NMU1 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7W53

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41467-022-29683-W

PUBLICATION DATE

April 20, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

78 interactions (Click to see)

LIGANDS

Neuromedin U-25 (human) - Agonist pubchem

PHYSIOLOGICAL LIGANDS

neuromedin S-36, neuromedin S-33, neuromedin U-23, neuromedin U-25



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 167 34x51 G.S3 V 194 G.S3.01
Van-der-waals ICL2 L 167 34x51 G.S3 V 194 G.S3.01
Hydrophobic TM5 L 258 5x65 G.H5 L 355 G.H5.20
Polar TM3 A 162 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 A 162 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 A 162 3x53 G.H5 N 354 G.H5.19
Hydrophobic ICL2 L 167 34x51 G.H5 I 350 G.H5.15
Van-der-waals ICL2 L 167 34x51 G.H5 I 350 G.H5.15
Hydrophobic ICL2 V 173 34x57 G.H5 Y 358 G.H5.23
Van-der-waals ICL2 V 173 34x57 G.H5 Y 358 G.H5.23
Ionic H8 R 362 8x49 G.H5 E 357 G.H5.22
Polar H8 R 362 8x49 G.H5 E 357 G.H5.22
Hydrophobic H8 R 362 8x49 G.H5 E 357 G.H5.22
Hydrophobic TM3 V 163 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 V 163 3x54 G.H5 L 355 G.H5.20
Polar ICL2 R 170 34x54 G.S1 T 33 G.S1.01
Van-der-waals ICL2 R 170 34x54 G.S1 T 33 G.S1.01
Polar H8 S 360 8x47 G.H5 N 359 G.H5.24
Hydrophobic H8 S 360 8x47 G.H5 N 359 G.H5.24
Van-der-waals H8 S 360 8x47 G.H5 N 359 G.H5.24
Hydrophobic H8 F 363 8x50 G.H5 N 359 G.H5.24
Van-der-waals H8 F 363 8x50 G.H5 N 359 G.H5.24
Polar ICL2 R 170 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 170 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 S 171 34x55 G.hns1 R 32 G.hns1.03
Polar TM2 T 95 2x39 G.H5 E 357 G.H5.22
Hydrophobic TM2 T 95 2x39 G.H5 E 357 G.H5.22
Polar ICL2 P 166 34x50 G.H5 N 354 G.H5.19
Van-der-waals ICL2 P 166 34x50 G.H5 N 354 G.H5.19
Polar TM3 R 159 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 159 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 159 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM5 L 258 5x65 G.H5 L 351 G.H5.16
Hydrophobic TM5 E 261 5x68 G.H5 L 351 G.H5.16
Van-der-waals TM5 E 261 5x68 G.H5 L 351 G.H5.16
Hydrophobic TM3 V 163 3x54 G.H5 L 360 G.H5.25
Van-der-waals TM3 V 163 3x54 G.H5 L 360 G.H5.25
Polar TM2 T 93 2x37 G.H5 E 357 G.H5.22
Van-der-waals TM2 T 93 2x37 G.H5 E 357 G.H5.22
Hydrophobic ICL2 R 170 34x54 G.H5 I 350 G.H5.15
Van-der-waals ICL2 R 170 34x54 G.H5 I 350 G.H5.15
Hydrophobic TM6 V 295 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 V 295 6x33 G.H5 L 360 G.H5.25
Hydrophobic ICL2 P 166 34x50 G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 166 34x50 G.H5 I 350 G.H5.15
Hydrophobic TM3 R 159 3x50 G.H5 L 360 G.H5.25
Van-der-waals TM3 R 159 3x50 G.H5 L 360 G.H5.25
Polar ICL2 S 171 34x55 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 S 171 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 R 170 34x54 G.S1 L 34 G.S1.02
Van-der-waals ICL2 R 170 34x54 G.S1 L 34 G.S1.02
Hydrophobic ICL2 L 167 34x51 G.S1 L 34 G.S1.02
Van-der-waals ICL2 A 169 34x53 G.H5 Y 358 G.H5.23
Hydrophobic TM6 L 299 6x37 G.H5 L 360 G.H5.25
Van-der-waals TM6 L 299 6x37 G.H5 L 360 G.H5.25
Hydrophobic H8 R 362 8x49 G.H5 R 356 G.H5.21
Van-der-waals H8 R 362 8x49 G.H5 R 356 G.H5.21
Hydrophobic ICL2 P 166 34x50 G.H5 L 351 G.H5.16
Van-der-waals ICL2 P 166 34x50 G.H5 L 351 G.H5.16
Hydrophobic TM2 L 99 2x43 G.H5 N 359 G.H5.24
Van-der-waals TM2 L 99 2x43 G.H5 N 359 G.H5.24
Polar TM3 E 158 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM3 E 158 3x49 G.H5 Y 358 G.H5.23
Van-der-waals TM3 E 158 3x49 G.H5 Y 358 G.H5.23
Hydrophobic H8 R 362 8x49 G.H5 N 359 G.H5.24
Van-der-waals H8 R 362 8x49 G.H5 N 359 G.H5.24
Hydrophobic TM3 V 163 3x54 G.H5 L 351 G.H5.16
Van-der-waals TM3 V 163 3x54 G.H5 L 351 G.H5.16
Hydrophobic TM3 A 162 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 A 162 3x53 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 L 167 34x51 G.H5 K 347 G.H5.12
Hydrophobic TM2 T 95 2x39 G.H5 Y 358 G.H5.23
Van-der-waals TM2 T 95 2x39 G.H5 Y 358 G.H5.23