	G.HN.51	Structure	Structure
G.HN	28	I	G.HN.52	Structure	Structure
G.HN	29	S	G.HN.53	Structure	Structure
G.hns1	30	A	G.hns1.01	Structure	Structure
G.hns1	31	A	G.hns1.02	Structure	Structure
G.hns1	32	K	G.hns1.03	Structure	Structure
G.S1	33	D	G.S1.01	Structure	Structure
G.S1	34	V	G.S1.02	Structure	Structure
G.S1	35	K	G.S1.03	Structure	Structure
G.S1	36	L	G.S1.04	Structure	Structure
G.S1	37	L	G.S1.05	Structure	Structure
G.S1	38	L	G.S1.06	Structure	Structure
G.S1	39	L	G.S1.07	Structure	Structure
G.s1h1	40	G	G.s1h1.01	Structure	Structure
G.s1h1	41	A	G.s1h1.02	Structure	Structure
G.s1h1	42	G	G.s1h1.03	Structure	AF2
G.s1h1	43	E	G.s1h1.04	Structure	AF2
G.s1h1	44	S	G.s1h1.05	Structure	Structure
G.s1h1	45	G	G.s1h1.06	Structure	Structure
G.H1	46	K	G.H1.01	Structure	Structure
G.H1	47	S	G.H1.02	Structure	Structure
G.H1	48	T	G.H1.03	Structure	Structure
G.H1	49	I	G.H1.04	Structure	Structure
G.H1	50	V	G.H1.05	Structure	Structure
G.H1	51	K	G.H1.06	Structure	Structure
G.H1	52	Q	G.H1.07	AF2	AF2
G.H1	53	M	G.H1.08	AF2	AF2
G.H1	54	K	G.H1.09	AF2	AF2
G.H1	55	I	G.H1.10	AF2	AF2
G.H1	56	I	G.H1.11	AF2	AF2
G.H1	57	H	G.H1.12	AF2	AF2
G.h1ha	58	E	G.h1ha.01	AF2	AF2
G.h1ha	59	D	G.h1ha.02	AF2	AF2
G.h1ha	60	G	G.h1ha.03	AF2	AF2
G.h1ha	61	F	G.h1ha.04	AF2	AF2
G.h1ha	62	S	G.h1ha.05	AF2	AF2
H.HA	63	G	H.HA.01	AF2	AF2
H.HA	64	E	H.HA.02	AF2	AF2
H.HA	65	D	H.HA.03	AF2	AF2
H.HA	66	V	H.HA.04	AF2	AF2
H.HA	67	K	H.HA.05	AF2	AF2
H.HA	68	Q	H.HA.06	AF2	AF2
H.HA	69	Y	H.HA.07	AF2	AF2
H.HA	70	K	H.HA.08	AF2	AF2
H.HA	71	P	H.HA.09	AF2	AF2
H.HA	72	V	H.HA.10	AF2	AF2
H.HA	73	V	H.HA.11	AF2	AF2
H.HA	74	Y	H.HA.12	AF2	AF2
H.HA	75	S	H.HA.13	AF2	AF2
H.HA	76	N	H.HA.14	AF2	AF2
H.HA	77	T	H.HA.15	AF2	AF2
H.HA	78	I	H.HA.16	AF2	AF2
H.HA	79	Q	H.HA.17	AF2	AF2
H.HA	80	S	H.HA.18	AF2	AF2
H.HA	81	L	H.HA.19	AF2	AF2
H.HA	82	A	H.HA.20	AF2	AF2
H.HA	83	A	H.HA.21	AF2	AF2
H.HA	84	I	H.HA.22	AF2	AF2
H.HA	85	V	H.HA.23	AF2	AF2
H.HA	86	R	H.HA.24	AF2	AF2
H.HA	87	A	H.HA.25	AF2	AF2
H.HA	88	M	H.HA.26	AF2	AF2
H.HA	89	D	H.HA.27	AF2	AF2
H.HA	90	T	H.HA.28	AF2	AF2
H.HA	91	L	H.HA.29	AF2	AF2
H.hahb	92	G	H.hahb.01	AF2	AF2
H.hahb	93	I	H.hahb.04	AF2	AF2
H.hahb	94	E	H.hahb.05	AF2	AF2
H.hahb	95	Y	H.hahb.06	AF2	AF2
H.hahb	96	G	H.hahb.07	AF2	AF2
H.hahb	97	D	H.hahb.08	AF2	AF2
H.hahb	98	K	H.hahb.09	AF2	AF2
H.HB	99	E	H.HB.01	AF2	AF2
H.HB	100	R	H.HB.02	AF2	AF2
H.HB	101	K	H.HB.03	AF2	AF2
H.HB	102	A	H.HB.04	AF2	AF2
H.HB	103	D	H.HB.05	AF2	AF2
H.HB	104	A	H.HB.06	AF2	AF2
H.HB	105	K	H.HB.07	AF2	AF2
H.HB	106	M	H.HB.08	AF2	AF2
H.HB	107	V	H.HB.09	AF2	AF2
H.HB	108	C	H.HB.10	AF2	AF2
H.HB	109	D	H.HB.11	AF2	AF2
H.HB	110	V	H.HB.12	AF2	AF2
H.HB	111	V	H.HB.13	AF2	AF2
H.HB	112	S	H.HB.14	AF2	AF2
H.hbhc	113	R	H.hbhc.01	AF2	AF2
H.hbhc	114	M	H.hbhc.02	AF2	AF2
H.hbhc	115	E	H.hbhc.03	AF2	AF2
H.hbhc	116	D	H.hbhc.04	AF2	AF2
H.hbhc	117	T	H.hbhc.05	AF2	AF2
H.hbhc	118	E	H.hbhc.12	AF2	AF2
H.hbhc	119	P	H.hbhc.13	AF2	AF2
