ADGRL3 - G13

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

G12/13

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7SF7

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41586-022-04575-7

PUBLICATION DATE

April 27, 2022

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 952 3x54 G.H5 L 227 G.H5.23
Hydrophobic TM5 M 1033 5x61 G.H5 L 227 G.H5.23
Van-der-waals TM5 M 1033 5x61 G.H5 L 227 G.H5.23
Hydrophobic TM3 L 956 3x58 G.H5 L 227 G.H5.23
Hydrophobic TM3 L 956 3x58 G.H5 L 224 G.H5.20
Van-der-waals TM3 L 956 3x58 G.H5 L 224 G.H5.20
Hydrophobic ICL2 V 959 - G.H5 K 216 G.H5.12
Hydrophobic H8 Q 1105 8x47 G.H5 L 229 G.H5.25
Van-der-waals H8 Q 1105 8x47 G.H5 L 229 G.H5.25
Hydrophobic ICL2 F 960 - G.H5 I 219 G.H5.15
Hydrophobic ICL2 F 960 - G.S3 V 79 G.S3.01
Hydrophobic TM3 L 956 3x58 G.H5 N 223 G.H5.19
Hydrophobic TM5 M 1033 5x61 G.H5 M 228 G.H5.24
Polar ICL3 K 1041 - G.h4s6 Q 191 G.h4s6.12
Polar ICL2 S 962 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 S 962 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 S 962 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 H 1036 5x64 G.H5 H 221 G.H5.17
Hydrophobic TM6 W 1053 6x38 G.H5 M 228 G.H5.24
Polar ICL2 E 963 - G.HN T 28 G.HN.52
Van-der-waals ICL2 E 963 - G.HN T 28 G.HN.52
Hydrophobic ICL2 E 963 - G.hns1 R 32 G.hns1.03
Polar TM6 S 1052 6x37 G.H5 Q 230 G.H5.26
Van-der-waals TM6 S 1052 6x37 G.H5 Q 230 G.H5.26
Polar ICL2 E 961 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 E 961 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 E 961 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 960 - G.H5 K 216 G.H5.12
Hydrophobic TM6 G 1056 6x41 G.H5 L 229 G.H5.25
Hydrophobic ICL2 V 959 - G.H5 I 219 G.H5.15
Van-der-waals ICL2 V 959 - G.H5 I 219 G.H5.15
Aromatic ICL2 F 960 - G.H5 F 212 G.H5.08
Hydrophobic ICL2 F 960 - G.H5 F 212 G.H5.08
Van-der-waals ICL2 F 960 - G.H5 F 212 G.H5.08
Hydrophobic TM6 I 1055 6x40 G.H5 L 229 G.H5.25
Van-der-waals TM6 I 1055 6x40 G.H5 L 229 G.H5.25
Hydrophobic TM2 R 896 2x46 G.H5 L 227 G.H5.23
Hydrophobic ICL2 V 959 - G.H5 L 220 G.H5.16
Van-der-waals ICL2 V 959 - G.H5 L 220 G.H5.16
Polar TM3 M 955 3x57 G.H5 N 223 G.H5.19
Hydrophobic TM3 M 955 3x57 G.H5 N 223 G.H5.19
Van-der-waals TM3 M 955 3x57 G.H5 N 223 G.H5.19
Hydrophobic TM3 M 955 3x57 G.H5 L 227 G.H5.23
Van-der-waals TM3 M 955 3x57 G.H5 L 227 G.H5.23