Structure information

NMU1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7W53

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-29683-W

PUBLICATION DATE

April 20, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Neuromedin U-25 (human) F60 1.32x32 TM1 hydrophobic
Neuromedin U-25 (human) Y67 1.39x39 TM1 polar (hydrogen bond)
Neuromedin U-25 (human) E117 2.61x60 TM2 polar (charge-assisted hydrogen bond)
Neuromedin U-25 (human) E117 2.61x60 TM2 polar (charge-charge)
Neuromedin U-25 (human) E120 2.64x63 TM2 polar (charge-charge)
Neuromedin U-25 (human) E120 2.64x63 TM2 polar (hydrogen bond with backbone)
Neuromedin U-25 (human) E120 2.64x63 TM2 polar (charge-assisted hydrogen bond)
Neuromedin U-25 (human) M121 2.65x64 TM2 Van der Waals
Neuromedin U-25 (human) M121 2.65x64 TM2 polar (hydrogen bond with backbone)
Neuromedin U-25 (human) T138 3.29x29 TM3 polar (hydrogen bond)
Neuromedin U-25 (human) T138 3.29x29 TM3 polar (hydrogen bond)
Neuromedin U-25 (human) F141 3.32x32 TM3 polar (hydrogen bond)
Neuromedin U-25 (human) E142 3.33x33 TM3 polar (charge-assisted hydrogen bond)
Neuromedin U-25 (human) N196 4.60x61 TM4 polar (hydrogen bond)
Neuromedin U-25 (human) N196 4.60x61 TM4 polar (hydrogen bond)
Neuromedin U-25 (human) H200 4.64x65 TM4 polar (hydrogen bond)
Neuromedin U-25 (human) V218 ECL2 polar (charge-assisted hydrogen bond)
Neuromedin U-25 (human) V218 ECL2 polar (hydrogen bond)
Neuromedin U-25 (human) C219 45.50x50 ECL2 polar (hydrogen bond with backbone)
Neuromedin U-25 (human) C219 45.50x50 ECL2 Van der Waals
Neuromedin U-25 (human) M220 45.51x51 ECL2 Van der Waals
Neuromedin U-25 (human) M220 45.51x51 ECL2 hydrophobic
Neuromedin U-25 (human) N229 5.36x36 TM5 Van der Waals
Neuromedin U-25 (human) Q233 5.40x40 TM5 polar (hydrogen bond)
Neuromedin U-25 (human) Q233 5.40x40 TM5 polar (hydrogen bond)
Neuromedin U-25 (human) F313 6.51x51 TM6 hydrophobic
Neuromedin U-25 (human) F313 6.51x51 TM6 Van der Waals
Neuromedin U-25 (human) D316 6.54x54 TM6 polar (charge-assisted hydrogen bond)
Neuromedin U-25 (human) R317 6.55x55 TM6 polar (charge-assisted hydrogen bond)
Neuromedin U-25 (human) W320 6.58x58 TM6 polar (hydrogen bond)
Neuromedin U-25 (human) H331 7.28x27 TM7 polar (hydrogen bond)
Neuromedin U-25 (human) H331 7.28x27 TM7 polar (hydrogen bond)
Neuromedin U-25 (human) F334 7.31x30 TM7 polar (hydrogen bond)
Neuromedin U-25 (human) Q335 7.32x31 TM7 polar (hydrogen bond)
Neuromedin U-25 (human) Q335 7.32x31 TM7 polar (hydrogen bond)
Neuromedin U-25 (human) H338 7.35x34 TM7 polar (hydrogen bond)
Neuromedin U-25 (human) H338 7.35x34 TM7 polar (hydrogen bond)
Neuromedin U-25 (human) H338 7.35x34 TM7 polar (hydrogen bond with backbone)
Neuromedin U-25 (human) V339 7.36x35 TM7 Van der Waals
Neuromedin U-25 (human) S341 7.38x37 TM7 Van der Waals
Neuromedin U-25 (human) G342 7.39x38 TM7 polar (hydrogen bond)
Neuromedin U-25 (human) G342 7.39x38 TM7 polar (hydrogen bond with backbone)
Neuromedin U-25 (human) G342 7.39x38 TM7 polar (charge-assisted hydrogen bond)
Neuromedin U-25 (human) Y346 7.43x42 TM7 polar (charge-assisted hydrogen bond)
Neuromedin U-25 (human) Y346 7.43x42 TM7 polar (hydrogen bond)

Ligands

Neuromedin U-25 (human)

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Residue Diagrams

G N G V A G V V F I L L Y T A C I P M F 1 F S L A V S D L L V L V L G L P L E L Y E 2 A T V N L V S A L C V M E F L L T R F Y 3 V R R V L G A V W G L A M L C S L P N 4 Y L V S M I A M P L C F F L L A T T Q V 5 F V L V V V F G I C W A P F H A D R V M 6 V P N A A S G L Y F F I G S I V H V H 7
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ICL1 K A M R ICL1ECL1 Y P F L L ECL1ICL2 P L Q A R S M V ICL2ECL2 G I R Q L H V P C R G P V P D S A V C M L V R P R A ECL2ICL3 K G R G S A A A R S R Y T C R L ICL3ECL3 S Q W T ECL3N-term M T P L C L N C S V L P G D L Y P G G A R N P M A C N G S A A R G H F D P E D L N L T D E A L R L K Y L G P Q N-termC-term C C H R L R P R H S S H S L S R M T T G S T L C D V G S L G S W V H P L A G N D G P E A Q Q E T D P S C-term Q T E L F M P I C A T Y L L I F V V G A V G N G L T C L V I L R H T P T N Y Y L F S L A V S D L L V L L V G L P L E L Y E M W H N G V G G C Y F R T L L F E M V C L A S V L N V T A L S V E R Y V A V V H T R A H V R R V L G A V W G L A M L C S L P N T S L H L Y N M V V Q T T A L L F F C L P M A I M S V L Y L L I G L R L R R E R L L L M Q E A Q Q H D R G R R Q V T K M L F V L V V V F G I C W A P F H A D R V M W S V V D G L H L A F Q H V H V I S G I F F Y L G S A A N P V L Y S L M S S R F Q E G A F R E T A L C L
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Residue Table


GPCRdb(A)
GPCRdb(A)
NMU1 receptor
TM1
1x32 1.32x32 F60
1x39 1.39x39 Y67
TM2
2x60 2.61x60 E117
2x63 2.64x63 E120
2x64 2.65x64 M121
TM3
3x29 3.29x29 T138
3x32 3.32x32 F141
3x33 3.33x33 E142
TM4
4x61 4.60x61 N196
4x65 4.64x65 H200
ECL2
45x50 45.50x50 C219
45x51 45.51x51 M220
TM5
5x36 5.36x36 N229
5x40 5.40x40 Q233
TM6
6x51 6.51x51 F313
6x54 6.54x54 D316
6x55 6.55x55 R317
6x58 6.58x58 W320
TM7
7x27 7.28x27 H331
7x30 7.31x30 F334
7x31 7.32x31 Q335
7x34 7.35x34 H338
7x35 7.36x35 V339
7x37 7.38x37 S341
7x38 7.39x38 G342
7x42 7.43x42 Y346