H.hbhc	120	F	H.hbhc.14	AF2	AF2
H.hbhc	121	S	H.hbhc.15	AF2	AF2
H.HC	122	A	H.HC.01	AF2	AF2
H.HC	123	E	H.HC.02	AF2	AF2
H.HC	124	L	H.HC.03	AF2	AF2
H.HC	125	L	H.HC.04	AF2	AF2
H.HC	126	S	H.HC.05	AF2	AF2
H.HC	127	A	H.HC.06	AF2	AF2
H.HC	128	M	H.HC.07	AF2	AF2
H.HC	129	M	H.HC.08	AF2	AF2
H.HC	130	R	H.HC.09	AF2	AF2
H.HC	131	L	H.HC.10	AF2	AF2
H.HC	132	W	H.HC.11	AF2	AF2
H.HC	133	G	H.HC.12	AF2	AF2
H.hchd	134	D	H.hchd.01	AF2	AF2
H.HD	135	S	H.HD.01	AF2	AF2
H.HD	136	G	H.HD.02	AF2	AF2
H.HD	137	I	H.HD.03	AF2	AF2
H.HD	138	Q	H.HD.04	AF2	AF2
H.HD	139	E	H.HD.05	AF2	AF2
H.HD	140	C	H.HD.06	AF2	AF2
H.HD	141	F	H.HD.07	AF2	AF2
H.HD	142	N	H.HD.08	AF2	AF2
H.HD	143	R	H.HD.09	AF2	AF2
H.HD	144	S	H.HD.10	AF2	AF2
H.HD	145	R	H.HD.11	AF2	AF2
H.HD	146	E	H.HD.12	AF2	AF2
H.hdhe	147	Y	H.hdhe.01	AF2	AF2
H.hdhe	148	Q	H.hdhe.02	AF2	AF2
H.hdhe	149	L	H.hdhe.03	AF2	AF2
H.hdhe	150	N	H.hdhe.04	AF2	AF2
H.hdhe	151	D	H.hdhe.05	AF2	AF2
H.HE	152	S	H.HE.01	AF2	AF2
H.HE	153	A	H.HE.02	AF2	AF2
H.HE	154	K	H.HE.03	AF2	AF2
H.HE	155	Y	H.HE.04	AF2	AF2
H.HE	156	Y	H.HE.05	AF2	AF2
H.HE	157	L	H.HE.06	AF2	AF2
H.HE	158	D	H.HE.07	AF2	AF2
H.HE	159	S	H.HE.08	AF2	AF2
H.HE	160	L	H.HE.09	AF2	AF2
H.HE	161	D	H.HE.10	AF2	AF2
H.HE	162	R	H.HE.11	AF2	AF2
H.HE	163	I	H.HE.12	AF2	AF2
H.HE	164	G	H.HE.13	AF2	AF2
H.hehf	165	A	H.hehf.01	AF2	AF2
H.hehf	166	A	H.hehf.02	AF2	AF2
H.hehf	167	D	H.hehf.03	AF2	AF2
H.hehf	168	Y	H.hehf.04	AF2	AF2
H.hehf	169	Q	H.hehf.05	AF2	AF2
H.hehf	170	P	H.hehf.06	AF2	AF2
H.hehf	171	T	H.hehf.07	AF2	AF2
H.HF	172	E	H.HF.01	AF2	AF2
H.HF	173	Q	H.HF.02	AF2	AF2
H.HF	174	D	H.HF.03	AF2	AF2
H.HF	175	I	H.HF.04	AF2	AF2
H.HF	176	L	H.HF.05	AF2	AF2
H.HF	177	R	H.HF.06	AF2	AF2
G.hfs2	178	T	G.hfs2.01	AF2	AF2
G.hfs2	179	R	G.hfs2.02	AF2	AF2
G.hfs2	180	V	G.hfs2.03	AF2	AF2
G.hfs2	181	K	G.hfs2.04	AF2	AF2
G.hfs2	182	T	G.hfs2.05	Structure	Structure
G.hfs2	183	T	G.hfs2.06	Structure	Structure
G.hfs2	184	G	G.hfs2.07	Structure	Structure
G.S2	185	I	G.S2.01	Structure	Structure
G.S2	186	V	G.S2.02	Structure	Structure
G.S2	187	E	G.S2.03	Structure	Structure
G.S2	188	T	G.S2.04	Structure	Structure
G.S2	189	H	G.S2.05	Structure	Structure
G.S2	190	F	G.S2.06	Structure	Structure
G.S2	191	T	G.S2.07	Structure	Structure
G.S2	192	F	G.S2.08	Structure	Structure
G.s2s3	193	K	G.s2s3.01	Structure	Structure
G.s2s3	194	N	G.s2s3.02	Structure	Structure
G.S3	195	L	G.S3.01	Structure	Structure
G.S3	196	H	G.S3.02	Structure	Structure
G.S3	197	F	G.S3.03	Structure	Structure
G.S3	198	R	G.S3.04	Structure	Structure
G.S3	199	L	G.S3.05	Structure	Structure
G.S3	200	F	G.S3.06	Structure	Structure
G.S3	201	D	G.S3.07	Structure	Structure
G.S3	202	V	G.S3.08	Structure	Structure
G.s3h2	203	G	G.s3h2.01	Structure	Structure
G.s3h2	204	G	G.s3h2.02	Structure	Structure
G.s3h2	205	Q	G.s3h2.03	Structure	Structure
G.H2	206	R	G.H2.01	Structure	AF2
G.H2	207	S	G.H2.02	Structure	Structure
G.H2	208	E	G.H2.03	Structure	Structure
G.H2	209	R	G.H2.04	Structure	Structure
