CCR6 - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6WWZ

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41467-020-16820-6

PUBLICATION DATE

June 24, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

59 interactions (Click to see)

LIGANDS

CCL20 - Agonist gtoplig

PHYSIOLOGICAL LIGANDS

CCL20, beta-defensin 4A



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 241 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 K 248 - G.H5 Y 354 G.H5.26
Van-der-waals ICL3 K 248 - G.H5 Y 354 G.H5.26
Hydrophobic ICL3 Q 245 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 Q 245 - G.S6 Y 320 G.S6.02
Polar H8 G 320 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 320 8x47 G.H5 G 352 G.H5.24
Van-der-waals ICL3 N 246 - G.H5 A 345 G.H5.17
Hydrophobic TM2 T 81 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 A 252 6x33 G.H5 L 348 G.H5.20
Polar H8 Q 321 8x48 G.H5 Y 354 G.H5.26
Hydrophobic H8 Q 321 8x48 G.H5 Y 354 G.H5.26
Van-der-waals H8 Q 321 8x48 G.H5 Y 354 G.H5.26
Polar ICL3 Q 245 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 Q 245 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 A 150 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 R 155 34x55 G.S3 L 195 G.S3.01
Hydrophobic ICL2 A 150 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM2 T 81 2x39 G.H5 G 350 G.H5.22
Van-der-waals TM2 T 81 2x39 G.H5 G 350 G.H5.22
Hydrophobic ICL2 R 157 - G.hns1 K 32 G.hns1.03
Polar ICL3 S 247 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 A 252 6x33 G.H5 L 353 G.H5.25
Polar ICL2 R 155 34x55 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 R 155 34x55 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 R 155 34x55 G.s2s3 N 194 G.s2s3.02
Aromatic TM6 K 251 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 251 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 251 6x32 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 F 154 34x54 G.S1 V 34 G.S1.02
Hydrophobic TM3 A 146 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 F 154 34x54 G.S1 D 33 G.S1.01
Hydrophobic TM3 I 147 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 147 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 143 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 I 256 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 157 - G.hns1 A 31 G.hns1.02
Polar TM3 A 146 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 146 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM7 I 319 7x56 G.H5 Y 354 G.H5.26
Hydrophobic TM3 R 143 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 143 3x50 G.H5 L 353 G.H5.25
Polar ICL3 K 248 - G.H5 A 345 G.H5.17