β2-adrenoceptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8UNR

RESOLUTION

3.4 Å

REFERENCE

10.1038/S41586-024-07153-1

PUBLICATION DATE

March 6, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

30 interactions (Click to see)

LIGANDS

(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol - Agonist pubchem

PHYSIOLOGICAL LIGANDS

(-)-noradrenaline, L-NOREPINEPHRINE, (-)-adrenaline, noradrenaline, Zn2+



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 275 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 139 - G.S3 V 217 G.S3.01
Polar TM6 T 274 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 274 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM5 V 222 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 233 5x72 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 233 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 P 138 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 138 - G.H5 I 383 G.H5.15
Polar TM5 Q 229 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 229 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 229 5x68 G.H5 R 385 G.H5.17
Aromatic ICL2 F 139 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 139 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 139 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 139 - G.S3 F 219 G.S3.03
Hydrophobic TM3 I 135 3x54 G.H5 Y 391 G.H5.23
Aromatic ICL2 F 139 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 139 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 139 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 Y 141 - G.H5 H 387 G.H5.19
Hydrophobic TM3 I 135 3x54 G.H5 L 393 G.H5.25
Ionic ICL3 R 239 - G.H4 D 343 G.H4.13
Polar ICL3 R 239 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 R 239 - G.H4 D 343 G.H4.13
Hydrophobic ICL3 F 240 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 F 240 - G.H4 D 343 G.H4.13
Hydrophobic TM6 A 271 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 E 237 5x76 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 E 237 5x76 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 F 139 - G.H5 C 379 G.H5.11
Hydrophobic TM5 Q 229 5x68 G.H5 L 388 G.H5.20
Polar TM3 A 134 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 135 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 135 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 A 226 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL3 F 240 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 F 240 - G.H4 L 346 G.H4.16
Hydrophobic ICL2 F 139 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 139 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 139 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 139 - G.H5 I 383 G.H5.15
Hydrophobic TM6 K 270 6x32 G.H5 L 393 G.H5.25
Polar TM3 I 135 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 F 240 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 F 240 - G.h4s6 T 350 G.h4s6.03
Aromatic TM3 R 131 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 230 5x69 G.H5 L 394 G.H5.26
Hydrophobic ICL3 F 240 - G.H4 R 347 G.H4.17
Van-der-waals ICL3 F 240 - G.H4 R 347 G.H4.17
Hydrophobic ICL2 P 138 - G.H5 R 380 G.H5.12
Hydrophobic TM5 I 233 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 233 5x72 G.H5 R 385 G.H5.17