G.H2	210	K	G.H2.05	Structure	Structure
G.H2	211	K	G.H2.06	Structure	Structure
G.H2	212	W	G.H2.07	Structure	Structure
G.H2	213	I	G.H2.08	Structure	Structure
G.H2	214	H	G.H2.09	Structure	Structure
G.H2	215	C	G.H2.10	Structure	Structure
G.h2s4	216	F	G.h2s4.01	Structure	Structure
G.h2s4	217	E	G.h2s4.02	Structure	Structure
G.h2s4	218	D	G.h2s4.03	Structure	Structure
G.h2s4	219	V	G.h2s4.04	Structure	Structure
G.h2s4	220	T	G.h2s4.05	Structure	Structure
G.S4	221	A	G.S4.01	Structure	Structure
G.S4	222	I	G.S4.02	Structure	Structure
G.S4	223	I	G.S4.03	Structure	Structure
G.S4	224	F	G.S4.04	Structure	Structure
G.S4	225	C	G.S4.05	Structure	Structure
G.S4	226	V	G.S4.06	Structure	Structure
G.S4	227	A	G.S4.07	Structure	AF2
G.s4h3	228	L	G.s4h3.01	Structure	Structure
G.s4h3	229	S	G.s4h3.02	Structure	Structure
G.s4h3	230	G	G.s4h3.03	Structure	AF2
G.s4h3	231	Y	G.s4h3.04	Structure	Structure
G.s4h3	232	D	G.s4h3.05	AF2	AF2
G.s4h3	233	Q	G.s4h3.06	AF2	AF2
G.s4h3	234	V	G.s4h3.07	AF2	AF2
G.s4h3	235	L	G.s4h3.08	AF2	AF2
G.s4h3	236	H	G.s4h3.09	AF2	AF2
G.s4h3	237	E	G.s4h3.10	AF2	AF2
G.s4h3	238	D	G.s4h3.11	AF2	AF2
G.s4h3	239	E	G.s4h3.12	AF2	AF2
G.s4h3	240	T	G.s4h3.13	AF2	AF2
G.s4h3	241	T	G.s4h3.14	AF2	AF2
G.s4h3	242	N	G.s4h3.15	Structure	Structure
G.H3	243	R	G.H3.01	Structure	Structure
G.H3	244	M	G.H3.02	Structure	Structure
G.H3	245	H	G.H3.03	Structure	Structure
G.H3	246	E	G.H3.04	Structure	Structure
G.H3	247	S	G.H3.05	Structure	Structure
G.H3	248	L	G.H3.06	Structure	Structure
G.H3	249	M	G.H3.07	Structure	Structure
G.H3	250	L	G.H3.08	Structure	AF2
G.H3	251	F	G.H3.09	Structure	Structure
G.H3	252	D	G.H3.10	Structure	Structure
G.H3	253	S	G.H3.11	Structure	Structure
G.H3	254	I	G.H3.12	Structure	Structure
G.H3	255	C	G.H3.13	Structure	Structure
G.H3	256	N	G.H3.14	Structure	Structure
G.H3	257	N	G.H3.15	Structure	Structure
G.H3	258	K	G.H3.16	Structure	Structure
G.H3	259	F	G.H3.17	Structure	Structure
G.H3	260	F	G.H3.18	Structure	Structure
G.h3s5	261	I	G.h3s5.01	Structure	Structure
G.h3s5	262	D	G.h3s5.02	Structure	Structure
G.h3s5	263	T	G.h3s5.03	Structure	Structure
G.S5	264	S	G.S5.01	Structure	Structure
G.S5	265	I	G.S5.02	Structure	Structure
G.S5	266	I	G.S5.03	Structure	Structure
G.S5	267	L	G.S5.04	Structure	Structure
G.S5	268	F	G.S5.05	Structure	Structure
G.S5	269	L	G.S5.06	Structure	Structure
G.S5	270	N	G.S5.07	Structure	Structure
G.s5hg	271	K	G.s5hg.01	Structure	Structure
G.HG	272	K	G.HG.01	Structure	Structure
G.HG	273	D	G.HG.02	Structure	Structure
G.HG	274	L	G.HG.03	Structure	Structure
G.HG	275	F	G.HG.04	Structure	Structure
G.HG	276	G	G.HG.05	Structure	Structure
G.HG	277	E	G.HG.06	Structure	Structure
G.HG	278	K	G.HG.07	Structure	Structure
G.HG	279	I	G.HG.08	Structure	Structure
G.HG	280	K	G.HG.09	Structure	Structure
G.HG	281	K	G.HG.12	Structure	Structure
G.HG	282	S	G.HG.13	Structure	Structure
G.HG	283	P	G.HG.14	Structure	Structure
