GLP-1 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8JIR

RESOLUTION

2.6 Å

REFERENCE

10.1073/PNAS.2303696120

PUBLICATION DATE

Sept. 6, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

104 interactions (Click to see)

LIGANDS

SAR425899 - Agonist

PHYSIOLOGICAL LIGANDS

glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 N 407 8x48 G.H5 E 359 G.H5.24
Van-der-waals H8 N 407 8x48 G.H5 E 359 G.H5.24
Polar TM6 S 352 6x41 G.H5 L 360 G.H5.25
Hydrophobic TM6 S 352 6x41 G.H5 L 360 G.H5.25
Van-der-waals TM6 S 352 6x41 G.H5 L 360 G.H5.25
Hydrophobic TM3 L 254 3x57 G.H5 Y 358 G.H5.23
Aromatic TM2 R 176 2x46 G.H5 Y 358 G.H5.23
Hydrophobic TM2 R 176 2x46 G.H5 Y 358 G.H5.23
Van-der-waals TM2 R 176 2x46 G.H5 Y 358 G.H5.23
Polar TM3 F 257 3x60 G.H5 R 347 G.H5.12
Hydrophobic TM3 L 251 3x54 G.H5 Y 358 G.H5.23
Ionic TM5 K 334 5x64 G.H5 D 348 G.H5.13
Polar TM5 K 334 5x64 G.H5 D 348 G.H5.13
Hydrophobic TM5 K 334 5x64 G.H5 D 348 G.H5.13
Hydrophobic H8 N 406 8x47 G.H5 E 359 G.H5.24
Van-der-waals H8 N 406 8x47 G.H5 E 359 G.H5.24
Polar TM6 R 348 6x37 G.H5 L 360 G.H5.25
Hydrophobic TM6 R 348 6x37 G.H5 L 360 G.H5.25
Van-der-waals TM6 R 348 6x37 G.H5 L 360 G.H5.25
Polar TM5 K 334 5x64 G.H5 R 352 G.H5.17
Hydrophobic TM5 K 334 5x64 G.H5 R 352 G.H5.17
Polar TM3 L 255 3x58 G.H5 Q 351 G.H5.16
Hydrophobic TM3 L 255 3x58 G.H5 Q 351 G.H5.16
Van-der-waals TM3 L 255 3x58 G.H5 Q 351 G.H5.16
Polar TM6 R 348 6x37 G.H5 L 361 G.H5.26
Hydrophobic TM6 R 348 6x37 G.H5 L 361 G.H5.26
Van-der-waals TM6 R 348 6x37 G.H5 L 361 G.H5.26
Hydrophobic TM3 L 254 3x57 G.H5 H 354 G.H5.19
Van-der-waals TM3 L 254 3x57 G.H5 H 354 G.H5.19
Hydrophobic TM5 V 331 5x61 G.H5 L 355 G.H5.20
Hydrophobic ICL2 V 259 - G.hns1 A 32 G.hns1.03
Hydrophobic TM5 V 331 5x61 G.H5 L 360 G.H5.25
Polar TM3 A 256 3x59 G.H5 R 347 G.H5.12
Hydrophobic TM5 K 334 5x64 G.H5 L 355 G.H5.20
Polar TM5 N 338 5x68 G.h4s6 Y 325 G.h4s6.20
Hydrophobic TM5 N 338 5x68 G.h4s6 Y 325 G.h4s6.20
Van-der-waals TM5 N 338 5x68 G.h4s6 Y 325 G.h4s6.20
Polar TM6 R 348 6x37 G.H5 E 359 G.H5.24
Van-der-waals TM6 R 348 6x37 G.H5 E 359 G.H5.24
Polar TM3 L 254 3x57 G.H5 R 347 G.H5.12
Van-der-waals TM3 Y 250 3x53 G.H5 Y 358 G.H5.23
Polar TM4 S 261 4x38 G.HN Q 28 G.HN.52
Hydrophobic TM4 S 261 4x38 G.HN Q 28 G.HN.52
Polar TM2 R 176 2x46 G.H5 Q 357 G.H5.22
Hydrophobic TM2 R 176 2x46 G.H5 Q 357 G.H5.22
Hydrophobic TM6 L 356 6x45 G.H5 L 360 G.H5.25
Polar TM5 K 334 5x64 G.H5 Q 351 G.H5.16
Hydrophobic TM5 K 334 5x64 G.H5 Q 351 G.H5.16
Van-der-waals TM5 K 334 5x64 G.H5 Q 351 G.H5.16
Hydrophobic TM7 Y 402 7x57 G.H5 Y 358 G.H5.23
Hydrophobic TM5 I 330 5x60 G.H5 L 355 G.H5.20
Hydrophobic TM6 T 355 6x44 G.H5 L 360 G.H5.25
Hydrophobic TM5 V 327 5x57 G.H5 L 360 G.H5.25
Van-der-waals TM5 V 327 5x57 G.H5 L 360 G.H5.25
Hydrophobic TM5 L 335 5x65 G.H5 L 361 G.H5.26
Polar TM3 E 247 3x50 G.H5 Y 358 G.H5.23
Van-der-waals H8 E 408 8x49 G.H5 Q 357 G.H5.22
Hydrophobic TM5 K 334 5x64 G.H5 L 361 G.H5.26
Van-der-waals TM5 K 334 5x64 G.H5 L 361 G.H5.26
Hydrophobic TM3 L 255 3x58 G.H5 H 354 G.H5.19
Hydrophobic TM3 L 255 3x58 G.H5 L 355 G.H5.20
Van-der-waals TM3 L 255 3x58 G.H5 L 355 G.H5.20
Hydrophobic TM6 L 359 6x48 G.H5 Y 358 G.H5.23