DP2 receptor (pd2r2_human)

FAMILY

Class A (Rhodopsin) Lipid receptors Prostanoid receptors DP2 receptor

GENE

PTGDR2 (CRTH2, DL1R, GPR44)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Prostaglandin D2 receptor 2, Chemoattractant receptor-homologous molecule expressed on Th2 cells, G-protein coupled receptor 44, CD294

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
S
A
N
A
T
L
K
P
L
10
                   
C
P
I
L
E
Q
M
S
R
L
20
                   
Q
S
H
S
N
T
S
I
R
Y
30
  TM1            
I
D
H
A
A
V
L
L
H
G
40
                   
L
A
S
L
L
G
L
V
E
N
50
                   
G
V
I
L
F
V
V
G
C
R
60
ICL1 TM2      
M
R
Q
T
V
V
T
T
W
V
70
                   
L
H
L
A
L
S
D
L
L
A
80
                   
S
A
S
L
P
F
F
T
Y
F
90
        ECL1    
L
A
V
G
H
S
W
E
L
G
100
TM3              
T
T
F
C
K
L
H
S
S
I
110
                   
F
F
L
N
M
F
A
S
G
F
120
                   
L
L
S
A
I
S
L
D
R
C
130
          ICL2  
L
Q
V
V
R
P
V
W
A
Q
140
      TM4        
N
H
R
T
V
A
A
A
H
K
150
                   
V
C
L
V
L
W
A
L
A
V
160
                   
L
N
T
V
P
Y
F
V
F
R
170
ECL2            
D
T
I
S
R
L
D
G
R
I
180
                   
M
C
Y
Y
N
V
L
L
L
N
190
      TM5        
P
G
P
D
R
D
A
T
C
N
200
                   
S
R
Q
V
A
L
A
V
S
K
210
                   
F
L
L
A
F
L
V
P
L
A
220
                   
I
I
A
S
S
H
A
A
V
S
230
            ICL3
L
R
L
Q
H
R
G
R
R
R
240
TM6              
P
G
R
F
V
R
L
V
A
A
250
                   
V
V
A
A
F
A
L
C
W
G
260
                   
P
Y
H
V
F
S
L
L
E
A
270
    ECL3   TM7
R
A
H
A
N
P
G
L
R
P
280
                   
L
V
W
R
G
L
P
F
V
T
290
                   
S
L
A
F
F
N
S
V
A
N
300
              H8  
P
V
L
Y
V
L
T
C
P
D
310
                   
M
L
R
K
L
R
R
S
L
R
320
                   
T
V
L
E
S
V
L
V
D
D
330
C-term        
S
E
L
G
G
A
G
S
S
R
340
                   
R
R
R
T
S
S
T
A
R
S
350
                   
A
S
P
L
A
L
C
S
R
P
360
                   
E
E
P
R
G
P
A
R
L
L
370
                   
G
W
L
L
G
S
C
A
A
S
380
                   
P
Q
T
G
P
L
N
R
A
L
390
         
S
S
T
S
S

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 M R Q ICL1ECL1 H S W E L ECL1ICL2 P V W A Q N H R ICL2ECL2 D T I S R L D G R I M C Y Y N V L L L N P G P ECL2ICL3 G R R R ICL3ECL3 H A N P G ECL3N-term M S A N A T L K P L C P I L E Q M S R L Q S H S N T S I R Y I N-termC-term V L V D D S E L G G A G S S R R R R T S S T A R S A S P L A L C S R P E E P R G P A R L L G W L L G S C A A S P Q T G P L N R A L S S T S S C-term D H A A V L L H G L A S L L G L V E N G V I L F V V G C R T V V T T W V L H L A L S D L L A S A S L P F F T Y F L A V G G T T F C K L H S S I F F L N M F A S G F L L S A I S L D R C L Q V V R T V A A A H K V C L V L W A L A V L N T V P Y F V F R D R D A T C N S R Q V A L A V S K F L L A F L V P L A I I A S S H A A V S L R L Q H R P G R F V R L V A A V V A A F A L C W G P Y H V F S L L E A R A L R P L V W R G L P F V T S L A F F N S V A N P V L Y V L T C P D L R R V L E M L R K S L R T S
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N E V L G L L S A L G H L L V A A H D 1 L H L A L S D L L A S A S L P F F T Y F 2 A S L L F G S A F M N L F F I S S H L K 3 A H K V C L V L W A L A V L N T V P Y 4 H S S A I I A L P V L F A L L F K S V A L 5 A A V V A A F A L C W G P Y H V F S L L 6 V P N A V S N F F A L S T V F P L G R 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

PGJ2, PGI2, PGD3, thromboxane A2, PGF2α, PGD2, PGE2

STRUCTURE MODELS

pd2r2_human inactive,

pd2r2_human active

STRUCTURES

Found 3 structure(s) - view all details on the Structures page

PDBs: 6D26, 6D27, 7M8W