G.HG	284	L	G.HG.15	Structure	Structure
G.HG	285	T	G.HG.16	Structure	Structure
G.HG	286	I	G.HG.17	Structure	Structure
G.hgh4	287	C	G.hgh4.01	Structure	Structure
G.hgh4	288	F	G.hgh4.02	Structure	Structure
G.hgh4	289	P	G.hgh4.03	Structure	Structure
G.hgh4	290	E	G.hgh4.04	Structure	AF2
G.hgh4	291	Y	G.hgh4.05	Structure	AF2
G.hgh4	292	T	G.hgh4.06	Structure	Structure
G.hgh4	293	G	G.hgh4.07	Structure	Structure
G.hgh4	294	P	G.hgh4.08	Structure	Structure
G.H4	295	N	G.H4.01	Structure	Structure
G.H4	296	T	G.H4.02	Structure	Structure
G.H4	297	Y	G.H4.03	Structure	Structure
G.H4	298	E	G.H4.04	Structure	Structure
G.H4	299	D	G.H4.05	Structure	Structure
G.H4	300	A	G.H4.06	Structure	Structure
G.H4	301	A	G.H4.07	Structure	Structure
G.H4	302	A	G.H4.08	Structure	Structure
G.H4	303	Y	G.H4.10	Structure	Structure
G.H4	304	I	G.H4.11	Structure	Structure
G.H4	305	Q	G.H4.12	Structure	Structure
G.H4	306	A	G.H4.13	Structure	Structure
G.H4	307	Q	G.H4.14	Structure	Structure
G.H4	308	F	G.H4.15	Structure	Structure
G.H4	309	E	G.H4.16	Structure	Structure
G.H4	310	S	G.H4.17	Structure	Structure
G.h4s6	311	K	G.h4s6.01	Structure	Structure
G.h4s6	312	N	G.h4s6.02	Structure	Structure
G.h4s6	313	R	G.h4s6.03	Structure	Structure
G.h4s6	314	S	G.h4s6.08	Structure	Structure
G.h4s6	315	P	G.h4s6.09	Structure	Structure
G.h4s6	316	N	G.h4s6.10	Structure	Structure
G.h4s6	317	K	G.h4s6.11	Structure	Structure
G.h4s6	318	E	G.h4s6.12	Structure	Structure
G.S6	319	I	G.S6.01	Structure	Structure
G.S6	320	Y	G.S6.02	Structure	Structure
G.S6	321	C	G.S6.03	Structure	Structure
G.S6	322	H	G.S6.04	Structure	Structure
G.S6	323	M	G.S6.05	Structure	Structure
G.s6h5	324	T	G.s6h5.01	Structure	Structure
G.s6h5	325	C	G.s6h5.02	Structure	Structure
G.s6h5	326	A	G.s6h5.03	Structure	Structure
G.s6h5	327	T	G.s6h5.04	Structure	Structure
G.s6h5	328	D	G.s6h5.05	Structure	Structure
G.H5	329	T	G.H5.01	Structure	Structure
G.H5	330	N	G.H5.02	Structure	Structure
G.H5	331	N	G.H5.03	Structure	Structure
G.H5	332	I	G.H5.04	Structure	AF2
G.H5	333	Q	G.H5.05	Structure	Structure
G.H5	334	V	G.H5.06	Structure	Structure
G.H5	335	V	G.H5.07	Structure	AF2
G.H5	336	F	G.H5.08	Structure	Structure
G.H5	337	D	G.H5.09	Structure	Structure
G.H5	338	A	G.H5.10	Structure	Structure
G.H5	339	V	G.H5.11	Structure	Structure
G.H5	340	T	G.H5.12	Structure	Structure
G.H5	341	D	G.H5.13	Structure	Structure
G.H5	342	I	G.H5.14	Structure	Structure
G.H5	343	I	G.H5.15	Structure	Structure
G.H5	344	I	G.H5.16	Structure	Structure
G.H5	345	A	G.H5.17	Structure	Structure
G.H5	346	N	G.H5.18	Structure	Structure
G.H5	347	N	G.H5.19	Structure	Structure
G.H5	348	L	G.H5.20	Structure	Structure
G.H5	349	R	G.H5.21	Structure	Structure
G.H5	350	G	G.H5.22	Structure	Structure
G.H5	351	C	G.H5.23	Structure	Structure
G.H5	352	G	G.H5.24	Structure	Structure
G.H5	353	L	G.H5.25	Structure	Structure
G.H5	354	Y	G.H5.26	Structure	Structure

REFINED GPCR RESIDUES

Residue backbones - 310 from structure (89.9%), 35 from model (10.1%)
Residue sidechains - 306 from structure (88.7%), 39 from model (11.3%)

Showing 1 to 345 of 345 entries

Search:

Segment	Seq.num.	AA	GPCRdb#	Backbone from	Sidechain from

N-term	1	M	-	AF2	AF2
N-term	2	S	-	AF2	AF2
N-term	3	G	-	AF2	AF2
N-term	4	E	-	AF2	AF2
N-term	5	S	-	AF2	AF2
N-term	6	M	-	AF2	AF2
N-term	7	N	-	AF2	AF2
N-term	8	F	-	AF2	AF2
N-term	9	S	-	AF2	AF2
N-term	10	D	-	AF2	AF2
N-term	11	V	-	AF2	AF2
N-term	12	F	-	AF2	AF2
N-term	13	D	-	AF2	AF2
N-term	14	S	-	AF2	AF2
N-term	15	S	-	AF2	AF2
N-term	16	E	-	AF2	AF2
N-term	17	D	-	AF2	AF2
N-term	18	Y	-	AF2	AF2
N-term	19	F	-	AF2	AF2
N-term	20	V	-	AF2	AF2
N-term	21	S	-	AF2	AF2
N-term	22	V	-	AF2	AF2
N-term	23	N	-	AF2	AF2
N-term	24	T	-	AF2	AF2
N-term	25	S	-	AF2	AF2
N-term	26	Y	-	AF2	AF2
N-term	27	Y	-	Structure	Structure
N-term	28	S	-	Structure	Structure
N-term	29	V	-	Structure	Structure
N-term	30	D	-	Structure	AF2
N-term	31	S	-	Structure	Structure
N-term	32	E	-	Structure	Structure
N-term	33	M	-	Structure	AF2
N-term	34	L	-	Structure	Structure
N-term	35	L	-	Structure	Structure
N-term	36	C	-	Structure	Structure
N-term	37	S	-	Structure	Structure
N-term	38	L	-	Structure	Structure
TM1	39	Q	1.25x25	Structure	Structure
TM1	40	E	1.26x26	Structure	Structure
TM1	41	V	1.27x27	Structure	Structure
TM1	42	R	1.28x28	Structure	Structure
TM1	43	Q	1.29x29	Structure	Structure
TM1	44	F	1.30x30	Structure	Structure
TM1	45	S	1.31x31	Structure	Structure
TM1	46	R	1.32x32	Structure	Structure
TM1	47	L	1.33x33	Structure	Structure
TM1	48	F	1.34x34	Structure	Structure
TM1	49	V	1.35x35	Structure	Structure
TM1	50	P	1.36x36	Structure	Structure
TM1	51	I	1.37x37	Structure	Structure
TM1	52	A	1.38x38	Structure	Structure
TM1	53	Y	1.39x39	Structure	Structure
TM1	54	S	1.40x40	Structure	Structure
TM1	55	L	1.41x41	Structure	Structure
TM1	56	I	1.42x42	Structure	Structure
TM1	57	C	1.43x43	Structure	Structure
TM1	58	V	1.44x44	Structure	Structure
TM1	59	F	1.45x45	Structure	Structure
TM1	60	G	1.46x46	Structure	Structure
TM1	61	L	1.47x47	Structure	Structure
TM1	62	L	1.48x48	Structure	Structure
TM1	63	G	1.49x49	Structure	Structure
TM1	64	N	1.50x50	Structure	Structure
TM1	65	I	1.51x51	Structure	Structure
TM1	66	L	1.52x52	Structure	Structure
TM1	67	V	1.53x53	Structure	Structure
TM1	68	V	1.54x54	Structure	Structure
TM1	69	I	1.55x55	Structure	Structure
TM1	70	T	1.56x56	Structure	Structure
TM1	71	F	1.57x57	Structure	Structure
TM1	72	A	1.58x58	Structure	Structure
TM1	73	F	1.59x59	Structure	Structure
TM1	74	Y	1.60x60	Structure	Structure
ICL1	75	K	12.48x48	Structure	Structure
ICL1	76	K	12.49x49	Structure	AF2
ICL1	77	A	12.50x50	Structure	Structure
ICL1	78	R	12.51x51	Structure	Structure
TM2	79	S	2.37x37	Structure	Structure
TM2	80	M	2.38x38	Structure	Structure
TM2	81	T	2.39x39	Structure	Structure
TM2	82	D	2.40x40	Structure	Structure
TM2	83	V	2.41x41	Structure	Structure
TM2	84	Y	2.42x42	Structure	Structure
TM2	85	L	2.43x43	Structure	Structure
TM2	86	L	2.44x44	Structure	Structure
TM2	87	N	2.45x45	Structure	Structure
TM2	88	M	2.46x46	Structure	Structure
TM2	89	A	2.47x47	Structure	Structure
TM2	90	I	2.48x48	Structure	Structure
TM2	91	A	2.49x49	Structure	Structure
TM2	92	D	2.50x50	Structure	Structure
TM2	93	I	2.51x51	Structure	Structure
TM2	94	L	2.52x52	Structure	Structure
TM2	95	F	2.53x53	Structure	Structure
TM2	96	V	2.54x54	Structure	Structure
TM2	97	L	2.55x55	Structure	Structure
TM2	98	T	2.56x56	Structure	Structure
TM2	99	L	2.57x57	Structure	Structure
TM2	100	P	2.58x58	Structure	Structure
TM2	101	F	2.59x59	Structure	Structure
TM2	102	W	2.60x60	Structure	Structure
TM2	103	A	2.61x61	Structure	Structure
TM2	104	V	2.62x62	Structure	Structure
TM2	105	S	2.63x63	Structure	Structure
TM2	106	H	2.64x64	Structure	Structure
TM2	107	A	2.65x65	Structure	Structure
TM2	108	T	2.66x66	Structure	Structure
TM2	109	G	2.67x67	Structure	Structure
ECL1	110	A	23.49x49	Structure	Structure
ECL1	111	W	23.50x50	Structure	Structure
ECL1	112	V	23.51x51	Structure	Structure
ECL1	113	F	23.52x52	Structure	Structure
TM3	114	S	3.21x21	Structure	Structure
TM3	115	N	3.22x22	Structure	Structure
TM3	116	A	3.23x23	Structure	Structure
TM3	117	T	3.24x24	Structure	Structure
TM3	118	C	3.25x25	Structure	Structure
TM3	119	K	3.26x26	Structure	Structure
TM3	120	L	3.27x27	Structure	Structure
TM3	121	L	3.28x28	Structure	Structure
TM3	122	K	3.29x29	Structure	Structure
TM3	123	G	3.30x30	Structure	Structure
TM3	124	I	3.31x31	Structure	Structure
TM3	125	Y	3.32x32	Structure	Structure
TM3	126	A	3.33x33	Structure	Structure
TM3	127	I	3.34x34	Structure	Structure
TM3	128	N	3.35x35	Structure	Structure
TM3	129	F	3.36x36	Structure	Structure
TM3	130	N	3.37x37	Structure	Structure
TM3	131	C	3.38x38	Structure	Structure
TM3	132	G	3.39x39	Structure	Structure
TM3	133	M	3.40x40	Structure	Structure
TM3	134	L	3.41x41	Structure	Structure
TM3	135	L	3.42x42	Structure	Structure
TM3	136	L	3.43x43	Structure	Structure
TM3	137	T	3.44x44	Structure	Structure
TM3	138	C	3.45x45	Structure	Structure
TM3	139	I	3.46x46	Structure	Structure
TM3	140	S	3.47x47	Structure	Structure
TM3	141	M	3.48x48	Structure	Structure
TM3	142	D	3.49x49	Structure	Structure
TM3	143	R	3.50x50	Structure	Structure
TM3	144	Y	3.51x51	Structure	Structure
TM3	145	I	3.52x52	Structure	Structure
TM3	146	A	3.53x53	Structure	Structure
TM3	147	I	3.54x54	Structure	Structure
TM3	148	V	3.55x55	Structure	Structure
TM3	149	Q	3.56x56	Structure	Structure
ICL2	150	A	34.50x50	Structure	Structure
ICL2	151	T	34.51x51	Structure	Structure
ICL2	152	K	34.52x52	Structure	Structure
ICL2	153	S	34.53x53	Structure	Structure
ICL2	154	F	34.54x54	Structure	Structure
ICL2	155	R	34.55x55	Structure	Structure
ICL2	156	L	34.56x56	Structure	Structure
ICL2	157	R	-	Structure	Structure
ICL2	158	S	-	Structure	Structure
ICL2	159	R	-	Structure	Structure
TM4	160	T	4.38x38	Structure	Structure
TM4	161	L	4.39x39	Structure	Structure
TM4	162	P	4.40x40	Structure	Structure
TM4	163	R	4.41x41	Structure	Structure
TM4	164	S	4.42x42	Structure	Structure
TM4	165	K	4.43x43	Structure	Structure
TM4	166	I	4.44x44	Structure	Structure
TM4	167	I	4.45x45	Structure	Structure
TM4	168	C	4.46x46	Structure	Structure
TM4	169	L	4.47x47	Structure	Structure
TM4	170	V	4.48x48	Structure	Structure
TM4	171	V	4.49x49	Structure	Structure
TM4	172	W	4.50x50	Structure	Structure
TM4	173	G	4.51x51	Structure	Structure
TM4	174	L	4.52x52	Structure	Structure
TM4	175	S	4.53x53	Structure	Structure
TM4	176	V	4.54x54	Structure	Structure
TM4	177	I	4.55x55	Structure	Structure
TM4	178	I	4.56x56	Structure	Structure
TM4	179	S	4.57x57	Structure	Structure
TM4	180	S	4.58x59	Structure	Structure
TM4	181	S	4.59x60	Structure	Structure
TM4	182	T	4.60x61	Structure	Structure
TM4	183	F	4.61x62	Structure	Structure
TM4	184	V	4.62x63	Structure	Structure
TM4	185	F	4.63x64	Structure	Structure
TM4	186	N	4.64x65	Structure	Structure
ECL2	187	Q	-	Structure	Structure
ECL2	188	K	-	Structure	Structure
ECL2	189	Y	-	Structure	Structure
ECL2	190	N	-	Structure	Structure
ECL2	191	T	-	Structure	Structure
ECL2	192	Q	-	Structure	Structure
ECL2	193	G	-	Structure	Structure
ECL2	194	S	-	Structure	Structure
ECL2	195	D	-	Structure	Structure
ECL2	196	V	-	Structure	Structure
ECL2	197	C	45.50x50	Structure	Structure
ECL2	198	E	45.51x51	Structure	Structure
ECL2	199	P	45.52x52	Structure	Structure
ECL2	200	K	-	Structure	Structure
ECL2	201	Y	-	Structure	Structure
ECL2	202	Q	-	Structure	Structure
ECL2	203	T	-	Structure	Structure
ECL2	204	V	-	Structure	Structure
ECL2	205	S	-	Structure	Structure
ECL2	206	E	-	Structure	Structure
TM5	207	P	5.31x32	Structure	Structure
TM5	208	I	5.32x33	Structure	Structure
TM5	209	R	5.33x34	Structure	Structure
TM5	210	W	5.34x35	Structure	Structure
TM5	211	K	5.35x36	Structure	Structure
TM5	212	L	5.36x37	Structure	Structure
TM5	213	L	5.37x38	Structure	Structure
TM5	214	M	5.38x39	Structure	Structure
TM5	215	L	5.39x40	Structure	Structure
TM5	216	G	5.40x41	Structure	Structure
TM5	217	L	5.41x42	Structure	Structure
TM5	218	E	5.42x43	Structure	Structure
TM5	219	L	5.43x44	Structure	Structure
TM5	220	L	5.44x45	Structure	Structure
TM5	221	F	5.45x46	Structure	Structure
TM5	222	G	5.46x461	Structure	Structure
TM5	223	F	5.47x47	Structure	Structure
TM5	224	F	5.48x48	Structure	Structure
TM5	225	I	5.49x49	Structure	Structure
TM5	226	P	5.50x50	Structure	Structure
TM5	227	L	5.51x51	Structure	Structure
TM5	228	M	5.52x52	Structure	Structure
TM5	229	F	5.53x53	Structure	Structure
TM5	230	M	5.54x54	Structure	Structure
TM5	231	I	5.55x55	Structure	Structure
TM5	232	F	5.56x56	Structure	Structure
TM5	233	C	5.57x57	Structure	Structure
TM5	234	Y	5.58x58	Structure	Structure
TM5	235	T	5.59x59	Structure	Structure
TM5	236	F	5.60x60	Structure	Structure
TM5	237	I	5.61x61	Structure	Structure
TM5	238	V	5.62x62	Structure	Structure
TM5	239	K	5.63x63	Structure	Structure
TM5	240	T	5.64x64	Structure	Structure
TM5	241	L	5.65x65	Structure	Structure
TM5	242	V	5.66x66	Structure	Structure
TM5	243	Q	5.67x67	Structure	Structure
TM5	244	A	5.68x68	Structure	Structure
ICL3	245	Q	-	Structure	Structure
ICL3	246	N	-	Structure	Structure
TM6	247	S	6.28x28	Structure	Structure
TM6	248	K	6.29x29	Structure	Structure
TM6	249	R	6.30x30	Structure	Structure
TM6	250	H	6.31x31	Structure	Structure
TM6	251	K	6.32x32	Structure	Structure
TM6	252	A	6.33x33	Structure	Structure
TM6	253	I	6.34x34	Structure	Structure
TM6	254	R	6.35x35	Structure	Structure
TM6	255	V	6.36x36	Structure	Structure
TM6	256	I	6.37x37	Structure	Structure
TM6	257	I	6.38x38	Structure	Structure
TM6	258	A	6.39x39	Structure	Structure
TM6	259	V	6.40x40	Structure	Structure
TM6	260	V	6.41x41	Structure	Structure
TM6	261	L	6.42x42	Structure	Structure
TM6	262	V	6.43x43	Structure	Structure
TM6	263	F	6.44x44	Structure	Structure
TM6	264	L	6.45x45	Structure	Structure
TM6	265	A	6.46x46	Structure	Structure
TM6	266	C	6.47x47	Structure	Structure
TM6	267	Q	6.48x48	Structure	Structure
TM6	268	I	6.49x49	Structure	Structure
TM6	269	P	6.50x50	Structure	Structure
TM6	270	H	6.51x51	Structure	Structure
TM6	271	N	6.52x52	Structure	Structure
TM6	272	M	6.53x53	Structure	Structure
TM6	273	V	6.54x54	Structure	Structure
TM6	274	L	6.55x55	Structure	Structure
TM6	275	L	6.56x56	Structure	Structure
TM6	276	V	6.57x57	Structure	Structure
TM6	277	T	6.58x58	Structure	Structure
TM6	278	A	6.59x59	Structure	Structure
TM6	279	A	6.60x60	Structure	Structure
TM6	280	N	6.61x61	Structure	Structure
TM6	281	L	6.62x62	Structure	Structure
TM6	282	G	6.63x63	Structure	Structure
TM6	283	K	6.64x64	Structure	Structure
TM6	284	M	6.65x65	Structure	Structure
ECL3	285	N	-	Structure	Structure
ECL3	286	R	-	Structure	Structure
TM7	287	S	7.24x23	Structure	Structure
TM7	288	C	7.25x24	Structure	Structure
TM7	289	Q	7.26x25	Structure	Structure
TM7	290	S	7.27x26	Structure	Structure
TM7	291	E	7.28x27	Structure	Structure
TM7	292	K	7.29x28	Structure	Structure
TM7	293	L	7.30x29	Structure	Structure
TM7	294	I	7.31x30	Structure	Structure
TM7	295	G	7.32x31	Structure	Structure
TM7	296	Y	7.33x32	Structure	Structure
TM7	297	T	7.34x33	Structure	Structure
TM7	298	K	7.35x34	Structure	Structure
TM7	299	T	7.36x35	Structure	Structure
TM7	300	V	7.37x36	Structure	Structure
TM7	301	T	7.38x37	Structure	Structure
TM7	302	E	7.39x38	Structure	Structure
TM7	303	V	7.40x39	Structure	Structure
TM7	304	L	7.41x40	Structure	Structure
TM7	305	A	7.42x41	Structure	Structure
TM7	306	F	7.43x42	Structure	Structure
TM7	307	L	7.44x43	Structure	Structure
TM7	308	H	7.45x45	Structure	Structure
TM7	309	C	7.46x46	Structure	Structure
TM7	310	C	7.47x47	Structure	Structure
TM7	311	L	7.48x48	Structure	Structure
TM7	312	N	7.49x49	Structure	Structure
TM7	313	P	7.50x50	Structure	Structure
TM7	314	V	7.51x51	Structure	Structure
TM7	315	L	7.52x52	Structure	Structure
TM7	316	Y	7.53x53	Structure	Structure
TM7	317	A	7.54x54	Structure	Structure
TM7	318	F	7.55x55	Structure	Structure
TM7	319	I	7.56x56	Structure	Structure
H8	320	G	8.47x47	Structure	Structure
H8	321	Q	8.48x48	Structure	Structure
H8	322	K	8.49x49	Structure	Structure
H8	323	F	8.50x50	Structure	Structure
H8	324	R	8.51x51	Structure	Structure
H8	325	N	8.52x52	Structure	Structure
H8	326	Y	8.53x53	Structure	Structure
H8	327	F	8.54x54	Structure	Structure
H8	328	L	8.55x55	Structure	Structure
H8	329	K	8.56x56	Structure	Structure
H8	330	I	8.57x57	Structure	Structure
H8	331	L	8.58x58	Structure	Structure
H8	332	K	8.59x59	Structure	Structure
H8	333	D	8.60x60	Structure	AF2
H8	334	L	8.61x61	Structure	Structure
H8	335	W	8.62x62	Structure	Structure
C-term	336	C	-	Structure	Structure
C-term	337	V	-	AF2	AF2
C-term	338	R	-	AF2	AF2
C-term	339	R	-	AF2	AF2
C-term	340	K	-	AF2	AF2
C-term	341	Y	-	AF2	AF2
C-term	342	K	-	AF2	AF2
C-term	343	S	-	AF2	AF2
C-term	344	S	-	AF2	AF2
C-term	345	G	-	AF2	AF2

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Aromatic	TM6	K	251	6x32	G.H5	Y	354	G.H5.26
Hydrophobic	TM2	T	81	2x39	G.H5	G	350	G.H5.22
Hydrophobic	ICL3	Q	245	-	G.S6	Y	320	G.S6.02
Hydrophobic	TM3	R	143	3x50	G.H5	L	353	G.H5.25
Hydrophobic	TM6	K	248	6x29	G.H5	Y	354	G.H5.26
Hydrophobic	ICL2	R	157	-	G.hns1	K	32	G.hns1.03
Hydrophobic	ICL2	F	154	34x54	G.S1	D	33	G.S1.01
Hydrophobic	ICL3	Q	245	-	G.H5	D	341	G.H5.13
Hydrophobic	ICL2	R	157	-	G.hns1	A	31	G.hns1.02
Hydrophobic	TM3	A	146	3x53	G.H5	C	351	G.H5.23
Hydrophobic	ICL2	A	150	34x50	G.H5	I	343	G.H5.15
Hydrophobic	ICL2	A	150	34x50	G.H5	I	344	G.H5.16
Hydrophobic	TM6	I	256	6x37	G.H5	L	353	G.H5.25
Hydrophobic	TM6	A	252	6x33	G.H5	L	353	G.H5.25
Hydrophobic	H8	Q	321	8x48	G.H5	Y	354	G.H5.26
Hydrophobic	TM3	R	143	3x50	G.H5	C	351	G.H5.23
Hydrophobic	ICL2	F	154	34x54	G.S1	V	34	G.S1.02
Hydrophobic	ICL2	R	155	34x55	G.S3	L	195	G.S3.01
Hydrophobic	TM6	A	252	6x33	G.H5	L	348	G.H5.20
Hydrophobic	TM5	L	241	5x65	G.H5	L	348	G.H5.20
Hydrophobic	TM2	T	81	2x39	G.H5	C	351	G.H5.23
Hydrophobic	TM6	K	251	6x32	G.H5	Y	354	G.H5.26
Hydrophobic	TM3	I	147	3x54	G.H5	L	348	G.H5.20
Hydrophobic	ICL2	R	155	34x55	G.s2s3	N	194	G.s2s3.02
Polar	TM3	A	146	3x53	G.H5	N	347	G.H5.19
Polar	H8	G	320	8x47	G.H5	G	352	G.H5.24
Polar	TM6	S	247	6x28	G.h4s6	E	318	G.h4s6.12
Polar	TM6	K	248	6x29	G.H5	A	345	G.H5.17
Polar	ICL3	Q	245	-	G.H5	D	341	G.H5.13
Polar	H8	Q	321	8x48	G.H5	Y	354	G.H5.26
Polar	ICL2	R	155	34x55	G.s2s3	N	194	G.s2s3.02
Van-der-waals	TM7	I	319	7x56	G.H5	Y	354	G.H5.26
Van-der-waals	TM3	A	146	3x53	G.H5	N	347	G.H5.19
Van-der-waals	TM2	T	81	2x39	G.H5	G	350	G.H5.22
Van-der-waals	ICL3	Q	245	-	G.S6	Y	320	G.S6.02
Van-der-waals	TM3	R	143	3x50	G.H5	L	353	G.H5.25
Van-der-waals	TM6	K	248	6x29	G.H5	Y	354	G.H5.26
Van-der-waals	H8	G	320	8x47	G.H5	G	352	G.H5.24
Van-der-waals	H8	Q	321	8x48	G.H5	Y	354	G.H5.26
Van-der-waals	TM6	K	251	6x32	G.H5	Y	354	G.H5.26
Van-der-waals	ICL3	N	246	-	G.H5	A	345	G.H5.17
Van-der-waals	TM3	I	147	3x54	G.H5	L	348	G.H5.20
Van-der-waals	ICL2	R	155	34x55	G.s2s3	N	194	G.s2s3.02

Showing 1 to 43 of 43 entries

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Main reference

Refined structure (6WWZ) of Go - CCR6 Download Full

GPCR CLASS (FAMILY)

SPECIES

G PROTEIN FAMILY

DATE

3D VIEW

REFINED G PROTEIN RESIDUES

REFINED GPCR RESIDUES

GPCR - G protein interface interactions

Structures

Refined structure (6WWZ) of G_o - CCR6

Full